peldesine and Leukemia--T-Cell

peldesine has been researched along with Leukemia--T-Cell* in 1 studies

Other Studies

1 other study(ies) available for peldesine and Leukemia--T-Cell

Article	Year
BCX-34: a novel T-cell selective immunosuppressant: purine nucleoside phosphorylase (PNP) inhibitor. Artificial organs, 1996, Volume: 20, Issue:8 We evaluated the efficacy of a new purine nucleoside phosphorylase inhibitor, BCX-34, as an immunosuppressive agent. BCX-34 showed a complete inhibitory effect on the proliferation of T-cells in an in vitro system, whereas no influence was observed in B-cell lines. In addition, it was revealed that this inhibitory effect was not due to the suppression of interleukin-2 production. Therefore, BCX-34 might be a potentially useful drug that can be used in combination, not competition, with cyclosporine A and FK506. Topics: Animals; B-Lymphocytes; Cell Division; Cells, Cultured; Cyclosporine; Drug Synergism; Guanine; Humans; Immunosuppressive Agents; Interleukin-2; Jurkat Cells; Leukemia, T-Cell; Mice; Purine-Nucleoside Phosphorylase; T-Lymphocytes; Tacrolimus; Tumor Cells, Cultured	1996

Article

Year

BCX-34: a novel T-cell selective immunosuppressant: purine nucleoside phosphorylase (PNP) inhibitor.

Artificial organs, 1996, Volume: 20, Issue:8

We evaluated the efficacy of a new purine nucleoside phosphorylase inhibitor, BCX-34, as an immunosuppressive agent. BCX-34 showed a complete inhibitory effect on the proliferation of T-cells in an in vitro system, whereas no influence was observed in B-cell lines. In addition, it was revealed that this inhibitory effect was not due to the suppression of interleukin-2 production. Therefore, BCX-34 might be a potentially useful drug that can be used in combination, not competition, with cyclosporine A and FK506.

Topics: Animals; B-Lymphocytes; Cell Division; Cells, Cultured; Cyclosporine; Drug Synergism; Guanine; Humans; Immunosuppressive Agents; Interleukin-2; Jurkat Cells; Leukemia, T-Cell; Mice; Purine-Nucleoside Phosphorylase; T-Lymphocytes; Tacrolimus; Tumor Cells, Cultured

1996