pd 98059 has been researched along with Neuroblastoma in 48 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Earlier studies demonstrated Arc induction in discrete brain regions by several psychoactive substances, including drugs of abuse." | 5.33 | Morphine activates Arc expression in the mouse striatum and in mouse neuroblastoma Neuro2A MOR1A cells expressing mu-opioid receptors. ( Bilecki, W; Przewłocki, R; Urbański, MJ; Wawrzczak-Bargieła, A; Ziółkowska, B, 2005) |
| " We demonstrate herein that treatment of differentiated SH-SY-5Y human neuroblastoma with the phosphatase inhibitor okadaic acid (OA) similarly may increase tau phosphorylation via sustained activation of the L-voltage-sensitive calcium channel." | 3.72 | Okadaic acid mediates tau phosphorylation via sustained activation of the L-voltage-sensitive calcium channel. ( Ekinci, FJ; Ortiz, D; Shea, TB, 2003) |
| "Activation of muscarinic receptors in human neuroblastoma SH-SY5Y cells with carbachol stimulated a rapid and large increase in early growth response-1 (Egr-1, also called zif268 and NGF1-A) protein levels and DNA binding activity." | 3.70 | Cholinergic stimulation of early growth response-1 DNA binding activity requires protein kinase C and mitogen-activated protein kinase kinase activation and is inhibited by sodium valproate in SH-SY5Y cells. ( Grimes, CA; Jope, RS, 1999) |
| "Neuroblastoma is the second most common pediatric malignancy, characterized by a high rate of unexplained spontaneous remissions." | 1.33 | Signalling pathways leading to neuroblastoma differentiation after serum withdrawal: HDL blocks neuroblastoma differentiation by inhibition of EGFR. ( Evangelopoulos, ME; Krüttgen, A; Weis, J, 2005) |
| "Earlier studies demonstrated Arc induction in discrete brain regions by several psychoactive substances, including drugs of abuse." | 1.33 | Morphine activates Arc expression in the mouse striatum and in mouse neuroblastoma Neuro2A MOR1A cells expressing mu-opioid receptors. ( Bilecki, W; Przewłocki, R; Urbański, MJ; Wawrzczak-Bargieła, A; Ziółkowska, B, 2005) |
| "Guanosine pre-treatment decreased betaA-induced apoptosis (maximal effect after 24 h, 300 microM, p<0." | 1.32 | Guanosine protects SH-SY5Y cells against beta-amyloid-induced apoptosis. ( Bau, CJ; Caciagli, F; Ciccarelli, R; Kleywegt, S; Pettifer, KM; Ramsbottom, JD; Rathbone, MP; Vertes, E; Werstiuk, ES, 2004) |
| "Here we show that L1 release in AR breast carcinoma cells is mediated by a member of the disintegrin metalloproteinase (ADAM) family of proteinases." | 1.31 | Role of Src kinases in the ADAM-mediated release of L1 adhesion molecule from human tumor cells. ( Agmon-Levin, N; Altevogt, P; Gutwein, P; Krauss, K; Mechtersheimer, S; Oleszewski, M, 2000) |
| "Phenserine treatment resulted in decreased secretion of soluble betaAPP and Abeta into the conditioned media of human neuroblastoma cells without cellular toxicity." | 1.31 | Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. ( Brossi, A; Ge, YW; Greig, NH; Lahiri, DK; Rogers, J; Sambamurti, K; Shaw, KT; Utsuki, T; Yu, QS, 2001) |
| "Prion diseases are neurodegenerative pathologies characterized by the accumulation in the brain of a protease-resistant form of the prion protein (PrP(c)), named PrP(Sc)." | 1.31 | p38 MAP kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells. ( Arena, S; Benatti, U; Corsaro, A; Damonte, G; Florio, T; Millo, E; Schettini, G; Tagliavini, F; Thellung, S; Villa, V, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (14.58) | 18.2507 |
| 2000's | 35 (72.92) | 29.6817 |
| 2010's | 6 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hernández-Bule, ML | 1 |
| Medel, E | 1 |
| Colastra, C | 1 |
| Roldán, R | 1 |
| Úbeda, A | 1 |
| Wan, Z | 1 |
| Mah, D | 1 |
| Simtchouk, S | 1 |
| Kluftinger, A | 1 |
| Little, JP | 1 |
| Yurinskaya, MM | 1 |
| Vinokurov, MG | 1 |
| Astashkin, EI | 1 |
| Grachev, SV | 1 |
| Orekhova, NS | 1 |
| Novikova, AN | 1 |
| Sokolova, IN | 1 |
| Yshii, LM | 1 |
| Denadai-Souza, A | 1 |
| Vasconcelos, AR | 1 |
| Avellar, MC | 1 |
| Scavone, C | 1 |
| Radha, V | 1 |
| Rajanna, A | 1 |
| Gupta, RK | 1 |
| Dayma, K | 1 |
| Raman, T | 1 |
| Cotta-Grand, N | 1 |
| Rovère, C | 1 |
| Guyon, A | 1 |
| Cervantes, A | 1 |
| Brau, F | 1 |
| Nahon, JL | 1 |
| Yaniv, SP | 1 |
| Lucki, A | 1 |
| Klein, E | 1 |
| Ben-Shachar, D | 1 |
| Valero, T | 1 |
| Moschopoulou, G | 1 |
| Mayor-Lopez, L | 1 |
| Kintzios, S | 1 |
| Kuo, YH | 1 |
| Chen, TT | 1 |
| Thakker, DR | 1 |
| Standifer, KM | 1 |
| Woessmann, W | 1 |
| Chen, X | 1 |
| Borkhardt, A | 1 |
| Hynds, DL | 1 |
| Spencer, ML | 1 |
| Andres, DA | 1 |
| Snow, DM | 1 |
| Pola, S | 1 |
| Cattaneo, MG | 1 |
| Vicentini, LM | 1 |
| Ekinci, FJ | 2 |
| Ortiz, D | 2 |
| Shea, TB | 3 |
| Frasca, G | 1 |
| Chiechio, S | 1 |
| Vancheri, C | 1 |
| Nicoletti, F | 1 |
| Copani, A | 1 |
| Angela Sortino, M | 1 |
| Pettifer, KM | 1 |
| Kleywegt, S | 1 |
| Bau, CJ | 1 |
| Ramsbottom, JD | 1 |
| Vertes, E | 1 |
| Ciccarelli, R | 1 |
| Caciagli, F | 1 |
| Werstiuk, ES | 1 |
| Rathbone, MP | 1 |
| Motegi, A | 1 |
| Fujimoto, J | 1 |
| Kotani, M | 1 |
| Sakuraba, H | 1 |
| Yamamoto, T | 1 |
| Evangelopoulos, ME | 1 |
| Weis, J | 1 |
| Krüttgen, A | 1 |
| Moran, CM | 1 |
| Donnelly, M | 1 |
| Pant, HC | 1 |
| Mandelkow, EM | 1 |
| Tencheva, ZS | 1 |
| Praskova, MD | 1 |
| Velichkova, AA | 1 |
| Mitev, VI | 1 |
| Tang, LL | 1 |
| Wang, R | 1 |
| Tang, XC | 1 |
| Ziółkowska, B | 1 |
| Urbański, MJ | 1 |
| Wawrzczak-Bargieła, A | 1 |
| Bilecki, W | 1 |
| Przewłocki, R | 1 |
| Gómez-Ramos, A | 1 |
| Domínguez, J | 1 |
| Zafra, D | 1 |
| Corominola, H | 1 |
| Gomis, R | 1 |
| Guinovart, JJ | 1 |
| Avila, J | 1 |
| Jung, HS | 1 |
| Kim, HS | 1 |
| Lee, MJ | 1 |
| Shin, HY | 1 |
| Ahn, HS | 1 |
| Ryu, KH | 1 |
| Seoh, JY | 1 |
| Kim, CJ | 1 |
| Jang, JJ | 1 |
| Kim, YJ | 1 |
| Kim, YS | 1 |
| Kim, MS | 1 |
| Ryu, JC | 1 |
| Jacobsen, KX | 1 |
| MacDonald, H | 1 |
| Lemonde, S | 1 |
| Daigle, M | 1 |
| Grimes, DA | 1 |
| Bulman, DE | 1 |
| Albert, PR | 1 |
| Wang, SF | 1 |
| Yen, JC | 1 |
| Yin, PH | 1 |
| Chi, CW | 1 |
| Lee, HC | 1 |
| Kim, B | 1 |
| Cheng, HL | 1 |
| Margolis, B | 1 |
| Feldman, EL | 1 |
| Tonini, R | 1 |
| Mancinelli, E | 1 |
| Balestrini, M | 1 |
| Mazzanti, M | 1 |
| Martegani, E | 1 |
| Ferroni, A | 1 |
| Sturani, E | 1 |
| Zippel, R | 1 |
| Luo, J | 1 |
| Miller, MW | 1 |
| Oh-hashi, K | 1 |
| Maruyama, W | 1 |
| Yi, H | 1 |
| Takahashi, T | 1 |
| Naoi, M | 1 |
| Isobe, K | 1 |
| Grimes, CA | 1 |
| Jope, RS | 1 |
| Encinas, M | 1 |
| Iglesias, M | 1 |
| Llecha, N | 1 |
| Comella, JX | 1 |
| Misawa, A | 1 |
| Hosoi, H | 1 |
| Arimoto, A | 1 |
| Shikata, T | 1 |
| Akioka, S | 1 |
| Matsumura, T | 1 |
| Houghton, PJ | 1 |
| Sawada, T | 1 |
| Eggert, A | 1 |
| Ikegaki, N | 1 |
| Liu, X | 1 |
| Chou, TT | 1 |
| Lee, VM | 1 |
| Trojanowski, JQ | 1 |
| Brodeur, GM | 1 |
| Tavarini, S | 1 |
| Colombaioni, L | 1 |
| Garcia-Gil, M | 1 |
| Gutwein, P | 1 |
| Oleszewski, M | 1 |
| Mechtersheimer, S | 1 |
| Agmon-Levin, N | 1 |
| Krauss, K | 1 |
| Altevogt, P | 1 |
| Saeki, M | 1 |
| Kamisaki, Y | 1 |
| Maeda, S | 1 |
| Bronisz-Kowalczyk, A | 1 |
| Buzańska, L | 1 |
| Kowalczyk, D | 1 |
| Domańska-Janik, K | 1 |
| Kurihara, S | 1 |
| Hakuno, F | 1 |
| Takahashi, S | 1 |
| Olsson, AK | 1 |
| Nånberg, E | 1 |
| Shaw, KT | 1 |
| Utsuki, T | 1 |
| Rogers, J | 1 |
| Yu, QS | 1 |
| Sambamurti, K | 1 |
| Brossi, A | 1 |
| Ge, YW | 1 |
| Lahiri, DK | 1 |
| Greig, NH | 1 |
| Bieberich, E | 1 |
| MacKinnon, S | 1 |
| Silva, J | 1 |
| Yu, RK | 1 |
| Wu, SN | 1 |
| Lo, YK | 1 |
| Kuo, BI | 1 |
| Chiang, HT | 1 |
| Trollér, U | 1 |
| Zeidman, R | 1 |
| Svensson, K | 1 |
| Larsson, C | 1 |
| Shapira, M | 1 |
| Keren, O | 1 |
| Gafni, M | 1 |
| Sarne, Y | 1 |
| Thellung, S | 1 |
| Villa, V | 1 |
| Corsaro, A | 1 |
| Arena, S | 1 |
| Millo, E | 1 |
| Damonte, G | 1 |
| Benatti, U | 1 |
| Tagliavini, F | 1 |
| Florio, T | 1 |
| Schettini, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Trial Aiming to Assess the Safety and Activity of the Combination of Cabozantinib Plus Lanreotide in Gastroenteropancreatic (GEP) and Thoracic Neuroendocrine Tumor (NET): The LOLA Trial[NCT04427787] | Phase 2 | 69 participants (Anticipated) | Interventional | 2020-06-20 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
48 other studies available for pd 98059 and Neuroblastoma
| Article | Year |
|---|---|
Response of neuroblastoma cells to RF currents as a function of the signal frequency.
Topics: Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Pro | 2019 |
Human adipose tissue conditioned media from lean subjects is protective against H2O2 induced neurotoxicity in human SH-SY5Y neuronal cells.
Topics: Adipose Tissue; Alzheimer Disease; Anthracenes; Cell Line, Tumor; Cell Survival; Chromones; Culture | 2015 |
[Calf blood hemodializate reduces neurotoxic effect of hydrogen peroxide on human neuroblastoma cells].
Topics: Animals; Apoptosis; Cattle; Cell Line, Tumor; Enzyme Inhibitors; Flavonoids; Humans; Hydrogen Peroxi | 2014 |
Suppression of MAPK attenuates neuronal cell death induced by activated glia-conditioned medium in alpha-synuclein overexpressing SH-SY5Y cells.
Topics: alpha-Synuclein; Animals; Animals, Newborn; Cell Death; Cells, Cultured; Cerebral Cortex; Culture Me | 2015 |
The guanine nucleotide exchange factor, C3G regulates differentiation and survival of human neuroblastoma cells.
Topics: cdc42 GTP-Binding Protein; Cell Differentiation; Cell Line, Tumor; Cell Survival; Colforsin; Culture | 2008 |
Melanin-concentrating hormone induces neurite outgrowth in human neuroblastoma SH-SY5Y cells through p53 and MAPKinase signaling pathways.
Topics: Blotting, Southern; Blotting, Western; Cell Line; Cell Line, Tumor; Early Growth Response Protein 1; | 2009 |
Dexamethasone enhances the norepinephrine-induced ERK/MAPK intracellular pathway possibly via dysregulation of the alpha2-adrenergic receptor: implications for antidepressant drug mechanism of action.
Topics: Antidepressive Agents; Butadienes; Cell Line, Tumor; Cyclic AMP Response Element-Binding Protein; De | 2010 |
Moderate superoxide production is an early promoter of mitochondrial biogenesis in differentiating N2a neuroblastoma cells.
Topics: Animals; Biomarkers; Bucladesine; Cell Cycle; Cell Line, Tumor; Colforsin; Culture Media, Serum-Free | 2012 |
Novel activities of pro-IGF-I E peptides: regulation of morphological differentiation and anchorage-independent growth in human neuroblastoma cells.
Topics: Biomarkers; Cell Differentiation; Cell Division; Cell Line; Cell Movement; Chromones; Dose-Response | 2002 |
Induction of G protein-coupled receptor kinases 2 and 3 contributes to the cross-talk between mu and ORL1 receptors following prolonged agonist exposure.
Topics: Analysis of Variance; beta-Adrenergic Receptor Kinases; Cell Membrane; Cyclic AMP; Cyclic AMP-Depend | 2002 |
Ras-mediated activation of ERK by cisplatin induces cell death independently of p53 in osteosarcoma and neuroblastoma cell lines.
Topics: Antineoplastic Agents; Apoptosis; Bone Neoplasms; Butadienes; Cisplatin; Drug Resistance, Neoplasm; | 2002 |
Rit promotes MEK-independent neurite branching in human neuroblastoma cells.
Topics: Adenoviridae; Blotting, Western; Cell Differentiation; Cell Line; Cell Line, Tumor; Enzyme Inhibitor | 2003 |
Anti-migratory and anti-invasive effect of somatostatin in human neuroblastoma cells: involvement of Rac and MAP kinase activity.
Topics: Androstadienes; Blotting, Western; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug | 2003 |
Okadaic acid mediates tau phosphorylation via sustained activation of the L-voltage-sensitive calcium channel.
Topics: Antibodies, Monoclonal; Antigens; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Densi | 2003 |
Beta-amyloid-activated cell cycle in SH-SY5Y neuroblastoma cells: correlation with the MAP kinase pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Different | 2004 |
Guanosine protects SH-SY5Y cells against beta-amyloid-induced apoptosis.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Amyloid beta-Peptides; Apoptosis; Blotting, Western; C | 2004 |
ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth.
Topics: Adaptor Proteins, Signal Transducing; Anaplastic Lymphoma Kinase; Animals; Antibodies, Monoclonal; C | 2004 |
Signalling pathways leading to neuroblastoma differentiation after serum withdrawal: HDL blocks neuroblastoma differentiation by inhibition of EGFR.
Topics: Cell Differentiation; Cell Line, Tumor; Cholesterol; Culture Media, Serum-Free; Enzyme Inhibitors; E | 2005 |
Cdk5 inhibits anterograde axonal transport of neurofilaments but not that of tau by inhibition of mitogen-activated protein kinase activity.
Topics: Animals; Axonal Transport; Cell Line, Tumor; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Dr | 2005 |
delta-Opioid agonist induced regulation of E2F1 DNA binding activity in NG108-15 cells.
Topics: Analgesics, Opioid; Animals; Blotting, Western; Cell Cycle Proteins; Cell Line, Tumor; Cell Prolifer | 2005 |
Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production.
Topics: Alkaloids; Androstadienes; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Carbazol | 2005 |
Morphine activates Arc expression in the mouse striatum and in mouse neuroblastoma Neuro2A MOR1A cells expressing mu-opioid receptors.
Topics: AIDS-Related Complex; Analysis of Variance; Animals; Blotting, Western; Cell Line, Tumor; Corpus Str | 2005 |
Sodium tungstate decreases the phosphorylation of tau through GSK3 inactivation.
Topics: Animals; Blotting, Western; Brain; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Interact | 2006 |
Arsenic trioxide concentration determines the fate of Ewing's sarcoma family tumors and neuroblastoma cells in vitro.
Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Differentiation; Cell Line, Tum | 2006 |
The inhibitory mechanism of methylmercury on differentiation of human neuroblastoma cells.
Topics: Blotting, Western; Cell Differentiation; Cell Line, Tumor; Cell Survival; Comet Assay; DNA Damage; D | 2007 |
A Nurr1 point mutant, implicated in Parkinson's disease, uncouples ERK1/2-dependent regulation of tyrosine hydroxylase transcription.
Topics: Cell Line, Transformed; Cysteine; DNA-Binding Proteins; Dopamine Agonists; Drug Interactions; Enzyme | 2008 |
Involvement of oxidative stress-activated JNK signaling in the methamphetamine-induced cell death of human SH-SY5Y cells.
Topics: Anthracenes; Antioxidants; Apoptosis; Cell Line, Tumor; Central Nervous System Stimulants; Enzyme In | 2008 |
Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Androstadienes; Cell Me | 1998 |
Hyperactivation of mitogen-activated protein kinase increases phospho-tau immunoreactivity within human neuroblastoma: additive and synergistic influence of alteration of additional kinase activities.
Topics: Alzheimer Disease; Androstadienes; Brain; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; | 1999 |
Expression of Ras-GRF in the SK-N-BE neuroblastoma accelerates retinoic-acid-induced neuronal differentiation and increases the functional expression of the IRK1 potassium channel.
Topics: Antineoplastic Agents; Blotting, Northern; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle | 1999 |
Transforming growth factor beta1-regulated cell proliferation and expression of neural cell adhesion molecule in B104 neuroblastoma cells: differential effects of ethanol.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Survival; Enzyme Activati | 1999 |
Mitogen-activated protein kinase pathway mediates peroxynitrite-induced apoptosis in human dopaminergic neuroblastoma SH-SY5Y cells.
Topics: Antioxidants; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Caspase 3; Caspase Inhibitors | 1999 |
Cholinergic stimulation of early growth response-1 DNA binding activity requires protein kinase C and mitogen-activated protein kinase kinase activation and is inhibited by sodium valproate in SH-SY5Y cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; DNA-Binding Proteins; DNA, Neoplasm; Early | 1999 |
Extracellular-regulated kinases and phosphatidylinositol 3-kinase are involved in brain-derived neurotrophic factor-mediated survival and neuritogenesis of the neuroblastoma cell line SH-SY5Y.
Topics: Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiatio | 1999 |
N-Myc induction stimulated by insulin-like growth factor I through mitogen-activated protein kinase signaling pathway in human neuroblastoma cells.
Topics: Enzyme Inhibitors; Flavonoids; G1 Phase; Humans; Insulin-Like Growth Factor I; Mitogen-Activated Pro | 2000 |
Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells.
Topics: Adaptor Proteins, Signal Transducing; Carrier Proteins; Cell Differentiation; Chromones; DNA-Binding | 2000 |
Sphingomyelinase metabolites control survival and apoptotic death in SH-SY5Y neuroblastoma cells.
Topics: Apoptosis; Cell Survival; Enzyme Inhibitors; Flavonoids; Humans; Neuroblastoma; Sphingomyelin Phosph | 2000 |
Role of Src kinases in the ADAM-mediated release of L1 adhesion molecule from human tumor cells.
Topics: Animals; Antigens, Surface; Breast Neoplasms; Cell Size; CHO Cells; Cricetinae; Disintegrins; Enzyme | 2000 |
Involvement of mitogen-activated protein kinase in peroxynitrite-induced cell death of human neuroblastoma SH-SY5Y cells.
Topics: Cell Survival; Enzyme Inhibitors; Flavonoids; Humans; Mitogen-Activated Protein Kinase Kinases; Mito | 2000 |
Extracellular signal-regulated kinase suppression is not involved in apoptosis of neuroblastoma N2a cells induced by protein kinase C inhibition.
Topics: Animals; Apoptosis; Blood Proteins; DNA Fragmentation; Enzyme Inhibitors; Flavonoids; Gene Expressio | 2000 |
Insulin-like growth factor-I-dependent signal transduction pathways leading to the induction of cell growth and differentiation of human neuroblastoma cell line SH-SY5Y: the roles of MAP kinase pathway and PI 3-kinase pathway.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Cell Differentiation; C | 2000 |
A functional role for ERK in gene induction, but not in neurite outgrowth in differentiating neuroblastoma cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; DNA-Binding Proteins; Enzyme Act | 2001 |
Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development.
Topics: 5' Untranslated Regions; Amyloid beta-Protein Precursor; Astrocytoma; Cell Survival; Chloramphenicol | 2001 |
Regulation of apoptosis during neuronal differentiation by ceramide and b-series complex gangliosides.
Topics: 1-Deoxynojirimycin; Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain; Carrier Proteins; Cell | 2001 |
Ceramide inhibits the inwardly rectifying potassium current in GH(3) lactotrophs.
Topics: Action Potentials; Animals; Butadienes; Calcium; Calcium Channels, L-Type; Ceramides; Cytokines; Dit | 2001 |
A PKCbeta isoform mediates phorbol ester-induced activation of Erk1/2 and expression of neuronal differentiation genes in neuroblastoma cells.
Topics: Cell Differentiation; Culture Media, Serum-Free; Enzyme Inhibitors; Flavonoids; GAP-43 Protein; Gene | 2001 |
Divers pathways mediate delta-opioid receptor down regulation within the same cell.
Topics: Acetylcysteine; Analgesics, Opioid; Animals; Antirheumatic Agents; Chloroquine; Cysteine Proteinase | 2001 |
p38 MAP kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase 3; Caspases; Cysteine Proteinase Inhibitors; Enz | 2002 |