pd 98059 has been researched along with Reperfusion Injury in 31 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Inflammation activation and necroptosis involved in CA/CPR-induced CIRI were regulated by the ERK/calpain-2 signaling pathway." | 8.02 | Inhibition of extracellular signal-regulated kinase/calpain-2 pathway reduces neuroinflammation and necroptosis after cerebral ischemia-reperfusion injury in a rat model of cardiac arrest. ( Chen, MH; Li, N; Tian, XY; Wang, WY; Wu, ZJ; Xie, L; Yang, YG; Zhao, GY; Zou, XS, 2021) |
| "Calcitriol has been demonstrated to provide neuroprotection against ischemia/reperfusion (I/R) injury." | 5.39 | Neuroprotective effect of calcitriol on ischemic/reperfusion injury through the NR3A/CREB pathways in the rat hippocampus. ( Fu, J; Gu, J; Pan, X; Ran, R; Xiao, Y; Xue, R; Zhong, H, 2013) |
| "To explore the effect of extracellular signal-regulated kinase (ERK) inhibitor PD98059 on calpain-related proteins in the brain, and to understand the pathophysiological changes of calpain in cerebral ischemia/reperfusion injury (CIRI)." | 4.12 | [Effect of extracellular signal-regulated kinase inhibitor on calpain in rat cerebral cortex after cardiopulmonary resuscitation]. ( Dai, C; Wang, W; Yang, Y; Zhong, R, 2022) |
| "Inflammation activation and necroptosis involved in CA/CPR-induced CIRI were regulated by the ERK/calpain-2 signaling pathway." | 4.02 | Inhibition of extracellular signal-regulated kinase/calpain-2 pathway reduces neuroinflammation and necroptosis after cerebral ischemia-reperfusion injury in a rat model of cardiac arrest. ( Chen, MH; Li, N; Tian, XY; Wang, WY; Wu, ZJ; Xie, L; Yang, YG; Zhao, GY; Zou, XS, 2021) |
| "Sevoflurane postconditioning prevents activation of caspase 3 and 9, mediators of apoptosis in ischemia-reperfusion injury." | 3.76 | Sevoflurane postconditioning prevents activation of caspase 3 and 9 through antiapoptotic signaling after myocardial ischemia-reperfusion. ( Domae, N; Inamura, Y; Kotani, J; Miyamae, M; Sugioka, S, 2010) |
| "Treatment with anisodamine ameliorated renal I/R injury, as evidenced by improvements of renal histology and kidney function, a decrease in paller's score and apoptosis index." | 1.62 | Anisodamine ameliorates ischemia/reperfusion-induced renal injury in rats through activation of the extracellular signal-regulated kinase (ERK) pathway and anti-apoptotic effect. ( Huang, Y; Ji, H; Jin, C; Sun, D; Sun, S; Xia, A; Xu, X; Zhang, S, 2021) |
| "D-allose was promising in the protection of ischemia/reperfusion (I/R) injury." | 1.56 | D-allose alleviates ischemia/reperfusion (I/R) injury in skin flap via MKP-1. ( Hou, R; Ju, J; Zhang, P, 2020) |
| "Calcitriol has been demonstrated to provide neuroprotection against ischemia/reperfusion (I/R) injury." | 1.39 | Neuroprotective effect of calcitriol on ischemic/reperfusion injury through the NR3A/CREB pathways in the rat hippocampus. ( Fu, J; Gu, J; Pan, X; Ran, R; Xiao, Y; Xue, R; Zhong, H, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (32.26) | 29.6817 |
| 2010's | 17 (54.84) | 24.3611 |
| 2020's | 4 (12.90) | 2.80 |
| Authors | Studies |
|---|---|
| Dai, C | 1 |
| Wang, W | 1 |
| Yang, Y | 2 |
| Zhong, R | 2 |
| Ju, J | 1 |
| Hou, R | 1 |
| Zhang, P | 1 |
| Wang, WY | 1 |
| Xie, L | 1 |
| Zou, XS | 1 |
| Li, N | 1 |
| Yang, YG | 1 |
| Wu, ZJ | 1 |
| Tian, XY | 1 |
| Zhao, GY | 1 |
| Chen, MH | 1 |
| Zhang, S | 1 |
| Xu, X | 1 |
| Huang, Y | 1 |
| Sun, S | 1 |
| Jin, C | 1 |
| Ji, H | 1 |
| Sun, D | 1 |
| Xia, A | 1 |
| Jiang, M | 1 |
| Wang, L | 4 |
| Jiang, HH | 1 |
| Fu, J | 1 |
| Xue, R | 1 |
| Gu, J | 1 |
| Xiao, Y | 1 |
| Zhong, H | 1 |
| Pan, X | 1 |
| Ran, R | 1 |
| Huang, P | 1 |
| Sun, Y | 1 |
| Yang, J | 1 |
| Chen, S | 1 |
| Liu, AD | 1 |
| Holmberg, L | 1 |
| Huang, X | 1 |
| Tang, C | 1 |
| Du, J | 1 |
| Jin, H | 1 |
| Zhang, X | 2 |
| Cui, H | 1 |
| Zhang, C | 1 |
| Zhu, C | 1 |
| Li, L | 2 |
| Cong, B | 1 |
| Zhu, X | 1 |
| Li, X | 1 |
| Liu, B | 1 |
| Ni, X | 1 |
| Jiang, X | 1 |
| Guo, CX | 1 |
| Zeng, XJ | 1 |
| Li, HH | 2 |
| Chen, BX | 1 |
| Du, FH | 1 |
| Mohamed, RA | 1 |
| Agha, AM | 1 |
| Abdel-Rahman, AA | 1 |
| Nassar, NN | 1 |
| Tang, M | 1 |
| Cui, M | 1 |
| Dong, Q | 1 |
| Ren, HM | 1 |
| Xiao, BG | 1 |
| Luo, BY | 1 |
| Shao, Y | 1 |
| Liu, L | 1 |
| Zhou, HG | 1 |
| Minutoli, L | 2 |
| Antonuccio, P | 2 |
| Polito, F | 2 |
| Bitto, A | 2 |
| Squadrito, F | 2 |
| Di Stefano, V | 1 |
| Nicotina, PA | 2 |
| Fazzari, C | 1 |
| Maisano, D | 1 |
| Romeo, C | 2 |
| Altavilla, D | 2 |
| Choi, DE | 1 |
| Jeong, JY | 1 |
| Lim, BJ | 1 |
| Chung, S | 1 |
| Chang, YK | 1 |
| Lee, SJ | 1 |
| Na, KR | 1 |
| Kim, SY | 1 |
| Shin, YT | 1 |
| Lee, KW | 1 |
| Bopassa, JC | 1 |
| Eghbali, M | 1 |
| Toro, L | 1 |
| Stefani, E | 1 |
| Inamura, Y | 1 |
| Miyamae, M | 1 |
| Sugioka, S | 1 |
| Domae, N | 1 |
| Kotani, J | 1 |
| Milano, G | 1 |
| von Segesser, LK | 1 |
| Morel, S | 1 |
| Joncic, A | 1 |
| Bianciardi, P | 1 |
| Vassalli, G | 1 |
| Samaja, M | 1 |
| Wu, XM | 1 |
| Qian, ZM | 1 |
| Zhu, L | 1 |
| Du, F | 1 |
| Yung, WH | 1 |
| Gong, Q | 1 |
| Ke, Y | 1 |
| Qiao, WL | 3 |
| Wang, GM | 2 |
| Shi, Y | 1 |
| Wu, JX | 1 |
| Qi, YJ | 1 |
| Zhang, JF | 3 |
| Sun, H | 1 |
| Yan, CD | 1 |
| Beharier, O | 1 |
| Dror, S | 1 |
| Levy, S | 1 |
| Kahn, J | 1 |
| Mor, M | 1 |
| Etzion, S | 1 |
| Gitler, D | 1 |
| Katz, A | 1 |
| Muslin, AJ | 1 |
| Moran, A | 1 |
| Etzion, Y | 1 |
| Vivar, R | 1 |
| Humeres, C | 1 |
| Varela, M | 1 |
| Ayala, P | 1 |
| Guzmán, N | 1 |
| Olmedo, I | 1 |
| Catalán, M | 1 |
| Boza, P | 1 |
| Muñoz, C | 1 |
| Díaz Araya, G | 1 |
| Zhu, Y | 1 |
| Li, J | 1 |
| Lv, Y | 1 |
| Jing, G | 1 |
| Wu, L | 1 |
| Miao, S | 1 |
| Zou, LB | 1 |
| Wu, P | 1 |
| Hao, H | 1 |
| Tang, K | 1 |
| Zeng, P | 1 |
| Xiong, J | 1 |
| Wu, Q | 1 |
| Cai, L | 1 |
| Ye, DY | 1 |
| Fahmi, A | 1 |
| Smart, N | 1 |
| Punn, A | 1 |
| Jabr, R | 1 |
| Marber, M | 1 |
| Heads, R | 1 |
| Bedard, EL | 1 |
| Potter, R | 1 |
| Alam, J | 1 |
| Choi, AM | 1 |
| Lee, PJ | 1 |
| Guo, J | 1 |
| Jiang, H | 1 |
| Wang, S | 1 |
| Watanabe, D | 1 |
| Takagi, H | 1 |
| Suzuma, K | 1 |
| Suzuma, I | 1 |
| Oh, H | 1 |
| Ohashi, H | 1 |
| Kemmochi, S | 1 |
| Uemura, A | 1 |
| Ojima, T | 1 |
| Suganami, E | 1 |
| Miyamoto, N | 1 |
| Sato, Y | 1 |
| Honda, Y | 1 |
| Arena, S | 1 |
| Turiaco, N | 1 |
| Cutrupi, A | 1 |
| Zuccarello, B | 1 |
| Pan, MX | 1 |
| Zhang, Y | 1 |
| Li, AH | 1 |
| Gao, Y | 1 |
| Zhang, YM | 2 |
| Wei, EQ | 1 |
31 other studies available for pd 98059 and Reperfusion Injury
| Article | Year |
|---|---|
[Effect of extracellular signal-regulated kinase inhibitor on calpain in rat cerebral cortex after cardiopulmonary resuscitation].
Topics: Animals; Brain Ischemia; Calpain; Cardiopulmonary Resuscitation; Cerebral Cortex; Dimethyl Sulfoxide | 2022 |
D-allose alleviates ischemia/reperfusion (I/R) injury in skin flap via MKP-1.
Topics: Animals; Dual Specificity Phosphatase 1; Flavonoids; Glucose; Male; Malondialdehyde; MAP Kinase Sign | 2020 |
Inhibition of extracellular signal-regulated kinase/calpain-2 pathway reduces neuroinflammation and necroptosis after cerebral ischemia-reperfusion injury in a rat model of cardiac arrest.
Topics: Animals; Brain Ischemia; Calpain; Dipeptides; Disease Models, Animal; Extracellular Signal-Regulated | 2021 |
Anisodamine ameliorates ischemia/reperfusion-induced renal injury in rats through activation of the extracellular signal-regulated kinase (ERK) pathway and anti-apoptotic effect.
Topics: Acute Kidney Injury; Animals; Apoptosis; Apoptosis Regulatory Proteins; Epithelial Cells; Flavonoids | 2021 |
[Role of spinal MAPK-ERK signal pathway in myocardial ischemia-reperfusion injury].
Topics: Animals; Apoptosis; Flavonoids; Male; MAP Kinase Signaling System; Myocardial Infarction; Myocardial | 2013 |
Neuroprotective effect of calcitriol on ischemic/reperfusion injury through the NR3A/CREB pathways in the rat hippocampus.
Topics: Animals; Brain Infarction; Brain Ischemia; Calcitriol; Cyclic AMP Response Element-Binding Protein; | 2013 |
The ERK1/2 signaling pathway is involved in sulfur dioxide preconditioning-induced protection against cardiac dysfunction in isolated perfused rat heart subjected to myocardial ischemia/reperfusion.
Topics: Animals; Cardiotonic Agents; Flavonoids; Heart Failure; Humans; Ischemic Preconditioning; Male; MAP | 2013 |
Apelin-13 protects the brain against ischemia/reperfusion injury through activating PI3K/Akt and ERK1/2 signaling pathways.
Topics: Animals; Apoptosis; Brain; Brain Edema; Brain Infarction; Brain Ischemia; Caspase 3; Chromones; Enzy | 2014 |
SGK1 is involved in cardioprotection of urocortin-1 against hypoxia/reoxygenation in cardiomyocytes.
Topics: Animals; Animals, Newborn; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, C | 2014 |
A soluble receptor for advanced glycation end-products inhibits myocardial apoptosis induced by ischemia/reperfusion via the JAK2/STAT3 pathway.
Topics: Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Chromones; Flavonoids; Gene Exp | 2015 |
Role of adenosine A2A receptor in cerebral ischemia reperfusion injury: Signaling to phosphorylated extracellular signal-regulated protein kinase (pERK1/2).
Topics: Adenosine A2 Receptor Antagonists; Animals; Apoptosis; Brain Ischemia; Brain-Derived Neurotrophic Fa | 2016 |
The bradykinin B2 receptor mediates hypoxia/reoxygenation induced neuronal cell apoptosis through the ERK1/2 pathway.
Topics: Animals; Apoptosis; Bradykinin; Bradykinin B2 Receptor Antagonists; Cell Hypoxia; Cells, Cultured; C | 2009 |
Mitogen-activated protein kinase 3/mitogen-activated protein kinase 1 activates apoptosis during testicular ischemia-reperfusion injury in a nuclear factor-kappaB-independent manner.
Topics: Animals; Apoptosis; Enzyme Inhibitors; Flavonoids; Male; Mice; Mice, Knockout; Mitogen-Activated Pro | 2009 |
Pretreatment of sildenafil attenuates ischemia-reperfusion renal injury in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blood Urea Nitrogen; Caspase 3; Creatinine; Cyclic G | 2009 |
A novel estrogen receptor GPER inhibits mitochondria permeability transition pore opening and protects the heart against ischemia-reperfusion injury.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Enzyme Inhibitors; Extracellular Signal-Regulate | 2010 |
Sevoflurane postconditioning prevents activation of caspase 3 and 9 through antiapoptotic signaling after myocardial ischemia-reperfusion.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Blotting, Western; Caspase 3; Caspase 9; Chromones; Enz | 2010 |
Phosphorylation of phosphatidylinositol-3-kinase-protein kinase B and extracellular signal-regulated kinases 1/2 mediate reoxygenation-induced cardioprotection during hypoxia.
Topics: Animals; Chromones; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hypox | 2010 |
Neuroprotective effect of ligustilide against ischaemia-reperfusion injury via up-regulation of erythropoietin and down-regulation of RTP801.
Topics: 4-Butyrolactone; Animals; Cell Line; Chromones; Erythropoietin; Flavonoids; Gene Expression Regulati | 2011 |
Differential expression of Bcl-2 and Bax during gastric ischemia-reperfusion of rats.
Topics: Animals; bcl-2-Associated X Protein; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regu | 2011 |
ZnT-1 protects HL-1 cells from simulated ischemia-reperfusion through activation of Ras-ERK signaling.
Topics: Animals; Cation Transport Proteins; Cell Death; Cell Line; Cell Survival; Enzyme Activation; Flavono | 2012 |
Cardiac fibroblast death by ischemia/reperfusion is partially inhibited by IGF-1 through both PI3K/Akt and MEK-ERK pathways.
Topics: Animals; Animals, Newborn; Apoptosis; Cells, Cultured; Chromones; Enzyme Inhibitors; Fibroblasts; Fl | 2012 |
[Effect of ischemic postconditioning on phosphatidylinositol-3-OH kinase and extracellular signal-regulated protein kinase in rats with hepatic ischemia-reperfusion injury].
Topics: Animals; Chromones; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Ischemic Postconditionin | 2012 |
Lipoxin A4 inhibits 5-lipoxygenase translocation and leukotrienes biosynthesis to exert a neuroprotective effect in cerebral ischemia/reperfusion injury.
Topics: Animals; Animals, Newborn; Arachidonate 5-Lipoxygenase; Astrocytes; Brain Edema; Brain Ischemia; Dis | 2012 |
p42/p44-MAPK and PI3K are sufficient for IL-6 family cytokines/gp130 to signal to hypertrophy and survival in cardiomyocytes in the absence of JAK/STAT activation.
Topics: Animals; Cell Survival; Cells, Cultured; Cytokine Receptor gp130; Flavonoids; Humans; Hypertrophy; I | 2013 |
Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury.
Topics: Animals; Aorta; Cells, Cultured; Enhancer Elements, Genetic; Enzyme Inhibitors; Flavonoids; Gene Exp | 2002 |
[The effect of metallothionein on delaying protection of ischemia/reperfusion].
Topics: Animals; Cell Hypoxia; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Ischemic Preco | 2002 |
Transcription factor Ets-1 mediates ischemia- and vascular endothelial growth factor-dependent retinal neovascularization.
Topics: Adenoviridae; Angiopoietin-2; Animals; Blotting, Northern; Blotting, Western; Butadienes; Carbazoles | 2004 |
Evidence for a role of mitogen-activated protein kinase 3/mitogen-activated protein kinase in the development of testicular ischemia-reperfusion injury.
Topics: Animals; Disease Models, Animal; Edema; Enzyme Inhibitors; Flavonoids; Male; Mitogen-Activated Prote | 2005 |
[Protective effect of protein kinase C and mitogen-activated protein kinases and its mechanism in liver ischemic preconditioning].
Topics: Alanine Transaminase; Alkaloids; Animals; Aspartate Aminotransferases; Benzophenanthridines; Enzyme | 2006 |
Extracellular signal-regulated kinase 1- and 2-mediated gastric mucosal injury and repair in gastric ischemia-reperfusion of rats.
Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Female; Flavonoids; Gastri | 2006 |
Extracellular signal-regulated kinase pathways may mediate the protective effect of electrical stimulation of the paraventricular nucleus against ischaemia-reperfusion injury of the gastric mucosa.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Celiac Artery; Cell Proliferation; Disease Models, A | 2007 |