pd 98059 has been researched along with Obesity in 9 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "One of the major manifestations of obesity is increased production of the adipocyte-derived 16-kDa peptide leptin, which is also elevated in heart disease, including congestive heart failure." | 7.72 | The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes. ( Gan, XT; Karmazyn, M; Kirshenbaum, LA; Rajapurohitam, V, 2003) |
| "One of the major manifestations of obesity is increased production of the adipocyte-derived 16-kDa peptide leptin, which is also elevated in heart disease, including congestive heart failure." | 3.72 | The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes. ( Gan, XT; Karmazyn, M; Kirshenbaum, LA; Rajapurohitam, V, 2003) |
| "Obesity is known to be an important risk factor for many types of cancer, such as breast, prostate, liver and endometrial cancer." | 1.39 | Leptin stimulates ovarian cancer cell growth and inhibits apoptosis by increasing cyclin D1 and Mcl-1 expression via the activation of the MEK/ERK1/2 and PI3K/Akt signaling pathways. ( Breslin, M; Chang, YC; Chen, C; Lan, MS, 2013) |
| "Also leptin treatment did not alter total tPA concentration or tPA activity in conditioned media." | 1.36 | Leptin upregulates the expression of plasminogen activator inhibitor-1 in human vascular endothelial cells. ( Barber, KR; Hoffmann, M; Jensen, A; Kuniyoshi, FS; Peterson, TE; Shamsuzzaman, AS; Singh, P; Somers, VK, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Romacho, T | 1 |
| Azcutia, V | 1 |
| Vázquez-Bella, M | 1 |
| Matesanz, N | 1 |
| Cercas, E | 1 |
| Nevado, J | 1 |
| Carraro, R | 1 |
| Rodríguez-Mañas, L | 1 |
| Sánchez-Ferrer, CF | 1 |
| Peiró, C | 1 |
| Singh, P | 1 |
| Peterson, TE | 1 |
| Barber, KR | 1 |
| Kuniyoshi, FS | 1 |
| Jensen, A | 1 |
| Hoffmann, M | 1 |
| Shamsuzzaman, AS | 1 |
| Somers, VK | 1 |
| Cheng, Q | 1 |
| Dong, W | 1 |
| Qian, L | 1 |
| Wu, J | 1 |
| Peng, Y | 1 |
| Ramos-Álvarez, I | 1 |
| Martín-Duce, A | 1 |
| Moreno-Villegas, Z | 1 |
| Sanz, R | 1 |
| Aparicio, C | 1 |
| Portal-Núñez, S | 1 |
| Mantey, SA | 1 |
| Jensen, RT | 1 |
| González, N | 1 |
| Chen, C | 1 |
| Chang, YC | 1 |
| Lan, MS | 1 |
| Breslin, M | 1 |
| Rajapurohitam, V | 1 |
| Gan, XT | 1 |
| Kirshenbaum, LA | 1 |
| Karmazyn, M | 1 |
| Qi, J | 1 |
| Xiao, YF | 1 |
| Zhang, DJ | 1 |
| Yang, GR | 1 |
| Huang, HC | 1 |
| Tanabe, K | 1 |
| Okuya, S | 1 |
| Tanizawa, Y | 1 |
| Matsutani, A | 1 |
| Oka, Y | 1 |
| Tsuchiya, T | 1 |
| Shimizu, H | 1 |
| Horie, T | 1 |
| Mori, M | 1 |
9 other studies available for pd 98059 and Obesity
| Article | Year |
|---|---|
Extracellular PBEF/NAMPT/visfatin activates pro-inflammatory signalling in human vascular smooth muscle cells through nicotinamide phosphoribosyltransferase activity.
Topics: Aorta; Cell Culture Techniques; Cytokines; Diabetes Mellitus; Flavonoids; Humans; Insulin-Secreting | 2009 |
Leptin upregulates the expression of plasminogen activator inhibitor-1 in human vascular endothelial cells.
Topics: Atherosclerosis; Cells, Cultured; Endothelium, Vascular; Flavonoids; Humans; Leptin; Mitogen-Activat | 2010 |
Visfatin inhibits apoptosis of pancreatic β-cell line, MIN6, via the mitogen-activated protein kinase/phosphoinositide 3-kinase pathway.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line; Cell Proliferation; Chromones; | 2011 |
Bombesin receptor subtype-3 (BRS-3), a novel candidate as therapeutic molecular target in obesity and diabetes.
Topics: Adult; Aged; Androstadienes; Animals; Biological Transport; Cells, Cultured; Diabetes Mellitus, Type | 2013 |
Leptin stimulates ovarian cancer cell growth and inhibits apoptosis by increasing cyclin D1 and Mcl-1 expression via the activation of the MEK/ERK1/2 and PI3K/Akt signaling pathways.
Topics: Apoptosis; Butadienes; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Enzyme Activation; Enzyme In | 2013 |
The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes.
Topics: Animals; Animals, Newborn; Blotting, Western; Cell Size; Cells, Cultured; Dose-Response Relationship | 2003 |
[High glucose downregulates the expression of podocalyxin protein in glomerular podocytes of mice].
Topics: Animals; Blotting, Western; Cells, Cultured; Down-Regulation; Flavonoids; Glucose; Immunohistochemis | 2007 |
Leptin induces proliferation of pancreatic beta cell line MIN6 through activation of mitogen-activated protein kinase.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Cell Survival; DNA; | 1997 |
Expression of leptin receptor in lung: leptin as a growth factor.
Topics: Animals; Bromodeoxyuridine; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cell Div | 1999 |