Page last updated: 2024-11-02

pemoline and ADDH

pemoline has been researched along with ADDH in 129 studies

Pemoline: A central nervous system stimulant used in fatigue and depressive states and to treat hyperkinetic disorders in children.
pemoline : A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted by an amino group at position 2 and by a phenyl group at position 5. A central nervous system stimulant, it was used to treat hyperactivity disorders in children, but withdrawn from use following reports of serious hepatotoxicity.

Research Excerpts

ExcerptRelevanceReference
"The onset, duration, and offset of pemoline action to improve cognitive performance is examined intensively in 25 prepubescent males suffering from attention-deficit disorder with hyperactivity (ADDH)."7.68Pharmacodynamics of pemoline in attention deficit disorder with hyperactivity. ( Perel, JM; Sallee, FR; Stiller, RL, 1992)
"Diagnosis of attention deficit disorder in a 35-year-old man and treatment with pemoline substantially improved his response to alcoholism treatment and aftercare."7.66Pemoline in attention deficit disorder and alcoholism: a case study. ( Frances, R; Mobarak, A; Rosenfeld, W; Turnquist, K, 1983)
"Pemoline is a central nervous system (CNS) stimulant approved for use as part of the comprehensive medical management of attention deficit hyperactivity disorder (ADHD)."6.40Pemoline-associated hepatic failure: a critical analysis of the literature. ( Schreiber, R; Shevell, M, 1997)
"Sixty-nine adolescents (aged 13-19) with conduct disorder (CD), SUD, and ADHD were recruited from the community and randomly assigned to a 12-week clinical trial of pemoline (n = 35) or placebo (n = 34), titrated over 4 weeks to a single morning dose of 75 to 112."5.11A randomized controlled trial of pemoline for attention-deficit/hyperactivity disorder in substance-abusing adolescents. ( Hall, SK; Kayser, A; Lohman, M; Mikulich-Gilbertson, SK; Riggs, PD, 2004)
"The onset, duration, and offset of pemoline action to improve cognitive performance is examined intensively in 25 prepubescent males suffering from attention-deficit disorder with hyperactivity (ADDH)."3.68Pharmacodynamics of pemoline in attention deficit disorder with hyperactivity. ( Perel, JM; Sallee, FR; Stiller, RL, 1992)
" These cases were selected from a prior quantitative study in which three antihistamines (meclizine, cyclizine, dimenhydrinate) and three stimulants (pemoline, methylphenidate, dextroamphetamine) were tested in variable combinations (using a specific clinical method) for favorable responses by 100 children characterized by diagnostic evidence of learning disabilities and cerebellar-vestibular dysfunctioning."3.68Dramatic favorable responses of children with learning disabilities or dyslexia and attention deficit disorder to antimotion sickness medications: four case reports. ( Levinson, HN, 1991)
"To test the hypothesis that any change in urinary noradrenergic excretion accompanies drug-induced improvement in attention deficit disorder with hyperactivity, the authors gave pemoline (mean dose, 2."3.67Pemoline and urinary excretion of catecholamines and indoleamines in children with attention deficit disorder. ( Karoum, F; Linnoila, M; Sallee, R; Zametkin, AJ, 1986)
"Diagnosis of attention deficit disorder in a 35-year-old man and treatment with pemoline substantially improved his response to alcoholism treatment and aftercare."3.66Pemoline in attention deficit disorder and alcoholism: a case study. ( Frances, R; Mobarak, A; Rosenfeld, W; Turnquist, K, 1983)
"Risperidone was a safe and effective treatment, with or without a combined psychostimulant, for both disruptive behavior disorders and comorbid ADHD in children."2.71Risperidone effects in the presence/absence of psychostimulant medicine in children with ADHD, other disruptive behavior disorders, and subaverage IQ. ( Aman, MG; Binder, C; Turgay, A, 2004)
"Treatment with pemoline in the final week of the 4-week active phase was best tolerated at doses substantially lower than the target dose of 3 mg/kg per day (mean dose, 2."2.69Controlled trial of high doses of pemoline for adults with attention-deficit/hyperactivity disorder. ( Abrantes, A; Biederman, J; Bostic, J; Frazier, J; Hatch, M; Millstein, RB; Prince, J; Rater, M; Sienna, M; Soriano, J; Spencer, TJ; Wilens, TE, 1999)
"Pemoline was well tolerated, with patients averaging 2."2.69Pemoline treatment of adolescents with attention deficit hyperactivity disorder: a short-term controlled trial. ( Biederman, J; Bostic, JQ; Hatch, M; Monuteaux, MC; Polisner, DA; Prince, JB; Sienna, M; Spencer, TJ; Wilens, TE, 2000)
"To evaluate the dose-response by time-response characteristics of pemoline (Cylert) on dependent measures of behavior and academic performance in a laboratory classroom."2.68Pemoline effects on children with ADHD: a time-response by dose-response analysis on classroom measures. ( Furman, MB; Pelham, WE; Schwindt, H; Swanson, JM, 1995)
" Postmedication assessments were obtained after at least 1 week at maximal dosage (1."2.68An open trial of pemoline in drug-dependent delinquents with attention-deficit hyperactivity disorder. ( Crowley, TJ; Mikulich, SK; Riggs, PD; Thompson, LL; Whitmore, EA, 1996)
"Pemoline is a central nervous system (CNS) stimulant approved for use as part of the comprehensive medical management of attention deficit hyperactivity disorder (ADHD)."2.40Pemoline-associated hepatic failure: a critical analysis of the literature. ( Schreiber, R; Shevell, M, 1997)
" We conclude that pemoline causes toxic liver damage in children."2.40Pemoline hepatotoxicity in children. ( Marotta, PJ; Roberts, EA, 1998)
" Since psychostimulant treatment often requires frequent dosing and may be associated with unacceptable side effects and risks, other classes of medication have been studied as possible treatment alternatives."2.40Psychopharmacology of ADHD: children and adolescents. ( Dogin, JW; Findling, RL, 1998)
" Thirty-two reports (29 studies) evaluated adverse effects of drug therapy; many of the side effects associated with stimulant use appear to be relatively mild and of short duration and to respond to dosing or timing adjustments."2.40Treatment of attention-deficit/hyperactivity disorder. ( Boyle, M; Cunningham, C; Jadad, AR; Kim, M; Schachar, R, 1999)
"Pemoline is a central nervous system stimulant used in treating children with attention deficit-hyperactivity disorder."2.39Pemoline-associated fulminant liver failure: testing the evidence for causation. ( Berkovitch, M; Koren, G; Phillips, J; Pope, E, 1995)
"Those disorders discussed are attention deficit disorder, conduct disorders, anxiety disorders, sleep disorders, schizophrenia, autism, Tourette's syndrome, mental retardation, depressive illness, manic depressive illness, eating disorders, and enuresis."2.37Pharmacologic treatment of psychiatric and neurodevelopmental disorders in children and adolescents (Part 1). ( McDaniel, KD, 1986)
"It typically takes many years before an association of a drug with a rare, serious adverse reaction is established."1.37Safety assessment in pediatric studies. ( Elzagallaai, A; Etwel, F; Koren, G, 2011)
"All case reports of acute liver failure associated with pemoline and reported to the US FDA from 1975 through 1999 were reviewed."1.35A surveillance method for the early identification of idiosyncratic adverse drug reactions. ( Bend, JR; Etwel, FA; Koren, G; Rieder, MJ, 2008)
"Pemoline therapy was discontinued, but the patient's liver function continued to decline."1.30Pemoline therapy resulting in liver transplantation. ( Adcock, KG; Farrington, EA; MacElroy, DE; Wolford, ET, 1998)
"To determine whether treatment of attention deficit hyperactivity disorder (ADHD) with methylphenidate hydrochloride or pemoline diminishes the response to growth hormone (GH) therapy in patients with idiopathic GH deficiency (IGHD) or idiopathic short stature (ISS)."1.30Response to growth hormone in attention deficit hyperactivity disorder: effects of methylphenidate and pemoline therapy. ( Blethen, SL; Breen, TJ; Julius, JR; Rao, JK, 1998)
" Personal or family tic history, medication selection, or dosage was not related to onset of T/D."1.29Tics and dyskinesias associated with stimulant treatment in attention-deficit hyperactivity disorder. ( Adesman, AR; Goldstein, IJ; Lipkin, PH, 1994)
"Treatment with pemoline produced no P300 changes."1.29Abnormal auditory P300 topography in attention deficit disorder predicts poor response to pemoline. ( Persky, B; Sangal, JM; Sangal, RB, 1995)
"Treatment with imipramine decreased auditory P300 latencies and increased auditory P300 amplitudes."1.29Prolonged P300 latency in attention deficit hyperactivity disorder predicts poor response to imipramine. ( Persky, B; Sangal, JM; Sangal, RB, 1996)
"Pemoline (Cylert) is an agent used to treat attention deficit disorders and other behavioral syndromes."1.28Hepatotoxicity due to pemoline (Cylert): a report of two cases. ( Dubois, RS; Pratt, DS, 1990)
"Pemoline was given orally in increasing doses ranging from 20 to 80 mg/day."1.27EEG and clinical findings during pemoline treatment in children and adults with attention deficit disorder. An 8-week open trial. ( Barteselli, F; Besana, R; Caresia, L; Guareschi Cazzullo, A; Musetti, L; Pugnetti, L; Scarone, S, 1984)
" While there have been a few reports of tolerance, it is possible that these were a reflection of inadequate dosing rather than actual tolerance to the drug's therapeutic effects."1.27Evidence of lack of abuse or dependence following pemoline treatment: results of a retrospective survey. ( Bartenbach, DE; Davis, PM; Langer, DH; Menander, KB; Sweeney, KP, 1986)
"Children who have attention deficit disorder with (or without) hyperactivity are handicapped by their inability to concentrate and control their impulsivity, especially while in school."1.27Clinical management of children with hyperactivity. A shift in diagnostic and therapeutic emphasis. ( Hesterly, SO, 1986)
"Research suggests that attention deficit disorder (ADD) may persist into adulthood, perhaps predisposing certain individuals to stimulant abuse."1.27Treatment of chronic cocaine abuse and attention deficit disorder, residual type, with magnesium pemoline. ( Mirin, SM; Pope, HG; Weiss, RD, 1985)
"The growth of 22 children with attention deficit disorder (ADD) was monitored longitudinally for up to four years."1.26Effect on growth in pemoline-treated children with attention deficit disorder. ( Carr, R; Elders, J; Friedmann, N; Ringdahl, I; Roche, A; Thomas, J, 1981)

Research

Studies (129)

TimeframeStudies, this research(%)All Research%
pre-199054 (41.86)18.7374
1990's49 (37.98)18.2507
2000's23 (17.83)29.6817
2010's3 (2.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Shaw, P1
Sharp, WS1
Morrison, M1
Eckstrand, K1
Greenstein, DK1
Clasen, LS1
Evans, AC1
Rapoport, JL2
McDonnell, MA1
Moffett, C1
Marcus, SC1
Durkin, M1
Koren, G3
Elzagallaai, A1
Etwel, F1
Willy, ME1
Manda, B1
Shatin, D1
Drinkard, CR1
Graham, DJ1
Schubiner, H1
Saules, KK1
Arfken, CL1
Johanson, CE1
Schuster, CR1
Lockhart, N1
Edwards, A1
Donlin, J1
Pihlgren, E1
Adler, LA1
Chua, HC1
Barkley, RA3
Sarkis, EH1
Maidment, ID1
Sangal, RB3
Sangal, JM3
Spencer, T1
Biederman, J5
Wilens, T1
Riggs, PD2
Hall, SK1
Mikulich-Gilbertson, SK1
Lohman, M1
Kayser, A1
Aman, MG1
Binder, C1
Turgay, A1
Gross-Tsur, V1
Joseph, A1
Shalev, RS1
Wilens, TE3
Hammerness, PG1
Kwon, A1
Spencer, TJ3
Clark, S1
Scott, M1
Podolski, A1
Ditterline, JW1
Morris, MC1
Moore, H1
Brown, RT2
Amler, RW1
Freeman, WS1
Perrin, JM1
Stein, MT1
Feldman, HM1
Pierce, K1
Wolraich, ML2
Bonnet, U1
Davids, E1
Epstein, JN1
Conners, CK6
Hervey, AS1
Tonev, ST1
Arnold, LE2
Abikoff, HB2
Elliott, G2
Greenhill, LL5
Hechtman, L2
Hoagwood, K1
Hinshaw, SP2
Hoza, B2
Jensen, PS2
March, JS2
Newcorn, JH2
Pelham, WE6
Severe, JB2
Swanson, JM5
Wells, K1
Vitiello, B1
Wigal, T1
Milstein, V1
Small, JG1
Novak, SP1
Kroutil, LA1
Williams, RL1
Van Brunt, DL1
Etwel, FA1
Rieder, MJ1
Bend, JR1
Steinhausen, HC1
Gauthier, M1
Turnquist, K1
Frances, R1
Rosenfeld, W1
Mobarak, A1
Martin, CA1
Welsh, RJ1
McKay, SE1
Bareuther, CM1
Brown, RP1
Ingber, PS1
Tross, S1
Caresia, L1
Pugnetti, L1
Besana, R1
Barteselli, F1
Guareschi Cazzullo, A1
Musetti, L1
Scarone, S1
Farmer, P1
Unis, AS1
Hsu, G1
Stephens, RS1
Skinner, R1
El-Defrawi, MH1
Peeke, S1
Halliday, R1
Callaway, E1
Prael, R1
Reus, V1
Sternbach, H1
Mitchell, E1
Matthews, KL1
Bachman, DS1
Wender, PH4
Reimherr, FW3
Wood, DR3
Dubey, DR1
Friedmann, N1
Thomas, J1
Carr, R1
Elders, J1
Ringdahl, I1
Roche, A1
White, JH1
Puig-Antich, J1
Halpern, F1
Sachar, EJ1
Rubinstein, B1
Chambers, W1
Fiscina, B1
Florea, J1
Taylor, E2
Elia, J2
Kwasman, A1
Tinsley, BJ1
Lepper, HS1
Zametkin, AJ2
Berkovitch, M1
Pope, E1
Phillips, J1
Walkup, JT1
Scahill, LD1
Riddle, MA1
Lipkin, PH1
Goldstein, IJ1
Adesman, AR1
Kelly, D1
Forney, J1
Parker-Fisher, S1
Jones, M1
Furman, MB1
Schwindt, H1
Persky, B2
Heiligenstein, E3
Johnston, HF1
Nielsen, JK1
Faigel, HC1
Thompson, LL1
Mikulich, SK1
Whitmore, EA1
Crowley, TJ1
Castellanos, FX1
Kruesi, MJ1
Marsh, WL1
Gulotta, CS1
Potter, WZ1
Ritchie, GF1
Hamburger, SD1
Shevell, M1
Schreiber, R1
Anders, J1
McCurry, L1
Cronquist, S1
Cantwell, DP1
Kraemer, HC1
Richters, JE1
Schiller, E1
Vereen, D1
Wells, KC1
Winsberg, B1
Barbato, M1
Hochman, JA1
Woodard, SA1
Cohen, MB1
Adcock, KG1
MacElroy, DE1
Wolford, ET1
Farrington, EA1
Rosh, JR1
Dellert, SF1
Narkewicz, M1
Birnbaum, A1
Whitington, G1
Marotta, PJ1
Roberts, EA1
Findling, RL1
Dogin, JW1
Rao, JK1
Julius, JR1
Breen, TJ1
Blethen, SL1
Cubbin, S1
Leahy, A1
Pliszka, SR1
Shuster, J1
Frazier, J1
Prince, J1
Bostic, J1
Rater, M1
Soriano, J1
Hatch, M2
Sienna, M2
Millstein, RB1
Abrantes, A1
Levin, FR1
Evans, SM1
Kleber, HD1
Cherland, E1
Fitzpatrick, R1
Littner, M1
Castaneda, R1
Levy, R1
Hardy, M1
Trujillo, M1
Jadad, AR1
Boyle, M1
Cunningham, C1
Kim, M1
Schachar, R1
Bostic, JQ1
Prince, JB1
Monuteaux, MC1
Polisner, DA1
Hogan, V1
Pliszka, S1
Dulcan, MK2
Bernet, W1
Arnold, V1
Beitchman, J1
Benson, RS1
Bukstein, O1
Kinlan, J1
McClellan, J1
Rue, D1
Shaw, JA1
Stock, S1
Hastings, JE1
Oettinger, L1
Johnson, GE1
Seals, JR1
Millichap, JG1
Sallee, FR2
Stiller, RL2
Perel, JM2
Vallée, L1
Pandit, F1
Levinson, HN1
Evans, SW1
Abikoff, H2
Anastopoulos, AD1
DuPaul, GJ1
Cantwell, D2
Lerner, M2
McBurnett, K1
Hanna, G1
Whalen, CK1
Henker, B1
Bloomingdale, LM1
Greenslade, KE1
Vodde-Hamilton, M1
Murphy, DA1
Greenstein, JJ1
Gnagy, EM1
Guthrie, KJ1
Hoover, MD1
Dahl, RE1
Heath, CT1
Wright, HH1
Batey, SR1
Pratt, DS1
Dubois, RS1
Waltz, G1
Elitsur, Y1
McDaniel, KD1
Linnoila, M1
Karoum, F1
Sallee, R1
Davy, T1
Rodgers, CL1
Phillips, S1
Stevenson, RD1
Everett, G1
Jaffe, SL1
Gittelman, R1
Golden, GS1
Merrill, RD1
Garfinkel, B1
Copeland, L1
Wolraich, M1
Lindgren, S1
Milich, R1
Woolson, R1
Saul, RC1
Ashby, CD1
Silver, LB1
Brunstetter, RW1
Langer, DH1
Sweeney, KP1
Bartenbach, DE1
Davis, PM1
Menander, KB1
Hesterly, SO1
Borden, KA1
Spunt, AL1
Medenis, R1
Sallee, F1
Stiller, R1
Perel, J1
Bates, T1
Weiss, RD1
Pope, HG1
Mirin, SM1
McConnell, H1
Plotnikoff, N1
Meo, G1
Kurtz, MA1
Fournier, M1
Peters, JE1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Integrated Brain, Body and Social Intervention (IBBS) for Attention Deficit Hyperactivity Disorder (ADHD)[NCT01542528]117 participants (Actual)Interventional2012-03-31Completed
Effects of Expectation, Medication and Placebo on Objective and Self-rated Performance During the Quantified Behavior Test in Patients With Untreated ADHD and Substance Use Disorder[NCT02477280]Phase 439 participants (Actual)Interventional2016-09-30Completed
Effects of Expectation, Medication and Placebo on Objective and Self-rated Performance During the Quantified Behavior Test in Patients With Untreated ADHD[NCT02473185]Phase 440 participants (Actual)Interventional2015-09-30Completed
Substance Dependent Teens - Impact of Treating Depression Study 1[NCT00061113]Phase 4126 participants (Actual)Interventional2001-02-28Completed
Multimodal Treatment Study of Children With ADHD[NCT00000388]Phase 40 participants Interventional1998-09-30Completed
The Effects of Methylphenidate (MPH) and Non-invasive Brain Stimulation (tDCS) on Inhibitory Control Children With Attention-Deficit/Hyperactivity Disorder (ADHD)[NCT04964427]26 participants (Actual)Interventional2021-02-08Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Improvement in ADHD Severity From Baseline to End of Intervention

ADHD severity was measured by the Swanson, Nolan, and Pelham Rating Scale (SNAP)-IV-ADHD consists of 18 items that closely parallel in wording the diagnostic symptoms for ADHD as they appear in the DSM-IV. The range of scores are from 0 to 54. Higher scores indicate greater ADHD severity . The blinded assessors (Clinicians) used clinical judgement to provide an overall rating, based on all available information from the parents, teachers, and the assessors' own direct interactions with the child on the day of the assessment. (NCT01542528)
Timeframe: End of intervention is at a maximum of 15 weeks from baseline.

Interventionunits on a scale (Mean)
IBBS3.0
Treatment as Usual (TAU)3.2

Overall Improvement

Clinical Global Improvement Scale (CGI-I) - responders vs. non-responders. CGI is a seven point scale with the following anchor point: 1=Very Much Improved, 2=Much Improved, 3=Improved, 4=No change, 5=Minimally worse, 6=Much worse, 7=Very much worse. Participants with a score of 1, 2, or 3 at Endpoint were considered Responders; all others were considered non-responders. (NCT01542528)
Timeframe: 15 weeks for a total of 60 IBBS sessions vs. treatment as usual (TAU)

InterventionPercentage of participants (Number)
IBBS60.8
Treatment as Usual (TAU)59.6

Reviews

26 reviews available for pemoline and ADDH

ArticleYear
Management of ADHD in adults.
    The Journal of clinical psychiatry, 2002, Volume: 63 Suppl 12

    Topics: Adolescent; Adult; Age Factors; Amphetamines; Antidepressive Agents; Antihypertensive Agents; Attent

2002
Management of ADHD in adults.
    The Journal of clinical psychiatry, 2002, Volume: 63 Suppl 12

    Topics: Adolescent; Adult; Age Factors; Amphetamines; Antidepressive Agents; Antihypertensive Agents; Attent

2002
Management of ADHD in adults.
    The Journal of clinical psychiatry, 2002, Volume: 63 Suppl 12

    Topics: Adolescent; Adult; Age Factors; Amphetamines; Antidepressive Agents; Antihypertensive Agents; Attent

2002
Management of ADHD in adults.
    The Journal of clinical psychiatry, 2002, Volume: 63 Suppl 12

    Topics: Adolescent; Adult; Age Factors; Amphetamines; Antidepressive Agents; Antihypertensive Agents; Attent

2002
Psychosocial treatments for attention-deficit/hyperactivity disorder in children.
    The Journal of clinical psychiatry, 2002, Volume: 63 Suppl 12

    Topics: Adolescent; Adult; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Behavior Th

2002
Efficacy of stimulants in adult ADHD.
    The Annals of pharmacotherapy, 2003, Volume: 37, Issue:12

    Topics: Adult; Amphetamines; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulant

2003
Treatment of attention-deficit/hyperactivity disorder: overview of the evidence.
    Pediatrics, 2005, Volume: 115, Issue:6

    Topics: Adolescent; Antidepressive Agents, Tricyclic; Atomoxetine Hydrochloride; Attention Deficit Disorder

2005
Stimulant medications in adults with attention deficit disorder.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1984, Volume: 29, Issue:5

    Topics: Adolescent; Adult; Amitriptyline; Attention Deficit Disorder with Hyperactivity; Central Nervous Sys

1984
Hyperactivity (attention-deficit disorder).
    The Journal of family practice, 1984, Volume: 19, Issue:3

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Family; Female; Humans; Hyp

1984
Drug treatment for hyperactive children. Therapeutic guidelines.
    Drugs, 1993, Volume: 46, Issue:5

    Topics: Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Child; Dextroamphet

1993
Pemoline-associated fulminant liver failure: testing the evidence for causation.
    Clinical pharmacology and therapeutics, 1995, Volume: 57, Issue:6

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Fatal Outcome; Hepatic Encephalopathy; Hu

1995
Disruptive behavior, hyperactivity, and learning disabilities in children with Tourette's syndrome.
    Advances in neurology, 1995, Volume: 65

    Topics: Adolescent; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Child;

1995
Pemoline-associated hepatic failure: a critical analysis of the literature.
    Pediatric neurology, 1997, Volume: 16, Issue:1

    Topics: Adverse Drug Reaction Reporting Systems; Attention Deficit Disorder with Hyperactivity; Central Nerv

1997
Pemoline hepatotoxicity in children.
    The Journal of pediatrics, 1998, Volume: 132, Issue:5

    Topics: Adolescent; Alkaline Phosphatase; Attention Deficit Disorder with Hyperactivity; Central Nervous Sys

1998
Attention-deficit/hyperactivity disorder: a life-span perspective.
    The Journal of clinical psychiatry, 1998, Volume: 59 Suppl 7

    Topics: Adolescent; Adult; Age Factors; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hy

1998
Psychopharmacology of ADHD: children and adolescents.
    The Journal of clinical psychiatry, 1998, Volume: 59 Suppl 7

    Topics: Adolescent; Age Factors; Amphetamines; Antidepressive Agents, Tricyclic; Attention Deficit Disorder

1998
Pharmacotherapy of attention-deficit/hyperactivity disorder in adults.
    The Journal of clinical psychiatry, 1998, Volume: 59 Suppl 7

    Topics: Adult; Age Factors; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants

1998
The use of psychostimulants in the pediatric patient.
    Pediatric clinics of North America, 1998, Volume: 45, Issue:5

    Topics: Adolescent; Amphetamines; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stim

1998
Treatment of attention-deficit/hyperactivity disorder.
    Evidence report/technology assessment (Summary), 1999, Issue:11

    Topics: Adrenergic Uptake Inhibitors; Adult; Antidepressive Agents, Tricyclic; Attention Deficit Disorder wi

1999
Practice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2002, Volume: 41, Issue:2 Suppl

    Topics: Adolescent; Adult; Amphetamines; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervo

2002
Pediatric psychopharmacology. A review with special reference to deanol.
    Diseases of the nervous system, 1977, Volume: 38, Issue:12 Pt 2

    Topics: Adolescent; Adult; Amphetamines; Animals; Antidepressive Agents, Tricyclic; Attention Deficit Disord

1977
MBD: advanced in understanding many bothersome dilemmas.
    Advances in pediatrics, 1976, Volume: 23

    Topics: Adolescent; Adult; Attention; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool

1976
Cognitive training in ADHD children: less to it than meets the eye.
    Journal of learning disabilities, 1991, Volume: 24, Issue:4

    Topics: Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Child; Combined Modality Therapy; D

1991
Stimulant medication and parent training therapies for attention deficit-hyperactivity disorder.
    Journal of learning disabilities, 1991, Volume: 24, Issue:4

    Topics: Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Child; Combined Modality Therapy; D

1991
Effects of stimulant medication on learning in children with ADHD.
    Journal of learning disabilities, 1991, Volume: 24, Issue:4

    Topics: Achievement; Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Humans; Learni

1991
Attention deficit hyperactivity disorder: does it affect adults too?
    Southern medical journal, 1990, Volume: 83, Issue:12

    Topics: Adolescent; Adult; Age Factors; Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetam

1990
Pharmacologic treatment of psychiatric and neurodevelopmental disorders in children and adolescents (Part 1).
    Clinical pediatrics, 1986, Volume: 25, Issue:2

    Topics: Adolescent; Aggression; Antidepressive Agents; Antipsychotic Agents; Anxiety, Separation; Attention

1986
Stimulant medication therapy in the treatment of children with attention deficit hyperactivity disorder.
    Pediatric clinics of North America, 1989, Volume: 36, Issue:5

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Dopamine; Growth; Humans; M

1989
Pemoline: review of performance.
    Texas reports on biology and medicine, 1971,Winter, Volume: 29, Issue:4

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior; Brain Diseases; Conditioning, Psyc

1971

Trials

26 trials available for pemoline and ADDH

ArticleYear
Double-blind placebo-controlled trial of methylphenidate in the treatment of adult ADHD patients with comorbid cocaine dependence.
    Experimental and clinical psychopharmacology, 2002, Volume: 10, Issue:3

    Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants;

2002
Attention-deficit/hyperactivity disorder: cognitive evoked potential (P300) topography predicts treatment response to methylphenidate.
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2004, Volume: 115, Issue:1

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Cognition;

2004
Stimulant treatment of adult attention-deficit/hyperactivity disorder.
    The Psychiatric clinics of North America, 2004, Volume: 27, Issue:2

    Topics: Adult; Amphetamine; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants

2004
A randomized controlled trial of pemoline for attention-deficit/hyperactivity disorder in substance-abusing adolescents.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2004, Volume: 43, Issue:4

    Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants;

2004
Risperidone effects in the presence/absence of psychostimulant medicine in children with ADHD, other disruptive behavior disorders, and subaverage IQ.
    Journal of child and adolescent psychopharmacology, 2004,Summer, Volume: 14, Issue:2

    Topics: Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorde

2004
Blood pressure changes associated with medication treatment of adults with attention-deficit/hyperactivity disorder.
    The Journal of clinical psychiatry, 2005, Volume: 66, Issue:2

    Topics: Adult; Amphetamines; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Blood Pre

2005
Assessing medication effects in the MTA study using neuropsychological outcomes.
    Journal of child psychology and psychiatry, and allied disciplines, 2006, Volume: 47, Issue:5

    Topics: Amphetamine; Analysis of Variance; Attention Deficit Disorder with Hyperactivity; Central Nervous Sy

2006
Assessing medication effects in the MTA study using neuropsychological outcomes.
    Journal of child psychology and psychiatry, and allied disciplines, 2006, Volume: 47, Issue:5

    Topics: Amphetamine; Analysis of Variance; Attention Deficit Disorder with Hyperactivity; Central Nervous Sy

2006
Assessing medication effects in the MTA study using neuropsychological outcomes.
    Journal of child psychology and psychiatry, and allied disciplines, 2006, Volume: 47, Issue:5

    Topics: Amphetamine; Analysis of Variance; Attention Deficit Disorder with Hyperactivity; Central Nervous Sy

2006
Assessing medication effects in the MTA study using neuropsychological outcomes.
    Journal of child psychology and psychiatry, and allied disciplines, 2006, Volume: 47, Issue:5

    Topics: Amphetamine; Analysis of Variance; Attention Deficit Disorder with Hyperactivity; Central Nervous Sy

2006
Stimulant medications in adults with attention deficit disorder.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1984, Volume: 29, Issue:5

    Topics: Adolescent; Adult; Amitriptyline; Attention Deficit Disorder with Hyperactivity; Central Nervous Sys

1984
State-dependent and main effects of methylphenidate and pemoline on paired-associate learning and spelling in hyperactive children.
    Journal of consulting and clinical psychology, 1984, Volume: 52, Issue:1

    Topics: Association Learning; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Female

1984
Effects of two doses of methylphenidate on verbal information processing in hyperactive children.
    Journal of clinical psychopharmacology, 1984, Volume: 4, Issue:2

    Topics: Attention; Attention Deficit Disorder with Hyperactivity; Child; Dose-Response Relationship, Drug; D

1984
Attention deficit disorder ('minimal brain dysfunction') in adults. A replication study of diagnosis and drug treatment.
    Archives of general psychiatry, 1981, Volume: 38, Issue:4

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Clinical Trials as Topic; Double-Blind Method;

1981
Pemoline, methylphenidate, and placebo in children with minimal brain dysfunction.
    Archives of general psychiatry, 1980, Volume: 37, Issue:8

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Double-Blind Method; Female; Humans; Male; Met

1980
Pemoline effects on children with ADHD: a time-response by dose-response analysis on classroom measures.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1995, Volume: 34, Issue:11

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Child, Pres

1995
An open trial of pemoline in drug-dependent delinquents with attention-deficit hyperactivity disorder.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1996, Volume: 35, Issue:8

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Humans

1996
Cerebrospinal fluid homovanillic acid predicts behavioral response to stimulants in 45 boys with attention deficit/hyperactivity disorder.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1996, Volume: 14, Issue:2

    Topics: Attention Deficit Disorder with Hyperactivity; Behavior; Biogenic Monoamines; Central Nervous System

1996
National Institute of Mental Health Collaborative Multimodal Treatment Study of Children with ADHD (the MTA). Design challenges and choices.
    Archives of general psychiatry, 1997, Volume: 54, Issue:9

    Topics: Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Child; Clinical Protocols; Combined

1997
Pemoline in ADHD.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1997, Volume: 36, Issue:12

    Topics: Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorder with Hyperactivity;

1997
Controlled trial of high doses of pemoline for adults with attention-deficit/hyperactivity disorder.
    Journal of clinical psychopharmacology, 1999, Volume: 19, Issue:3

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cross-Over

1999
Pemoline treatment of adolescents with attention deficit hyperactivity disorder: a short-term controlled trial.
    Journal of child and adolescent psychopharmacology, 2000,Fall, Volume: 10, Issue:3

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child;

2000
Diagnosis and treatment of minimal brain dysfunction in adults: a preliminary report.
    Archives of general psychiatry, 1976, Volume: 33, Issue:12

    Topics: Adult; Alcoholism; Antisocial Personality Disorder; Anxiety; Attention Deficit Disorder with Hyperac

1976
Pemoline (Cylert) for minimal brain dysfunction.
    The Medical letter on drugs and therapeutics, 1976, Jan-16, Volume: 18, Issue:2

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Clinical Trials as Topic; Dextroamphetamine; D

1976
Psychostimulant effects on academic and behavioral measures for ADHD junior high school students in a lecture format classroom.
    Journal of abnormal child psychology, 1991, Volume: 19, Issue:5

    Topics: Achievement; Adolescent; Attention; Attention Deficit Disorder with Hyperactivity; Dose-Response Rel

1991
Relative efficacy of long-acting stimulants on children with attention deficit-hyperactivity disorder: a comparison of standard methylphenidate, sustained-release methylphenidate, sustained-release dextroamphetamine, and pemoline.
    Pediatrics, 1990, Volume: 86, Issue:2

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Child Behavior; Delayed-Action Pre

1990
Hyperactive children treated with stimulants. Is cognitive training a useful adjunct?
    Archives of general psychiatry, 1985, Volume: 42, Issue:10

    Topics: Achievement; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Central Nervous System

1985
Symposium: behavior modification by drugs. II. Psychological effects of stimulant drugs in children with minimal brain dysfunction.
    Pediatrics, 1972, Volume: 49, Issue:5

    Topics: Achievement; Attention Deficit Disorder with Hyperactivity; Bender-Gestalt Test; Brain Damage, Chron

1972
Magnesium pemoline and dextroamphetamine: a controlled study in children with minimal brain dysfunction.
    Psychopharmacologia, 1972, Volume: 26, Issue:4

    Topics: Analysis of Variance; Anxiety; Attention; Attention Deficit Disorder with Hyperactivity; Child; Dext

1972

Other Studies

78 other studies available for pemoline and ADDH

ArticleYear
Psychostimulant treatment and the developing cortex in attention deficit hyperactivity disorder.
    The American journal of psychiatry, 2009, Volume: 166, Issue:1

    Topics: Adolescent; Amphetamines; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stim

2009
Coming into focus. Pharmacologic treatment for ADHD.
    Advance for NPs & PAs, 2010, Volume: 1, Issue:4

    Topics: Adrenergic alpha-2 Receptor Agonists; Antidepressive Agents; Attention Deficit Disorder with Hyperac

2010
Stimulant adherence and academic performance in urban youth with attention-deficit/hyperactivity disorder.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2011, Volume: 50, Issue:5

    Topics: Achievement; Adolescent; Amphetamine; Anxiety Disorders; Attention Deficit and Disruptive Behavior D

2011
Safety assessment in pediatric studies.
    Handbook of experimental pharmacology, 2011, Volume: 205

    Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Canada; Cell Death; Drug Hypersensit

2011
A study of compliance with FDA recommendations for pemoline (Cylert).
    Journal of the American Academy of Child and Adolescent Psychiatry, 2002, Volume: 41, Issue:7

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Guidelines

2002
Compliance with FDA recommendations for pemoline.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2003, Volume: 42, Issue:4

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child;

2003
Hallucinations during methylphenidate therapy.
    Neurology, 2004, Aug-24, Volume: 63, Issue:4

    Topics: Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorder with Hyperactivity;

2004
A rare case of dependence on pemoline.
    Progress in neuro-psychopharmacology & biological psychiatry, 2006, Sep-30, Volume: 30, Issue:7

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Female; Hum

2006
Photic responses in "minimal brain dysfunction".
    Diseases of the nervous system, 1974, Volume: 35, Issue:8

    Topics: Attention Deficit Disorder with Hyperactivity; Brain; Central Nervous System Stimulants; Child; Elec

1974
The nonmedical use of prescription ADHD medications: results from a national Internet panel.
    Substance abuse treatment, prevention, and policy, 2007, Oct-31, Volume: 2

    Topics: Adolescent; Adult; Alcoholism; Amphetamine-Related Disorders; Appetite Depressants; Attention Defici

2007
A surveillance method for the early identification of idiosyncratic adverse drug reactions.
    Drug safety, 2008, Volume: 31, Issue:2

    Topics: Adverse Drug Reaction Reporting Systems; Attention Deficit Disorder with Hyperactivity; Central Nerv

2008
[Stimulant therapy in children].
    Pharmacopsychiatria, 1982, Volume: 15, Issue:6

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Dextroamphe

1982
Pemoline in attention deficit disorder and alcoholism: a case study.
    The American journal of psychiatry, 1983, Volume: 140, Issue:5

    Topics: Adult; Aftercare; Alcoholism; Antisocial Personality Disorder; Attention Deficit Disorder with Hyper

1983
Pemoline and lithium in a patient with attention deficit disorder.
    The Journal of clinical psychiatry, 1983, Volume: 44, Issue:4

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Chlorpromazine; Diagnos

1983
EEG and clinical findings during pemoline treatment in children and adults with attention deficit disorder. An 8-week open trial.
    Neuropsychobiology, 1984, Volume: 11, Issue:3

    Topics: Adolescent; Adult; Anxiety Disorders; Attention Deficit Disorder with Hyperactivity; Child; Depressi

1984
Pemoline, depressive symptoms, and escape from dexamethasone suppression.
    Journal of clinical psychopharmacology, 1983, Volume: 3, Issue:5

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Depression; Dexamethasone; Humans; Hydroc

1983
Substituting stimulants in treating behavior disorders.
    The American journal of psychiatry, 1984, Volume: 141, Issue:4

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Dyskinesia, Drug-Induced; Humans; Male; Methyl

1984
Pemoline-induced mania.
    Biological psychiatry, 1981, Volume: 16, Issue:10

    Topics: Acting Out; Adult; Affective Disorders, Psychotic; Attention; Attention Deficit Disorder with Hypera

1981
Gilles de la Tourette's disorder associated with pemoline.
    The American journal of psychiatry, 1980, Volume: 137, Issue:12

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Humans; Male; Pemoline; Tourette Syndrome

1980
Pemoline-induced Tourette's disorder: a case report.
    The American journal of psychiatry, 1981, Volume: 138, Issue:8

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Diseases in Twins; Haloperidol; Humans; M

1981
The hyperkinetic child: current status.
    Comprehensive therapy, 1982, Volume: 8, Issue:5

    Topics: Attention; Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Dose-Response Re

1982
Effect on growth in pemoline-treated children with attention deficit disorder.
    American journal of diseases of children (1960), 1981, Volume: 135, Issue:4

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Body Height; Body Weight; Child; Female;

1981
The hyperactive child in adolescence: some pharmacologic approaches.
    Journal of adolescence, 1981, Volume: 4, Issue:1

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Child Behavior Disorder

1981
Growth disturbances in hyperkinetic children.
    Pediatrics, 1980, Volume: 66, Issue:1

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Growth Disorders; Humans; H

1980
Pediatricians' knowledge and attitudes concerning diagnosis and treatment of attention deficit and hyperactivity disorders. A national survey approach.
    Archives of pediatrics & adolescent medicine, 1995, Volume: 149, Issue:11

    Topics: Adult; Aged; Amphetamines; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperac

1995
Attention-deficit disorder. Born to be hyperactive?
    JAMA, 1995, Jun-21, Volume: 273, Issue:23

    Topics: Adult; Aged; Attention Deficit Disorder with Hyperactivity; Child; Diagnosis, Differential; Educatio

1995
Tics and dyskinesias associated with stimulant treatment in attention-deficit hyperactivity disorder.
    Archives of pediatrics & adolescent medicine, 1994, Volume: 148, Issue:8

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Chronic Disease;

1994
Evaluating and managing attention deficit disorder in children who are deaf or hard of hearing.
    American annals of the deaf, 1993, Volume: 138, Issue:4

    Topics: Achievement; Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Counseling; Deafness;

1993
Abnormal auditory P300 topography in attention deficit disorder predicts poor response to pemoline.
    Clinical EEG (electroencephalography), 1995, Volume: 26, Issue:4

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Brain Mapping; Central Nervous System Sti

1995
Pemoline therapy in college students with attention deficit hyperactivity disorder: a retrospective study.
    Journal of American college health : J of ACH, 1996, Volume: 45, Issue:1

    Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants;

1996
Medication for attention deficit hyperactivity disorder: commentary and response.
    Journal of American college health : J of ACH, 1996, Volume: 45, Issue:1

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Humans; Pem

1996
Pemoline in adult attention deficit hyperactivity disorder: predictors of nonresponse.
    Journal of American college health : J of ACH, 1997, Volume: 45, Issue:5

    Topics: Adolescent; Adult; Age Factors; Analysis of Variance; Attention Deficit Disorder with Hyperactivity;

1997
Pemoline and hepatotoxicity.
    The American journal of psychiatry, 1997, Volume: 154, Issue:5

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Chemical and Drug Induced Liver Injury; Drug T

1997
Exacerbation of autoimmune hepatitis: another hepatotoxic effect of pemoline therapy.
    Pediatrics, 1998, Volume: 101, Issue:1 Pt 1

    Topics: Acute Kidney Injury; Attention Deficit Disorder with Hyperactivity; Autoimmune Diseases; Central Ner

1998
Prolonged P300 latency in attention deficit hyperactivity disorder predicts poor response to imipramine.
    Clinical EEG (electroencephalography), 1996, Volume: 27, Issue:4

    Topics: Adolescent; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Brain M

1996
Pemoline therapy resulting in liver transplantation.
    The Annals of pharmacotherapy, 1998, Volume: 32, Issue:4

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Chemical and Drug

1998
Four cases of severe hepatotoxicity associated with pemoline: possible autoimmune pathogenesis.
    Pediatrics, 1998, Volume: 101, Issue:5

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Autoimmune Diseases; Central Nervous Syst

1998
Response to growth hormone in attention deficit hyperactivity disorder: effects of methylphenidate and pemoline therapy.
    Pediatrics, 1998, Volume: 102, Issue:2 Pt 3

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Female; Gro

1998
Attention deficit hyperactivity in adults.
    The British journal of psychiatry : the journal of mental science, 1998, Volume: 172

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Humans; Pem

1998
Adverse drug reaction. Pemoline and dyskinesia.
    Nursing, 1999, Volume: 29, Issue:2

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Humans; Mal

1999
Practical guidelines for the treatment of substance abusers with adult attention-deficit hyperactivity disorder.
    Psychiatric services (Washington, D.C.), 1999, Volume: 50, Issue:8

    Topics: Adult; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Central Nervous System

1999
Psychotic side effects of psychostimulants: a 5-year review.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1999, Volume: 44, Issue:8

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Child, Pres

1999
Sleep practitioners need to be aware of new changes in the labeling of pemoline (CYLERT)
    Sleep, 1999, Nov-01, Volume: 22, Issue:7

    Topics: Attention Deficit Disorder with Hyperactivity; Awareness; Central Nervous System Stimulants; Disorde

1999
Long-acting stimulants for the treatment of attention-deficit disorder in cocaine-dependent adults.
    Psychiatric services (Washington, D.C.), 2000, Volume: 51, Issue:2

    Topics: Adult; Algorithms; Amphetamines; Antidepressive Agents, Second-Generation; Attention Deficit Disorde

2000
Pemoline (Cylert): market withdrawal.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2000, Jan-11, Volume: 162, Issue:1

    Topics: Adverse Drug Reaction Reporting Systems; Attention Deficit Disorder with Hyperactivity; Canada; Cent

2000
Effectiveness of attention-deficit/hyperactivity treatment and diagnosis methods tested.
    Report on medical guidelines & outcomes research, 2000, Feb-17, Volume: 11, Issue:4

    Topics: Adult; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Central Nervous System

2000
A review of psychophysiological research with hyperkinetic children.
    Journal of abnormal child psychology, 1978, Volume: 6, Issue:4

    Topics: Amphetamines; Attention Deficit Disorder with Hyperactivity; Autonomic Nervous System; Blood Pressur

1978
The hyperactive child.
    The Practitioner, 1976, Volume: 217, Issue:1297

    Topics: Achievement; Age Factors; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Cr

1976
Pharmacodynamics of pemoline in attention deficit disorder with hyperactivity.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1992, Volume: 31, Issue:2

    Topics: Attention; Attention Deficit Disorder with Hyperactivity; Child; Dose-Response Relationship, Drug; H

1992
[Hyperkinetic disorders with attention deficit. Diagnostic and therapeutic approach].
    Pediatrie, 1991, Volume: 46, Issue:11

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Drug Administration Schedul

1991
Dramatic favorable responses of children with learning disabilities or dyslexia and attention deficit disorder to antimotion sickness medications: four case reports.
    Perceptual and motor skills, 1991, Volume: 73, Issue:3 Pt 1

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Cyclizine;

1991
Social impact of stimulant treatment for hyperactive children.
    Journal of learning disabilities, 1991, Volume: 24, Issue:4

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Humans; Interpersonal Relat

1991
Change from Mg-pemoline to bupropion in a 12-year-old boy with attention-deficit hyperactivity disorder.
    Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:5

    Topics: Antidepressive Agents; Attention; Attention Deficit Disorder with Hyperactivity; Bupropion; Child; D

1990
Hepatotoxicity due to pemoline (Cylert): a report of two cases.
    Journal of pediatric gastroenterology and nutrition, 1990, Volume: 10, Issue:2

    Topics: Attention Deficit Disorder with Hyperactivity; Chemical and Drug Induced Liver Injury; Child; Humans

1990
Change in response to pemoline at puberty.
    The American journal of psychiatry, 1990, Volume: 147, Issue:3

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Humans; Male; Pemoline; Puberty

1990
Pemoline (Cylert)-induced hepatotoxicity.
    Journal of pediatric gastroenterology and nutrition, 1990, Volume: 11, Issue:1

    Topics: Attention Deficit Disorder with Hyperactivity; Chemical and Drug Induced Liver Injury; Child; Female

1990
Pemoline and urinary excretion of catecholamines and indoleamines in children with attention deficit disorder.
    The American journal of psychiatry, 1986, Volume: 143, Issue:3

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Humans; Hydroxyindoleacetic

1986
Stimulant medication and short attention span: a clinical approach.
    Journal of developmental and behavioral pediatrics : JDBP, 1989, Volume: 10, Issue:6

    Topics: Attention; Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Dose-Response Re

1989
The use of stimulant medication with children.
    Journal of developmental and behavioral pediatrics : JDBP, 1989, Volume: 10, Issue:6

    Topics: Attention; Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Dose-Response Re

1989
Pemoline-induced abnormal involuntary movements.
    Journal of clinical psychopharmacology, 1989, Volume: 9, Issue:2

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Humans; Male; Movement Disorders; Pemoline

1989
Pemoline and liver function.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1989, Volume: 28, Issue:3

    Topics: Attention Deficit Disorder with Hyperactivity; Chemical and Drug Induced Liver Injury; Child; Humans

1989
Attention deficit disorder: evaluation and treatment.
    Pediatric annals, 1985, Volume: 14, Issue:5

    Topics: Age Factors; Anorexia; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Body Height;

1985
The relationship between stimulant medication and tics.
    Pediatric annals, 1988, Volume: 17, Issue:6

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Dextroamphe

1988
Unexpected consequence of treatment for attention deficit disorder.
    The American journal of psychiatry, 1987, Volume: 144, Issue:2

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Forensic Psychiatry; Humans; Male; Marijuana A

1987
Blood levels and tolerance to stimulants in ADDH children.
    Clinical neuropharmacology, 1986, Volume: 9 Suppl 4

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Cognition; Drug Tolerance; H

1986
Pediatricians' reported practices in the assessment and treatment of attention deficit disorders.
    Journal of developmental and behavioral pediatrics : JDBP, 1987, Volume: 8, Issue:4

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Humans; Manuals as Topic; M

1987
American Academy of Pediatrics Committee on Children with Disabilities, Committee on Drugs: Medication for children with an attention deficit disorder.
    Pediatrics, 1987, Volume: 80, Issue:5

    Topics: Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Child; Dextroamphet

1987
Measurement of whole blood serotonin as a guide in prescribing psychostimulant medication for children with attentional deficits.
    Clinical neuropharmacology, 1986, Volume: 9, Issue:2

    Topics: Administration, Oral; Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Child, Presc

1986
Attention deficit disorder in adolescents.
    Hospital & community psychiatry, 1986, Volume: 37, Issue:6

    Topics: Adolescent; Arousal; Attention Deficit Disorder with Hyperactivity; Combined Modality Therapy; Dextr

1986
Evidence of lack of abuse or dependence following pemoline treatment: results of a retrospective survey.
    Drug and alcohol dependence, 1986, Volume: 17, Issue:2-3

    Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Child; Child Behavior Disorders; C

1986
Pharmacological treatment of attention deficit disorder, residual type (ADD,RT, "minimal brain dysfunction," "hyperactivity") in adults.
    Psychopharmacology bulletin, 1985, Volume: 21, Issue:2

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Humans; Methylphenidate; Pargyline; Pemoline;

1985
Clinical management of children with hyperactivity. A shift in diagnostic and therapeutic emphasis.
    Postgraduate medicine, 1986, Volume: 79, Issue:5

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Child Behavior; Child Development; Humans; Med

1986
Depression following pemoline withdrawal in a hyperactive child.
    Clinical pediatrics, 1985, Volume: 24, Issue:3

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Depression; Female; Humans; Pemoline; Substanc

1985
Oral pemoline kinetics in hyperactive children.
    Clinical pharmacology and therapeutics, 1985, Volume: 37, Issue:6

    Topics: Absorption; Administration, Oral; Attention Deficit Disorder with Hyperactivity; Child; Child, Presc

1985
Treatment of chronic cocaine abuse and attention deficit disorder, residual type, with magnesium pemoline.
    Drug and alcohol dependence, 1985, Volume: 15, Issue:1-2

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Cocaine; Female; Humans; Male; Pemoline; Subst

1985
Catecholamine metabolism in the attention deficit disorder: implications for the use of amino acid precursor therapy.
    Medical hypotheses, 1985, Volume: 17, Issue:4

    Topics: Attention Deficit Disorder with Hyperactivity; Catecholamines; Dopamine; Humans; Levodopa; Methylphe

1985
Psychological assessment of children with minimal brain dysfunction.
    Annals of the New York Academy of Sciences, 1973, Feb-28, Volume: 205

    Topics: Achievement; Analysis of Variance; Attention; Attention Deficit Disorder with Hyperactivity; Auditor

1973
Minimal brain dysfunctions in children.
    American family physician, 1974, Volume: 10, Issue:1

    Topics: Amphetamine; Attention; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Comm

1974