pectins has been researched along with Carcinoma--Pancreatic-Ductal* in 2 studies
2 other study(ies) available for pectins and Carcinoma--Pancreatic-Ductal
| Article | Year |
|---|---|
Plant-derived saccharides and their inhibitory potential on metastasis associated cellular processes of pancreatic ductal adenocarcinoma cells.
This study intends to investigate the inhibitory potential of different plant derived saccharides on cell migration and adhesion of pancreatic ductal adenocarcinoma (PDAC) cells to microvascular liver endothelium, particularly considering the role of transmembranous galectin-3. PDAC cell lines PancTu1 and Panc1 were characterized by considerable (transmembranous) galectin-3 (Gal3) expression. SiRNA mediated Gal3 knockdown as well as treatment with differentially processed pectins and arabinogalactan-proteins (AGPs) did not impact on cell migration of either PDAC cell line. In contrast, Gal3 knockdown reduced adhesion of PDAC cells to the liver endothelial cell line TMNK-1 being more pronounced in Panc1 cells. Similarly, plant derived substances did not impact cell adhesion of PancTu1 cells while partially hydrolyzed citrus pectin (MCP), pectinase-treated MCP (MCP Topics: Blood Proteins; Carcinoma, Pancreatic Ductal; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cell Survival; Citrus; Galectin 3; Galectins; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Mucoproteins; Neoplasm Metastasis; Pancreatic Neoplasms; Pectins; Plant Proteins | 2020 |
Isolation and structural characterization of a pectin from Lycium ruthenicum Murr and its anti-pancreatic ductal adenocarcinoma cell activity.
Crude polysaccharides were obtained from fruits of Lycium ruthenicum Murr using hot water extraction followed by ethanol precipitation. A homogeneous polysaccharide, LRP3-S1 with a relative molecular weight of 114.8 kDa was purified by anion-exchange chromatography on DEAE Sepharose Topics: Antineoplastic Agents; Carbohydrate Conformation; Carcinoma, Pancreatic Ductal; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Lycium; Pancreatic Neoplasms; Pectins; Structure-Activity Relationship | 2019 |