pd 98059 has been researched along with Stomach Neoplasms in 36 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Stomach Neoplasms: Tumors or cancer of the STOMACH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "PHLDA2 plays a role in gastric cancer tumorigenesis by inhibiting apoptosis through the PI3K/AKT pathway." | 1.62 | HGF-mediated Up-regulation of PHLDA2 Is Associated With Apoptosis in Gastric Cancer. ( Koh, SA; Lee, KH, 2021) |
| "However, how to regulate cortactin in gastric cancer remains largely unknown." | 1.40 | FBXL5 targets cortactin for ubiquitination-mediated destruction to regulate gastric cancer cell migration. ( Cen, G; Ding, HH; Liu, B; Wu, WD, 2014) |
| "Cadmium exposure has been linked to human cancers, including stomach cancer." | 1.40 | Cadmium induces urokinase-type plasminogen activator receptor expression and the cell invasiveness of human gastric cancer cells via the ERK-1/2, NF-κB, and AP-1 signaling pathways. ( Chay, KO; Joo, YE; Jung, YD; Khoi, PN; Kim, DH; Kim, HD; Kim, KK; Lian, S; Xia, Y, 2014) |
| "A panel of gastric and esophageal cancer cell lines was treated with wortmannin as an Akt-signal inhibitor; the MAPK signal inhibitor PD98059; lapatinib, which inhibits both the epidermal growth factor receptor and HER2 tyrosine kinase; or siRNA for MAPK." | 1.39 | The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer. ( Fujii, H; Izawa, S; Kiessling, R; Kono, K; Kua, LF; Mimura, K; Mueller, A; Seliger, B; Shiraishi, K; So, J; Yong, WP, 2013) |
| "Migration in gastric cancer cells, SNU638 and SNU668, was dependent on a relative expression level of Tβ4." | 1.38 | Regulation of glycogen synthase kinase-3 by thymosin beta-4 is associated with gastric cancer cell migration. ( Kim, YS; Lee, GH; Lee, YS; Moon, EY; Ryu, YK; Song, KS, 2012) |
| "Ursodeoxycholic acid (UDCA) has been regarded as a suppressor of gastrointestinal cancer, but the mechanisms underlying its antitumor effects are not fully understood." | 1.38 | Pro-apoptotic role of the MEK/ERK pathway in ursodeoxycholic acid-induced apoptosis in SNU601 gastric cancer cells. ( Duong, HQ; Han, SI; Lim, SC; Parajuli, KR, 2012) |
| "MKN28 human gastric cancer cells were treated with trypsin, a PAR-2 activator, and subjected to real-time reverse transcription polymerase chain reaction (qRT-PCR), western blotting and ELISA for gene expression analyses." | 1.38 | Protease-activated receptor-2 induces expression of vascular endothelial growth factor and cyclooxygenase-2 via the mitogen-activated protein kinase pathway in gastric cancer cells. ( Gao, GR; Lv, CG; Zhang, BL; Zhang, C; Zhang, XF; Zhang, ZL, 2012) |
| "The effect of thimerosal on human gastric cancer cells is unknown." | 1.34 | Thimerosal-induced apoptosis in human SCM1 gastric cancer cells: activation of p38 MAP kinase and caspase-3 pathways without involvement of [Ca2+]i elevation. ( Chang, PM; Chen, WC; Chou, CT; Chu, ST; Fang, YC; Huang, CC; Huang, CJ; Jan, CR; Liu, SI; Lu, YC; Wang, BW; Wang, JL, 2007) |
| "Our results demonstrated that in human gastric cancer cells, IL-1beta upregulates the COX-2 gene expression through the activation of MEK/p44/42 and p38 MAP kinases pathway." | 1.31 | Interleukin-1beta induces cyclo-oxygenase-2 expression in gastric cancer cells by the p38 and p44/42 mitogen-activated protein kinase signaling pathways. ( Cho, CH; Fan, XM; Kung, HF; Lam, SK; Lin, MC; Wang, WP; Wong, BC, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.78) | 18.2507 |
| 2000's | 17 (47.22) | 29.6817 |
| 2010's | 17 (47.22) | 24.3611 |
| 2020's | 1 (2.78) | 2.80 |
| Authors | Studies |
|---|---|
| Koh, SA | 4 |
| Lee, KH | 6 |
| Qiang, Z | 1 |
| Meng, L | 1 |
| Yi, C | 1 |
| Yu, L | 1 |
| Chen, W | 1 |
| Sha, W | 1 |
| Qiu, F | 1 |
| Shi, CH | 1 |
| Zheng, J | 1 |
| Liu, YB | 1 |
| Yao, J | 3 |
| Qian, C | 2 |
| Shu, T | 1 |
| Zhang, X | 3 |
| Zhao, Z | 1 |
| Liang, Y | 2 |
| Kim, JR | 4 |
| Lin, YC | 1 |
| Wei, PL | 1 |
| Tsai, YT | 1 |
| Wong, JH | 1 |
| Chang, CM | 1 |
| Wang, JY | 1 |
| Hou, MF | 1 |
| Lee, YC | 1 |
| Chuang, HY | 1 |
| Chang, WC | 1 |
| Wang, J | 2 |
| Wang, L | 2 |
| Xue, M | 1 |
| Zhou, T | 1 |
| Liu, W | 1 |
| Si, J | 1 |
| Mimura, K | 1 |
| Shiraishi, K | 1 |
| Mueller, A | 1 |
| Izawa, S | 1 |
| Kua, LF | 1 |
| So, J | 1 |
| Yong, WP | 1 |
| Fujii, H | 1 |
| Seliger, B | 1 |
| Kiessling, R | 1 |
| Kono, K | 1 |
| Cen, G | 1 |
| Ding, HH | 1 |
| Liu, B | 1 |
| Wu, WD | 1 |
| Khoi, PN | 1 |
| Xia, Y | 1 |
| Lian, S | 1 |
| Kim, HD | 1 |
| Kim, DH | 1 |
| Joo, YE | 1 |
| Chay, KO | 1 |
| Kim, KK | 1 |
| Jung, YD | 1 |
| Wang, X | 1 |
| Sun, DF | 1 |
| Lu, R | 1 |
| Chen, ZF | 1 |
| Chen, YX | 1 |
| Fang, JY | 1 |
| Li, D | 1 |
| Qu, X | 1 |
| Hou, K | 1 |
| Zhang, Y | 1 |
| Dong, Q | 1 |
| Teng, Y | 1 |
| Zhang, J | 1 |
| Liu, Y | 1 |
| Song, EJ | 1 |
| Kang, MJ | 1 |
| Kim, YS | 2 |
| Kim, SM | 1 |
| Lee, SE | 1 |
| Kim, CH | 1 |
| Kim, DJ | 1 |
| Park, JH | 1 |
| Choi, EY | 2 |
| Kim, MK | 2 |
| Kim, KO | 1 |
| Lee, SH | 1 |
| Jang, BI | 2 |
| Kim, SW | 3 |
| Song, SK | 2 |
| Choi, JH | 1 |
| Ryu, YK | 1 |
| Lee, YS | 1 |
| Lee, GH | 1 |
| Song, KS | 1 |
| Moon, EY | 1 |
| Qian, CJ | 1 |
| Ye, B | 1 |
| Pan, G | 1 |
| Ren, J | 1 |
| Lu, J | 1 |
| Li, W | 1 |
| Fu, H | 1 |
| Zhang, S | 1 |
| Li, J | 1 |
| Lim, SC | 1 |
| Duong, HQ | 1 |
| Parajuli, KR | 1 |
| Han, SI | 1 |
| Zhang, C | 1 |
| Gao, GR | 1 |
| Lv, CG | 1 |
| Zhang, BL | 1 |
| Zhang, ZL | 1 |
| Zhang, XF | 1 |
| Raychowdhury, R | 1 |
| Schäfer, G | 1 |
| Fleming, J | 1 |
| Rosewicz, S | 1 |
| Wiedenmann, B | 1 |
| Wang, TC | 1 |
| Höcker, M | 1 |
| Shin, EY | 1 |
| Ma, EK | 1 |
| Kim, CK | 1 |
| Kwak, SJ | 1 |
| Kim, EG | 1 |
| Liu, ZM | 1 |
| Chen, GG | 1 |
| Ng, EK | 1 |
| Leung, WK | 1 |
| Sung, JJ | 1 |
| Chung, SC | 1 |
| Tominaga, K | 1 |
| Higuchi, K | 1 |
| Sasaki, E | 1 |
| Suto, R | 1 |
| Watanabe, T | 1 |
| Fujiwara, Y | 1 |
| Oshitani, N | 1 |
| Matsumoto, T | 1 |
| Kim, S | 1 |
| Iwao, H | 1 |
| Arakawa, T | 1 |
| Kang, W | 1 |
| Nielsen, O | 1 |
| Fenger, C | 1 |
| Leslie, G | 1 |
| Holmskov, U | 1 |
| Reid, KB | 1 |
| Ding, YB | 1 |
| Shi, RH | 1 |
| Tong, JD | 1 |
| Li, XY | 1 |
| Zhang, GX | 1 |
| Xiao, WM | 1 |
| Yang, JG | 1 |
| Bao, Y | 1 |
| Wu, J | 1 |
| Yan, ZG | 1 |
| Wang, XH | 1 |
| Chen, Y | 1 |
| Wang, Y | 2 |
| Xu, W | 1 |
| Zhang, Z | 1 |
| Hyun, MS | 1 |
| Kim, TN | 1 |
| Kim, JH | 1 |
| Liu, SQ | 1 |
| Yu, JP | 1 |
| Yu, HG | 1 |
| Lv, P | 1 |
| Chen, HL | 1 |
| Pan, Y | 1 |
| Zhao, L | 1 |
| Liang, J | 1 |
| Liu, J | 1 |
| Shi, Y | 1 |
| Liu, N | 1 |
| Zhang, G | 1 |
| Jin, H | 1 |
| Gao, J | 1 |
| Xie, H | 1 |
| Liu, Z | 1 |
| Fan, D | 1 |
| Chen, YC | 1 |
| Li, JY | 1 |
| Xu, WR | 1 |
| Zhang, YL | 1 |
| Liu, SI | 1 |
| Huang, CC | 1 |
| Huang, CJ | 1 |
| Wang, BW | 1 |
| Chang, PM | 1 |
| Fang, YC | 1 |
| Chen, WC | 1 |
| Wang, JL | 1 |
| Lu, YC | 1 |
| Chu, ST | 1 |
| Chou, CT | 1 |
| Jan, CR | 1 |
| Merchant, JL | 2 |
| Du, M | 1 |
| Todisco, A | 2 |
| Fan, XM | 1 |
| Wong, BC | 1 |
| Lin, MC | 1 |
| Cho, CH | 1 |
| Wang, WP | 1 |
| Kung, HF | 1 |
| Lam, SK | 1 |
| Suzuki, T | 1 |
| Grand, E | 1 |
| Bowman, C | 1 |
| Del Valle, J | 1 |
36 other studies available for pd 98059 and Stomach Neoplasms
| Article | Year |
|---|---|
HGF-mediated Up-regulation of PHLDA2 Is Associated With Apoptosis in Gastric Cancer.
Topics: Apoptosis; Cell Line, Tumor; Chromones; Flavonoids; Gene Expression Profiling; Gene Expression Regul | 2021 |
Curcumin regulates the miR-21/PTEN/Akt pathway and acts in synergy with PD98059 to induce apoptosis of human gastric cancer MGC-803 cells.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Proliferation | 2019 |
Periostin mediates the increased pro-angiogenic activity of gastric cancer cells under hypoxic conditions.
Topics: Cell Adhesion Molecules; Cell Communication; Cell Hypoxia; Cell Line, Tumor; Coculture Techniques; F | 2013 |
Combination treatment of PD98059 and DAPT in gastric cancer through induction of apoptosis and downregulation of WNT/β-catenin.
Topics: Aged; Aged, 80 and over; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; beta Ca | 2013 |
Hepatocyte growth factor-mediated gastrin-releasing peptide induces IL-8 expression through Ets-1 in gastric cancer cells.
Topics: Adenocarcinoma; Base Sequence; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Flavono | 2013 |
Pb²⁺ induced IL-8 gene expression by extracellular signal-regulated kinases and the transcription factor, activator protein 1, in human gastric carcinoma cells.
Topics: Cell Line, Tumor; Environmental Pollutants; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal- | 2015 |
ERK1/2 inhibition enhances apoptosis induced by JAK2 silencing in human gastric cancer SGC7901 cells.
Topics: Adenocarcinoma; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Female; Flavonoids; G2 Pha | 2014 |
The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer.
Topics: Androstadienes; Antigen Presentation; Antigens, Neoplasm; Cell Line, Tumor; Epidermal Growth Factor; | 2013 |
FBXL5 targets cortactin for ubiquitination-mediated destruction to regulate gastric cancer cell migration.
Topics: Binding Sites; Blotting, Western; Cell Line, Tumor; Cell Movement; Cortactin; Extracellular Signal-R | 2014 |
Cadmium induces urokinase-type plasminogen activator receptor expression and the cell invasiveness of human gastric cancer cells via the ERK-1/2, NF-κB, and AP-1 signaling pathways.
Topics: Cadmium; Cell Line, Tumor; Cell Movement; Flavonoids; Gene Expression Regulation, Neoplastic; Humans | 2014 |
HGF mediated upregulation of lipocalin 2 regulates MMP9 through nuclear factor-κB activation.
Topics: Acute-Phase Proteins; Cell Line; Cell Proliferation; Chromones; Flavonoids; Gene Expression Regulati | 2015 |
RAF may induce cell proliferation through hypermethylation of tumor suppressor gene promoter in gastric epithelial cells.
Topics: Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase | 2009 |
PI3K/Akt is involved in bufalin-induced apoptosis in gastric cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; | 2009 |
Kiss-1 suppresses MMP-9 expression by activating p38 MAP kinase in human stomach cancer.
Topics: Cell Line, Tumor; Cell Proliferation; Down-Regulation; Enzyme Activation; Flavonoids; Gene Expressio | 2009 |
Flagellin promotes the proliferation of gastric cancer cells via the Toll-like receptor 5.
Topics: Cell Line, Tumor; Cell Transformation, Neoplastic; Flagellin; Flavonoids; Humans; Interleukin-8; MAP | 2011 |
Down-regulation of survivin suppresses uro-plasminogen activator through transcription factor JunB.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Flavonoids; Gene Expression Regulation, Neoplastic; | 2011 |
Regulation of glycogen synthase kinase-3 by thymosin beta-4 is associated with gastric cancer cell migration.
Topics: Animals; beta Catenin; Butadienes; Cadherins; Calcium-Calmodulin-Dependent Protein Kinases; Cell Lin | 2012 |
ERK inhibition enhances TSA-induced gastric cancer cell apoptosis via NF-κB-dependent and Notch-independent mechanism.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dow | 2012 |
Semaphorin 5A, an axon guidance molecule, enhances the invasion and metastasis of human gastric cancer through activation of MMP9.
Topics: Analysis of Variance; Cell Line, Tumor; Cell Movement; Flavonoids; Humans; Integrins; MAP Kinase Sig | 2013 |
Pro-apoptotic role of the MEK/ERK pathway in ursodeoxycholic acid-induced apoptosis in SNU601 gastric cancer cells.
Topics: Apoptosis; Butadienes; Caspases; Cell Line, Tumor; Enzyme Activation; Flavonoids; Humans; MAP Kinase | 2012 |
Protease-activated receptor-2 induces expression of vascular endothelial growth factor and cyclooxygenase-2 via the mitogen-activated protein kinase pathway in gastric cancer cells.
Topics: Cell Line, Tumor; Cyclooxygenase 2; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; | 2012 |
Interaction of early growth response protein 1 (Egr-1), specificity protein 1 (Sp1), and cyclic adenosine 3'5'-monophosphate response element binding protein (CREB) at a proximal response element is critical for gastrin-dependent activation of the chromog
Topics: Binding Sites; Cell Nucleus; Chromogranin A; Chromogranins; Cyclic AMP Response Element-Binding Prot | 2002 |
Src/ERK but not phospholipase D is involved in keratinocyte growth factor-stimulated secretion of matrix metalloprotease-9 and urokinase-type plasminogen activator in SNU-16 human stomach cancer cell.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Collagen; Drug Combinations; Enzyme Inhibitors; Fibrob | 2002 |
Upregulation of heme oxygenase-1 and p21 confers resistance to apoptosis in human gastric cancer cells.
Topics: Apoptosis; Cadmium; Caspase 3; Caspases; Cell Division; Cell Line, Tumor; Cyclin-Dependent Kinase In | 2004 |
Correlation of MAP kinases with COX-2 induction differs between MKN45 and HT29 cells.
Topics: Blotting, Western; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygen | 2004 |
Induction of DMBT1 expression by reduced ERK activity during a gastric mucosa differentiation-like process and its association with human gastric cancer.
Topics: Adenocarcinoma; Agglutinins; Calcium-Binding Proteins; Cell Cycle Proteins; Cell Differentiation; Ce | 2005 |
PGE2 up-regulates vascular endothelial growth factor expression in MKN28 gastric cancer cells via epidermal growth factor receptor signaling system.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Dinoprostone; Enzyme Inhibitors; ErbB Receptors; Flavo | 2005 |
Analysis on the mechanism of Helicobacter pylori-induced apoptosis in gastric cancer cell line BGC-823.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Calcium-Calmodul | 2005 |
Regulation of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MEK/ERK activation in human stomach cancer cell lines.
Topics: Cell Line, Tumor; Cell Proliferation; Culture Media, Serum-Free; Dose-Response Relationship, Drug; E | 2006 |
Activation of Akt and ERK signalling pathways induced by etoposide confer chemoresistance in gastric cancer cells.
Topics: Androstadienes; Antineoplastic Agents, Phytogenic; Cell Division; Cell Line, Tumor; Drug Resistance, | 2006 |
Cellular prion protein promotes invasion and metastasis of gastric cancer.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; CD8-Positive T-Lymphocytes; Cell Adhesion; En | 2006 |
H pylori stimulates proliferation of gastric cancer cells through activating mitogen-activated protein kinase cascade.
Topics: Adenocarcinoma; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Enzyme Inhibitors; Epitheli | 2006 |
Thimerosal-induced apoptosis in human SCM1 gastric cancer cells: activation of p38 MAP kinase and caspase-3 pathways without involvement of [Ca2+]i elevation.
Topics: Anthracenes; Apoptosis; Calcium Signaling; Caspase 3; Cell Line, Tumor; Cell Survival; Chelating Age | 2007 |
Sp1 phosphorylation by Erk 2 stimulates DNA binding.
Topics: Adenocarcinoma; Base Sequence; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme I | 1999 |
Interleukin-1beta induces cyclo-oxygenase-2 expression in gastric cancer cells by the p38 and p44/42 mitogen-activated protein kinase signaling pathways.
Topics: Adenocarcinoma; Blotting, Western; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Flavonoids; Ge | 2001 |
TNF-alpha and interleukin 1 activate gastrin gene expression via MAPK- and PKC-dependent mechanisms.
Topics: Adenocarcinoma; Animals; Cells, Cultured; Dogs; Enzyme Inhibitors; Flavonoids; Gastrins; Gene Expres | 2001 |