pd 98059 has been researched along with Sjogren's Syndrome in 2 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Sjogren's Syndrome: Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lisi, S | 1 |
| Sisto, M | 1 |
| D'Amore, M | 1 |
| Lofrumento, DD | 1 |
| Hsu, SD | 1 |
| Dickinson, DP | 1 |
| Qin, H | 1 |
| Borke, J | 1 |
| Ogbureke, KU | 1 |
| Winger, JN | 1 |
| Camba, AM | 1 |
| Bollag, WB | 1 |
| Stöppler, HJ | 1 |
| Sharawy, MM | 1 |
| Schuster, GS | 1 |
2 other studies available for pd 98059 and Sjogren's Syndrome
| Article | Year |
|---|---|
Co-culture system of human salivary gland epithelial cells and immune cells from primary Sjögren's syndrome patients: an in vitro approach to study the effects of Rituximab on the activation of the Raf-1/ERK1/2 pathway.
Topics: B-Lymphocytes; Cells, Cultured; Coculture Techniques; Cytokines; Enzyme Activation; Epithelial Cells | 2015 |
Green tea polyphenols reduce autoimmune symptoms in a murine model for human Sjogren's syndrome and protect human salivary acinar cells from TNF-alpha-induced cytotoxicity.
Topics: Animals; Autoimmunity; Catechin; Cell Line; Cell Survival; Disease Models, Animal; Flavonoids; Human | 2007 |