pd 98059 has been researched along with Niemann-Pick Disease, Type C in 1 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Niemann-Pick Disease, Type C: An autosomal recessive lipid storage disorder that is characterized by accumulation of CHOLESTEROL and SPHINGOMYELINS in cells of the VISCERA and the CENTRAL NERVOUS SYSTEM. Type C (or C1) and type D are allelic disorders caused by mutation of the NPC1 gene, which encodes a protein that mediates intracellular cholesterol transport from LYSOSOMES. Clinical signs include hepatosplenomegaly and chronic neurological symptoms. Type D is a variant in people with a Nova Scotia ancestry.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, M | 1 |
| Hallows, JL | 1 |
| Wang, X | 1 |
| Bu, B | 1 |
| Wang, W | 1 |
| Vincent, I | 1 |
1 other study available for pd 98059 and Niemann-Pick Disease, Type C
| Article | Year |
|---|---|
Mitogen-activated protein kinase activity may not be necessary for the neuropathology of Niemann-Pick type C mice.
Topics: Animals; Blotting, Western; Brain; Disease Models, Animal; Enzyme Inhibitors; Flavonoids; Immunohist | 2008 |