pd 98059 has been researched along with Seizures in 3 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Preconditioning by N-methyl-d-aspartate (NMDA) may be promoted in vivo by the administration of a sub-convulsing dose of NMDA, with a neuroprotective effect against seizures and neuronal death induced by the infusion of quinolinic acid (QA) in mice." | 7.77 | NMDA preconditioning protects against quinolinic acid-induced seizures via PKA, PI3K and MAPK/ERK signaling pathways. ( Boeck, CR; de Araújo Herculano, B; Martins, WC; Tasca, CI; Vandresen-Filho, S, 2011) |
| "Preconditioning by N-methyl-d-aspartate (NMDA) may be promoted in vivo by the administration of a sub-convulsing dose of NMDA, with a neuroprotective effect against seizures and neuronal death induced by the infusion of quinolinic acid (QA) in mice." | 3.77 | NMDA preconditioning protects against quinolinic acid-induced seizures via PKA, PI3K and MAPK/ERK signaling pathways. ( Boeck, CR; de Araújo Herculano, B; Martins, WC; Tasca, CI; Vandresen-Filho, S, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, S | 1 |
| Yang, M | 1 |
| Kim, J | 2 |
| Son, Y | 1 |
| Kang, S | 1 |
| Ahn, W | 1 |
| Kim, SH | 1 |
| Kim, JC | 1 |
| Shin, T | 1 |
| Wang, H | 1 |
| Moon, C | 1 |
| de Araújo Herculano, B | 1 |
| Vandresen-Filho, S | 1 |
| Martins, WC | 1 |
| Boeck, CR | 1 |
| Tasca, CI | 1 |
| Murray, B | 1 |
| Alessandrini, A | 1 |
| Cole, AJ | 1 |
| Yee, AG | 1 |
| Furshpan, EJ | 1 |
3 other studies available for pd 98059 and Seizures
| Article | Year |
|---|---|
Involvement of BDNF/ERK signaling in spontaneous recovery from trimethyltin-induced hippocampal neurotoxicity in mice.
Topics: Animals; Brain-Derived Neurotrophic Factor; Butadienes; Cells, Cultured; Disease Models, Animal; Enz | 2016 |
NMDA preconditioning protects against quinolinic acid-induced seizures via PKA, PI3K and MAPK/ERK signaling pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Androstadienes; Animals; Calcium-Calmodulin-Dependent | 2011 |
Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Death; Cells, Cultured; Enzyme Inhibitor | 1998 |