pectins and Chronic-Disease

Although ileal pouch-anal anastomosis is the procedure of choice for most patients with ulcerative colitis or familial adenomatous polyposis, most patients have problems with stool frequency and/or consistency. Although most clinicians recommend fiber supplementation for these patients, we could find no studies that prove the efficacy of this practice. The first purpose of this study was to document the effect of fiber supplementation on intestinal function in patients after ileal pouch-anal anastomosis. Because pectin, a soluble fiber supplement, has been reported to slow gastric and intestinal transit, we also hypothesized that pectin would be a superior fiber supplement in these patients. The second purpose, therefore, was to determine whether the effects of pectin on intestinal transit would result in decreased stool frequency in patients with an ileal pouch.. Thirteen patients who had undergone ileal pouch-anal anastomosis for ulcerative colitis were entered into a 9-wk crossover study. The protocol consisted of three 2-wk study periods, each of which was preceded by a 1-wk washout period. During the three study periods patients supplemented their diets, in random order, with Citrucel, 1 tablespoon twice daily; pectin, 1 tablespoon twice daily; or no supplement. Patients maintained detailed dietary and bowel function diaries.. The effects (mean +/- SE) of Citrucel and pectin supplementation are summarized in Table 1. There was no significant effect of either supplement on stool frequency, pouch function, bloating, or stool consistency. In addition, there were no differences in continence.. We found no evidence to support the common practice of fiber supplementation in patients with an ileal pouch. Furthermore, this study did not find that stool frequency decreased during supplementation with pectin. We conclude that there is little role for fiber supplementation in patients with an ileal pouch.

Topics: Adult; Chronic Disease; Colitis, Ulcerative; Cross-Over Studies; Defecation; Diet Records; Dietary Fiber; Female; Gastrointestinal Motility; Humans; Intestines; Male; Methylcellulose; Middle Aged; Pectins; Proctocolectomy, Restorative

Twenty-two patients with chronic ulcers of the lower limb were treated with 'Varihesive', a modified form of 'Stomahesive'. The results showed that granulation was stimulated by the dressing, and no side-effects were encountered. The treatment is considered to be a useful adjunct to routine supportive measures. I should like to thank E.R. Squibb & Sons for providing the material for this study.

Topics: Aged; Bandages; Carboxymethylcellulose Sodium; Chronic Disease; Clinical Trials as Topic; Female; Gelatin; Granulation Tissue; Humans; Leg Ulcer; Male; Middle Aged; Pectins

Topics: Adult; Chronic Disease; Clinical Trials as Topic; Duodenal Ulcer; Humans; Male; Middle Aged; Pectins; Placebos; Propantheline; Sulfates

Topics: Chronic Disease; Clinical Trials as Topic; Duodenal Ulcer; Female; Follow-Up Studies; Humans; Male; Middle Aged; Parasympatholytics; Pectins; Placebos; Propantheline; Quaternary Ammonium Compounds; Xanthenes

Topics: Chronic Disease; Clinical Trials as Topic; Duodenal Ulcer; Humans; Parasympatholytics; Pectins; Propantheline; Quaternary Ammonium Compounds; Xanthenes

The protective capacities of fresh green (unripe) sweet bananas and of phosphatidylcholine and pectin (banana ingredients) against acute (ethanol- or indomethacin-induced) and chronic (indomethacin-induced) gastric mucosal lesions were evaluated in rats. Banana pulp was mixed with saline and given by gavage, as a pretreatment in a single dose. The identical protocol was used for pectin and phosphatidylcholine solution, and the dosages were adjusted to equal the amount of ingredients in the banana mixture, but higher concentrations were also given. The banana suspension reduced acute lesions, as did pectin and phosphatidylcholine in higher concentrations, but in concentrations as in fresh fruit no protective effects were observed except by pectin against indomethacin injury. In the model of chronic ulcers the banana suspension provided an incomplete and temporary protective effect. We conclude that the protective capacity of fresh green sweet bananas cannot be confined to only one active component. Pectin and phosphatidylcholine may protect gastric mucosa by strengthening the mucous-phospholipid layer, but the mechanism of protection afforded by bananas has to be further elucidated.

Topics: Acute Disease; Animals; Chronic Disease; Ethanol; Fruit; Gastric Mucosa; Indomethacin; Male; Models, Biological; Pectins; Phosphatidylcholines; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Suspensions

Sixty-four workers having contact with fluorine compounds under industrial conditions showed a rise in urine fluorine concentration, prolongation of the period of left ventricle tension primarily due to the isometric tension phase. The ejection was shortened mainly due to the phase of rapid ejection. The shortening of the time of pulse wave distribution, a decrease in vascular elasticity, and an increase in the peripheral resistance index were noted. Intake of fruit gel from apple pectin promoted a decrease in urine fluorine concentration, improved the hemodynamics and myocardial contractility.

Topics: Adult; Cardiovascular Diseases; Chronic Disease; Fluoride Poisoning; Fluorine; Heart; Heart Rate; Hemodynamics; Humans; Middle Aged; Occupational Diseases; Pectins

Recent epidemiological studies have shown that death-rates from certain chronic diseases are higher in areas with soft than in areas with hard drinking-water. In the striking negative correlation found in the county boroughs of England and Wales between cardiovascular mortality and water hardness the important underlying factor is apparently the water calcium. Interest is therefore focused on the dietary significance of calcium present in drinking-water. In relation to that interest, the present report gives a quantitative account of the composition of tea infusions prepared with waters containing different amounts of calcium. It is shown that a substantial part of water calcium is taken up by the tea leaf during the preparation of infusions. The analysis of the infusions covers a wide range of individual components, including trace metals and polyphenolic substances. It appears that the principal change caused in infusion composition by the presence of calcium in the water is a substantial reduction in the relatively high oxalate content. The question is raised whether there may be some connexion between the ;water factor' in cardiovascular disease and the absorption of oxalates from foods.

Topics: Caffeine; Calcium; Calcium, Dietary; Chronic Disease; England; Humans; Inositol; Metals; Mortality; Nitrogen; Oxalates; Pectins; Phenols; Phosphates; Tea; Wales; Water; Water Supply

Topics: Chronic Disease; Disease; Gingivitis; Humans; Pectins; Periodontal Diseases; Periodontium