pederin has been researched along with Leukemia-P388* in 2 studies
1 review(s) available for pederin and Leukemia-P388
| Article | Year |
|---|---|
Isolation, biological activity, synthesis, and medicinal chemistry of the pederin/mycalamide family of natural products.
This review highlights the broad range of science that has arisen from the isolation of pederin, the mycalamides, theopederins, and onnamides, and psymberin. Specific topics include structure determination, biological activity, synthesis, and analog preparation and analysis. Topics: Animals; Antineoplastic Agents; Biological Products; Chemistry, Pharmaceutical; Coleoptera; Coumarins; Drug Screening Assays, Antitumor; Leukemia P388; Molecular Structure; Porifera; Pyrans; Pyrones; Structure-Activity Relationship | 2012 |
1 other study(ies) available for pederin and Leukemia-P388
| Article | Year |
|---|---|
Pederin-type pathways of uncultivated bacterial symbionts: analysis of o-methyltransferases and generation of a biosynthetic hybrid.
The complex polyketide pederin is a potent antitumor agent isolated from Paederus spp. rove beetles. We have previously isolated a set of genes from a bacterial endosymbiont that are good candidates for pederin biosynthesis. To biochemically study this pathway, we expressed three methyltransferases from the putative pederin pathway and used the partially unmethylated analogue mycalamide A from the marine sponge Mycale hentscheli as test substrate. Analysis by high-resolution MS/MS and NMR revealed that PedO regiospecifically methylates the marine compound to generate the nonnatural hybrid compound 18-O-methylmycalamide A with increased cytotoxicity. To our knowledge, this is the first biochemical evidence that invertebrates can obtain defensive complex polyketides from bacterial symbionts. Topics: Animals; Leukemia P388; Methyltransferases; Mice; Nuclear Magnetic Resonance, Biomolecular; Porifera; Pseudomonas; Pyrans; Symbiosis; Tandem Mass Spectrometry | 2009 |