pd 98059 has been researched along with Psoriasis in 2 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Psoriasis: A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Psoriasis is a multisystem disease affecting about 2% of the population, while keratin16 (KRT16) has been reported to participate in psoriasis." | 1.51 | Silencing KRT16 inhibits keratinocyte proliferation and VEGF secretion in psoriasis via inhibition of ERK signaling pathway. ( Cai, TG; Chen, JG; Fan, HY; Lin, LY; Wang, T, 2019) |
| "Dimethylfumarate (DMF) is used in the treatment of psoriasis." | 1.37 | Dimethylfumarate inhibits MIF-induced proliferation of keratinocytes by inhibiting MSK1 and RSK1 activation and by inducing nuclear p-c-Jun (S63) and p-p53 (S15) expression. ( Gesser, B; Iversen, L; Johansen, C; Kjellerup, RB; Kragballe, K; Raaby, L; Rasmussen, MK; Rosada, C, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, JG | 1 |
| Fan, HY | 1 |
| Wang, T | 1 |
| Lin, LY | 1 |
| Cai, TG | 1 |
| Gesser, B | 1 |
| Rasmussen, MK | 1 |
| Raaby, L | 1 |
| Rosada, C | 1 |
| Johansen, C | 1 |
| Kjellerup, RB | 1 |
| Kragballe, K | 1 |
| Iversen, L | 1 |
2 other studies available for pd 98059 and Psoriasis
| Article | Year |
|---|---|
Silencing KRT16 inhibits keratinocyte proliferation and VEGF secretion in psoriasis via inhibition of ERK signaling pathway.
Topics: Adult; Aged; Case-Control Studies; Cell Proliferation; Female; Flavonoids; Gene Expression Profiling | 2019 |
Dimethylfumarate inhibits MIF-induced proliferation of keratinocytes by inhibiting MSK1 and RSK1 activation and by inducing nuclear p-c-Jun (S63) and p-p53 (S15) expression.
Topics: Cell Proliferation; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Dermatologic Agent | 2011 |