pd 98059 has been researched along with Mouth Neoplasms in 11 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Mouth Neoplasms: Tumors or cancer of the MOUTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Licochalcone A (Lico-A) is a natural phenol licorice compound with multiple bioactivities, including anti-inflammatory, anti-microbial, anti-fungal and osteogenesis-inducing properties." | 1.40 | Licochalcone A induces apoptosis in KB human oral cancer cells via a caspase-dependent FasL signaling pathway. ( Cho, SS; Im, HJ; Kim, CS; Kim, DK; Kim, JS; Kim, SG; Lee, SY; Moon, SM; Oh, JS; Park, MR; Yoon, G; You, JS, 2014) |
| "Oral squamous cell carcinoma (OSCC) has a striking tendency to migrate and metastasize." | 1.38 | Cyr61 increases matrix metalloproteinase-3 expression and cell motility in human oral squamous cell carcinoma cells. ( Chiang, IP; Chuang, JY; Lai, CH; Lin, CD; Tang, CH; Yu, NY, 2012) |
| "Arecoline was found to elevate HSP27 expression in a dose- and time-dependent manner (P < 0." | 1.38 | Heat shock protein 27 expression in areca quid chewing-associated oral squamous cell carcinomas. ( Chang, YC; Ho, YC; Lee, SS; Tsai, CH; Yu, CC, 2012) |
| "Arecoline was found to elevate HIF-1α expression in a dose- and time-dependent manner (P<0." | 1.36 | Hypoxia inducible factor-1α expression in areca quid chewing-associated oral squamous cell carcinomas. ( Chang, YC; Ho, YC; Lee, SS; Tsai, CH; Yang, SF, 2010) |
| "Oral cancer is a prevalent type of cancer in Asian countries." | 1.35 | S-allylcysteine modulates the expression of E-cadherin and inhibits the malignant progression of human oral cancer. ( Chiang, EP; Chung, JG; Hsu, CY; Lee, HZ; Tang, FY, 2009) |
| "Arecoline was found to elevate HSP70 expression in a dose- and time-dependent manner (p<0." | 1.35 | The upregulation of heat shock protein 70 expression in areca quid chewing-associated oral squamous cell carcinomas. ( Chang, YC; Ho, YC; Lee, SS; Tsai, CH, 2008) |
| " This was to study the signal transduction pathways that might exert the apoptotic effects of bleomycin A5 on tumor cells, as well as to examine the possibility of lower dosing of such drug in combinative treatment with other compounds in vitro." | 1.32 | MEK inhibition enhances bleomycin A5-induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities. ( Chou, MY; Tai, KW; Yang, JJ; Yang, LC; Yang, SH, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 7 (63.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, HJ | 1 |
| Shin, JA | 1 |
| Lee, SO | 1 |
| Kwon, KH | 1 |
| Cho, SD | 1 |
| Kim, JS | 1 |
| Park, MR | 1 |
| Lee, SY | 1 |
| Kim, DK | 1 |
| Moon, SM | 1 |
| Kim, CS | 1 |
| Cho, SS | 1 |
| Yoon, G | 1 |
| Im, HJ | 1 |
| You, JS | 1 |
| Oh, JS | 1 |
| Kim, SG | 1 |
| Ko, SY | 1 |
| Ko, HA | 1 |
| Shieh, TM | 1 |
| Chang, WC | 1 |
| Chen, HI | 1 |
| Chang, SS | 1 |
| Lin, IH | 1 |
| Tang, FY | 1 |
| Chiang, EP | 1 |
| Chung, JG | 1 |
| Lee, HZ | 1 |
| Hsu, CY | 1 |
| Lee, SS | 3 |
| Tsai, CH | 3 |
| Yang, SF | 1 |
| Ho, YC | 3 |
| Chang, YC | 3 |
| Chuang, JY | 1 |
| Yu, NY | 1 |
| Chiang, IP | 1 |
| Lai, CH | 1 |
| Lin, CD | 1 |
| Tang, CH | 1 |
| Yu, CC | 1 |
| Yang, SH | 2 |
| Liao, PH | 1 |
| Pan, YF | 1 |
| Chen, SL | 1 |
| Chou, SS | 1 |
| Chou, MY | 2 |
| Yang, LC | 1 |
| Tai, KW | 1 |
| Yang, JJ | 1 |
| Lee, SK | 2 |
| Jang, HJ | 1 |
| Lee, HJ | 1 |
| Lee, J | 1 |
| Jeon, BH | 1 |
| Jun, CD | 1 |
| Kim, EC | 1 |
11 other studies available for pd 98059 and Mouth Neoplasms
| Article | Year |
|---|---|
Extracellular signal‑regulated kinase inhibition is required for methanol extract of Smilax china L.‑induced apoptosis through death receptor 5 in human oral mucoepidermoid carcinoma cells.
Topics: Apoptosis; Carcinoma, Mucoepidermoid; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; | 2014 |
Licochalcone A induces apoptosis in KB human oral cancer cells via a caspase-dependent FasL signaling pathway.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase 3; Caspase 8; Caspase Inhibitors; Cell Line, Tum | 2014 |
Cell migration is regulated by AGE-RAGE interaction in human oral cancer cells in vitro.
Topics: Adult; Cell Line, Tumor; Cell Movement; Cell Proliferation; Diabetes Complications; Diabetes Mellitu | 2014 |
S-allylcysteine modulates the expression of E-cadherin and inhibits the malignant progression of human oral cancer.
Topics: Adherens Junctions; Cadherins; Cell Proliferation; Cysteine; Disease Progression; Enzyme Activation; | 2009 |
Hypoxia inducible factor-1α expression in areca quid chewing-associated oral squamous cell carcinomas.
Topics: Acetylcysteine; Areca; Arecoline; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; C | 2010 |
Cyr61 increases matrix metalloproteinase-3 expression and cell motility in human oral squamous cell carcinoma cells.
Topics: Antibodies, Monoclonal; Butadienes; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cyste | 2012 |
Heat shock protein 27 expression in areca quid chewing-associated oral squamous cell carcinomas.
Topics: Acetylcysteine; Areca; Arecoline; Carcinoma, Squamous Cell; Case-Control Studies; Catechin; Cyclooxy | 2012 |
The novel p53-dependent metastatic and apoptotic pathway induced by vitexin in human oral cancer OC2 cells.
Topics: Antineoplastic Agents, Phytogenic; Apigenin; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; | 2013 |
MEK inhibition enhances bleomycin A5-induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities.
Topics: Antibiotics, Antineoplastic; Apoptosis; Bleomycin; Calcium-Calmodulin-Dependent Protein Kinases; Car | 2004 |
p38 and ERK MAP kinase mediates iron chelator-induced apoptosis and -suppressed differentiation of immortalized and malignant human oral keratinocytes.
Topics: Apoptosis; Caspase 3; Caspase 8; Caspases; Cell Differentiation; Cell Proliferation; Cytochromes c; | 2006 |
The upregulation of heat shock protein 70 expression in areca quid chewing-associated oral squamous cell carcinomas.
Topics: Adult; Aged; Antineoplastic Agents; Areca; Arecoline; Blotting, Western; Carcinoma, Squamous Cell; C | 2008 |