pd 98059 has been researched along with Osteogenic Sarcoma in 11 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a previous study, we found that melatonin inhibits MG-63 osteosarcoma cell proliferation; however, the underlying mechanisms remain elusive." | 7.83 | Inhibition of ERK1/2 Signaling Pathway is Involved in Melatonin's Antiproliferative Effect on Human MG-63 Osteosarcoma Cells. ( Chen, D; Jiang, L; Li, Z; Liu, L; Liu, Y; Pan, Y; Pu, X; Reiter, RJ; Xu, Y, 2016) |
| "Chlorogenic acid (CGA) is a phenolic compound contained in plant-related products that modulates many cellular functions and inhibits cell proliferation in several cancer types." | 5.56 | Chlorogenic acid activates ERK1/2 and inhibits proliferation of osteosarcoma cells. ( Catauro, M; Chiosi, E; Illiano, M; Naviglio, S; Pacifico, S; Ragone, A; Salzillo, A; Sapio, L; Spina, A, 2020) |
| "In a previous study, we found that melatonin inhibits MG-63 osteosarcoma cell proliferation; however, the underlying mechanisms remain elusive." | 3.83 | Inhibition of ERK1/2 Signaling Pathway is Involved in Melatonin's Antiproliferative Effect on Human MG-63 Osteosarcoma Cells. ( Chen, D; Jiang, L; Li, Z; Liu, L; Liu, Y; Pan, Y; Pu, X; Reiter, RJ; Xu, Y, 2016) |
| "Chlorogenic acid (CGA) is a phenolic compound contained in plant-related products that modulates many cellular functions and inhibits cell proliferation in several cancer types." | 1.56 | Chlorogenic acid activates ERK1/2 and inhibits proliferation of osteosarcoma cells. ( Catauro, M; Chiosi, E; Illiano, M; Naviglio, S; Pacifico, S; Ragone, A; Salzillo, A; Sapio, L; Spina, A, 2020) |
| "Osteosarcoma is a type of malignant bone tumor with high metastasis and poor prognosis." | 1.40 | LIM kinase 1 is required for insulin‑dependent cell growth of osteosarcoma cell lines. ( Ji, QY; Meng, LJ; Wang, H; Wang, Y; Xing, FJ; Yang, ST; Zhang, HS; Zhang, HY; Zhao, JW, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 8 (72.73) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Sapio, L | 1 |
| Salzillo, A | 1 |
| Illiano, M | 1 |
| Ragone, A | 1 |
| Spina, A | 1 |
| Chiosi, E | 1 |
| Pacifico, S | 1 |
| Catauro, M | 1 |
| Naviglio, S | 1 |
| Zhang, HS | 1 |
| Zhao, JW | 1 |
| Wang, H | 1 |
| Zhang, HY | 1 |
| Ji, QY | 1 |
| Meng, LJ | 1 |
| Xing, FJ | 1 |
| Yang, ST | 1 |
| Wang, Y | 1 |
| Kim, KO | 2 |
| Hsu, AC | 1 |
| Lee, HG | 1 |
| Patel, N | 1 |
| Chandhanayingyong, C | 1 |
| Hickernell, T | 1 |
| Lee, FY | 2 |
| Liu, L | 1 |
| Xu, Y | 1 |
| Reiter, RJ | 1 |
| Pan, Y | 1 |
| Chen, D | 1 |
| Liu, Y | 1 |
| Pu, X | 1 |
| Jiang, L | 1 |
| Li, Z | 1 |
| Harisi, R | 1 |
| Kenessey, I | 1 |
| Olah, JN | 1 |
| Timar, F | 1 |
| Babo, I | 1 |
| Pogany, G | 1 |
| Paku, S | 1 |
| Jeney, A | 1 |
| Matsuda, T | 1 |
| Kondo, A | 1 |
| Tsunashima, Y | 1 |
| Togari, A | 1 |
| Cao, T | 1 |
| Zhang, T | 1 |
| Wang, L | 1 |
| Zhang, L | 1 |
| Adachi, T | 1 |
| Sato, T | 1 |
| Yamagata, S | 1 |
| Yamagata, T | 1 |
| Healey, JH | 1 |
| Noh, K | 1 |
| Patel, NR | 1 |
| Staples, JR | 1 |
| Minematsu, H | 1 |
| Nair, K | 1 |
| Park, H | 1 |
| Drevelle, O | 1 |
| Daviau, A | 1 |
| Senta, H | 1 |
| Bergeron, E | 1 |
| Faucheux, N | 1 |
| Woessmann, W | 1 |
| Chen, X | 1 |
| Borkhardt, A | 1 |
11 other studies available for pd 98059 and Osteogenic Sarcoma
| Article | Year |
|---|---|
Chlorogenic acid activates ERK1/2 and inhibits proliferation of osteosarcoma cells.
Topics: Adolescent; Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferat | 2020 |
LIM kinase 1 is required for insulin‑dependent cell growth of osteosarcoma cell lines.
Topics: Actin Depolymerizing Factors; Cell Line, Tumor; Cell Proliferation; Cholecalciferol; Chromones; Flav | 2014 |
Proteomic identification of 14-3-3ϵ as a linker protein between pERK1/2 inhibition and BIM upregulation in human osteosarcoma cells.
Topics: 14-3-3 Proteins; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cell Line, Tumor; | 2014 |
Inhibition of ERK1/2 Signaling Pathway is Involved in Melatonin's Antiproliferative Effect on Human MG-63 Osteosarcoma Cells.
Topics: Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclin B1; Cyclin D1; Cyclin-Dependent | 2016 |
Differential inhibition of single and cluster type tumor cell migration.
Topics: Adolescent; Bone Neoplasms; Cell Culture Techniques; Cell Movement; Cell Proliferation; Chromones; D | 2009 |
Inhibitory effect of vitamin K(2) on interleukin-1beta-stimulated proliferation of human osteoblasts.
Topics: Adult; Anticoagulants; Bone Neoplasms; Cell Line; Cell Proliferation; Cyclooxygenase 2; Cyclooxygena | 2010 |
Ganglioside GD1a suppression of NOS2 expression via ERK1 pathway in mouse osteosarcoma FBJ cells.
Topics: Animals; Blotting, Western; Butadienes; Cell Line, Tumor; Cell Movement; Cell Proliferation; Enzyme | 2010 |
Commentary on an article by Kyucheol Noh, MD, et al.: "Targeting inflammatory kinase as an adjuvant treatment for osteosarcomas".
Topics: Animals; Apoptosis; Bone Neoplasms; Cell Death; Cell Survival; Doxorubicin; Flavonoids; Humans; Infl | 2011 |
Targeting inflammatory kinase as an adjuvant treatment for osteosarcomas.
Topics: Animals; Apoptosis; Bone Neoplasms; Cell Death; Cell Survival; Doxorubicin; Flavonoids; Flow Cytomet | 2011 |
Preventing MEK1 activation influences the responses of human osteosarcoma cells to bone morphogenetic proteins 2 and 9.
Topics: Amino Acid Sequence; Bone Morphogenetic Protein 2; Bone Neoplasms; Dose-Response Relationship, Drug; | 2013 |
Ras-mediated activation of ERK by cisplatin induces cell death independently of p53 in osteosarcoma and neuroblastoma cell lines.
Topics: Antineoplastic Agents; Apoptosis; Bone Neoplasms; Butadienes; Cisplatin; Drug Resistance, Neoplasm; | 2002 |