pd 98059 has been researched along with Rheumatoid Arthritis in 19 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this research is to study the effect of genistein on cytokines or growth factor-induced proliferation and transformation phenotype of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS)." | 7.78 | Genistein inhibit cytokines or growth factor-induced proliferation and transformation phenotype in fibroblast-like synoviocytes of rheumatoid arthritis. ( Dong, J; He, P; Li, N; Li, W; Sun, T; Zhang, Q; Zhang, Y, 2012) |
| "The purpose of this research is to study the effect of genistein on cytokines or growth factor-induced proliferation and transformation phenotype of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS)." | 3.78 | Genistein inhibit cytokines or growth factor-induced proliferation and transformation phenotype in fibroblast-like synoviocytes of rheumatoid arthritis. ( Dong, J; He, P; Li, N; Li, W; Sun, T; Zhang, Q; Zhang, Y, 2012) |
| "Melatonin has been shown to have potent anti-proliferative effect in various cancer cells such as breast and prostate cancer cells." | 1.35 | Melatonin inhibits human fibroblast-like synoviocyte proliferation via extracellular signal-regulated protein kinase/P21(CIP1)/P27(KIP1) pathways. ( Baik, HH; Cho, HY; Chung, JH; Ha, E; Nah, SS; Park, HJ; Won, HJ, 2009) |
| "Apigenin treatment resulted in activation of the mitogen-activated protein kinase (MAPK) ERK1/2, and pretreatment with an ERK inhibitor PD98059 dramatically reduced apigenin-induced apoptosis." | 1.35 | Apigenin-induced apoptosis is mediated by reactive oxygen species and activation of ERK1/2 in rheumatoid fibroblast-like synoviocytes. ( Cho, J; Cho, WS; Jeong, M; Kim, C; Lee, JM; Lee, K; Lee, SG; Shin, GC, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 12 (63.16) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, K | 1 |
| Fu, W | 1 |
| Zhao, S | 1 |
| Jiao, T | 1 |
| Wu, D | 1 |
| Wang, Y | 1 |
| Tang, C | 1 |
| Li, Y | 1 |
| Lin, X | 1 |
| Ye, J | 1 |
| Li, W | 2 |
| He, Z | 1 |
| Li, F | 2 |
| Cai, X | 1 |
| Liu, Y | 1 |
| Wang, D | 1 |
| Shi, G | 1 |
| Xing, R | 1 |
| Jin, Y | 1 |
| Sun, L | 1 |
| Yang, L | 1 |
| Li, C | 1 |
| Li, Z | 1 |
| Liu, X | 1 |
| Zhao, J | 1 |
| Hashizume, M | 1 |
| Hayakawa, N | 1 |
| Mihara, M | 1 |
| Gang, C | 1 |
| Jiahui, Y | 1 |
| Huaizhou, W | 1 |
| Qing, C | 1 |
| Dongbao, Z | 1 |
| Qian, S | 1 |
| Nah, SS | 1 |
| Won, HJ | 1 |
| Park, HJ | 1 |
| Ha, E | 1 |
| Chung, JH | 1 |
| Cho, HY | 1 |
| Baik, HH | 1 |
| Shin, GC | 1 |
| Kim, C | 1 |
| Lee, JM | 1 |
| Cho, WS | 1 |
| Lee, SG | 1 |
| Jeong, M | 1 |
| Cho, J | 1 |
| Lee, K | 1 |
| Westra, J | 1 |
| Brouwer, E | 1 |
| Bouwman, E | 1 |
| Doornbos-van der Meer, B | 1 |
| Posthumus, MD | 1 |
| van Leeuwen, MA | 1 |
| Limburg, PC | 1 |
| Ueda, Y | 1 |
| Kallenberg, CG | 1 |
| Zhang, Y | 1 |
| Dong, J | 1 |
| He, P | 1 |
| Zhang, Q | 1 |
| Li, N | 1 |
| Sun, T | 1 |
| Yasuda, T | 1 |
| Shimizu, M | 1 |
| Nakagawa, T | 1 |
| Julovi, SM | 1 |
| Nakamura, T | 1 |
| Hsieh, MS | 1 |
| Ho, HC | 1 |
| Chou, DT | 1 |
| Pan, S | 1 |
| Liang, YC | 1 |
| Hsieh, TY | 1 |
| Lan, JL | 1 |
| Tsai, SH | 1 |
| Kim, KW | 1 |
| Cho, ML | 1 |
| Park, MK | 1 |
| Yoon, CH | 1 |
| Park, SH | 1 |
| Lee, SH | 1 |
| Kim, HY | 1 |
| Wang, CH | 1 |
| Chen, LN | 1 |
| Zhu, P | 1 |
| Fan, CM | 1 |
| Wang, YH | 1 |
| Jia, JF | 1 |
| Li, WQ | 1 |
| Zafarullah, M | 1 |
| Miyazawa, K | 1 |
| Mori, A | 1 |
| Okudaira, H | 1 |
| Vincenti, MP | 1 |
| Brinckerhoff, CE | 1 |
| Neff, L | 1 |
| Zeisel, M | 1 |
| Sibilia, J | 1 |
| Schöller-Guinard, M | 1 |
| Klein, JP | 1 |
| Wachsmann, D | 1 |
| Kitasato, H | 1 |
| Noda, M | 1 |
| Akahoshi, T | 1 |
| Okamoto, R | 1 |
| Koshino, T | 1 |
| Murakami, Y | 1 |
| Inoue, M | 1 |
| Kawai, S | 1 |
19 other studies available for pd 98059 and Rheumatoid Arthritis
| Article | Year |
|---|---|
miR-483-3p Promotes IL-33 Production from Fibroblast-Like Synoviocytes by Regulating ERK Signaling in Rheumatoid Arthritis.
Topics: Arthritis, Rheumatoid; Cell Line; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoid | 2021 |
Prolactin increases tumor necrosis factor alpha expression in peripheral CD14 monocytes of patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Flavonoids; Gene Expression Regulation; Gene Silencing; Humans; Lipopolysacch | 2014 |
Gαq controls rheumatoid arthritis via regulation of Th17 differentiation.
Topics: Animals; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; Dendritic Cells; Flavonoids; Gene Expres | 2015 |
Interleukin-21 induces migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cadherins; CD4-Positive T-Lymphocytes; Cell Movement; Cells, Cul | 2016 |
IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Blotting, Western; | 2008 |
Defects of mitogen-activated protein kinase in ICOS signaling pathway lead to CD4(+) and CD8(+) T-cell dysfunction in patients with active SLE.
Topics: Adult; Aged; Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; Arthritis, Rheumatoid; | 2009 |
Melatonin inhibits human fibroblast-like synoviocyte proliferation via extracellular signal-regulated protein kinase/P21(CIP1)/P27(KIP1) pathways.
Topics: Aged; Arthritis, Rheumatoid; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor | 2009 |
Apigenin-induced apoptosis is mediated by reactive oxygen species and activation of ERK1/2 in rheumatoid fibroblast-like synoviocytes.
Topics: Apigenin; Apoptosis; Arthritis, Rheumatoid; Caspases; Cell Line; Cell Survival; Enzyme Activation; F | 2009 |
Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts.
Topics: Arthritis, Rheumatoid; Benzylamines; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase | 2009 |
Genistein inhibit cytokines or growth factor-induced proliferation and transformation phenotype in fibroblast-like synoviocytes of rheumatoid arthritis.
Topics: Anthracenes; Arthritis, Rheumatoid; Cell Cycle; Cell Proliferation; Cells, Cultured; Epidermal Growt | 2012 |
Matrix metalloproteinase production by COOH-terminal heparin-binding fibronectin fragment in rheumatoid synovial cells.
Topics: Arthritis, Rheumatoid; Carrier Proteins; Cells, Cultured; Enzyme Induction; Enzyme Inhibitors; Fibro | 2003 |
Expression of matrix metalloproteinase-9 (gelatinase B) in gouty arthritis and stimulation of MMP-9 by urate crystals in macrophages.
Topics: Animals; Arthritis, Gouty; Arthritis, Rheumatoid; Blotting, Western; Enzyme Inhibitors; Enzyme Precu | 2003 |
Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor kappaB-dependent pathway in patients with rheumatoid arthritis.
Topics: Adult; Aged; Androstadienes; Antibodies, Monoclonal; Arthritis, Rheumatoid; CD28 Antigens; CD3 Compl | 2005 |
[CD147 stimulates the angiogenesis in rheumatoid synovium via the activation of vascular endothelial growth factor].
Topics: Adult; Aged; Anthracenes; Arthritis, Rheumatoid; Basigin; Calcium-Calmodulin-Dependent Protein Kinas | 2007 |
Oncostatin M up-regulates tissue inhibitor of metalloproteinases-3 gene expression in articular chondrocytes via de novo transcription, protein synthesis, and tyrosine kinase- and mitogen-activated protein kinase-dependent mechanisms.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Calcium-Calmodulin-Dependent Protein Kinas | 1998 |
Establishment and characterization of a novel human rheumatoid fibroblast-like synoviocyte line, MH7A, immortalized with SV40 T antigen.
Topics: Antigens, Polyomavirus Transforming; Antigens, Surface; Arthritis, Rheumatoid; Calcium-Calmodulin-De | 1998 |
The potential of signal transduction inhibitors for the treatment of arthritis: Is it all just JNK?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Collagenases; Enzyme Inhibi | 2001 |
NF-kappaB and the MAP kinases/AP-1 pathways are both involved in interleukin-6 and interleukin-8 expression in fibroblast-like synoviocytes stimulated by protein I/II, a modulin from oral streptococci.
Topics: Anti-Bacterial Agents; Apigenin; Arthritis, Rheumatoid; Bacterial Proteins; Cells, Cultured; Curcumi | 2001 |
Activated Ras modifies the proliferative response of rheumatoid synovial cells to TNF-alpha and TGF-alpha.
Topics: Apoptosis; Arthritis, Rheumatoid; Blotting, Northern; Cell Division; Cell Survival; Cells, Cultured; | 2001 |