pd 98059 and Skin Neoplasms
pd 98059 has been researched along with Skin Neoplasms in 9 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Skin Neoplasms: Tumors or cancer of the SKIN.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"In this study we have investigated the role of mitogen-induced and stress-activated MAP kinase pathways in the cellular response to taxol, etoposide and ceramide in three different human cancer cell lines: HeLa cervical carcinoma, MCF7 breast cancer and A431 squamous carcinoma cells." | 3.71 | The role of MAPK pathways in the action of chemotherapeutic drugs. ( Boldt, S; Kolch, W; Weidle, UH, 2002) |
"The combined treatment of melanoma cells with sorafenib and rapamycin led to an approximately twofold increase of cell death compared with sorafenib monotreatment (P<0." | 1.35 | Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells. ( Flaherty, KT; Garbe, C; Kulms, D; Lasithiotakis, KG; Maczey, E; Meier, FE; Schittek, B; Sinnberg, TW, 2008) |
"Melanoma is a malignant skin cancer that displays a high rate of tumor cell migration and metastasis." | 1.34 | Enhancement of cell migration by corticotropin-releasing hormone through ERK1/2 pathway in murine melanoma cell line, B16F10. ( Bang, SI; Cho, D; Kim, TS; Park, H; Yang, Y, 2007) |
Research
Studies (9)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 6 (66.67) | 29.6817 |
2010's | 3 (33.33) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Rho, O | 1 |
Kiguchi, K | 1 |
Jiang, G | 1 |
DiGiovanni, J | 1 |
Slipicevic, A | 1 |
Jørgensen, K | 1 |
Skrede, M | 1 |
Rosnes, AK | 1 |
Trøen, G | 1 |
Davidson, B | 1 |
Flørenes, VA | 1 |
Zhang, X | 1 |
Makino, T | 1 |
Muchemwa, FC | 1 |
Lin, T | 1 |
Wakasugi, S | 1 |
Egawa, K | 1 |
Ihn, H | 1 |
Jalili, A | 1 |
Moser, A | 1 |
Pashenkov, M | 1 |
Wagner, C | 1 |
Pathria, G | 1 |
Borgdorff, V | 1 |
Gschaider, M | 1 |
Stingl, G | 1 |
Ramaswamy, S | 1 |
Wagner, SN | 1 |
Kawaguchi, M | 1 |
Valencia, JC | 1 |
Namiki, T | 1 |
Suzuki, T | 1 |
Hearing, VJ | 1 |
Boldt, S | 1 |
Weidle, UH | 1 |
Kolch, W | 1 |
Katsanakis, KD | 1 |
Gorgoulis, V | 1 |
Papavassiliou, AG | 1 |
Zoumpourlis, VK | 1 |
Yang, Y | 2 |
Park, H | 1 |
Kim, TS | 1 |
Bang, SI | 1 |
Cho, D | 1 |
Lasithiotakis, KG | 1 |
Sinnberg, TW | 1 |
Schittek, B | 1 |
Flaherty, KT | 1 |
Kulms, D | 1 |
Maczey, E | 1 |
Garbe, C | 1 |
Meier, FE | 1 |
Other Studies
9 other studies available for pd 98059 and Skin Neoplasms
Article | Year |
---|---|
Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild-type and BK5.AktWT mice.
Topics: Animals; Antibiotics, Antineoplastic; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell | 2014 |
The fatty acid binding protein 7 (FABP7) is involved in proliferation and invasion of melanoma cells.
Topics: Biomarkers, Tumor; Carcinogens; Carrier Proteins; Cell Nucleus; Cell Proliferation; Cytoplasm; Disea | 2008 |
Activation of the extracellular signal-regulated kinases signaling pathway in squamous cell carcinoma of the skin.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Extracellular Signal-Regulated MAP K | 2007 |
Polo-like kinase 1 is a potential therapeutic target in human melanoma.
Topics: Apoptosis; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Flavonoids; G1 P | 2011 |
Diacylglycerol kinase regulates tyrosinase expression and function in human melanocytes.
Topics: Adenoviridae; alpha-MSH; Animals; Cell Line, Tumor; Diacylglycerol Kinase; Endoplasmic Reticulum; En | 2012 |
The role of MAPK pathways in the action of chemotherapeutic drugs.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma, Squamous Cell; Cell C | 2002 |
The progression in the mouse skin carcinogenesis model correlates with ERK1/2 signaling.
Topics: Animals; Cell Transformation, Neoplastic; Disease Models, Animal; Flavonoids; Genes, ras; Immunohist | 2002 |
Enhancement of cell migration by corticotropin-releasing hormone through ERK1/2 pathway in murine melanoma cell line, B16F10.
Topics: Animals; Cell Line, Tumor; Cell Movement; Corticotropin-Releasing Hormone; Dose-Response Relationshi | 2007 |
Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells.
Topics: Androstadienes; Apoptosis; Benzenesulfonates; Butadienes; Cell Line, Tumor; Cell Proliferation; Chro | 2008 |