pd 98059 has been researched along with Muscle Contraction in 39 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Angiotensin II (Ang II) is one of the primary regulators of vascular tension and arterial blood pressure, and the p44/42 mitogen-activated protein kinases (p44/42 MAPK) are involved in Ang II-mediated vascular smooth muscle contraction." | 3.73 | The inhibitory effects of sevoflurane on angiotensin II- induced, p44/42 mitogen-activated protein kinase-mediated contraction of rat aortic smooth muscle. ( Hatano, Y; Mizumoto, K; Ogawa, K; Tokinaga, Y; Yu, J, 2005) |
| "We investigated whether p42/p44 mitogen-activated protein kinase (MAPK) and/or p38 MAPK participates in the regulation of vascular smooth muscle contraction by endothelin-1 (ET-1) in Wistar-Kyoto rat (WKY) and spontaneously hypertensive rat (SHR)." | 3.72 | p38 Mitogen-activated protein kinase regulates vasoconstriction in spontaneously hypertensive rats. ( Ahn, HY; Fang, LH; Ha, TS; Kim, B; Kwon, S; Lee, SJ, 2004) |
| " Cumulative dexmedetomidine (10⁻⁹ to 10⁻⁶ M) dose-response curves were generated in the presence or absence of extracellular signal-regulated kinase (ERK) inhibitor PD 98059, p38 MAPK inhibitor SB 203580, c-Jun NH₂-terminal kinase (JNK) inhibitor SP 600125, L-type calcium channel blocker (verapamil and nifedipine), and α₂-adrenoceptor inhibitor atipamezole." | 1.37 | c-Jun NH₂-terminal kinase contributes to dexmedetomidine-induced contraction in isolated rat aortic smooth muscle. ( Chang, KC; Jeong, YS; Kim, HJ; Kim, JG; Kwon, SC; Lee, SM; Ok, SH; Sohn, JT; Sung, HJ, 2011) |
| "Smooth muscle contraction is initiated by myosin light chain (MLC) phosphorylation catalyzed by the Ca(2+) dependent MLC kinase." | 1.32 | Caldesmon phosphorylation is catalyzed by two kinases in permeabilized and intact vascular smooth muscle. ( Gorenne, I; Moreland, RS; Su, X, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (17.95) | 18.2507 |
| 2000's | 29 (74.36) | 29.6817 |
| 2010's | 3 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kunduri, SS | 1 |
| Mustafa, SJ | 1 |
| Ponnoth, DS | 1 |
| Dick, GM | 1 |
| Nayeem, MA | 1 |
| Huang, LH | 1 |
| Zhang, PA | 1 |
| He, JY | 1 |
| Liu, J | 1 |
| Cao, YX | 1 |
| Ok, SH | 1 |
| Jeong, YS | 1 |
| Kim, JG | 1 |
| Lee, SM | 2 |
| Sung, HJ | 1 |
| Kim, HJ | 2 |
| Chang, KC | 1 |
| Kwon, SC | 1 |
| Sohn, JT | 1 |
| Puri, RN | 2 |
| Fan, YP | 2 |
| Rattan, S | 2 |
| Carter, RW | 1 |
| Kanagy, NL | 1 |
| Kwon, S | 2 |
| Lee, WJ | 1 |
| Fang, LH | 2 |
| Kim, B | 4 |
| Ahn, HY | 2 |
| Pearce, WJ | 1 |
| Williams, JM | 1 |
| Chang, MM | 1 |
| Gerthoffer, WT | 1 |
| Cao, W | 1 |
| Sohn, UD | 1 |
| Bitar, KN | 1 |
| Behar, J | 1 |
| Biancani, P | 1 |
| Harnett, KM | 1 |
| Zhao, Y | 1 |
| Long, W | 1 |
| Zhang, L | 4 |
| Longo, LD | 2 |
| Streefkerk, JO | 1 |
| Hoogaars, WM | 1 |
| Christoffels, VM | 1 |
| Sand, C | 1 |
| Pfaffendorf, M | 1 |
| Peters, SL | 1 |
| Van Zwieten, PA | 1 |
| Gorenne, I | 1 |
| Su, X | 1 |
| Moreland, RS | 1 |
| Rohra, DK | 1 |
| Yamakuni, T | 1 |
| Ito, S | 1 |
| Saito, SY | 1 |
| Ohizumi, Y | 1 |
| Ha, TS | 1 |
| Lee, SJ | 1 |
| Bryborn, M | 1 |
| Adner, M | 1 |
| Cardell, LO | 1 |
| Xiao, D | 3 |
| Kim, J | 3 |
| Lee, YR | 1 |
| Lee, CH | 1 |
| Choi, WH | 1 |
| Lee, CK | 2 |
| Bae, YM | 1 |
| Cho, S | 1 |
| Yu, J | 1 |
| Mizumoto, K | 1 |
| Tokinaga, Y | 1 |
| Ogawa, K | 1 |
| Hatano, Y | 1 |
| Buchholz, JN | 1 |
| Nakamura, A | 1 |
| Harada, N | 1 |
| Takahashi, A | 1 |
| Mawatari, K | 1 |
| Nakano, M | 1 |
| Tsutsumi, K | 1 |
| Nakaya, Y | 1 |
| Won, KJ | 1 |
| Lee, HM | 1 |
| Roh, HY | 1 |
| Park, HJ | 1 |
| Shin, HS | 1 |
| Park, TK | 1 |
| Raney, MA | 1 |
| Turcotte, LP | 1 |
| Watts, SW | 2 |
| Dessy, C | 1 |
| Kim, I | 2 |
| Sougnez, CL | 1 |
| Laporte, R | 1 |
| Morgan, KG | 2 |
| Touyz, RM | 1 |
| El Mabrouk, M | 1 |
| He, G | 1 |
| Wu, XH | 1 |
| Schiffrin, EL | 1 |
| Lagaud, GJ | 1 |
| Lam, E | 1 |
| Lui, A | 1 |
| van Breemen, C | 1 |
| Laher, I | 1 |
| Hayashi, T | 1 |
| Hirshman, MF | 1 |
| Dufresne, SD | 1 |
| Goodyear, LJ | 2 |
| Wojtaszewski, JF | 1 |
| Lynge, J | 1 |
| Jakobsen, AB | 1 |
| Richter, EA | 1 |
| Ryder, JW | 1 |
| Fahlman, R | 1 |
| Wallberg-Henriksson, H | 1 |
| Alessi, DR | 1 |
| Krook, A | 1 |
| Zierath, JR | 1 |
| Je, HD | 1 |
| Gallant, C | 1 |
| Zhan, Q | 1 |
| Riper, DV | 1 |
| Badwey, JA | 1 |
| Singer, HA | 1 |
| Yang, ZW | 1 |
| Wang, J | 1 |
| Zheng, T | 1 |
| Altura, BT | 1 |
| Altura, BM | 1 |
| Zeidan, A | 1 |
| Nordström, I | 1 |
| Dreja, K | 1 |
| Malmqvist, U | 1 |
| Hellstrand, P | 1 |
| Yousufzai, SY | 1 |
| Gao, G | 1 |
| Abdel-Latif, AA | 2 |
| Koch, A | 1 |
| Nasuhara, Y | 1 |
| Barnes, PJ | 1 |
| Lindsay, MA | 1 |
| Giembycz, MA | 1 |
| Roy, J | 1 |
| Kazi, M | 1 |
| Hedin, U | 1 |
| Thyberg, J | 1 |
| Wong, JA | 1 |
| Gosmanov, AR | 1 |
| Schneider, EG | 1 |
| Thomason, DB | 1 |
| Ansari, HR | 1 |
| Husain, S | 1 |
1 review available for pd 98059 and Muscle Contraction
| Article | Year |
|---|---|
Activation of the mitogen-activated protein kinase pathway via the 5-HT2A receptor.
Topics: Animals; Calcium Channels; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinases; E | 1998 |
38 other studies available for pd 98059 and Muscle Contraction
| Article | Year |
|---|---|
Adenosine A1 receptors link to smooth muscle contraction via CYP4a, protein kinase C-α, and ERK1/2.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Blotting, Western; Carbazoles; Cytochrome P-450 | 2013 |
DMSO-soluble cigarette smoke particles alter the expression of endothelin B receptor in rat coronary artery.
Topics: Animals; Coronary Vessels; Cycloheximide; Dactinomycin; Dimethyl Sulfoxide; Female; Flavonoids; Gene | 2013 |
c-Jun NH₂-terminal kinase contributes to dexmedetomidine-induced contraction in isolated rat aortic smooth muscle.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Anthracenes; Aorta; Dexmedetomidine; Enzyme Inhibitor | 2011 |
Role of pp60(c-src) and p(44/42) MAPK in ANG II-induced contraction of rat tonic gastrointestinal smooth muscles.
Topics: Angiotensin II; Animals; Antibodies; Benzoquinones; Calmodulin-Binding Proteins; Digestive System; D | 2002 |
Tyrosine kinases regulate intracellular calcium during alpha(2)-adrenergic contraction in rat aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta; Brimonidine Tartrate; Calcium; Enzyme Inhibitors; Flavono | 2002 |
Mitogen-activated protein kinases partially regulate endothelin-1-induced contractions through a myosin light chain phosphorylation-independent pathway.
Topics: Animals; Aorta, Thoracic; Calcium; Dose-Response Relationship, Drug; Endothelin-1; Flavonoids; Imida | 2003 |
ERK inhibition attenuates 5-HT-induced contractions in fetal and adult ovine carotid arteries.
Topics: Age Factors; Animals; Butadienes; Calmodulin-Binding Proteins; Carotid Arteries; Dose-Response Relat | 2003 |
MAPK mediates PKC-dependent contraction of cat esophageal and lower esophageal sphincter circular smooth muscle.
Topics: Acetylcholine; Animals; Cats; Enzyme Inhibitors; Esophagogastric Junction; Esophagus; Flavonoids; Im | 2003 |
Extracellular signal-regulated kinases and contractile responses in ovine adult and fetal cerebral arteries.
Topics: Adrenergic alpha-Agonists; Animals; Blotting, Western; Butadienes; Calcium; Cerebral Arteries; Dose- | 2003 |
Vasopressin-induced vasoconstriction is dependent on MAPKerk1/2 phosphorylation.
Topics: Animals; Aorta, Thoracic; Blotting, Western; Butadienes; Enzyme Inhibitors; Flavonoids; In Vitro Tec | 2004 |
Caldesmon phosphorylation is catalyzed by two kinases in permeabilized and intact vascular smooth muscle.
Topics: Adenosine Triphosphate; Animals; Calmodulin-Binding Proteins; Catalysis; Electrophoresis, Gel, Two-D | 2004 |
Evidence for the involvement of protein kinase C in acidic pH-induced contraction in spontaneously hypertensive rat aorta.
Topics: Animals; Aorta, Thoracic; Bridged-Ring Compounds; Butadienes; Drug Synergism; Estrenes; Flavonoids; | 2004 |
p38 Mitogen-activated protein kinase regulates vasoconstriction in spontaneously hypertensive rats.
Topics: Animals; Endothelin-1; Enzyme Inhibitors; Flavonoids; Hypertension; Imidazoles; Mitogen-Activated Pr | 2004 |
Interleukin-4 increases murine airway response to kinins, via up-regulation of bradykinin B1-receptors and altered signalling along mitogen-activated protein kinase pathways.
Topics: Animals; Anthracenes; Bradykinin; Dactinomycin; Dexamethasone; Electromyography; Enzyme Inhibitors; | 2004 |
Alpha1-adrenoceptor-mediated phosphorylation of MYPT-1 and CPI-17 in the uterine artery: role of ERK/PKC.
Topics: Animals; Arteries; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids | 2005 |
Mitogen-activated protein kinase contributes to elevated basal tone in aortic smooth muscle from hypertensive rats.
Topics: Amides; Animals; Aorta, Thoracic; Blood Pressure; Desoxycorticosterone; Dose-Response Relationship, | 2005 |
The inhibitory effects of sevoflurane on angiotensin II- induced, p44/42 mitogen-activated protein kinase-mediated contraction of rat aortic smooth muscle.
Topics: Anesthetics, Inhalation; Angiotensin II; Animals; Aorta, Thoracic; Blotting, Western; Dose-Response | 2005 |
Pregnancy attenuates uterine artery pressure-dependent vascular tone: role of PKC/ERK pathway.
Topics: Animals; Arteries; Blood Pressure; Calcium; Calcium Signaling; Enzyme Inhibitors; Extracellular Sign | 2006 |
NO-1886, a lipoprotein lipase activator, attenuates vascular smooth muscle contraction in rat aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Benzamides; Calcium; Calcium Channel Blockers; | 2007 |
Phorbol ester-induced contraction through p38 mitogen-activated protein kinase is diminished in aortas from DOCA-salt hypertensive rats.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Body Weight; Desoxycorticosterone; Enzyme Inhibitors; Flav | 2006 |
Evidence for the regulation of contraction-induced fatty acid oxidation via extracellular signal-regulated kinase 1/2 activation independent of changes in fatty acid uptake.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Dose-Response Relationship, Drug; Fatty Acids | 2007 |
Serotonin activates the mitogen-activated protein kinase pathway in vascular smooth muscle: use of the mitogen-activated protein kinase kinase inhibitor PD098059.
Topics: Animals; Calcium Channels; Enzyme Activation; Enzyme Inhibitors; Flavonoids; In Vitro Techniques; Ma | 1996 |
A role for MAP kinase in differentiated smooth muscle contraction evoked by alpha-adrenoceptor stimulation.
Topics: Adrenergic alpha-Agonists; Animals; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin- | 1998 |
Mitogen-activated protein/extracellular signal-regulated kinase inhibition attenuates angiotensin II-mediated signaling and contraction in spontaneously hypertensive rat vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enz | 1999 |
Nonspecific inhibition of myogenic tone by PD98059, a MEK1 inhibitor, in rat middle cerebral arteries.
Topics: Animals; Arginine Vasopressin; Blood Pressure; Calcium Chloride; Cerebral Arteries; Flavonoids; Male | 1999 |
Skeletal muscle contractile activity in vitro stimulates mitogen-activated protein kinase signaling.
Topics: Animals; Enzyme Inhibitors; Flavonoids; Glucose; Glycogen Synthase; In Vitro Techniques; Insulin; Ma | 1999 |
Differential regulation of MAP kinase by contraction and insulin in skeletal muscle: metabolic implications.
Topics: Amino Acids; Androstadienes; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Glucose; Glycogen Sy | 1999 |
Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle. Involvement Of the mitogen- and stress-activated protein kinase 1.
Topics: 3-O-Methylglucose; Amino Acid Sequence; Animals; Biological Transport; Electric Stimulation; Enzyme | 2000 |
Ca2+-calmodulin-dependent protein kinase II-dependent activation of contractility in ferret aorta.
Topics: Animals; Aorta, Thoracic; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium- | 2000 |
Low [Mg(2+)](o) induces contraction of cerebral arteries: roles of tyrosine and mitogen-activated protein kinases.
Topics: Animals; Basilar Artery; Butadienes; Dogs; Enzyme Inhibitors; Flavonoids; Genistein; Imidazoles; In | 2000 |
Stretch-dependent modulation of contractility and growth in smooth muscle of rat portal vein.
Topics: Animals; Benzoquinones; Cattle; Culture Media; Culture Media, Serum-Free; DNA Replication; Enzyme Ac | 2000 |
Mitogen-activated protein kinase inhibitors suppress prostaglandin F(2alpha)-induced myosin-light chain phosphorylation and contraction in iris sphincter smooth muscle.
Topics: Animals; Carbachol; Cats; Dinoprost; Enzyme Inhibitors; Flavonoids; Imidazoles; Iris; Miotics; Mitog | 2000 |
Extracellular signal-regulated kinase 1/2 control Ca(2+)-independent force development in histamine-stimulated bovine tracheal smooth muscle.
Topics: Animals; Calcium; Cattle; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Flavonoids; Histamine; I | 2000 |
Phenotypic modulation of arterial smooth muscle cells is associated with prolonged activation of ERK1/2.
Topics: Animals; Arteries; Cells, Cultured; Culture Media, Serum-Free; Enzyme Activation; Enzyme Inhibitors; | 2001 |
Insulin-independent, MAPK-dependent stimulation of NKCC activity in skeletal muscle.
Topics: Adrenergic Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonis | 2001 |
Activation of p42/p44 mitogen-activated protein kinase and contraction by prostaglandin F2alpha, ionomycin, and thapsigargin in cat iris sphincter smooth muscle: inhibition by PD98059, KN-93, and isoproterenol.
Topics: Adrenergic beta-Agonists; Animals; Benzylamines; Blotting, Western; Calcium-Transporting ATPases; Ca | 2001 |
ERK MAP kinases regulate smooth muscle contraction in ovine uterine artery: effect of pregnancy.
Topics: Animals; Arteries; Enzyme Inhibitors; Female; Flavonoids; In Vitro Techniques; Mitogen-Activated Pro | 2002 |
Comparison of angiotensin II (Ang II) effects in the internal anal sphincter (IAS) and lower esophageal sphincter smooth muscles.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Anal Canal; Angiotensin II; Animals; Dose-Response Re | 2002 |