pederin and Dermatitis--Contact

Topics: Animals; Coleoptera; Conjunctivitis; Dermatitis, Contact; Female; Humans; Male; Pyrans

Topics: Adolescent; Adult; Aged; Angola; Animals; Child; Child, Preschool; Coleoptera; Dermatitis, Contact; Disease Outbreaks; Female; Humans; Male; Middle Aged; Pyrans; Toxins, Biological; Young Adult

Topics: Adult; Animals; Coleoptera; Dermatitis, Contact; Female; Humans; Male; Pyrans; Toxins, Biological

Topics: Adolescent; Animals; Arm; Coleoptera; Dermatitis, Contact; Female; Hemolymph; Humans; Pyrans; Tanzania; Volunteers

Outbreaks of Paederus dermatitis have been documented worldwide. A case of Paederus dermatitis from Ethiopia is presented to highlight the importance of this clinical entity in the deployed setting.. A 31-year-old male presented with a 3- day history of scattered areas of a purulent, vesicating erythematous rash to his mid-back and neck. The largest of these measured 5 × 7 cm with erythematous borders and an erosive center. One to 2 days prior, 15 troops reported similar and less severe vesicating lesions to their extremities and backs. All patients participated in the same outdoor recreational event. A survey of the event's location revealed signs of the Paederus beetle.. Although a known phenomenon, there are no literature reports of Paederus dermatitis within AFRICOM. Crushing the Paederus beetle against the skin causes an intense rash because of paederin in the hemolymph. Most present with typical linear lesions likely caused by brushing off the beetle from the skin. Fortunately, patients respond favorably to topical steroid treatment.. Paederus beetle exposure in the deployed setting can impact force health. Increased awareness among providers and personnel should mitigate potential exposure and limit the morbidity associated with this beetle.

Topics: Adult; Animals; Anti-Inflammatory Agents; Blister; Coleoptera; Dermatitis, Contact; Ethiopia; Fluocinonide; Humans; Male; Military Personnel; Pyrans; Skin

Linear dermatitis (or dermatitis linearis, DL) is a skin blistering inflammatory lesion caused by exposure to the pederin toxin from rove beetles. Although it is prevalent in many countries of the Middle East region, this is not a notifiable disease. In recent years, a number of clinical symptoms outbreaks of DL has been reported from a few neighboring countries of Iran, but no report of experimental treatment among small laboratory rodents is known. This is a prerequisite to ascertain the nature of the best treatment strategy in cases of infestation with these beetles, as it occurs among local settlers during hot seasons in certain parts of the southern Iranian province of Fars. Live Paederus beetles were collected, identified to species level, sexed apart and partly processed to obtain their hemolymph toxin pederin in ethanol for dermal application on guinea pigs. Two Paederus species were found. Paederus ilsae (Bernhauer) (Coleoptera: Staphylinidae) was more abundant than P. iliensis (Coiffait). Recovery from DL due to live P. ilsae beetles was quicker and less complex than that of pederin in ethanol on guinea pigs. The application of potassium permanganate with calamine to heal DL was also more effective than fluocinolone treatment. This topical corticosteroid is thus considered less able to avert the cytotoxic action of pederin on the skin of guinea pigs than the antipruritic and cleansing agents. It seems likely that fluocinolone has certain effects which delays the recovery period for the treated skin.

Topics: Animals; Anti-Inflammatory Agents; Coleoptera; Dermatitis, Contact; Disease Models, Animal; Drug Combinations; Female; Ferric Compounds; Fluocinolone Acetonide; Guinea Pigs; Insect Bites and Stings; Iran; Male; Potassium Permanganate; Pyrans; Treatment Outcome; Zinc Oxide

To evaluate the clinical features of and to identify the pathogen responsible for an outbreak of acute dermatitis in a toy-building factory in Chibi city, central China.. Physical examinations were carried out on all the factory staff. Records were made. The factory district, its surrounding environment and the accommodation conditions were investigated. The insects collected in the area were identified by a parasitologist at the Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan.. Two hundred and sixty-eight cases of Paederus dermatitis were diagnosed in a total of 316 staff at the toy-building factory. The total incidence rate was 84.81%. The incidence rates in administrators and workers were 43.75% and 87%, respectively. The face and neck were the most common sites of involvement. The most common lesions consisted of linear erythema and papulopustules. In 71.27% of patients, more than one lesion was present.. This outbreak of acute dermatitis was diagnosed as Paederus dermatitis caused by Paederus fuscipes. The favorable environment, lighting, humidity, and poor accommodation may have been responsible for the outbreak. Increased public awareness of this condition may decrease the incidence of Paederus dermatitis.

Topics: Acute Disease; Adult; Aged; Animals; China; Coleoptera; Dermatitis, Contact; Disease Outbreaks; Female; Humans; Incidence; Male; Middle Aged; Occupational Diseases; Occupational Exposure; Play and Playthings; Pyrans; Young Adult

In Egypt, the rove beetle; Paederus alfierii Koch, is an active predator of several insects pests attacking a wide variety of cultivated plants as maize, cotton, clover ... etc. On the other hand, members of genus Paederus contain pederin (potent toxin) which in contact with human skin causes a necrotizing lesion (dermatitis linearis) and with the eye causes conjunctivitis. After the sudden flood of the year 1994, this beetle attacked a factory and about forty factors suffered a form of contact dermatitis and conjunctivitis. The majority of such factors needed hospitalization. To fill the gap in the knowledge of medical importance on such a predator, the present investigation was aimed. The aqueous extract from twenty wild collected adults (0.0101 gm) was tested on different groups of albino mice. No cutaneous reaction was seen macroscopically. On the other hand, another group of mice (3/4) showed mild conjunctival congestion faded on the next day. However, these experimental findings do not indicate the innocence of this rove-beetle from being harmful to man. The discussion was given on the light of work done abroad.

Topics: Agriculture; Animals; Coleoptera; Conjunctivitis; Dermatitis, Contact; Gossypium; Humans; Insecta; Mice; Necrosis; Poaceae; Predatory Behavior; Pyrans; Skin; Toxins, Biological; Zea mays