pectins and Lead-Poisoning

Topics: Adult; Female; Humans; Lead Poisoning; Occupational Diseases; Pectins; Rosales

Topics: Chelating Agents; Clinical Trials as Topic; Conflict of Interest; Humans; Lead; Lead Poisoning; Metals, Heavy; Pectins

Study of the effects of low-esterified pectin in toxic damage to the liver caused by enteral treatment with lead acetate showed that pectin treatment promoted the decrease in lead content in the liver, reduction of LPO activity, and recovery of parameters of lipid metabolism.

Topics: Animals; Drug Evaluation, Preclinical; Esters; Lead; Lead Poisoning; Liver Diseases; Male; Pectins; Rats

Lead is a ubiquitous heavy metal and its toxicity remains an important public health issue. In previous work, we reported that ingestion of rhamnogalacturonan-II dimer (dRGII), a pectic polysaccharide, may decrease intestinal absorption and status of Pb in rats. Here, we evaluated the potential detoxifying effect of different doses of dRGII after chronic oral Pb exposure in rats. For this purpose, six groups of ten male Wistar rats weighing 150g were treated as follows: group A received a semi-purified control diet for 6 weeks; groups B, C, D, E and F received the same diet plus 3 mg Pb (as acetate) for 3 weeks. Group B was then killed. Groups C, D, E, and F continued to receive the semi-purified control diet containing 0, 2, 6 or 18g dRGII/kg diet for 3 additional weeks. During the last 5 d, a Pb conventional balance study was performed. Rats were then anaesthetized and tissues were sampled for Pb and essential minerals assay. The results showed that residual Pb in the added dRGII was not available for absorption. However, the added dRGII failed to induce any significant increase in faecal or urinary Pb excretion. Consequently, at the end of the study the intestinal Pb absorption and balance remained unchanged in the animals receiving the different doses of dRGII. In line with this, we showed that dRGII administration was not effective in decreasing tibia or kidney Pb levels in rats. In conclusion, Pb complexed by dRGII in fruits and vegetables and fruit juice is thus mostly unavailable for intestinal absorption. However, the addition of dRGII after chronic Pb exposure does not help Pb detoxification.

Topics: Analysis of Variance; Animals; Diet; Drug Administration Schedule; Feces; Fermentation; Inactivation, Metabolic; Intestinal Absorption; Lead; Lead Poisoning; Male; Pectins; Rats; Rats, Wistar

Topics: Animals; Calcium Gluconate; Chenopodiaceae; Enterosorption; Female; Food Additives; Lead; Lead Poisoning; Pectins; Phytotherapy; Rats; Sodium Glutamate

Topics: Administration, Oral; Americium; Animals; Bacteria; Colon; Data Interpretation, Statistical; Esterification; Food Additives; Lead; Lead Poisoning; Pectins; Plutonium; Rats; Yeasts

Topics: Animals; Growth; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Kaolin; Kidney; Lead Poisoning; Male; Pectins; Rats

Topics: Administration, Oral; Bulgaria; Humans; Lead Poisoning; Occupational Diseases; Pectins

Topics: Aerosols; Animals; Lead; Lead Poisoning; Male; Pectins; Rats