pd 98059 has been researched along with Myocardial Ischemia in 14 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 11 (78.57) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, W | 1 |
| Liang, X | 1 |
| Fu, D | 1 |
| Tie, R | 1 |
| Xing, W | 1 |
| Ji, L | 1 |
| Liu, F | 1 |
| Zhang, H | 1 |
| Li, R | 1 |
| Clanachan, AS | 1 |
| Jaswal, JS | 1 |
| Gandhi, M | 1 |
| Bottorff, DA | 1 |
| Coughlin, J | 1 |
| Finegan, BA | 1 |
| Stone, JC | 1 |
| Hilfiker-Kleiner, D | 1 |
| Kaminski, K | 1 |
| Kaminska, A | 1 |
| Fuchs, M | 1 |
| Klein, G | 1 |
| Podewski, E | 1 |
| Grote, K | 1 |
| Kiian, I | 1 |
| Wollert, KC | 1 |
| Hilfiker, A | 1 |
| Drexler, H | 1 |
| Liu, HR | 1 |
| Gao, F | 1 |
| Tao, L | 1 |
| Yan, WL | 1 |
| Gao, E | 1 |
| Christopher, TA | 1 |
| Lopez, BL | 1 |
| Hu, A | 1 |
| Ma, XL | 2 |
| Mizukami, Y | 1 |
| Iwamatsu, A | 1 |
| Aki, T | 1 |
| Kimura, M | 1 |
| Nakamura, K | 1 |
| Nao, T | 1 |
| Okusa, T | 1 |
| Matsuzaki, M | 1 |
| Yoshida, K | 1 |
| Kobayashi, S | 1 |
| He, Z | 1 |
| Opland, DM | 1 |
| Way, KJ | 1 |
| Ueki, K | 1 |
| Bodyak, N | 1 |
| Kang, PM | 1 |
| Izumo, S | 1 |
| Kulkarni, RN | 1 |
| Wang, B | 1 |
| Liao, R | 1 |
| Kahn, CR | 1 |
| King, GL | 1 |
| Naitoh, K | 1 |
| Ichikawa, Y | 1 |
| Miura, T | 1 |
| Nakamura, Y | 1 |
| Miki, T | 1 |
| Ikeda, Y | 1 |
| Kobayashi, H | 1 |
| Nishihara, M | 1 |
| Ohori, K | 1 |
| Shimamoto, K | 1 |
| Pagel, PS | 1 |
| Krolikowski, JG | 1 |
| Shim, YH | 1 |
| Venkatapuram, S | 1 |
| Kersten, JR | 1 |
| Weihrauch, D | 1 |
| Warltier, DC | 1 |
| Pratt, PF | 1 |
| Nagarkatti, DS | 1 |
| Sha'afi, RI | 1 |
| Tauskela, JS | 1 |
| chakravarthy, BR | 1 |
| Murray, CL | 1 |
| Wang, Y | 1 |
| Comas, T | 1 |
| Hogan, M | 1 |
| Hakim, A | 1 |
| Morley, P | 1 |
| Brar, BK | 1 |
| Jonassen, AK | 1 |
| Stephanou, A | 1 |
| Santilli, G | 1 |
| Railson, J | 1 |
| Knight, RA | 1 |
| Yellon, DM | 1 |
| Latchman, DS | 1 |
| Yue, TL | 1 |
| Wang, C | 1 |
| Gu, JL | 1 |
| Kumar, S | 1 |
| Lee, JC | 1 |
| Feuerstein, GZ | 1 |
| Thomas, H | 1 |
| Maleeff, B | 1 |
| Ohlstein, EH | 1 |
| Moor, AN | 1 |
| Gan, XT | 1 |
| Karmazyn, M | 1 |
| Fliegel, L | 1 |
| Fryer, RM | 1 |
| Hsu, AK | 1 |
| Gross, GJ | 1 |
14 other studies available for pd 98059 and Myocardial Ischemia
| Article | Year |
|---|---|
Apocynum venetum leaf attenuates myocardial ischemia/reperfusion injury by inhibiting oxidative stress.
Topics: Androstadienes; Antioxidants; Apocynum; Apoptosis; Creatine Kinase; Drugs, Chinese Herbal; Flavonoid | 2015 |
Effects of inhibition of myocardial extracellular-responsive kinase and P38 mitogen-activated protein kinase on mechanical function of rat hearts after prolonged hypothermic ischemia.
Topics: Animals; Enzyme Activation; Flavonoids; Hypothermia, Induced; Imidazoles; Male; Mitogen-Activated Pr | 2003 |
Regulation of proangiogenic factor CCN1 in cardiac muscle: impact of ischemia, pressure overload, and neurohumoral activation.
Topics: Alkaloids; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoat | 2004 |
Antiapoptotic mechanisms of benidipine in the ischemic/reperfused heart.
Topics: Animals; Apoptosis; Calcium Channel Blockers; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Co | 2004 |
ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation.
Topics: Adenosine Triphosphate; Animals; Cell Death; Flavonoids; Hypoxia; MAP Kinase Kinase Kinases; Mitogen | 2004 |
Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia.
Topics: Androstadienes; Animals; Cells, Cultured; Coronary Vessels; Flavonoids; Humans; Insulin; Insulin Res | 2006 |
MitoKATP channel activation suppresses gap junction permeability in the ischemic myocardium by an ERK-dependent mechanism.
Topics: Adenosine Triphosphate; Animals; Cell Membrane Permeability; Connexin 43; Diazoxide; Enzyme Inhibito | 2006 |
Noble gases without anesthetic properties protect myocardium against infarction by activating prosurvival signaling kinases and inhibiting mitochondrial permeability transition in vivo.
Topics: Androstadienes; Animals; Argon; Atractyloside; Cardiotonic Agents; Disease Models, Animal; Enzyme Ac | 2007 |
Role of p38 MAP kinase in myocardial stress.
Topics: Adenosine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Cells, Cultured; En | 1998 |
Evidence from cultured rat cortical neurons of differences in the mechanism of ischemic preconditioning of brain and heart.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain Ischemia; Calcium; Calcium-Calmodulin-Dependent | 1999 |
Urocortin protects against ischemic and reperfusion injury via a MAPK-dependent pathway.
Topics: Animals; Cell Death; Cell Hypoxia; Cells, Cultured; Corticotropin-Releasing Hormone; Flavonoids; Hea | 2000 |
Inhibition of extracellular signal-regulated kinase enhances Ischemia/Reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart.
Topics: Animals; Animals, Newborn; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; | 2000 |
Activation of Na+/H+ exchanger-directed protein kinases in the ischemic and ischemic-reperfused rat myocardium.
Topics: Animals; Animals, Newborn; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Heart; Heart Ventricles; | 2001 |
ERK and p38 MAP kinase activation are components of opioid-induced delayed cardioprotection.
Topics: Analgesics; Animals; Blood Pressure; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Heart Rate; I | 2001 |