pectins and Anaphylaxis

Topics: Anacardium; Anaphylaxis; Baths; Child; Citrus; Humans; Intradermal Tests; Male; Nut Hypersensitivity; Nuts; Pectins

Topics: Allergens; Anaphylaxis; Child; Cross Reactions; Diet Therapy; Female; Food Hypersensitivity; Fruit; Humans; Immunoglobulin E; Male; Nuts; Pectins; Yogurt

Inhalation of pectin has been identified as a cause of occupational asthma. However, allergic reactions to orally ingested pectin have not been reported.. To describe a child with pectin-induced food anaphylaxis and to discuss its possible relationship to cashew allergy.. A 3 1/2-year-old boy developed anaphylaxis once after eating cashews and later after eating a pectin-containing fruit "smoothie." He also has a history of generalized pruritus after eating grapefruit. Skin tests or radioallergosorbent tests (RASTs) were performed to pectin and other suspected food allergens.. The child had a positive skin prick test reaction to pectin and a high RAST reaction to cashew and pistachio. He had a low-level positive RAST reaction to grapefruit. Results of allergy tests for the other potential food allergens were negative. The pectin in the smoothie was confirmed to be of citrus origin. Review of previous case reports of pectin-induced occupational asthma revealed several patients with allergies to and cross-reactivity with cashew.. Ingestion, not only inhalation, of pectin can cause hypersensitivity reactions. Cashew, and possibly pistachio, allergy may be associated with pectin allergy, and the possibility of pectin allergy should be considered in cashew- or pistachio-allergic patients who have unexplained allergic reactions.

Topics: Anacardium; Anaphylaxis; Child, Preschool; Citrus; Humans; Male; Nut Hypersensitivity; Pectins; Radioallergosorbent Test; Skin Tests

Rats received dietary supplement of milk whey concentrate (KSP) being manufactured from skimmed milk by addition of apple pectin (Pec), KSP ultrafiltrated fractions and pure Pec during 21 day. A part of animals were sensitized i/p with chicken ovalbumin and finally subjected to systemic anaphylaxis (SA) by i/v antigen challenge. Gastrointestinal barrier macromolecular permeability (MP) for polyethylene glycol 4000 (PEG-4000) was measured by its urinary excretion after an intragastric load. MP increased significantly in nonsensitized rats after feeding with KSP and its high molecular (HM) fraction but not after feeding with low molecular (LM) KSP fraction compared to NaCl fed group. Feeding with Pec dramatically (5-fold) increased permeability. On the contrary the permeability decreased in sensitized rats subjected to SA when fed with KSP, its LM and particularly HM fraction the later group permeability being normalized down to normal value found in nonsensitized animals. It's concluded that KSP whey protein may be recommended for incorporation into specialized foods for patients with impaired gastrointestinal function.

Topics: Anaphylaxis; Animals; Cell Membrane Permeability; Drug Evaluation, Preclinical; Food Hypersensitivity; Immunization; Intestinal Mucosa; Intestines; Macromolecular Substances; Male; Milk Proteins; Molecular Weight; Pectins; Polyethylene Glycols; Rats; Rats, Wistar; Time Factors; Whey Proteins