pd 98059 has been researched along with Parkinson Disease in 6 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Icariin pretreatment could ameliorate the decreased striatum DA content and the loss of TH-IR neurons in the SNpc induced by MPTP." | 1.46 | Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson's disease: Involvement of PI3K/Akt and MEK/ERK signaling pathways. ( Chen, L; Chen, WF; Chen, XH; Du, ZR; Teng, JJ; Wong, MS; Wu, L; Xu, AL, 2017) |
| "It is thought that Parkinson's disease involves apoptosis, and NGF prevents apoptosis in an in vivo model system." | 1.31 | Nerve growth factor prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells: relevance to therapeutical application for Parkinson's disease. ( Chiba, H; Shimoke, K, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, WF | 1 |
| Wu, L | 1 |
| Du, ZR | 1 |
| Chen, L | 1 |
| Xu, AL | 1 |
| Chen, XH | 1 |
| Teng, JJ | 1 |
| Wong, MS | 1 |
| Sun, X | 1 |
| Huang, L | 1 |
| Zhang, M | 1 |
| Sun, S | 1 |
| Wu, Y | 1 |
| Wang, G | 1 |
| Qi, C | 1 |
| Fan, GH | 1 |
| Zhou, HY | 1 |
| Chen, SD | 1 |
| Weng, Z | 1 |
| Signore, AP | 1 |
| Gao, Y | 1 |
| Wang, S | 1 |
| Zhang, F | 1 |
| Hastings, T | 1 |
| Yin, XM | 1 |
| Chen, J | 1 |
| Shimoke, K | 1 |
| Chiba, H | 1 |
| Kulich, SM | 1 |
| Chu, CT | 1 |
6 other studies available for pd 98059 and Parkinson Disease
| Article | Year |
|---|---|
Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson's disease: Involvement of PI3K/Akt and MEK/ERK signaling pathways.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Chromones; Corpus Striatum; Disease Models, A | 2017 |
Insulin like growth factor-1 prevents 1-mentyl-4-phenylphyridinium-induced apoptosis in PC12 cells through activation of glycogen synthase kinase-3beta.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis; Blotting, Western; Cell Survival; | 2010 |
PACAP protects neuronal differentiated PC12 cells against the neurotoxicity induced by a mitochondrial complex I inhibitor, rotenone.
Topics: Animals; Bucladesine; Caspase 3; Caspases; Cell Differentiation; Cell Survival; Colforsin; Dose-Resp | 2005 |
Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling.
Topics: Adipocytes; Animals; Apoptosis; Caspase 3; Caspase 9; Catecholamines; Cell Line; Cell Survival; CREB | 2007 |
Nerve growth factor prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells: relevance to therapeutical application for Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amino Acid Chloromethyl Ketones; Amino Acid Substituti | 2001 |
Sustained extracellular signal-regulated kinase activation by 6-hydroxydopamine: implications for Parkinson's disease.
Topics: Animals; Cell Line; Cell Survival; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Fla | 2001 |