pd 98059 has been researched along with Pregnancy in 67 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Normal pregnancy is associated with high angiotensin II (ANG II) concentrations in the maternal and fetal circulation." | 3.73 | Angiotensin II elevates nitric oxide synthase 3 expression and nitric oxide production via a mitogen-activated protein kinase cascade in ovine fetoplacental artery endothelial cells. ( Bird, IM; Chen, DB; Magness, RR; Wen, Y; Zheng, J, 2005) |
| " Therefore, decreased VEGF bioavailability during preeclampsia may result in higher vulnerability to placental oxidative cell damage and a further reduction of VEGF bioavailability, a vicious circle that may end up in preeclampsia." | 1.37 | Interplay between vascular endothelial growth factor (VEGF) and nuclear factor erythroid 2-related factor-2 (Nrf2): implications for preeclampsia. ( Fragoulis, A; Kweider, N; Pecks, U; Pufe, T; Rath, W; Rosen, C; Wruck, CJ, 2011) |
| "An additive increase in embryo resorption was observed after induction with both poly (I:C) and R837, and was associated with elevated numbers of both TNF-alpha- and IFN-gamma-producing CD45(+) cells in the uterus." | 1.35 | Effect of TLR3 and TLR7 activation in uterine NK cells from non-obese diabetic (NOD) mice. ( Di, J; Lin, Y; Ren, L; Saito, S; Wang, W; Zeng, S, 2009) |
| "Pregnancy is established in ruminants through inhibitory actions of interferon (IFN)-tau on the release of prostaglandin F2alpha (PGF), which allows the corpus luteum to survive and continue to produce progesterone." | 1.31 | Interferon-tau suppresses prostaglandin F2alpha secretion independently of the mitogen-activated protein kinase and nuclear factor kappa B pathways. ( Austin, KJ; Guzeloglu, A; Hansen, TR; Pru, JK; Rueda, BR; Thatcher, WW, 2001) |
| "Nifedipine treatment reduced mPer1 induction, suggesting that mPer1 mRNA expression depends on intracellular calcium concentration regulated through a voltage-dependent Ca2+ channel." | 1.31 | Calcium and pituitary adenylate cyclase-activating polypeptide induced expression of circadian clock gene mPer1 in the mouse cerebellar granule cell culture. ( Akiyama, M; Minami, Y; Moriya, T; Nakajima, T; Shibata, S, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (8.96) | 18.2507 |
| 2000's | 47 (70.15) | 29.6817 |
| 2010's | 14 (20.90) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tang, X | 1 |
| Liu, Y | 2 |
| Xiao, Q | 1 |
| Yao, Q | 1 |
| Allen, M | 1 |
| Wang, Y | 3 |
| Gao, L | 1 |
| Qi, Y | 1 |
| Zhang, P | 1 |
| Winters, SJ | 1 |
| Ghooray, DT | 1 |
| Yang, RQ | 1 |
| Holmes, JB | 1 |
| O'Brien, AR | 1 |
| Morgan, J | 1 |
| Moore, JP | 1 |
| Inoue, S | 1 |
| Okita, Y | 1 |
| de Toledo, A | 1 |
| Miyazaki, H | 1 |
| Hirano, E | 1 |
| Morinaga, T | 1 |
| Wang, CY | 1 |
| Lin, HC | 1 |
| Song, YP | 1 |
| Hsu, YT | 1 |
| Lin, SY | 1 |
| Hsu, PC | 1 |
| Lin, CH | 1 |
| Hung, CC | 1 |
| Hsu, MC | 1 |
| Kuo, YM | 1 |
| Lee, YJ | 1 |
| Hsu, CY | 1 |
| Lee, YH | 1 |
| Peng, B | 1 |
| Zhu, H | 1 |
| Klausen, C | 1 |
| Ma, L | 1 |
| Wang, YL | 1 |
| Leung, PC | 1 |
| Deng, Q | 1 |
| Chen, Y | 3 |
| Yin, N | 1 |
| Shan, N | 1 |
| Luo, X | 2 |
| Yuan, Y | 1 |
| Liu, X | 1 |
| Qi, H | 1 |
| Zhou, J | 1 |
| Ni, X | 1 |
| Huang, X | 2 |
| Yao, J | 1 |
| He, Q | 1 |
| Wang, K | 2 |
| Duan, T | 1 |
| Lu, CW | 1 |
| Yabuuchi, A | 1 |
| Chen, L | 1 |
| Viswanathan, S | 1 |
| Kim, K | 1 |
| Daley, GQ | 1 |
| Chappaz, E | 1 |
| Albornoz, MS | 1 |
| Campos, D | 1 |
| Che, L | 1 |
| Palin, MF | 1 |
| Murphy, BD | 1 |
| Bordignon, V | 1 |
| Moosavi, M | 1 |
| Maghsoudi, N | 1 |
| Zahedi-Asl, S | 1 |
| Naghdi, N | 1 |
| Yousefpour, M | 1 |
| Trounce, IA | 1 |
| Daoud, G | 2 |
| Le bellego, F | 1 |
| Lafond, J | 3 |
| Maymó, JL | 2 |
| Pérez Pérez, A | 2 |
| Sánchez-Margalet, V | 3 |
| Dueñas, JL | 3 |
| Calvo, JC | 2 |
| Varone, CL | 2 |
| Doungpunta, J | 1 |
| Santhi, A | 1 |
| Sathanawongs, A | 1 |
| Jarujinda, Y | 1 |
| Oranratnachai, A | 1 |
| Chang, K | 1 |
| Xiao, D | 6 |
| Longo, LD | 4 |
| Zhang, L | 8 |
| Pérez-Pérez, A | 1 |
| Maymó, J | 1 |
| Gambino, Y | 1 |
| Goberna, R | 1 |
| Varone, C | 1 |
| Lin, Y | 2 |
| Ren, L | 1 |
| Wang, W | 1 |
| Di, J | 2 |
| Zeng, S | 2 |
| Saito, S | 2 |
| Cook, IH | 1 |
| Evans, J | 1 |
| Maldonado-Pérez, D | 1 |
| Critchley, HO | 1 |
| Sales, KJ | 1 |
| Jabbour, HN | 1 |
| Jiang, YZ | 1 |
| Chen, DB | 2 |
| Zheng, J | 2 |
| da Conceição, AO | 1 |
| Rossi, MH | 1 |
| de Oliveira, FF | 1 |
| Takser, L | 1 |
| Yu, PL | 1 |
| Lin, HW | 1 |
| Wang, SW | 1 |
| Wang, PS | 1 |
| Kweider, N | 1 |
| Fragoulis, A | 1 |
| Rosen, C | 1 |
| Pecks, U | 1 |
| Rath, W | 1 |
| Pufe, T | 1 |
| Wruck, CJ | 1 |
| Zhuang, Y | 1 |
| Zhou, F | 1 |
| Huang, L | 1 |
| Zhao, X | 1 |
| Zou, Y | 1 |
| Xu, H | 1 |
| Fan, L | 1 |
| Guo, H | 1 |
| Li, X | 1 |
| Li, G | 1 |
| Zhang, X | 2 |
| Dong, M | 1 |
| Akiyama-Uchida, Y | 1 |
| Ashizawa, N | 1 |
| Ohtsuru, A | 1 |
| Seto, S | 1 |
| Tsukazaki, T | 1 |
| Kikuchi, H | 1 |
| Yamashita, S | 1 |
| Yano, K | 1 |
| Oldenhof, AD | 1 |
| Shynlova, OP | 1 |
| Liu, M | 1 |
| Langille, BL | 1 |
| Lye, SJ | 1 |
| Uzumcu, M | 1 |
| Westfall, SD | 1 |
| Dirks, KA | 1 |
| Skinner, MK | 1 |
| Hovey, RC | 1 |
| Harris, J | 1 |
| Hadsell, DL | 1 |
| Lee, AV | 1 |
| Ormandy, CJ | 1 |
| Vonderhaar, BK | 1 |
| Pearce, WJ | 2 |
| Williams, JM | 1 |
| Chang, MM | 1 |
| Gerthoffer, WT | 1 |
| Zhao, Y | 1 |
| Long, W | 1 |
| Qian, D | 1 |
| Lin, HY | 1 |
| Wang, HM | 1 |
| Liu, DL | 1 |
| Li, QL | 1 |
| Zhu, C | 1 |
| Marcelo, P | 1 |
| Lefèvre, F | 1 |
| Miyahara, T | 1 |
| Katoh, T | 1 |
| Watanabe, M | 1 |
| Mikami, Y | 1 |
| Uchida, S | 1 |
| Hosoe, M | 1 |
| Sakuma, T | 1 |
| Nemoto, N | 1 |
| Takayama, K | 1 |
| Komurasaki, T | 1 |
| Zhang, SS | 1 |
| Wei, J | 1 |
| Qin, H | 1 |
| Xie, B | 1 |
| Hui, P | 1 |
| Deisseroth, A | 1 |
| Barnstable, CJ | 1 |
| Fu, XY | 1 |
| Jaleel, MA | 1 |
| Tsai, AC | 1 |
| Sarkar, S | 1 |
| Freedman, PV | 1 |
| Rubin, LP | 1 |
| Liu, J | 1 |
| Nethery, D | 1 |
| Kern, JA | 1 |
| Wen, Y | 1 |
| Bird, IM | 1 |
| Magness, RR | 1 |
| Paliga, AJ | 1 |
| Natale, DR | 1 |
| Watson, AJ | 1 |
| Amyot, M | 1 |
| Rassart, E | 1 |
| Masse, A | 1 |
| Simoneau, L | 1 |
| Zhai, H | 1 |
| Nakade, K | 1 |
| Oda, M | 1 |
| Mitsumoto, Y | 1 |
| Akagi, M | 1 |
| Sakurai, J | 1 |
| Fukuyama, Y | 1 |
| Kim, JH | 1 |
| Lee, JH | 1 |
| Park, JY | 1 |
| Park, CH | 1 |
| Yun, CO | 1 |
| Lee, SH | 1 |
| Lee, YS | 1 |
| Son, H | 1 |
| Chung, D | 1 |
| Loch Caruso, R | 1 |
| Köbel, M | 1 |
| Pohl, G | 1 |
| Schmitt, WD | 1 |
| Hauptmann, S | 1 |
| Wang, TL | 1 |
| Shih, IeM | 1 |
| Buchholz, JN | 1 |
| Delaney, J | 1 |
| Chiarello, R | 1 |
| Villar, D | 1 |
| Kandalam, U | 1 |
| Castejon, AM | 1 |
| Clark, MA | 1 |
| Zhong, Y | 1 |
| Shen, W | 1 |
| LaMarca, HL | 1 |
| Dash, PR | 1 |
| Vishnuthevan, K | 1 |
| Harvey, E | 1 |
| Sullivan, DE | 1 |
| Morris, CA | 1 |
| Whitley, GS | 1 |
| Takahashi, Y | 1 |
| Okimura, Y | 1 |
| Mizuno, I | 1 |
| Iida, K | 1 |
| Takahashi, T | 1 |
| Kaji, H | 1 |
| Abe, H | 1 |
| Chihara, K | 1 |
| Ohmichi, M | 1 |
| Koike, K | 1 |
| Kimura, A | 1 |
| Masuhara, K | 1 |
| Ikegami, H | 1 |
| Ikebuchi, Y | 1 |
| Kanzaki, T | 1 |
| Touhara, K | 1 |
| Sakaue, M | 1 |
| Kobayashi, Y | 1 |
| Akabane, M | 1 |
| Miyake, A | 1 |
| Murata, Y | 1 |
| Mills, J | 1 |
| Laurent Charest, D | 1 |
| Lam, F | 1 |
| Beyreuther, K | 1 |
| Ida, N | 1 |
| Pelech, SL | 1 |
| Reiner, PB | 1 |
| Guo, Z | 1 |
| Du, X | 1 |
| Iacovitti, L | 2 |
| Kanda, Y | 1 |
| Richards, RG | 1 |
| Handwerger, S | 1 |
| Hertig, CM | 1 |
| Kubalak, SW | 1 |
| Chien, KR | 1 |
| Peters, CA | 1 |
| Maizels, ET | 1 |
| Robertson, MC | 1 |
| Shiu, RP | 1 |
| Soloff, MS | 1 |
| Hunzicker-Dunn, M | 1 |
| Learish, RD | 1 |
| Bruss, MD | 1 |
| Haak-Frendscho, M | 1 |
| Kanekar, S | 1 |
| Borg, TK | 1 |
| Terracio, L | 1 |
| Carver, W | 1 |
| Pru, JK | 1 |
| Rueda, BR | 1 |
| Austin, KJ | 1 |
| Thatcher, WW | 1 |
| Guzeloglu, A | 1 |
| Hansen, TR | 1 |
| Cras-Méneur, C | 1 |
| Elghazi, L | 1 |
| Czernichow, P | 1 |
| Scharfmann, R | 1 |
| Akiyama, M | 1 |
| Minami, Y | 1 |
| Nakajima, T | 1 |
| Moriya, T | 1 |
| Shibata, S | 1 |
| McKinnon, T | 1 |
| Chakraborty, C | 1 |
| Gleeson, LM | 1 |
| Chidiac, P | 1 |
| Lala, PK | 1 |
| Chang, JG | 1 |
| Hsieh-Li, HM | 1 |
| Jong, YJ | 1 |
| Wang, NM | 1 |
| Tsai, CH | 1 |
| Li, H | 1 |
| Stull, ND | 1 |
| Jung, JW | 1 |
| Ricono, JM | 1 |
| Arar, M | 1 |
| Choudhury, GG | 1 |
| Abboud, HE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| In Vivo Study of Safety, Tolerability and Dosing Effect on SMN mRNA and Protein Levels of Valproic Acid in Patients With Spinal Muscular Atrophy[NCT00374075] | Phase 1 | 42 participants | Interventional | 2003-09-30 | Completed | ||
| Phase I/II Trial of Valproic Acid and Carnitine in Infants With Spinal Muscular Atrophy Type I (CARNI-VAL Type I)[NCT00661453] | Phase 1/Phase 2 | 40 participants (Actual) | Interventional | 2008-04-30 | Completed | ||
| Multi-center Phase II Trial of Valproic Acid and Carnitine in Patients With Spinal Muscular Atrophy (SMA CARNI-VAL Trial)[NCT00227266] | Phase 2 | 94 participants (Actual) | Interventional | 2005-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00661453)
Timeframe: -2 weeks, time 0, 3 months, 6 months
| Intervention | g (Mean) | |||||
|---|---|---|---|---|---|---|
| Lean Mass Baseline | Lean Mass 3 months | Lean Mass 6 months | Fat Mass Baseline | Fat Mass 3 months | Fat Mass 6 months | |
| SMA Type 1 | 4317.15 | 4993.92 | 5133.83 | 3011.37 | 3618.25 | 4316.08 |
The maximum Compound Motor Action Potential (CMAP) is a measurement obtained through EMG testing that is associated with disease progression. In this study, we measure the maximum CMAP by stimulating one nerve in the hand and measuring the response of the muscle. This is done multiple times, the outcome used is the highest peak, or response observed. (NCT00227266)
Timeframe: 1 month prior to official enrollment, beginning of study (0 months), 6 months, 12 months (data point not available)
| Intervention | mV (Mean) | |
|---|---|---|
| Baseline | 6 months | |
| Cohort 1a Sitters Placebo Then Treatment | 2.28 | 2.32 |
| Cohort 1b Sitters Treatment | 2.93 | 2.37 |
| Cohort 2 Standers and Walkers - Treatment | 5.52 | 6.56 |
The maximum Compound Motor Action Potential (CMAP) is a measurement obtained through EMG testing that is associated with disease progression. In this study, we measure the maximum CMAP by stimulating one nerve in the hand and measuring the response of the muscle. This is done multiple times, the outcome used is the highest peak, or response observed. (NCT00227266)
Timeframe: 1 month prior to official enrollment, beginning of study (0 months), 6 months, 12 months (data point not available)
| Intervention | mV (Median) | |
|---|---|---|
| Baseline | 6 months | |
| Cohort 1a Sitters Placebo Then Treatment | 1.91 | 1.44 |
| Cohort 1b Sitters Treatment | 2.2 | 1.8 |
| Cohort 2 Standers and Walkers - Treatment | 5.3 | 5.85 |
The maximum Compound Motor Action Potential (CMAP) area is a measurement obtained through EMG testing that is associated with disease progression. In this study, we measure the maximum CMAP by stimulating one nerve in the hand and measuring the response of the muscle. This procedure is repeated multiple times. The maximum area is the response that results in the largest area under the response curve. (NCT00227266)
Timeframe: 1 month prior to official enrollment, beginning of study (0 months), 6 months, 12 months (data point not available)
| Intervention | mVms (Mean) | |
|---|---|---|
| Baseline | 6 months | |
| Cohort 1a Sitters Placebo Then Treatment | 5.46 | 5.28 |
| Cohort 1b Sitters Treatment | 5.45 | 5.26 |
| Cohort 2 Standers and Walkers - Treatment | 14.85 | 16.26 |
The maximum Compound Motor Action Potential (CMAP) area is a measurement obtained through EMG testing that is associated with disease progression. In this study, we measure the maximum CMAP by stimulating one nerve in the hand and measuring the response of the muscle. This procedure is repeated multiple times. The maximum area is the response that results in the largest area under the response curve. (NCT00227266)
Timeframe: 1 month prior to official enrollment, beginning of study (0 months), 6 months, 12 months (data point not available)
| Intervention | mVms (Median) | |
|---|---|---|
| Baseline | 6 months | |
| Cohort 1a Sitters Placebo Then Treatment | 3.6 | 3.74 |
| Cohort 1b Sitters Treatment | 4.6 | 3.4 |
| Cohort 2 Standers and Walkers - Treatment | 13.65 | 16.85 |
Comparison of Modified Hammersmith Change from baseline to 6 months. Scores range from 0 to 40. A higher score indicates a better outcome. This scale is used to assess gross motor abilities of non-ambulant children with SMA in multiple research trials as well as in clinical settings. (NCT00227266)
Timeframe: 0 months, 6 months
| Intervention | Score (Mean) | ||
|---|---|---|---|
| Baseline visit (0 weeks) | 6 Month visit (V2) | Change from Baseline | |
| Cohort 1a Sitters Placebo Then Treatment | 20.0 | 20.6 | 0.6 |
| Cohort 1b Sitters Treatment | 16.6 | 16.8 | 0.2 |
"Baseline Modified Hammersmith Extend testing. The baseline test is the score they receive during their screening visits. This scale ranges from 0 to 56. A higher score indicates a better outcome.~This scale is used to assess gross motor abilities of children with SMA in multiple research trials as well as in clinical settings." (NCT00227266)
Timeframe: 1 month prior to enrollment, at enrollment (0 months)
| Intervention | Score (Mean) | |
|---|---|---|
| Modified Hammersmith Extend at S1 (-4 weeks) | Modified Hammersmith Extend at S2 (0 weeks) | |
| Cohort 2 Experimental | 47.0 | 48.3 |
67 other studies available for pd 98059 and Pregnancy
| Article | Year |
|---|---|
Pathological cyclic strain promotes proliferation of vascular smooth muscle cells via the ACTH/ERK/STAT3 pathway.
Topics: Adrenocorticotropic Hormone; Animals; Biomechanical Phenomena; Cell Proliferation; Disease Models, A | 2018 |
Dopamine-2 receptor activation suppresses PACAP expression in gonadotrophs.
Topics: Animals; Animals, Newborn; Blotting, Western; Bromocriptine; Cells, Cultured; Cyclic AMP; Dopamine D | 2014 |
Pyroglutamic acid stimulates DNA synthesis in rat primary hepatocytes through the mitogen-activated protein kinase pathway.
Topics: Animals; Cells, Cultured; Chromatography, Liquid; DNA; Female; Flavonoids; Hepatocytes; Humans; Imid | 2015 |
Protein kinase C-dependent growth-associated protein 43 phosphorylation regulates gephyrin aggregation at developing GABAergic synapses.
Topics: Animals; Carrier Proteins; Cells, Cultured; Female; Flavonoids; GABAergic Neurons; GAP-43 Protein; H | 2015 |
GnRH regulates trophoblast invasion via RUNX2-mediated MMP2/9 expression.
Topics: Abortion, Legal; Adult; Cell Line, Transformed; Cell Movement; Chorionic Villi; Chromones; Core Bind | 2016 |
The Role of MGAT5 in Human Umbilical Vein Endothelial Cells.
Topics: Adult; Apoptosis; Decidua; Female; Flavonoids; Gene Knockdown Techniques; Human Umbilical Vein Endot | 2017 |
Potential Role of Hyperglycemia in Fetoplacental Endothelial Dysfunction in Gestational Diabetes Mellitus.
Topics: Adult; Case-Control Studies; Cell Movement; Cell Proliferation; Diabetes, Gestational; Diffusion Cha | 2016 |
Ras-MAPK signaling promotes trophectoderm formation from embryonic stem cells and mouse embryos.
Topics: Animals; Blastocyst; Butadienes; Cells, Cultured; Chimera; Ectoderm; Embryo, Mammalian; Embryonic De | 2008 |
Adiponectin enhances in vitro development of swine embryos.
Topics: Adiponectin; Animals; Butadienes; Embryonic Development; Female; Flavonoids; Imidazoles; Immunohisto | 2008 |
The role of PI3/Akt pathway in the protective effect of insulin against corticosterone cell death induction in hippocampal cell culture.
Topics: Animals; Apoptosis; Cells, Cultured; Chromones; Corticosterone; Enzyme Inhibitors; Female; Flavonoid | 2008 |
PP2 regulates human trophoblast cells differentiation by activating p38 and ERK1/2 and inhibiting FAK activation.
Topics: Benzoquinones; Cell Differentiation; Cells, Cultured; CSK Tyrosine-Protein Kinase; Enzyme Activation | 2008 |
Up-regulation of placental leptin by human chorionic gonadotropin.
Topics: Androstadienes; Cell Line, Tumor; Cesarean Section; Choriocarcinoma; Chorionic Gonadotropin; Deliver | 2009 |
Fivefold increase in derivation rates of mouse embryonic stem cells after supplementation of the media with multiple factors.
Topics: Animals; Blastocyst; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Divisi | 2009 |
Chronic hypoxia increases pressure-dependent myogenic tone of the uterine artery in pregnant sheep: role of ERK/PKC pathway.
Topics: Altitude; Animals; Arteries; Blood Pressure; Calcium; Carcinogens; Chronic Disease; Enzyme Inhibitor | 2009 |
Leptin stimulates protein synthesis-activating translation machinery in human trophoblastic cells.
Topics: Adaptor Proteins, Signal Transducing; Analysis of Variance; Androstadienes; Blotting, Western; Cell | 2009 |
Effect of TLR3 and TLR7 activation in uterine NK cells from non-obese diabetic (NOD) mice.
Topics: Aminoquinolines; Animals; Anthracenes; Antigens, CD; Cytotoxicity, Immunologic; Embryo Loss; Extrace | 2009 |
Prokineticin-1 (PROK1) modulates interleukin (IL)-11 expression via prokineticin receptor 1 (PROKR1) and the calcineurin/NFAT signalling pathway.
Topics: Calcineurin; Calcineurin Inhibitors; Cell Line, Tumor; Cyclosporine; Decidua; Egtazic Acid; Endometr | 2010 |
Hypoxia enhances FGF2- and VEGF-stimulated human placental artery endothelial cell proliferation: roles of MEK1/2/ERK1/2 and PI3K/AKT1 pathways.
Topics: Arteries; Butadienes; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Chromones; Culture Media, S | 2009 |
Regulation of placental leptin expression by cyclic adenosine 5'-monophosphate involves cross talk between protein kinase A and mitogen-activated protein kinase signaling pathways.
Topics: Cells, Cultured; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Prote | 2010 |
Genipa americana (Rubiaceae) fruit extract affects mitogen-activated protein kinase cell pathways in human trophoblast-derived BeWo cells: implications for placental development.
Topics: Adenosine Monophosphate; Cell Differentiation; Cell Line; Cell Proliferation; Chorionic Gonadotropin | 2011 |
Effects of nonylphenol on the production of progesterone on the rats granulosa cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cells, Cultured; Chorionic Gonadotropin; Colforsin; | 2011 |
Interplay between vascular endothelial growth factor (VEGF) and nuclear factor erythroid 2-related factor-2 (Nrf2): implications for preeclampsia.
Topics: Butadienes; Cell Line, Tumor; Cell Survival; Enzyme-Linked Immunosorbent Assay; Female; Flavonoids; | 2011 |
Mifepristone increases the cytotoxicity of uterine natural killer cells by acting as a glucocorticoid antagonist via ERK activation.
Topics: Adult; Blotting, Western; Butadienes; Cell Survival; Cells, Cultured; Decidua; Dose-Response Relatio | 2012 |
Gastrodin protect primary cultured rat hippocampal neurons against amyloid-beta peptide-induced neurotoxicity via ERK1/2-Nrf2 pathway.
Topics: Amyloid beta-Peptides; Animals; Antioxidants; Benzyl Alcohols; Cells, Cultured; Dose-Response Relati | 2012 |
Norepinephrine enhances fibrosis mediated by TGF-beta in cardiac fibroblasts.
Topics: Activating Transcription Factor 2; Animals; Animals, Newborn; Blotting, Western; Cell Division; Coll | 2002 |
Mitogen-activated protein kinases mediate stretch-induced c-fos mRNA expression in myometrial smooth muscle cells.
Topics: Animals; Butadienes; Cells, Cultured; Curcumin; Enzyme Inhibitors; Female; Flavonoids; Gene Expressi | 2002 |
Embryonic testis cord formation and mesonephric cell migration requires the phosphotidylinositol 3-kinase signaling pathway.
Topics: Animals; Apoptosis; Cell Movement; Chromones; Enzyme Inhibitors; Female; Flavonoids; Gestational Age | 2002 |
Local insulin-like growth factor-II mediates prolactin-induced mammary gland development.
Topics: Animals; Enzyme Inhibitors; Female; Flavonoids; Immunohistochemistry; Insulin Receptor Substrate Pro | 2003 |
ERK inhibition attenuates 5-HT-induced contractions in fetal and adult ovine carotid arteries.
Topics: Age Factors; Animals; Butadienes; Calmodulin-Binding Proteins; Carotid Arteries; Dose-Response Relat | 2003 |
Extracellular signal-regulated kinases and contractile responses in ovine adult and fetal cerebral arteries.
Topics: Adrenergic alpha-Agonists; Animals; Blotting, Western; Butadienes; Calcium; Cerebral Arteries; Dose- | 2003 |
Normoxic induction of the hypoxic-inducible factor-1 alpha by interleukin-1 beta involves the extracellular signal-regulated kinase 1/2 pathway in normal human cytotrophoblast cells.
Topics: Base Sequence; DNA; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; | 2004 |
IFN-gamma gene expression in epithelial trophectoderm cells is linked to downregulation of the p44/p42 MAP kinase pathway.
Topics: Animals; Blastocyst; Blotting, Western; Butadienes; Cell Polarity; Down-Regulation; Enzyme-Linked Im | 2004 |
ERK-mediated uterine artery contraction: role of thick and thin filament regulatory pathways.
Topics: Animals; Arteries; Calcium; Enzyme Inhibitors; Female; Flavonoids; Intracellular Membranes; Mitogen- | 2004 |
Involvement of mitogen-activated protein kinases and protein kinase C in cadmium-induced prostaglandin E2 production in primary mouse osteoblastic cells.
Topics: Animals; Blotting, Western; Cadmium; Dinoprostone; Enzyme Inhibitors; Female; Flavonoids; Imidazoles | 2004 |
STAT3-mediated signaling in the determination of rod photoreceptor cell fate in mouse retina.
Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell | 2004 |
Adaptation of uterine artery thick- and thin-filament regulatory pathways to pregnancy.
Topics: Adaptation, Physiological; Animals; Arteries; Calcium; Enzyme Inhibitors; Extracellular Signal-Regul | 2005 |
Stromal cell-derived factor-1 (SDF-1) signalling regulates human placental trophoblast cell survival.
Topics: Antibodies; Apoptosis; Cell Differentiation; Cell Survival; Cells, Cultured; Chemokine CXCL12; Chemo | 2004 |
Neuregulin-1 induces branching morphogenesis in the developing lung through a P13K signal pathway.
Topics: Animals; Antibodies, Monoclonal; DNA; Drug Combinations; Female; Flavonoids; Lung; Mice; Morphogenes | 2004 |
Alpha1-adrenoceptor-mediated phosphorylation of MYPT-1 and CPI-17 in the uterine artery: role of ERK/PKC.
Topics: Animals; Arteries; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids | 2005 |
Angiotensin II elevates nitric oxide synthase 3 expression and nitric oxide production via a mitogen-activated protein kinase cascade in ovine fetoplacental artery endothelial cells.
Topics: Angiotensin II; Animals; Arteries; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Enzyme | 2005 |
p38 mitogen-activated protein kinase (MAPK) first regulates filamentous actin at the 8-16-cell stage during preimplantation development.
Topics: Actins; alpha Catenin; Animals; Blastocyst; Cadherins; Cell Adhesion Molecules; Cytoskeletal Protein | 2005 |
ERK1/2 and p38 regulate trophoblasts differentiation in human term placenta.
Topics: Adult; Blotting, Western; Cell Differentiation; Cell Separation; Chorionic Gonadotropin; Culture Med | 2005 |
Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2).
Topics: Animals; Benzylamines; Biphenyl Compounds; Blotting, Western; Calcium-Calmodulin-Dependent Protein K | 2005 |
Retrovirally transduced NCAM140 facilitates neuronal fate choice of hippocampal progenitor cells.
Topics: Animals; Blotting, Western; Cell Count; Cell Differentiation; Cells, Cultured; Drug Interactions; Em | 2005 |
2,2'-Dichlorobiphenyl decreases amplitude and synchronization of uterine contractions through MAPK1-mediated phosphorylation of GJA1 (connexin43) and inhibition of myometrial gap junctions.
Topics: Animals; Connexin 43; Enzyme Inhibitors; Female; Flavonoids; Gap Junctions; In Vitro Techniques; Mit | 2005 |
Activation of mitogen-activated protein kinase is required for migration and invasion of placental site trophoblastic tumor.
Topics: Benzamides; Case-Control Studies; Cell Movement; Cells, Cultured; Enzyme Activation; Female; Flavono | 2005 |
Pregnancy attenuates uterine artery pressure-dependent vascular tone: role of PKC/ERK pathway.
Topics: Animals; Arteries; Blood Pressure; Calcium; Calcium Signaling; Enzyme Inhibitors; Extracellular Sign | 2006 |
Regulation of c-fos, c-jun and c-myc gene expression by angiotensin II in primary cultured rat astrocytes: role of ERK1/2 MAP kinases.
Topics: Actins; Angiotensin II; Animals; Astrocytes; Brain Stem; Enzyme Inhibitors; Female; Flavonoids; Gene | 2008 |
Characterization of natural killer cells in nonobese diabetic/severely compromised immunodeficient mice during pregnancy.
Topics: Animals; Anthracenes; Chromones; Female; Flavonoids; Interleukin-10; Killer Cells, Natural; Mice; Mi | 2009 |
Epidermal growth factor-stimulated extravillous cytotrophoblast motility is mediated by the activation of PI3-K, Akt and both p38 and p42/44 mitogen-activated protein kinases.
Topics: Benzazepines; beta Catenin; Cell Movement; Chromones; Epidermal Growth Factor; Female; Flavonoids; G | 2008 |
Leptin induces mitogen-activated protein kinase-dependent proliferation of C3H10T1/2 cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Dose-Response Relat | 1997 |
Role of mitogen-activated protein kinase pathway in prostaglandin F2alpha-induced rat puerperal uterine contraction.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dinoprost; Enzyme Activation | 1997 |
Regulation of amyloid precursor protein catabolism involves the mitogen-activated protein kinase signal transduction pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Calcium-Calmoduli | 1997 |
Regulation of tyrosine hydroxylase gene expression during transdifferentiation of striatal neurons: changes in transcription factors binding the AP-1 site.
Topics: 1-Methyl-3-isobutylxanthine; Activating Transcription Factor 2; Animals; Base Sequence; Calcium-Calm | 1998 |
Apolipoprotein A-I stimulates human placental lactogen release by activation of MAP kinase.
Topics: Apolipoprotein A-I; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chamomile; Enzyme | 1998 |
Synergistic roles of neuregulin-1 and insulin-like growth factor-I in activation of the phosphatidylinositol 3-kinase pathway and cardiac chamber morphogenesis.
Topics: Animals; Bromodeoxyuridine; Cell Division; DNA; Drug Synergism; Female; Flavonoids; Heart; Insulin-L | 1999 |
Induction of relaxin messenger RNA expression in response to prolactin receptor activation requires protein kinase C delta signaling.
Topics: Acetophenones; Animals; Benzopyrans; DNA-Binding Proteins; Estradiol; Female; Flavonoids; Gene Expre | 2000 |
Inhibition of mitogen-activated protein kinase kinase blocks proliferation of neural progenitor cells.
Topics: Animals; Apoptosis; Astrocytes; Butadienes; Cell Differentiation; Cell Division; Cells, Cultured; En | 2000 |
Modulation of heart fibroblast migration and collagen gel contraction by IGF-I.
Topics: Animals; Animals, Newborn; Antigens, CD; Cell Adhesion; Cell Movement; Chromones; Collagen; Enzyme I | 2000 |
Interferon-tau suppresses prostaglandin F2alpha secretion independently of the mitogen-activated protein kinase and nuclear factor kappa B pathways.
Topics: Animals; Cattle; Cell Line; Cyclooxygenase 2; Dinoprost; DNA-Binding Proteins; Endometrium; Enzyme I | 2001 |
Epidermal growth factor increases undifferentiated pancreatic embryonic cells in vitro: a balance between proliferation and differentiation.
Topics: Animals; Cell Differentiation; Cell Division; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; | 2001 |
Calcium and pituitary adenylate cyclase-activating polypeptide induced expression of circadian clock gene mPer1 in the mouse cerebellar granule cell culture.
Topics: Animals; Biological Clocks; Bucladesine; Butadienes; Calcium; Calcium Channel Blockers; Calcium-Calm | 2001 |
Stimulation of human extravillous trophoblast migration by IGF-II is mediated by IGF type 2 receptor involving inhibitory G protein(s) and phosphorylation of MAPK.
Topics: Adenylyl Cyclases; Antibodies; Antibodies, Monoclonal; Cell Line; Cell Movement; Enzyme Inhibitors; | 2001 |
Treatment of spinal muscular atrophy by sodium butyrate.
Topics: Abnormalities, Multiple; Alternative Splicing; Animals; Butyrates; Cell Line, Transformed; Crosses, | 2001 |
Treatment of spinal muscular atrophy by sodium butyrate.
Topics: Abnormalities, Multiple; Alternative Splicing; Animals; Butyrates; Cell Line, Transformed; Crosses, | 2001 |
Treatment of spinal muscular atrophy by sodium butyrate.
Topics: Abnormalities, Multiple; Alternative Splicing; Animals; Butyrates; Cell Line, Transformed; Crosses, | 2001 |
Treatment of spinal muscular atrophy by sodium butyrate.
Topics: Abnormalities, Multiple; Alternative Splicing; Animals; Butyrates; Cell Line, Transformed; Crosses, | 2001 |
Treatment of spinal muscular atrophy by sodium butyrate.
Topics: Abnormalities, Multiple; Alternative Splicing; Animals; Butyrates; Cell Line, Transformed; Crosses, | 2001 |
Treatment of spinal muscular atrophy by sodium butyrate.
Topics: Abnormalities, Multiple; Alternative Splicing; Animals; Butyrates; Cell Line, Transformed; Crosses, | 2001 |
Treatment of spinal muscular atrophy by sodium butyrate.
Topics: Abnormalities, Multiple; Alternative Splicing; Animals; Butyrates; Cell Line, Transformed; Crosses, | 2001 |
Treatment of spinal muscular atrophy by sodium butyrate.
Topics: Abnormalities, Multiple; Alternative Splicing; Animals; Butyrates; Cell Line, Transformed; Crosses, | 2001 |
Treatment of spinal muscular atrophy by sodium butyrate.
Topics: Abnormalities, Multiple; Alternative Splicing; Animals; Butyrates; Cell Line, Transformed; Crosses, | 2001 |
Induction of a dopaminergic phenotype in cultured striatal neurons by bone morphogenetic proteins.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 6; B | 2001 |
ERK MAP kinases regulate smooth muscle contraction in ovine uterine artery: effect of pregnancy.
Topics: Animals; Arteries; Enzyme Inhibitors; Female; Flavonoids; In Vitro Techniques; Mitogen-Activated Pro | 2002 |
Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells.
Topics: Animals; Becaplermin; Cell Movement; Cells, Cultured; DNA; Female; Flavonoids; Fluorescent Antibody | 2002 |