pemoline and ADDH
pemoline has been researched along with ADDH in 129 studies
Pemoline: A central nervous system stimulant used in fatigue and depressive states and to treat hyperkinetic disorders in children.
pemoline : A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted by an amino group at position 2 and by a phenyl group at position 5. A central nervous system stimulant, it was used to treat hyperactivity disorders in children, but withdrawn from use following reports of serious hepatotoxicity.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "The onset, duration, and offset of pemoline action to improve cognitive performance is examined intensively in 25 prepubescent males suffering from attention-deficit disorder with hyperactivity (ADDH)." | 7.68 | Pharmacodynamics of pemoline in attention deficit disorder with hyperactivity. ( Perel, JM; Sallee, FR; Stiller, RL, 1992) |
| "Diagnosis of attention deficit disorder in a 35-year-old man and treatment with pemoline substantially improved his response to alcoholism treatment and aftercare." | 7.66 | Pemoline in attention deficit disorder and alcoholism: a case study. ( Frances, R; Mobarak, A; Rosenfeld, W; Turnquist, K, 1983) |
| "Pemoline is a central nervous system (CNS) stimulant approved for use as part of the comprehensive medical management of attention deficit hyperactivity disorder (ADHD)." | 6.40 | Pemoline-associated hepatic failure: a critical analysis of the literature. ( Schreiber, R; Shevell, M, 1997) |
| "Sixty-nine adolescents (aged 13-19) with conduct disorder (CD), SUD, and ADHD were recruited from the community and randomly assigned to a 12-week clinical trial of pemoline (n = 35) or placebo (n = 34), titrated over 4 weeks to a single morning dose of 75 to 112." | 5.11 | A randomized controlled trial of pemoline for attention-deficit/hyperactivity disorder in substance-abusing adolescents. ( Hall, SK; Kayser, A; Lohman, M; Mikulich-Gilbertson, SK; Riggs, PD, 2004) |
| "The onset, duration, and offset of pemoline action to improve cognitive performance is examined intensively in 25 prepubescent males suffering from attention-deficit disorder with hyperactivity (ADDH)." | 3.68 | Pharmacodynamics of pemoline in attention deficit disorder with hyperactivity. ( Perel, JM; Sallee, FR; Stiller, RL, 1992) |
| " These cases were selected from a prior quantitative study in which three antihistamines (meclizine, cyclizine, dimenhydrinate) and three stimulants (pemoline, methylphenidate, dextroamphetamine) were tested in variable combinations (using a specific clinical method) for favorable responses by 100 children characterized by diagnostic evidence of learning disabilities and cerebellar-vestibular dysfunctioning." | 3.68 | Dramatic favorable responses of children with learning disabilities or dyslexia and attention deficit disorder to antimotion sickness medications: four case reports. ( Levinson, HN, 1991) |
| "To test the hypothesis that any change in urinary noradrenergic excretion accompanies drug-induced improvement in attention deficit disorder with hyperactivity, the authors gave pemoline (mean dose, 2." | 3.67 | Pemoline and urinary excretion of catecholamines and indoleamines in children with attention deficit disorder. ( Karoum, F; Linnoila, M; Sallee, R; Zametkin, AJ, 1986) |
| "Diagnosis of attention deficit disorder in a 35-year-old man and treatment with pemoline substantially improved his response to alcoholism treatment and aftercare." | 3.66 | Pemoline in attention deficit disorder and alcoholism: a case study. ( Frances, R; Mobarak, A; Rosenfeld, W; Turnquist, K, 1983) |
| "Risperidone was a safe and effective treatment, with or without a combined psychostimulant, for both disruptive behavior disorders and comorbid ADHD in children." | 2.71 | Risperidone effects in the presence/absence of psychostimulant medicine in children with ADHD, other disruptive behavior disorders, and subaverage IQ. ( Aman, MG; Binder, C; Turgay, A, 2004) |
| "Treatment with pemoline in the final week of the 4-week active phase was best tolerated at doses substantially lower than the target dose of 3 mg/kg per day (mean dose, 2." | 2.69 | Controlled trial of high doses of pemoline for adults with attention-deficit/hyperactivity disorder. ( Abrantes, A; Biederman, J; Bostic, J; Frazier, J; Hatch, M; Millstein, RB; Prince, J; Rater, M; Sienna, M; Soriano, J; Spencer, TJ; Wilens, TE, 1999) |
| "Pemoline was well tolerated, with patients averaging 2." | 2.69 | Pemoline treatment of adolescents with attention deficit hyperactivity disorder: a short-term controlled trial. ( Biederman, J; Bostic, JQ; Hatch, M; Monuteaux, MC; Polisner, DA; Prince, JB; Sienna, M; Spencer, TJ; Wilens, TE, 2000) |
| "To evaluate the dose-response by time-response characteristics of pemoline (Cylert) on dependent measures of behavior and academic performance in a laboratory classroom." | 2.68 | Pemoline effects on children with ADHD: a time-response by dose-response analysis on classroom measures. ( Furman, MB; Pelham, WE; Schwindt, H; Swanson, JM, 1995) |
| " Postmedication assessments were obtained after at least 1 week at maximal dosage (1." | 2.68 | An open trial of pemoline in drug-dependent delinquents with attention-deficit hyperactivity disorder. ( Crowley, TJ; Mikulich, SK; Riggs, PD; Thompson, LL; Whitmore, EA, 1996) |
| "Pemoline is a central nervous system (CNS) stimulant approved for use as part of the comprehensive medical management of attention deficit hyperactivity disorder (ADHD)." | 2.40 | Pemoline-associated hepatic failure: a critical analysis of the literature. ( Schreiber, R; Shevell, M, 1997) |
| " We conclude that pemoline causes toxic liver damage in children." | 2.40 | Pemoline hepatotoxicity in children. ( Marotta, PJ; Roberts, EA, 1998) |
| " Since psychostimulant treatment often requires frequent dosing and may be associated with unacceptable side effects and risks, other classes of medication have been studied as possible treatment alternatives." | 2.40 | Psychopharmacology of ADHD: children and adolescents. ( Dogin, JW; Findling, RL, 1998) |
| " Thirty-two reports (29 studies) evaluated adverse effects of drug therapy; many of the side effects associated with stimulant use appear to be relatively mild and of short duration and to respond to dosing or timing adjustments." | 2.40 | Treatment of attention-deficit/hyperactivity disorder. ( Boyle, M; Cunningham, C; Jadad, AR; Kim, M; Schachar, R, 1999) |
| "Pemoline is a central nervous system stimulant used in treating children with attention deficit-hyperactivity disorder." | 2.39 | Pemoline-associated fulminant liver failure: testing the evidence for causation. ( Berkovitch, M; Koren, G; Phillips, J; Pope, E, 1995) |
| "Those disorders discussed are attention deficit disorder, conduct disorders, anxiety disorders, sleep disorders, schizophrenia, autism, Tourette's syndrome, mental retardation, depressive illness, manic depressive illness, eating disorders, and enuresis." | 2.37 | Pharmacologic treatment of psychiatric and neurodevelopmental disorders in children and adolescents (Part 1). ( McDaniel, KD, 1986) |
| "It typically takes many years before an association of a drug with a rare, serious adverse reaction is established." | 1.37 | Safety assessment in pediatric studies. ( Elzagallaai, A; Etwel, F; Koren, G, 2011) |
| "All case reports of acute liver failure associated with pemoline and reported to the US FDA from 1975 through 1999 were reviewed." | 1.35 | A surveillance method for the early identification of idiosyncratic adverse drug reactions. ( Bend, JR; Etwel, FA; Koren, G; Rieder, MJ, 2008) |
| "Pemoline therapy was discontinued, but the patient's liver function continued to decline." | 1.30 | Pemoline therapy resulting in liver transplantation. ( Adcock, KG; Farrington, EA; MacElroy, DE; Wolford, ET, 1998) |
| "To determine whether treatment of attention deficit hyperactivity disorder (ADHD) with methylphenidate hydrochloride or pemoline diminishes the response to growth hormone (GH) therapy in patients with idiopathic GH deficiency (IGHD) or idiopathic short stature (ISS)." | 1.30 | Response to growth hormone in attention deficit hyperactivity disorder: effects of methylphenidate and pemoline therapy. ( Blethen, SL; Breen, TJ; Julius, JR; Rao, JK, 1998) |
| " Personal or family tic history, medication selection, or dosage was not related to onset of T/D." | 1.29 | Tics and dyskinesias associated with stimulant treatment in attention-deficit hyperactivity disorder. ( Adesman, AR; Goldstein, IJ; Lipkin, PH, 1994) |
| "Treatment with pemoline produced no P300 changes." | 1.29 | Abnormal auditory P300 topography in attention deficit disorder predicts poor response to pemoline. ( Persky, B; Sangal, JM; Sangal, RB, 1995) |
| "Treatment with imipramine decreased auditory P300 latencies and increased auditory P300 amplitudes." | 1.29 | Prolonged P300 latency in attention deficit hyperactivity disorder predicts poor response to imipramine. ( Persky, B; Sangal, JM; Sangal, RB, 1996) |
| "Pemoline (Cylert) is an agent used to treat attention deficit disorders and other behavioral syndromes." | 1.28 | Hepatotoxicity due to pemoline (Cylert): a report of two cases. ( Dubois, RS; Pratt, DS, 1990) |
| "Pemoline was given orally in increasing doses ranging from 20 to 80 mg/day." | 1.27 | EEG and clinical findings during pemoline treatment in children and adults with attention deficit disorder. An 8-week open trial. ( Barteselli, F; Besana, R; Caresia, L; Guareschi Cazzullo, A; Musetti, L; Pugnetti, L; Scarone, S, 1984) |
| " While there have been a few reports of tolerance, it is possible that these were a reflection of inadequate dosing rather than actual tolerance to the drug's therapeutic effects." | 1.27 | Evidence of lack of abuse or dependence following pemoline treatment: results of a retrospective survey. ( Bartenbach, DE; Davis, PM; Langer, DH; Menander, KB; Sweeney, KP, 1986) |
| "Children who have attention deficit disorder with (or without) hyperactivity are handicapped by their inability to concentrate and control their impulsivity, especially while in school." | 1.27 | Clinical management of children with hyperactivity. A shift in diagnostic and therapeutic emphasis. ( Hesterly, SO, 1986) |
| "Research suggests that attention deficit disorder (ADD) may persist into adulthood, perhaps predisposing certain individuals to stimulant abuse." | 1.27 | Treatment of chronic cocaine abuse and attention deficit disorder, residual type, with magnesium pemoline. ( Mirin, SM; Pope, HG; Weiss, RD, 1985) |
| "The growth of 22 children with attention deficit disorder (ADD) was monitored longitudinally for up to four years." | 1.26 | Effect on growth in pemoline-treated children with attention deficit disorder. ( Carr, R; Elders, J; Friedmann, N; Ringdahl, I; Roche, A; Thomas, J, 1981) |
Research
Studies (129)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 54 (41.86) | 18.7374 |
| 1990's | 49 (37.98) | 18.2507 |
| 2000's | 23 (17.83) | 29.6817 |
| 2010's | 3 (2.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Shaw, P | 1 |
| Sharp, WS | 1 |
| Morrison, M | 1 |
| Eckstrand, K | 1 |
| Greenstein, DK | 1 |
| Clasen, LS | 1 |
| Evans, AC | 1 |
| Rapoport, JL | 2 |
| McDonnell, MA | 1 |
| Moffett, C | 1 |
| Marcus, SC | 1 |
| Durkin, M | 1 |
| Koren, G | 3 |
| Elzagallaai, A | 1 |
| Etwel, F | 1 |
| Willy, ME | 1 |
| Manda, B | 1 |
| Shatin, D | 1 |
| Drinkard, CR | 1 |
| Graham, DJ | 1 |
| Schubiner, H | 1 |
| Saules, KK | 1 |
| Arfken, CL | 1 |
| Johanson, CE | 1 |
| Schuster, CR | 1 |
| Lockhart, N | 1 |
| Edwards, A | 1 |
| Donlin, J | 1 |
| Pihlgren, E | 1 |
| Adler, LA | 1 |
| Chua, HC | 1 |
| Barkley, RA | 3 |
| Sarkis, EH | 1 |
| Maidment, ID | 1 |
| Sangal, RB | 3 |
| Sangal, JM | 3 |
| Spencer, T | 1 |
| Biederman, J | 5 |
| Wilens, T | 1 |
| Riggs, PD | 2 |
| Hall, SK | 1 |
| Mikulich-Gilbertson, SK | 1 |
| Lohman, M | 1 |
| Kayser, A | 1 |
| Aman, MG | 1 |
| Binder, C | 1 |
| Turgay, A | 1 |
| Gross-Tsur, V | 1 |
| Joseph, A | 1 |
| Shalev, RS | 1 |
| Wilens, TE | 3 |
| Hammerness, PG | 1 |
| Kwon, A | 1 |
| Spencer, TJ | 3 |
| Clark, S | 1 |
| Scott, M | 1 |
| Podolski, A | 1 |
| Ditterline, JW | 1 |
| Morris, MC | 1 |
| Moore, H | 1 |
| Brown, RT | 2 |
| Amler, RW | 1 |
| Freeman, WS | 1 |
| Perrin, JM | 1 |
| Stein, MT | 1 |
| Feldman, HM | 1 |
| Pierce, K | 1 |
| Wolraich, ML | 2 |
| Bonnet, U | 1 |
| Davids, E | 1 |
| Epstein, JN | 1 |
| Conners, CK | 6 |
| Hervey, AS | 1 |
| Tonev, ST | 1 |
| Arnold, LE | 2 |
| Abikoff, HB | 2 |
| Elliott, G | 2 |
| Greenhill, LL | 5 |
| Hechtman, L | 2 |
| Hoagwood, K | 1 |
| Hinshaw, SP | 2 |
| Hoza, B | 2 |
| Jensen, PS | 2 |
| March, JS | 2 |
| Newcorn, JH | 2 |
| Pelham, WE | 6 |
| Severe, JB | 2 |
| Swanson, JM | 5 |
| Wells, K | 1 |
| Vitiello, B | 1 |
| Wigal, T | 1 |
| Milstein, V | 1 |
| Small, JG | 1 |
| Novak, SP | 1 |
| Kroutil, LA | 1 |
| Williams, RL | 1 |
| Van Brunt, DL | 1 |
| Etwel, FA | 1 |
| Rieder, MJ | 1 |
| Bend, JR | 1 |
| Steinhausen, HC | 1 |
| Gauthier, M | 1 |
| Turnquist, K | 1 |
| Frances, R | 1 |
| Rosenfeld, W | 1 |
| Mobarak, A | 1 |
| Martin, CA | 1 |
| Welsh, RJ | 1 |
| McKay, SE | 1 |
| Bareuther, CM | 1 |
| Brown, RP | 1 |
| Ingber, PS | 1 |
| Tross, S | 1 |
| Caresia, L | 1 |
| Pugnetti, L | 1 |
| Besana, R | 1 |
| Barteselli, F | 1 |
| Guareschi Cazzullo, A | 1 |
| Musetti, L | 1 |
| Scarone, S | 1 |
| Farmer, P | 1 |
| Unis, AS | 1 |
| Hsu, G | 1 |
| Stephens, RS | 1 |
| Skinner, R | 1 |
| El-Defrawi, MH | 1 |
| Peeke, S | 1 |
| Halliday, R | 1 |
| Callaway, E | 1 |
| Prael, R | 1 |
| Reus, V | 1 |
| Sternbach, H | 1 |
| Mitchell, E | 1 |
| Matthews, KL | 1 |
| Bachman, DS | 1 |
| Wender, PH | 4 |
| Reimherr, FW | 3 |
| Wood, DR | 3 |
| Dubey, DR | 1 |
| Friedmann, N | 1 |
| Thomas, J | 1 |
| Carr, R | 1 |
| Elders, J | 1 |
| Ringdahl, I | 1 |
| Roche, A | 1 |
| White, JH | 1 |
| Puig-Antich, J | 1 |
| Halpern, F | 1 |
| Sachar, EJ | 1 |
| Rubinstein, B | 1 |
| Chambers, W | 1 |
| Fiscina, B | 1 |
| Florea, J | 1 |
| Taylor, E | 2 |
| Elia, J | 2 |
| Kwasman, A | 1 |
| Tinsley, BJ | 1 |
| Lepper, HS | 1 |
| Zametkin, AJ | 2 |
| Berkovitch, M | 1 |
| Pope, E | 1 |
| Phillips, J | 1 |
| Walkup, JT | 1 |
| Scahill, LD | 1 |
| Riddle, MA | 1 |
| Lipkin, PH | 1 |
| Goldstein, IJ | 1 |
| Adesman, AR | 1 |
| Kelly, D | 1 |
| Forney, J | 1 |
| Parker-Fisher, S | 1 |
| Jones, M | 1 |
| Furman, MB | 1 |
| Schwindt, H | 1 |
| Persky, B | 2 |
| Heiligenstein, E | 3 |
| Johnston, HF | 1 |
| Nielsen, JK | 1 |
| Faigel, HC | 1 |
| Thompson, LL | 1 |
| Mikulich, SK | 1 |
| Whitmore, EA | 1 |
| Crowley, TJ | 1 |
| Castellanos, FX | 1 |
| Kruesi, MJ | 1 |
| Marsh, WL | 1 |
| Gulotta, CS | 1 |
| Potter, WZ | 1 |
| Ritchie, GF | 1 |
| Hamburger, SD | 1 |
| Shevell, M | 1 |
| Schreiber, R | 1 |
| Anders, J | 1 |
| McCurry, L | 1 |
| Cronquist, S | 1 |
| Cantwell, DP | 1 |
| Kraemer, HC | 1 |
| Richters, JE | 1 |
| Schiller, E | 1 |
| Vereen, D | 1 |
| Wells, KC | 1 |
| Winsberg, B | 1 |
| Barbato, M | 1 |
| Hochman, JA | 1 |
| Woodard, SA | 1 |
| Cohen, MB | 1 |
| Adcock, KG | 1 |
| MacElroy, DE | 1 |
| Wolford, ET | 1 |
| Farrington, EA | 1 |
| Rosh, JR | 1 |
| Dellert, SF | 1 |
| Narkewicz, M | 1 |
| Birnbaum, A | 1 |
| Whitington, G | 1 |
| Marotta, PJ | 1 |
| Roberts, EA | 1 |
| Findling, RL | 1 |
| Dogin, JW | 1 |
| Rao, JK | 1 |
| Julius, JR | 1 |
| Breen, TJ | 1 |
| Blethen, SL | 1 |
| Cubbin, S | 1 |
| Leahy, A | 1 |
| Pliszka, SR | 1 |
| Shuster, J | 1 |
| Frazier, J | 1 |
| Prince, J | 1 |
| Bostic, J | 1 |
| Rater, M | 1 |
| Soriano, J | 1 |
| Hatch, M | 2 |
| Sienna, M | 2 |
| Millstein, RB | 1 |
| Abrantes, A | 1 |
| Levin, FR | 1 |
| Evans, SM | 1 |
| Kleber, HD | 1 |
| Cherland, E | 1 |
| Fitzpatrick, R | 1 |
| Littner, M | 1 |
| Castaneda, R | 1 |
| Levy, R | 1 |
| Hardy, M | 1 |
| Trujillo, M | 1 |
| Jadad, AR | 1 |
| Boyle, M | 1 |
| Cunningham, C | 1 |
| Kim, M | 1 |
| Schachar, R | 1 |
| Bostic, JQ | 1 |
| Prince, JB | 1 |
| Monuteaux, MC | 1 |
| Polisner, DA | 1 |
| Hogan, V | 1 |
| Pliszka, S | 1 |
| Dulcan, MK | 2 |
| Bernet, W | 1 |
| Arnold, V | 1 |
| Beitchman, J | 1 |
| Benson, RS | 1 |
| Bukstein, O | 1 |
| Kinlan, J | 1 |
| McClellan, J | 1 |
| Rue, D | 1 |
| Shaw, JA | 1 |
| Stock, S | 1 |
| Hastings, JE | 1 |
| Oettinger, L | 1 |
| Johnson, GE | 1 |
| Seals, JR | 1 |
| Millichap, JG | 1 |
| Sallee, FR | 2 |
| Stiller, RL | 2 |
| Perel, JM | 2 |
| Vallée, L | 1 |
| Pandit, F | 1 |
| Levinson, HN | 1 |
| Evans, SW | 1 |
| Abikoff, H | 2 |
| Anastopoulos, AD | 1 |
| DuPaul, GJ | 1 |
| Cantwell, D | 2 |
| Lerner, M | 2 |
| McBurnett, K | 1 |
| Hanna, G | 1 |
| Whalen, CK | 1 |
| Henker, B | 1 |
| Bloomingdale, LM | 1 |
| Greenslade, KE | 1 |
| Vodde-Hamilton, M | 1 |
| Murphy, DA | 1 |
| Greenstein, JJ | 1 |
| Gnagy, EM | 1 |
| Guthrie, KJ | 1 |
| Hoover, MD | 1 |
| Dahl, RE | 1 |
| Heath, CT | 1 |
| Wright, HH | 1 |
| Batey, SR | 1 |
| Pratt, DS | 1 |
| Dubois, RS | 1 |
| Waltz, G | 1 |
| Elitsur, Y | 1 |
| McDaniel, KD | 1 |
| Linnoila, M | 1 |
| Karoum, F | 1 |
| Sallee, R | 1 |
| Davy, T | 1 |
| Rodgers, CL | 1 |
| Phillips, S | 1 |
| Stevenson, RD | 1 |
| Everett, G | 1 |
| Jaffe, SL | 1 |
| Gittelman, R | 1 |
| Golden, GS | 1 |
| Merrill, RD | 1 |
| Garfinkel, B | 1 |
| Copeland, L | 1 |
| Wolraich, M | 1 |
| Lindgren, S | 1 |
| Milich, R | 1 |
| Woolson, R | 1 |
| Saul, RC | 1 |
| Ashby, CD | 1 |
| Silver, LB | 1 |
| Brunstetter, RW | 1 |
| Langer, DH | 1 |
| Sweeney, KP | 1 |
| Bartenbach, DE | 1 |
| Davis, PM | 1 |
| Menander, KB | 1 |
| Hesterly, SO | 1 |
| Borden, KA | 1 |
| Spunt, AL | 1 |
| Medenis, R | 1 |
| Sallee, F | 1 |
| Stiller, R | 1 |
| Perel, J | 1 |
| Bates, T | 1 |
| Weiss, RD | 1 |
| Pope, HG | 1 |
| Mirin, SM | 1 |
| McConnell, H | 1 |
| Plotnikoff, N | 1 |
| Meo, G | 1 |
| Kurtz, MA | 1 |
| Fournier, M | 1 |
| Peters, JE | 1 |
Clinical Trials (6)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Integrated Brain, Body and Social Intervention (IBBS) for Attention Deficit Hyperactivity Disorder (ADHD)[NCT01542528] | 117 participants (Actual) | Interventional | 2012-03-31 | Completed | |||
| Effects of Expectation, Medication and Placebo on Objective and Self-rated Performance During the Quantified Behavior Test in Patients With Untreated ADHD and Substance Use Disorder[NCT02477280] | Phase 4 | 39 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| Effects of Expectation, Medication and Placebo on Objective and Self-rated Performance During the Quantified Behavior Test in Patients With Untreated ADHD[NCT02473185] | Phase 4 | 40 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| Substance Dependent Teens - Impact of Treating Depression Study 1[NCT00061113] | Phase 4 | 126 participants (Actual) | Interventional | 2001-02-28 | Completed | ||
| Multimodal Treatment Study of Children With ADHD[NCT00000388] | Phase 4 | 0 participants | Interventional | 1998-09-30 | Completed | ||
| The Effects of Methylphenidate (MPH) and Non-invasive Brain Stimulation (tDCS) on Inhibitory Control Children With Attention-Deficit/Hyperactivity Disorder (ADHD)[NCT04964427] | 26 participants (Actual) | Interventional | 2021-02-08 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Improvement in ADHD Severity From Baseline to End of Intervention
ADHD severity was measured by the Swanson, Nolan, and Pelham Rating Scale (SNAP)-IV-ADHD consists of 18 items that closely parallel in wording the diagnostic symptoms for ADHD as they appear in the DSM-IV. The range of scores are from 0 to 54. Higher scores indicate greater ADHD severity . The blinded assessors (Clinicians) used clinical judgement to provide an overall rating, based on all available information from the parents, teachers, and the assessors' own direct interactions with the child on the day of the assessment. (NCT01542528)
Timeframe: End of intervention is at a maximum of 15 weeks from baseline.
| Intervention | units on a scale (Mean) |
|---|---|
| IBBS | 3.0 |
| Treatment as Usual (TAU) | 3.2 |
Overall Improvement
Clinical Global Improvement Scale (CGI-I) - responders vs. non-responders. CGI is a seven point scale with the following anchor point: 1=Very Much Improved, 2=Much Improved, 3=Improved, 4=No change, 5=Minimally worse, 6=Much worse, 7=Very much worse. Participants with a score of 1, 2, or 3 at Endpoint were considered Responders; all others were considered non-responders. (NCT01542528)
Timeframe: 15 weeks for a total of 60 IBBS sessions vs. treatment as usual (TAU)
| Intervention | Percentage of participants (Number) |
|---|---|
| IBBS | 60.8 |
| Treatment as Usual (TAU) | 59.6 |
Reviews
26 reviews available for pemoline and ADDH
| Article | Year |
|---|---|
Management of ADHD in adults.
Topics: Adolescent; Adult; Age Factors; Amphetamines; Antidepressive Agents; Antihypertensive Agents; Attent | 2002 |
Management of ADHD in adults.
Topics: Adolescent; Adult; Age Factors; Amphetamines; Antidepressive Agents; Antihypertensive Agents; Attent | 2002 |
Management of ADHD in adults.
Topics: Adolescent; Adult; Age Factors; Amphetamines; Antidepressive Agents; Antihypertensive Agents; Attent | 2002 |
Management of ADHD in adults.
Topics: Adolescent; Adult; Age Factors; Amphetamines; Antidepressive Agents; Antihypertensive Agents; Attent | 2002 |
Psychosocial treatments for attention-deficit/hyperactivity disorder in children.
Topics: Adolescent; Adult; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Behavior Th | 2002 |
Efficacy of stimulants in adult ADHD.
Topics: Adult; Amphetamines; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulant | 2003 |
Treatment of attention-deficit/hyperactivity disorder: overview of the evidence.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Atomoxetine Hydrochloride; Attention Deficit Disorder | 2005 |
Stimulant medications in adults with attention deficit disorder.
Topics: Adolescent; Adult; Amitriptyline; Attention Deficit Disorder with Hyperactivity; Central Nervous Sys | 1984 |
Hyperactivity (attention-deficit disorder).
Topics: Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Family; Female; Humans; Hyp | 1984 |
Drug treatment for hyperactive children. Therapeutic guidelines.
Topics: Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Child; Dextroamphet | 1993 |
Pemoline-associated fulminant liver failure: testing the evidence for causation.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Fatal Outcome; Hepatic Encephalopathy; Hu | 1995 |
Disruptive behavior, hyperactivity, and learning disabilities in children with Tourette's syndrome.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Child; | 1995 |
Pemoline-associated hepatic failure: a critical analysis of the literature.
Topics: Adverse Drug Reaction Reporting Systems; Attention Deficit Disorder with Hyperactivity; Central Nerv | 1997 |
Pemoline hepatotoxicity in children.
Topics: Adolescent; Alkaline Phosphatase; Attention Deficit Disorder with Hyperactivity; Central Nervous Sys | 1998 |
Attention-deficit/hyperactivity disorder: a life-span perspective.
Topics: Adolescent; Adult; Age Factors; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hy | 1998 |
Psychopharmacology of ADHD: children and adolescents.
Topics: Adolescent; Age Factors; Amphetamines; Antidepressive Agents, Tricyclic; Attention Deficit Disorder | 1998 |
Pharmacotherapy of attention-deficit/hyperactivity disorder in adults.
Topics: Adult; Age Factors; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants | 1998 |
The use of psychostimulants in the pediatric patient.
Topics: Adolescent; Amphetamines; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stim | 1998 |
Treatment of attention-deficit/hyperactivity disorder.
Topics: Adrenergic Uptake Inhibitors; Adult; Antidepressive Agents, Tricyclic; Attention Deficit Disorder wi | 1999 |
Practice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults.
Topics: Adolescent; Adult; Amphetamines; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervo | 2002 |
Pediatric psychopharmacology. A review with special reference to deanol.
Topics: Adolescent; Adult; Amphetamines; Animals; Antidepressive Agents, Tricyclic; Attention Deficit Disord | 1977 |
MBD: advanced in understanding many bothersome dilemmas.
Topics: Adolescent; Adult; Attention; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool | 1976 |
Cognitive training in ADHD children: less to it than meets the eye.
Topics: Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Child; Combined Modality Therapy; D | 1991 |
Stimulant medication and parent training therapies for attention deficit-hyperactivity disorder.
Topics: Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Child; Combined Modality Therapy; D | 1991 |
Effects of stimulant medication on learning in children with ADHD.
Topics: Achievement; Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Humans; Learni | 1991 |
Attention deficit hyperactivity disorder: does it affect adults too?
Topics: Adolescent; Adult; Age Factors; Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetam | 1990 |
Pharmacologic treatment of psychiatric and neurodevelopmental disorders in children and adolescents (Part 1).
Topics: Adolescent; Aggression; Antidepressive Agents; Antipsychotic Agents; Anxiety, Separation; Attention | 1986 |
Stimulant medication therapy in the treatment of children with attention deficit hyperactivity disorder.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Dopamine; Growth; Humans; M | 1989 |
Pemoline: review of performance.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior; Brain Diseases; Conditioning, Psyc | 1971 |
Trials
26 trials available for pemoline and ADDH
| Article | Year |
|---|---|
Double-blind placebo-controlled trial of methylphenidate in the treatment of adult ADHD patients with comorbid cocaine dependence.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; | 2002 |
Attention-deficit/hyperactivity disorder: cognitive evoked potential (P300) topography predicts treatment response to methylphenidate.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Cognition; | 2004 |
Stimulant treatment of adult attention-deficit/hyperactivity disorder.
Topics: Adult; Amphetamine; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants | 2004 |
A randomized controlled trial of pemoline for attention-deficit/hyperactivity disorder in substance-abusing adolescents.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; | 2004 |
Risperidone effects in the presence/absence of psychostimulant medicine in children with ADHD, other disruptive behavior disorders, and subaverage IQ.
Topics: Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorde | 2004 |
Blood pressure changes associated with medication treatment of adults with attention-deficit/hyperactivity disorder.
Topics: Adult; Amphetamines; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Blood Pre | 2005 |
Assessing medication effects in the MTA study using neuropsychological outcomes.
Topics: Amphetamine; Analysis of Variance; Attention Deficit Disorder with Hyperactivity; Central Nervous Sy | 2006 |
Assessing medication effects in the MTA study using neuropsychological outcomes.
Topics: Amphetamine; Analysis of Variance; Attention Deficit Disorder with Hyperactivity; Central Nervous Sy | 2006 |
Assessing medication effects in the MTA study using neuropsychological outcomes.
Topics: Amphetamine; Analysis of Variance; Attention Deficit Disorder with Hyperactivity; Central Nervous Sy | 2006 |
Assessing medication effects in the MTA study using neuropsychological outcomes.
Topics: Amphetamine; Analysis of Variance; Attention Deficit Disorder with Hyperactivity; Central Nervous Sy | 2006 |
Stimulant medications in adults with attention deficit disorder.
Topics: Adolescent; Adult; Amitriptyline; Attention Deficit Disorder with Hyperactivity; Central Nervous Sys | 1984 |
State-dependent and main effects of methylphenidate and pemoline on paired-associate learning and spelling in hyperactive children.
Topics: Association Learning; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Female | 1984 |
Effects of two doses of methylphenidate on verbal information processing in hyperactive children.
Topics: Attention; Attention Deficit Disorder with Hyperactivity; Child; Dose-Response Relationship, Drug; D | 1984 |
Attention deficit disorder ('minimal brain dysfunction') in adults. A replication study of diagnosis and drug treatment.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Clinical Trials as Topic; Double-Blind Method; | 1981 |
Pemoline, methylphenidate, and placebo in children with minimal brain dysfunction.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Double-Blind Method; Female; Humans; Male; Met | 1980 |
Pemoline effects on children with ADHD: a time-response by dose-response analysis on classroom measures.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Child, Pres | 1995 |
An open trial of pemoline in drug-dependent delinquents with attention-deficit hyperactivity disorder.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Humans | 1996 |
Cerebrospinal fluid homovanillic acid predicts behavioral response to stimulants in 45 boys with attention deficit/hyperactivity disorder.
Topics: Attention Deficit Disorder with Hyperactivity; Behavior; Biogenic Monoamines; Central Nervous System | 1996 |
National Institute of Mental Health Collaborative Multimodal Treatment Study of Children with ADHD (the MTA). Design challenges and choices.
Topics: Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Child; Clinical Protocols; Combined | 1997 |
Pemoline in ADHD.
Topics: Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorder with Hyperactivity; | 1997 |
Controlled trial of high doses of pemoline for adults with attention-deficit/hyperactivity disorder.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cross-Over | 1999 |
Pemoline treatment of adolescents with attention deficit hyperactivity disorder: a short-term controlled trial.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; | 2000 |
Diagnosis and treatment of minimal brain dysfunction in adults: a preliminary report.
Topics: Adult; Alcoholism; Antisocial Personality Disorder; Anxiety; Attention Deficit Disorder with Hyperac | 1976 |
Pemoline (Cylert) for minimal brain dysfunction.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Clinical Trials as Topic; Dextroamphetamine; D | 1976 |
Psychostimulant effects on academic and behavioral measures for ADHD junior high school students in a lecture format classroom.
Topics: Achievement; Adolescent; Attention; Attention Deficit Disorder with Hyperactivity; Dose-Response Rel | 1991 |
Relative efficacy of long-acting stimulants on children with attention deficit-hyperactivity disorder: a comparison of standard methylphenidate, sustained-release methylphenidate, sustained-release dextroamphetamine, and pemoline.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Child Behavior; Delayed-Action Pre | 1990 |
Hyperactive children treated with stimulants. Is cognitive training a useful adjunct?
Topics: Achievement; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Central Nervous System | 1985 |
Symposium: behavior modification by drugs. II. Psychological effects of stimulant drugs in children with minimal brain dysfunction.
Topics: Achievement; Attention Deficit Disorder with Hyperactivity; Bender-Gestalt Test; Brain Damage, Chron | 1972 |
Magnesium pemoline and dextroamphetamine: a controlled study in children with minimal brain dysfunction.
Topics: Analysis of Variance; Anxiety; Attention; Attention Deficit Disorder with Hyperactivity; Child; Dext | 1972 |
Other Studies
78 other studies available for pemoline and ADDH
| Article | Year |
|---|---|
Psychostimulant treatment and the developing cortex in attention deficit hyperactivity disorder.
Topics: Adolescent; Amphetamines; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stim | 2009 |
Coming into focus. Pharmacologic treatment for ADHD.
Topics: Adrenergic alpha-2 Receptor Agonists; Antidepressive Agents; Attention Deficit Disorder with Hyperac | 2010 |
Stimulant adherence and academic performance in urban youth with attention-deficit/hyperactivity disorder.
Topics: Achievement; Adolescent; Amphetamine; Anxiety Disorders; Attention Deficit and Disruptive Behavior D | 2011 |
Safety assessment in pediatric studies.
Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Canada; Cell Death; Drug Hypersensit | 2011 |
A study of compliance with FDA recommendations for pemoline (Cylert).
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Guidelines | 2002 |
Compliance with FDA recommendations for pemoline.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; | 2003 |
Hallucinations during methylphenidate therapy.
Topics: Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorder with Hyperactivity; | 2004 |
A rare case of dependence on pemoline.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Female; Hum | 2006 |
Photic responses in "minimal brain dysfunction".
Topics: Attention Deficit Disorder with Hyperactivity; Brain; Central Nervous System Stimulants; Child; Elec | 1974 |
The nonmedical use of prescription ADHD medications: results from a national Internet panel.
Topics: Adolescent; Adult; Alcoholism; Amphetamine-Related Disorders; Appetite Depressants; Attention Defici | 2007 |
A surveillance method for the early identification of idiosyncratic adverse drug reactions.
Topics: Adverse Drug Reaction Reporting Systems; Attention Deficit Disorder with Hyperactivity; Central Nerv | 2008 |
[Stimulant therapy in children].
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Dextroamphe | 1982 |
Pemoline in attention deficit disorder and alcoholism: a case study.
Topics: Adult; Aftercare; Alcoholism; Antisocial Personality Disorder; Attention Deficit Disorder with Hyper | 1983 |
Pemoline and lithium in a patient with attention deficit disorder.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Chlorpromazine; Diagnos | 1983 |
EEG and clinical findings during pemoline treatment in children and adults with attention deficit disorder. An 8-week open trial.
Topics: Adolescent; Adult; Anxiety Disorders; Attention Deficit Disorder with Hyperactivity; Child; Depressi | 1984 |
Pemoline, depressive symptoms, and escape from dexamethasone suppression.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Depression; Dexamethasone; Humans; Hydroc | 1983 |
Substituting stimulants in treating behavior disorders.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Dyskinesia, Drug-Induced; Humans; Male; Methyl | 1984 |
Pemoline-induced mania.
Topics: Acting Out; Adult; Affective Disorders, Psychotic; Attention; Attention Deficit Disorder with Hypera | 1981 |
Gilles de la Tourette's disorder associated with pemoline.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Humans; Male; Pemoline; Tourette Syndrome | 1980 |
Pemoline-induced Tourette's disorder: a case report.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Diseases in Twins; Haloperidol; Humans; M | 1981 |
The hyperkinetic child: current status.
Topics: Attention; Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Dose-Response Re | 1982 |
Effect on growth in pemoline-treated children with attention deficit disorder.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Body Height; Body Weight; Child; Female; | 1981 |
The hyperactive child in adolescence: some pharmacologic approaches.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Child Behavior Disorder | 1981 |
Growth disturbances in hyperkinetic children.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Growth Disorders; Humans; H | 1980 |
Pediatricians' knowledge and attitudes concerning diagnosis and treatment of attention deficit and hyperactivity disorders. A national survey approach.
Topics: Adult; Aged; Amphetamines; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperac | 1995 |
Attention-deficit disorder. Born to be hyperactive?
Topics: Adult; Aged; Attention Deficit Disorder with Hyperactivity; Child; Diagnosis, Differential; Educatio | 1995 |
Tics and dyskinesias associated with stimulant treatment in attention-deficit hyperactivity disorder.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Chronic Disease; | 1994 |
Evaluating and managing attention deficit disorder in children who are deaf or hard of hearing.
Topics: Achievement; Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Counseling; Deafness; | 1993 |
Abnormal auditory P300 topography in attention deficit disorder predicts poor response to pemoline.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Brain Mapping; Central Nervous System Sti | 1995 |
Pemoline therapy in college students with attention deficit hyperactivity disorder: a retrospective study.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; | 1996 |
Medication for attention deficit hyperactivity disorder: commentary and response.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Humans; Pem | 1996 |
Pemoline in adult attention deficit hyperactivity disorder: predictors of nonresponse.
Topics: Adolescent; Adult; Age Factors; Analysis of Variance; Attention Deficit Disorder with Hyperactivity; | 1997 |
Pemoline and hepatotoxicity.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Chemical and Drug Induced Liver Injury; Drug T | 1997 |
Exacerbation of autoimmune hepatitis: another hepatotoxic effect of pemoline therapy.
Topics: Acute Kidney Injury; Attention Deficit Disorder with Hyperactivity; Autoimmune Diseases; Central Ner | 1998 |
Prolonged P300 latency in attention deficit hyperactivity disorder predicts poor response to imipramine.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Brain M | 1996 |
Pemoline therapy resulting in liver transplantation.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Chemical and Drug | 1998 |
Four cases of severe hepatotoxicity associated with pemoline: possible autoimmune pathogenesis.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Autoimmune Diseases; Central Nervous Syst | 1998 |
Response to growth hormone in attention deficit hyperactivity disorder: effects of methylphenidate and pemoline therapy.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Female; Gro | 1998 |
Attention deficit hyperactivity in adults.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Humans; Pem | 1998 |
Adverse drug reaction. Pemoline and dyskinesia.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Humans; Mal | 1999 |
Practical guidelines for the treatment of substance abusers with adult attention-deficit hyperactivity disorder.
Topics: Adult; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Central Nervous System | 1999 |
Psychotic side effects of psychostimulants: a 5-year review.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Child, Pres | 1999 |
Sleep practitioners need to be aware of new changes in the labeling of pemoline (CYLERT)
Topics: Attention Deficit Disorder with Hyperactivity; Awareness; Central Nervous System Stimulants; Disorde | 1999 |
Long-acting stimulants for the treatment of attention-deficit disorder in cocaine-dependent adults.
Topics: Adult; Algorithms; Amphetamines; Antidepressive Agents, Second-Generation; Attention Deficit Disorde | 2000 |
Pemoline (Cylert): market withdrawal.
Topics: Adverse Drug Reaction Reporting Systems; Attention Deficit Disorder with Hyperactivity; Canada; Cent | 2000 |
Effectiveness of attention-deficit/hyperactivity treatment and diagnosis methods tested.
Topics: Adult; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Central Nervous System | 2000 |
A review of psychophysiological research with hyperkinetic children.
Topics: Amphetamines; Attention Deficit Disorder with Hyperactivity; Autonomic Nervous System; Blood Pressur | 1978 |
The hyperactive child.
Topics: Achievement; Age Factors; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Cr | 1976 |
Pharmacodynamics of pemoline in attention deficit disorder with hyperactivity.
Topics: Attention; Attention Deficit Disorder with Hyperactivity; Child; Dose-Response Relationship, Drug; H | 1992 |
[Hyperkinetic disorders with attention deficit. Diagnostic and therapeutic approach].
Topics: Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Drug Administration Schedul | 1991 |
Dramatic favorable responses of children with learning disabilities or dyslexia and attention deficit disorder to antimotion sickness medications: four case reports.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Cyclizine; | 1991 |
Social impact of stimulant treatment for hyperactive children.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Humans; Interpersonal Relat | 1991 |
Change from Mg-pemoline to bupropion in a 12-year-old boy with attention-deficit hyperactivity disorder.
Topics: Antidepressive Agents; Attention; Attention Deficit Disorder with Hyperactivity; Bupropion; Child; D | 1990 |
Hepatotoxicity due to pemoline (Cylert): a report of two cases.
Topics: Attention Deficit Disorder with Hyperactivity; Chemical and Drug Induced Liver Injury; Child; Humans | 1990 |
Change in response to pemoline at puberty.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Humans; Male; Pemoline; Puberty | 1990 |
Pemoline (Cylert)-induced hepatotoxicity.
Topics: Attention Deficit Disorder with Hyperactivity; Chemical and Drug Induced Liver Injury; Child; Female | 1990 |
Pemoline and urinary excretion of catecholamines and indoleamines in children with attention deficit disorder.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Humans; Hydroxyindoleacetic | 1986 |
Stimulant medication and short attention span: a clinical approach.
Topics: Attention; Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Dose-Response Re | 1989 |
The use of stimulant medication with children.
Topics: Attention; Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Dose-Response Re | 1989 |
Pemoline-induced abnormal involuntary movements.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Humans; Male; Movement Disorders; Pemoline | 1989 |
Pemoline and liver function.
Topics: Attention Deficit Disorder with Hyperactivity; Chemical and Drug Induced Liver Injury; Child; Humans | 1989 |
Attention deficit disorder: evaluation and treatment.
Topics: Age Factors; Anorexia; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Body Height; | 1985 |
The relationship between stimulant medication and tics.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Dextroamphe | 1988 |
Unexpected consequence of treatment for attention deficit disorder.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Forensic Psychiatry; Humans; Male; Marijuana A | 1987 |
Blood levels and tolerance to stimulants in ADDH children.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Cognition; Drug Tolerance; H | 1986 |
Pediatricians' reported practices in the assessment and treatment of attention deficit disorders.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Humans; Manuals as Topic; M | 1987 |
American Academy of Pediatrics Committee on Children with Disabilities, Committee on Drugs: Medication for children with an attention deficit disorder.
Topics: Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Child; Dextroamphet | 1987 |
Measurement of whole blood serotonin as a guide in prescribing psychostimulant medication for children with attentional deficits.
Topics: Administration, Oral; Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Child, Presc | 1986 |
Attention deficit disorder in adolescents.
Topics: Adolescent; Arousal; Attention Deficit Disorder with Hyperactivity; Combined Modality Therapy; Dextr | 1986 |
Evidence of lack of abuse or dependence following pemoline treatment: results of a retrospective survey.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Child; Child Behavior Disorders; C | 1986 |
Pharmacological treatment of attention deficit disorder, residual type (ADD,RT, "minimal brain dysfunction," "hyperactivity") in adults.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Humans; Methylphenidate; Pargyline; Pemoline; | 1985 |
Clinical management of children with hyperactivity. A shift in diagnostic and therapeutic emphasis.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Child Behavior; Child Development; Humans; Med | 1986 |
Depression following pemoline withdrawal in a hyperactive child.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Depression; Female; Humans; Pemoline; Substanc | 1985 |
Oral pemoline kinetics in hyperactive children.
Topics: Absorption; Administration, Oral; Attention Deficit Disorder with Hyperactivity; Child; Child, Presc | 1985 |
Treatment of chronic cocaine abuse and attention deficit disorder, residual type, with magnesium pemoline.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Cocaine; Female; Humans; Male; Pemoline; Subst | 1985 |
Catecholamine metabolism in the attention deficit disorder: implications for the use of amino acid precursor therapy.
Topics: Attention Deficit Disorder with Hyperactivity; Catecholamines; Dopamine; Humans; Levodopa; Methylphe | 1985 |
Psychological assessment of children with minimal brain dysfunction.
Topics: Achievement; Analysis of Variance; Attention; Attention Deficit Disorder with Hyperactivity; Auditor | 1973 |
Minimal brain dysfunctions in children.
Topics: Amphetamine; Attention; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Comm | 1974 |