pd 98059 has been researched along with Pancreatic Neoplasms in 35 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present evidence that pyrrolidine dithiocarbamate (PDTC) inhibits growth of p53-negative pancreatic adenocarcinoma cell lines via cell cycle arrest in the S-phase, while it has no effect on primary fibroblast proliferation." | 7.73 | Increased stability of P21(WAF1/CIP1) mRNA is required for ROS/ERK-dependent pancreatic adenocarcinoma cell growth inhibition by pyrrolidine dithiocarbamate. ( Costanzo, C; Dalla Pozza, E; Donadelli, M; Palmieri, M; Piacentini, P; Scarpa, A; Scupoli, MT, 2006) |
| "Curcumin is a potential anticancer agent for pancreatic cancer." | 5.51 | Curcumin attenuates hyperglycemia-driven EGF-induced invasive and migratory abilities of pancreatic cancer via suppression of the ERK and AKT pathways. ( Cao, L; Han, L; Li, W; Ma, Q; Wang, Z; Wu, Z; Xiao, X, 2019) |
| "Human pancreatic cancer Panc-1 cells were exposed to high glucose condition with or without resveratrol, N-acetylcysteine (NAC, a scavenger of free radicals), PD 98059 (an ERK inhibitor) or SB 203580 (a p38 MAPK inhibitor)." | 5.43 | Resveratrol inhibits hyperglycemia-driven ROS-induced invasion and migration of pancreatic cancer cells via suppression of the ERK and p38 MAPK signaling pathways. ( Cao, L; Chen, X; Li, W; Ma, Q; Xiao, X, 2016) |
| "We present evidence that pyrrolidine dithiocarbamate (PDTC) inhibits growth of p53-negative pancreatic adenocarcinoma cell lines via cell cycle arrest in the S-phase, while it has no effect on primary fibroblast proliferation." | 3.73 | Increased stability of P21(WAF1/CIP1) mRNA is required for ROS/ERK-dependent pancreatic adenocarcinoma cell growth inhibition by pyrrolidine dithiocarbamate. ( Costanzo, C; Dalla Pozza, E; Donadelli, M; Palmieri, M; Piacentini, P; Scarpa, A; Scupoli, MT, 2006) |
| "Curcumin is a potential anticancer agent for pancreatic cancer." | 1.51 | Curcumin attenuates hyperglycemia-driven EGF-induced invasive and migratory abilities of pancreatic cancer via suppression of the ERK and AKT pathways. ( Cao, L; Han, L; Li, W; Ma, Q; Wang, Z; Wu, Z; Xiao, X, 2019) |
| "We examined KIF15 expression in pancreatic cancer tissues and the effect of KIF15 on cell proliferation in vitro and in vivo." | 1.46 | KIF15 promotes pancreatic cancer proliferation via the MEK-ERK signalling pathway. ( Guo, X; Jiang, J; Wang, J; Xie, C, 2017) |
| "Human pancreatic cancer Panc-1 cells were exposed to high glucose condition with or without resveratrol, N-acetylcysteine (NAC, a scavenger of free radicals), PD 98059 (an ERK inhibitor) or SB 203580 (a p38 MAPK inhibitor)." | 1.43 | Resveratrol inhibits hyperglycemia-driven ROS-induced invasion and migration of pancreatic cancer cells via suppression of the ERK and p38 MAPK signaling pathways. ( Cao, L; Chen, X; Li, W; Ma, Q; Xiao, X, 2016) |
| "Human pancreatic cancer cells BxPC-3 and Panc-1 were utilized to examine the level of hydrogen peroxide (H2O) in the absence or presence of SOD and catalase (CAT)." | 1.42 | Superoxide dismutase promotes the epithelial-mesenchymal transition of pancreatic cancer cells via activation of the H2O2/ERK/NF-κB axis. ( Cao, L; Han, L; Li, W; Ma, Q; Xu, Q, 2015) |
| "The level of leukotriene B₄ is high in pancreatic cancers." | 1.38 | Novel involvement of leukotriene B₄ receptor 2 through ERK activation by PP2A down-regulation in leukotriene B₄-induced keratin phosphorylation and reorganization of pancreatic cancer cells. ( Kim, S; Lee, CH; Lee, HJ; Park, MK; Park, Y; Shim, J, 2012) |
| "We have previously demonstrated that in pancreatic cancer ErbB3 is the preferred dimerization partner of EGFR, ErbB3 protein expression level directly correlates with the anti-proliferative effect of erlotinib (an EGFR-specific tyrosine kinase inhibitor), and transient knockdown of ErbB3 expression results in acquired resistance to EGFR-targeted therapy." | 1.36 | ErbB3 expression promotes tumorigenesis in pancreatic adenocarcinoma. ( Arnoletti, JP; Frolov, A; Heslin, MJ; Howard, JH; Kossenkov, AV; Kulesza, P; Liles, JS; Tzeng, CW, 2010) |
| " The effects of PD98059, LY294002, rapamycin and its analogue CCI-779 were tested in dose-response experiments." | 1.33 | Inhibition of different intracellular signal cascades in human pancreatic cancer cells. ( Axelson, J; Hörlin, K; Lindell, M; Ohlsson, B, 2005) |
| "Genetic mutations found in pancreatic cancer (K-ras, p16, p53) lead to inappropriate cellular proliferation." | 1.31 | Pancreatic cancer cell proliferation is phosphatidylinositol 3-kinase dependent. ( Callery, MP; McDade, TP; Perugini, RA; Vittimberga, FJ, 2000) |
| "Five pancreatic cancer cell lines, CD11, CD18, HPAF, PANC-1, and MiaPaCa2 were used to investigate the effect of islet hormones on cell proliferation, glucose utilization, and GLUT-1 expression." | 1.31 | Physiological concentrations of insulin augment pancreatic cancer cell proliferation and glucose utilization by activating MAP kinase, PI3 kinase and enhancing GLUT-1 expression. ( Adrian, TE; Ding, XZ; Fehsenfeld, DM; Murphy, LO; Permert, J, 2000) |
| "When pancreatic cancer cells were grown without change of medium, proliferation was greater than when either medium was replaced frequently (HPAF, CAPAN-2, PANC-1 or SW1990) or cells were grown in the presence of the EGF receptor tyrosine kinase inhibitor AG1478 or the MEK inhibitor PD098059 (HPAF or CAPAN-2)." | 1.31 | Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditions. ( Adrian, TE; Cluck, MW; Knezetic, JA; Larsson, J; Lovas, S; Murphy, LO; Murphy, RF; Otvös, F; Permert, J; Schally, AV, 2001) |
| "However, the role of P38 kinase in pancreatic cancer cell proliferation and its relationship with ERK are unclear." | 1.31 | MEK/ERK-mediated proliferation is negatively regulated by P38 map kinase in the human pancreatic cancer cell line, PANC-1. ( Adrian, TE; Ding, XZ, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.86) | 18.2507 |
| 2000's | 15 (42.86) | 29.6817 |
| 2010's | 18 (51.43) | 24.3611 |
| 2020's | 1 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, W | 1 |
| Park, C | 1 |
| Oh, E | 1 |
| Sung, Y | 1 |
| Lee, J | 1 |
| Park, KH | 1 |
| Kang, H | 1 |
| Chen, Y | 1 |
| Liu, P | 1 |
| Shen, D | 2 |
| Liu, H | 1 |
| Xu, L | 1 |
| Wang, J | 2 |
| Sun, H | 1 |
| Wu, H | 1 |
| Guo, X | 1 |
| Xie, C | 1 |
| Jiang, J | 1 |
| Li, W | 3 |
| Wang, Z | 1 |
| Xiao, X | 2 |
| Han, L | 2 |
| Wu, Z | 1 |
| Ma, Q | 3 |
| Cao, L | 3 |
| Chao, MW | 1 |
| Chang, LH | 2 |
| Tu, HJ | 1 |
| Chang, CD | 1 |
| Lai, MJ | 1 |
| Chen, YY | 1 |
| Liou, JP | 1 |
| Teng, CM | 2 |
| Pan, SL | 2 |
| Amrutkar, M | 1 |
| Aasrum, M | 1 |
| Verbeke, CS | 1 |
| Gladhaug, IP | 1 |
| Lai, CY | 1 |
| Tsai, AC | 1 |
| Pham, H | 1 |
| Rodriguez, CE | 1 |
| Donald, GW | 1 |
| Hertzer, KM | 1 |
| Jung, XS | 1 |
| Chang, HH | 1 |
| Moro, A | 1 |
| Reber, HA | 1 |
| Hines, OJ | 1 |
| Eibl, G | 1 |
| Darabi, M | 4 |
| Byagowi, S | 2 |
| Fayezi, S | 2 |
| Mirshahvaladi, S | 2 |
| Sahmani, M | 2 |
| Bu, HQ | 1 |
| Liu, DL | 1 |
| Wei, WT | 1 |
| Chen, L | 1 |
| Huang, H | 1 |
| Li, Y | 1 |
| Cui, JH | 1 |
| Naserpour Farivar, T | 1 |
| Najafipour, R | 1 |
| Xu, Q | 1 |
| Wang, F | 1 |
| Jin, R | 1 |
| Zou, BB | 1 |
| Li, L | 1 |
| Cheng, FW | 1 |
| Luo, X | 1 |
| Geng, X | 1 |
| Zhang, SQ | 1 |
| Chen, X | 1 |
| Wong, MH | 1 |
| Xue, A | 1 |
| Baxter, RC | 1 |
| Pavlakis, N | 1 |
| Smith, RC | 1 |
| Han, F | 1 |
| Zhu, HG | 1 |
| Liles, JS | 1 |
| Arnoletti, JP | 1 |
| Tzeng, CW | 1 |
| Howard, JH | 1 |
| Kossenkov, AV | 1 |
| Kulesza, P | 1 |
| Heslin, MJ | 1 |
| Frolov, A | 1 |
| Tang, Y | 1 |
| Liu, F | 1 |
| Zheng, C | 1 |
| Sun, S | 1 |
| Jiang, Y | 1 |
| Park, MK | 1 |
| Park, Y | 1 |
| Shim, J | 1 |
| Lee, HJ | 1 |
| Kim, S | 1 |
| Lee, CH | 1 |
| Kiehne, K | 1 |
| Herzig, KH | 1 |
| Fölsch, UR | 1 |
| Bondar, VM | 1 |
| Sweeney-Gotsch, B | 1 |
| Andreeff, M | 1 |
| Mills, GB | 1 |
| McConkey, DJ | 1 |
| Lee, KH | 1 |
| Hyun, MS | 1 |
| Kim, JR | 1 |
| Imamura, T | 1 |
| Kanai, F | 1 |
| Kawakami, T | 1 |
| Amarsanaa, J | 1 |
| Ijichi, H | 1 |
| Hoshida, Y | 1 |
| Tanaka, Y | 1 |
| Ikenoue, T | 1 |
| Tateishi, K | 1 |
| Kawabe, T | 1 |
| Arakawa, Y | 1 |
| Miyagishi, M | 1 |
| Taira, K | 1 |
| Yokosuka, O | 1 |
| Omata, M | 1 |
| Axelson, J | 1 |
| Lindell, M | 1 |
| Hörlin, K | 1 |
| Ohlsson, B | 1 |
| Tong, WG | 1 |
| Ding, XZ | 4 |
| Talamonti, MS | 2 |
| Bell, RH | 2 |
| Adrian, TE | 5 |
| Sarinella, F | 1 |
| Calistri, A | 1 |
| Sette, P | 1 |
| Palù, G | 1 |
| Parolin, C | 1 |
| Salabat, MR | 1 |
| Flesche, JB | 1 |
| Ujiki, MB | 1 |
| Robin, TP | 1 |
| Donadelli, M | 1 |
| Dalla Pozza, E | 1 |
| Costanzo, C | 1 |
| Scupoli, MT | 1 |
| Piacentini, P | 1 |
| Scarpa, A | 1 |
| Palmieri, M | 1 |
| Chow, JY | 1 |
| Quach, KT | 1 |
| Cabrera, BL | 1 |
| Cabral, JA | 1 |
| Beck, SE | 1 |
| Carethers, JM | 1 |
| Khoo, S | 1 |
| Cobb, MH | 1 |
| Perugini, RA | 1 |
| McDade, TP | 1 |
| Vittimberga, FJ | 1 |
| Callery, MP | 1 |
| Boucher, MJ | 1 |
| Morisset, J | 1 |
| Vachon, PH | 1 |
| Reed, JC | 1 |
| Lainé, J | 1 |
| Rivard, N | 1 |
| Fehsenfeld, DM | 1 |
| Murphy, LO | 2 |
| Permert, J | 2 |
| Cluck, MW | 1 |
| Lovas, S | 1 |
| Otvös, F | 1 |
| Murphy, RF | 1 |
| Schally, AV | 1 |
| Larsson, J | 1 |
| Knezetic, JA | 1 |
35 other studies available for pd 98059 and Pancreatic Neoplasms
| Article | Year |
|---|---|
Benzophenone Compounds, from a Marine-Derived Strain of the Fungus
Topics: Antineoplastic Agents; Benzophenones; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, A | 2019 |
FAM172A inhibits EMT in pancreatic cancer via ERK-MAPK signaling.
Topics: Adult; Aged; Cadherins; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Female; Flavonoids; Gen | 2020 |
KIF15 promotes pancreatic cancer proliferation via the MEK-ERK signalling pathway.
Topics: Aged; Animals; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Cyclin-Dependent | 2017 |
Curcumin attenuates hyperglycemia-driven EGF-induced invasive and migratory abilities of pancreatic cancer via suppression of the ERK and AKT pathways.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Curcumin; Epi | 2019 |
Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Cell | 2019 |
Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells.
Topics: Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Survival; Coculture Techniques; Deoxycytidine; | 2019 |
Activated PAR-2 regulates pancreatic cancer progression through ILK/HIF-α-induced TGF-α expression and MEK/VEGF-A-mediated angiogenesis.
Topics: Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Down-Regulation; Flavonoids; Humans; | 2013 |
miR-143 decreases COX-2 mRNA stability and expression in pancreatic cancer cells.
Topics: Butadienes; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Dinoprostone; DNA-Binding Protei | 2013 |
Transcriptional regulation of Δ6-desaturase by peroxisome proliferative-activated receptor δ agonist in human pancreatic cancer cells: role of MEK/ERK1/2 pathway.
Topics: Cell Line, Tumor; ErbB Receptors; Fatty Acid Desaturases; Flavonoids; Gene Expression Regulation, En | 2013 |
Oridonin induces apoptosis in SW1990 pancreatic cancer cells via p53- and caspase-dependent induction of p38 MAPK.
Topics: Anthracenes; Apoptosis; Benzothiazoles; Caspase 3; Caspase 9; Cell Line, Tumor; Cyclin-Dependent Kin | 2014 |
Effect of PPARδ agonist on stearoyl-CoA desaturase 1 in human pancreatic cancer cells: role of MEK/ERK1/2 pathway.
Topics: Cell Line, Tumor; Flavonoids; Humans; MAP Kinase Signaling System; Pancreatic Neoplasms; PPAR delta; | 2015 |
Superoxide dismutase promotes the epithelial-mesenchymal transition of pancreatic cancer cells via activation of the H2O2/ERK/NF-κB axis.
Topics: Catalase; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Flavonoids; Humans; Hy | 2015 |
Activation of Toll-like receptor 7 regulates the expression of IFN-λ1, p53, PTEN, VEGF, TIMP-1 and MMP-9 in pancreatic cancer cells.
Topics: Aminoquinolines; Cell Line, Tumor; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fl | 2016 |
Resveratrol inhibits hyperglycemia-driven ROS-induced invasion and migration of pancreatic cancer cells via suppression of the ERK and p38 MAPK signaling pathways.
Topics: Acetylcysteine; Cell Line, Tumor; Cell Movement; Diabetes Complications; Flavonoids; Free Radical Sc | 2016 |
Upstream and Downstream Co-inhibition of Mitogen-Activated Protein Kinase and PI3K/Akt/mTOR Pathways in Pancreatic Ductal Adenocarcinoma.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Pancrea | 2016 |
Caveolin-1 regulating the invasion and expression of matrix metalloproteinase (MMPs) in pancreatic carcinoma cells.
Topics: Carcinoma; Caveolin 1; Cell Line, Tumor; Chromones; Epithelial Cells; Extracellular Signal-Regulated | 2010 |
ErbB3 expression promotes tumorigenesis in pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Animals; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Chromones; Dose-Re | 2010 |
Knockdown of clusterin sensitizes pancreatic cancer cells to gemcitabine chemotherapy by ERK1/2 inactivation.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Clusterin; Deoxycytidine; Flavonoids; Gemcitabine; | 2012 |
Novel involvement of leukotriene B₄ receptor 2 through ERK activation by PP2A down-regulation in leukotriene B₄-induced keratin phosphorylation and reorganization of pancreatic cancer cells.
Topics: Anesthetics, Inhalation; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Down-R | 2012 |
Differential activation of p42ERK2 and p125FAK by cholecystokinin and bombesin in the secretion and proliferation of the pancreatic amphicrine cell line AR42J.
Topics: Animals; Bombesin; Cell Division; Cholecystokinin; Dose-Response Relationship, Drug; Enzyme Activati | 2002 |
Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo.
Topics: Androstadienes; Animals; Apoptosis; Carcinoma; Chromones; Collagen; Dose-Response Relationship, Drug | 2002 |
Growth factor-dependent activation of the MAPK pathway in human pancreatic cancer: MEK/ERK and p38 MAP kinase interaction in uPA synthesis.
Topics: Cell Division; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; I | 2003 |
Proteomic analysis of the TGF-beta signaling pathway in pancreatic carcinoma cells using stable RNA interference to silence Smad4 expression.
Topics: Blotting, Western; Cell Line, Tumor; DNA-Binding Proteins; Electrophoresis, Gel, Two-Dimensional; En | 2004 |
Inhibition of different intracellular signal cascades in human pancreatic cancer cells.
Topics: Antibiotics, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Division; Chromones; Culture Media, | 2005 |
LTB4 stimulates growth of human pancreatic cancer cells via MAPK and PI-3 kinase pathways.
Topics: Androstadienes; Arachidonate 5-Lipoxygenase; Benzoates; Butadienes; Cell Division; Cell Line, Tumor; | 2005 |
Oncolysis of pancreatic tumour cells by a gamma34.5-deleted HSV-1 does not rely upon Ras-activation, but on the PI 3-kinase pathway.
Topics: Adenocarcinoma; Cell Line, Tumor; Chromones; Flavonoids; Gene Deletion; Genes, ras; Genetic Therapy; | 2006 |
On the mechanisms of 12-O-tetradecanoylphorbol-13-acetate-induced growth arrest in pancreatic cancer cells.
Topics: Cell Division; Cell Line, Tumor; Cell Proliferation; Cyclin A; Cyclin B; Cyclin B1; Cyclin E; Cyclin | 2006 |
Increased stability of P21(WAF1/CIP1) mRNA is required for ROS/ERK-dependent pancreatic adenocarcinoma cell growth inhibition by pyrrolidine dithiocarbamate.
Topics: Acetylcysteine; Adenocarcinoma; Animals; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin-De | 2006 |
RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells.
Topics: Blotting, Western; Cell Line; Flavonoids; Humans; Mitogen-Activated Protein Kinases; Pancreatic Neop | 2007 |
Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Colforsin; Deoxyglucose; Enzyme Activation; E | 1997 |
Pancreatic cancer cell proliferation is phosphatidylinositol 3-kinase dependent.
Topics: Cell Cycle; Cell Division; Chromones; Flavonoids; Humans; Mitogen-Activated Protein Kinases; Morphol | 2000 |
MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells.
Topics: Apoptosis; bcl-X Protein; Carcinoma; Caspases; Cell Cycle; Cell Survival; Cysteine Endopeptidases; C | 2000 |
Physiological concentrations of insulin augment pancreatic cancer cell proliferation and glucose utilization by activating MAP kinase, PI3 kinase and enhancing GLUT-1 expression.
Topics: Androstadienes; Cell Division; DNA, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gluc | 2000 |
Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditions.
Topics: Cell Division; Culture Media, Serum-Free; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Fac | 2001 |
MEK/ERK-mediated proliferation is negatively regulated by P38 map kinase in the human pancreatic cancer cell line, PANC-1.
Topics: Cell Cycle; Cell Division; DNA, Neoplasm; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; JNK Mit | 2001 |