pd 98059 has been researched along with Nerve Degeneration in 7 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zheng, W | 1 |
| Chong, CM | 1 |
| Wang, H | 1 |
| Zhou, X | 1 |
| Zhang, L | 1 |
| Wang, R | 1 |
| Meng, Q | 1 |
| Lazarovici, P | 1 |
| Fang, J | 1 |
| Frasca, G | 1 |
| Chiechio, S | 1 |
| Vancheri, C | 1 |
| Nicoletti, F | 1 |
| Copani, A | 1 |
| Angela Sortino, M | 1 |
| Maier, K | 1 |
| Rau, CR | 1 |
| Storch, MK | 1 |
| Sättler, MB | 1 |
| Demmer, I | 1 |
| Weissert, R | 1 |
| Taheri, N | 1 |
| Kuhnert, AV | 1 |
| Bähr, M | 1 |
| Diem, R | 1 |
| Jiang, W | 1 |
| Van Cleemput, J | 1 |
| Sheerin, AH | 1 |
| Ji, SP | 1 |
| Zhang, Y | 1 |
| Saucier, DM | 1 |
| Corcoran, ME | 1 |
| Zhang, X | 1 |
| Rundén, E | 1 |
| Seglen, PO | 1 |
| Haug, FM | 1 |
| Ottersen, OP | 1 |
| Wieloch, T | 1 |
| Shamloo, M | 1 |
| Laake, JH | 1 |
| Rapoport, M | 1 |
| Ferreira, A | 1 |
| Gu, Z | 1 |
| Jiang, Q | 1 |
| Zhang, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double Blind, Placebo-controlled Study to Determine the Safety and Efficacy of Erythropoietin as an add-on Therapy of Methylprednisolone in Subjects With Acute Optic Neuritis (VISION PROTECT)[NCT00355095] | Phase 2 | 40 participants (Actual) | Interventional | 2006-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for pd 98059 and Nerve Degeneration
| Article | Year |
|---|---|
Artemisinin conferred ERK mediated neuroprotection to PC12 cells and cortical neurons exposed to sodium nitroprusside-induced oxidative insult.
Topics: Animals; Artemisinins; Cell Death; Cell Survival; Chromones; Flavonoids; MAP Kinase Signaling System | 2016 |
Beta-amyloid-activated cell cycle in SH-SY5Y neuroblastoma cells: correlation with the MAP kinase pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Different | 2004 |
Ciliary neurotrophic factor protects retinal ganglion cells from secondary cell death during acute autoimmune optic neuritis in rats.
Topics: Analysis of Variance; Animals; bcl-2-Associated X Protein; Blotting, Western; Cell Count; Cell Death | 2004 |
Involvement of extracellular regulated kinase and p38 kinase in hippocampal seizure tolerance.
Topics: Animals; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hippocampus; Imi | 2005 |
Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Apoptosis; Benzylamines; Calci | 1998 |
PD98059 prevents neurite degeneration induced by fibrillar beta-amyloid in mature hippocampal neurons.
Topics: Amyloid beta-Peptides; Animals; Cellular Senescence; Enzyme Activation; Enzyme Inhibitors; Flavonoid | 2000 |
Extracellular signal-regulated kinase 1/2 activation in hippocampus after cerebral ischemia may not interfere with postischemic cell death.
Topics: Animals; Brain Ischemia; Cell Death; Cell Survival; Enzyme Inhibitors; Flavonoids; Hippocampus; Immu | 2001 |