Page last updated: 2024-11-02

pd 98059 and Skin Neoplasms

pd 98059 has been researched along with Skin Neoplasms in 9 studies

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.

Skin Neoplasms: Tumors or cancer of the SKIN.

Research Excerpts

ExcerptRelevanceReference
"In this study we have investigated the role of mitogen-induced and stress-activated MAP kinase pathways in the cellular response to taxol, etoposide and ceramide in three different human cancer cell lines: HeLa cervical carcinoma, MCF7 breast cancer and A431 squamous carcinoma cells."3.71The role of MAPK pathways in the action of chemotherapeutic drugs. ( Boldt, S; Kolch, W; Weidle, UH, 2002)
"The combined treatment of melanoma cells with sorafenib and rapamycin led to an approximately twofold increase of cell death compared with sorafenib monotreatment (P<0."1.35Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells. ( Flaherty, KT; Garbe, C; Kulms, D; Lasithiotakis, KG; Maczey, E; Meier, FE; Schittek, B; Sinnberg, TW, 2008)
"Melanoma is a malignant skin cancer that displays a high rate of tumor cell migration and metastasis."1.34Enhancement of cell migration by corticotropin-releasing hormone through ERK1/2 pathway in murine melanoma cell line, B16F10. ( Bang, SI; Cho, D; Kim, TS; Park, H; Yang, Y, 2007)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (66.67)29.6817
2010's3 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rho, O1
Kiguchi, K1
Jiang, G1
DiGiovanni, J1
Slipicevic, A1
Jørgensen, K1
Skrede, M1
Rosnes, AK1
Trøen, G1
Davidson, B1
Flørenes, VA1
Zhang, X1
Makino, T1
Muchemwa, FC1
Lin, T1
Wakasugi, S1
Egawa, K1
Ihn, H1
Jalili, A1
Moser, A1
Pashenkov, M1
Wagner, C1
Pathria, G1
Borgdorff, V1
Gschaider, M1
Stingl, G1
Ramaswamy, S1
Wagner, SN1
Kawaguchi, M1
Valencia, JC1
Namiki, T1
Suzuki, T1
Hearing, VJ1
Boldt, S1
Weidle, UH1
Kolch, W1
Katsanakis, KD1
Gorgoulis, V1
Papavassiliou, AG1
Zoumpourlis, VK1
Yang, Y2
Park, H1
Kim, TS1
Bang, SI1
Cho, D1
Lasithiotakis, KG1
Sinnberg, TW1
Schittek, B1
Flaherty, KT1
Kulms, D1
Maczey, E1
Garbe, C1
Meier, FE1

Other Studies

9 other studies available for pd 98059 and Skin Neoplasms

ArticleYear
Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild-type and BK5.AktWT mice.
    Molecular carcinogenesis, 2014, Volume: 53, Issue:11

    Topics: Animals; Antibiotics, Antineoplastic; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell

2014
The fatty acid binding protein 7 (FABP7) is involved in proliferation and invasion of melanoma cells.
    BMC cancer, 2008, Sep-30, Volume: 8

    Topics: Biomarkers, Tumor; Carcinogens; Carrier Proteins; Cell Nucleus; Cell Proliferation; Cytoplasm; Disea

2008
Activation of the extracellular signal-regulated kinases signaling pathway in squamous cell carcinoma of the skin.
    Bioscience trends, 2007, Volume: 1, Issue:3

    Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Extracellular Signal-Regulated MAP K

2007
Polo-like kinase 1 is a potential therapeutic target in human melanoma.
    The Journal of investigative dermatology, 2011, Volume: 131, Issue:9

    Topics: Apoptosis; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Flavonoids; G1 P

2011
Diacylglycerol kinase regulates tyrosinase expression and function in human melanocytes.
    The Journal of investigative dermatology, 2012, Volume: 132, Issue:12

    Topics: Adenoviridae; alpha-MSH; Animals; Cell Line, Tumor; Diacylglycerol Kinase; Endoplasmic Reticulum; En

2012
The role of MAPK pathways in the action of chemotherapeutic drugs.
    Carcinogenesis, 2002, Volume: 23, Issue:11

    Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma, Squamous Cell; Cell C

2002
The progression in the mouse skin carcinogenesis model correlates with ERK1/2 signaling.
    Molecular medicine (Cambridge, Mass.), 2002, Volume: 8, Issue:10

    Topics: Animals; Cell Transformation, Neoplastic; Disease Models, Animal; Flavonoids; Genes, ras; Immunohist

2002
Enhancement of cell migration by corticotropin-releasing hormone through ERK1/2 pathway in murine melanoma cell line, B16F10.
    Experimental dermatology, 2007, Volume: 16, Issue:1

    Topics: Animals; Cell Line, Tumor; Cell Movement; Corticotropin-Releasing Hormone; Dose-Response Relationshi

2007
Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells.
    The Journal of investigative dermatology, 2008, Volume: 128, Issue:8

    Topics: Androstadienes; Apoptosis; Benzenesulfonates; Butadienes; Cell Line, Tumor; Cell Proliferation; Chro

2008
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