pectins and Immunologic-Deficiency-Syndromes

It is established that arabinogalactan and pectinaceous polysaccharides isolated from Ferula kuchistanica are capable of stimulating a primary immune response in mice by increasing the number of antibody-producing cells in the spleen in response to immunization with sheep red blood cells in both intact animals (on average by 51.0%; p < 0.005) and those with secondary immunodeficiency caused by irradiation (on average by 164.4%; p < 0.005). The treatment with compounds studied also significantly increased the functional condition of cells of the mononuclear phagocyte system (on average by 27.0%; p < 0.005).

Topics: Adjuvants, Immunologic; Animals; Disease Models, Animal; Female; Ferula; Galactans; Immunologic Deficiency Syndromes; Male; Mice; Pectins; Phagocytes

Fifty-eight patients aged from 18 to 65 years with peritonitis of different etiology in toxic and terminal phases were treated. Nasoenteral intubation, enterosorption and early nutritious support with pectin-containing preparation (PCP) were carried out in all the patients just after surgery with standard course of 5 days. Baseline data was compared with that after PCP-supported treatment. Powder products of red beet were used as PCP. Immunodeficiency in peritonitis is characterized by imbalance of stress-realizing and stress-limiting mechanisms of immunocompetent cells. Enterosorption and early nutritious support with PCP in peritonitis decrease the level of plasmic cortisol and enhance stress-limiting reception that reduces a harmful effect of cortisol and reestablishes immunity.

Topics: Adolescent; Adult; Aged; Antidiarrheals; B-Lymphocytes; CD4-CD8 Ratio; Enterosorption; Follow-Up Studies; Humans; Immunity, Cellular; Immunologic Deficiency Syndromes; Intubation, Gastrointestinal; Middle Aged; Nutritional Support; Pectins; Peritonitis; Stress, Physiological; T-Lymphocytes; Treatment Outcome