pd 98059 has been researched along with Pancreatitis in 4 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Pancreatitis: INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "During acute pancreatitis, protease-activated receptor 2 (PAR2) can be activated by interstitially released trypsin." | 1.35 | PAR2 exerts local protection against acute pancreatitis via modulation of MAP kinase and MAP kinase phosphatase signaling. ( Kim, KH; Lee, MG; Namkung, W; Yoon, JS, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yao, W | 1 |
| Zhu, D | 1 |
| Lu, H | 1 |
| Liu, C | 1 |
| Sun, B | 1 |
| Zhang, W | 1 |
| Xue, D | 1 |
| García-Hernández, V | 1 |
| Sarmiento, N | 1 |
| Sánchez-Bernal, C | 1 |
| Matellán, L | 1 |
| Calvo, JJ | 1 |
| Sánchez-Yagüe, J | 1 |
| Namkung, W | 1 |
| Yoon, JS | 1 |
| Kim, KH | 1 |
| Lee, MG | 1 |
| Clemons, AP | 1 |
| Holstein, DM | 1 |
| Galli, A | 1 |
| Saunders, C | 1 |
4 other studies available for pd 98059 and Pancreatitis
| Article | Year |
|---|---|
The Regulatory Effect of the Kinase Inhibitor PD98059 on Autophagic Flux During Trypsinogen Activation in Pancreatic Acinar Cells.
Topics: Acinar Cells; Acute Disease; Animals; Autophagosomes; Autophagy; Cell Line; Enzyme Activation; Flavo | 2020 |
Modulation in the expression of SHP-1, SHP-2 and PTP1B due to the inhibition of MAPKs, cAMP and neutrophils early on in the development of cerulein-induced acute pancreatitis in rats.
Topics: Acute Disease; Animals; Anthracenes; Ceruletide; Cyclic AMP; Flavonoids; Immunoblotting; Immunohisto | 2014 |
PAR2 exerts local protection against acute pancreatitis via modulation of MAP kinase and MAP kinase phosphatase signaling.
Topics: Animals; Butadienes; Ceruletide; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expres | 2008 |
Cerulein-induced acute pancreatitis in the rat is significantly ameliorated by treatment with MEK1/2 inhibitors U0126 and PD98059.
Topics: Acute Disease; Animals; Butadienes; Ceruletide; Enzyme Inhibitors; Flavonoids; Male; MAP Kinase Kina | 2002 |