Page last updated: 2024-11-02

pd 98059 and Parasitemia

pd 98059 has been researched along with Parasitemia in 1 studies

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.

Parasitemia: The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
"Here, using a mouse cerebral malaria model and small-molecule inhibitors, we demonstrate that inhibiting MEK1/2, the upstream kinases of ERK1/2 signaling, alters multifactorial components of the innate and adaptive immune responses, controls parasitemia, and blocks pathogenesis."1.46Small molecule-based inhibition of MEK1/2 proteins dampens inflammatory responses to malaria, reduces parasite load, and mitigates pathogenic outcomes. ( Dayanand, KK; Gowda, DC; Norbury, CC; Thylur, RP; Wu, X, 2017)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wu, X1
Dayanand, KK1
Thylur, RP1
Norbury, CC1
Gowda, DC1

Other Studies

1 other study available for pd 98059 and Parasitemia

ArticleYear
Small molecule-based inhibition of MEK1/2 proteins dampens inflammatory responses to malaria, reduces parasite load, and mitigates pathogenic outcomes.
    The Journal of biological chemistry, 2017, 08-18, Volume: 292, Issue:33

    Topics: Adaptive Immunity; Animals; Antimalarials; Bone Marrow Cells; Cells, Cultured; Coculture Techniques;

2017