pd 98059 has been researched along with Metastase in 25 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human hepatocellular carcinoma (HCC) cell lines SMMC7721 and Huh7 were used." | 1.39 | Insufficient radiofrequency ablation promotes epithelial-mesenchymal transition of hepatocellular carcinoma cells through Akt and ERK signaling pathways. ( Ding, X; Dong, S; Gao, J; Ke, S; Kong, F; Kong, J; Sun, W; Wang, S; Zheng, L, 2013) |
| "EMT in prostate cancer induced by FGF8b can be mediated by ERK kinase pathway, in which mitogen-activated/extraceluer signal regulated kinase 1 (MEK1) may be a key factor." | 1.38 | [Molecular mechanism of FGF8b regulation of epithelial-mesenchymal transition in prostate cancer cells]. ( Fan, B; Li, Z; Liu, H; Qi, F; Wang, G, 2012) |
| "Metastatic breast cancer cells frequently and ectopically express the transcription factor RUNX2, which normally attenuates proliferation and promotes maturation of osteoblasts." | 1.36 | Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility. ( Cool, SM; Dobson, JR; Goh, X; Ito, Y; Kwok, HS; Leong, DT; Lian, JB; Lim, J; Nathan, SS; Pereira, BP; Pratap, J; Salto-Tellez, M; Stein, GS; van Wijnen, AJ; Voorhoeve, PM, 2010) |
| "The human hepatocellular carcinoma (HCC)-derived cell line KYN-2 is thought to provide a good model for studying the molecular basis of invasion and metastasis of human HCC, because it often shows cell scattering in vitro and intrahepatic metastasis in vivo." | 1.33 | MEK/ERK signaling is a critical mediator for integrin-induced cell scattering in highly metastatic hepatocellular carcinoma cells. ( Aoyagi, Y; Genda, T; Honma, N; Ichida, T; Matsuda, Y; Takamura, M; Yamagiwa, S, 2006) |
| "Primary cancer of the gallbladder is not unusual." | 1.32 | A MEK inhibitor (U0126) markedly inhibits direct liver invasion of orthotopically inoculated human gallbladder cancer cells in nude mice. ( Ajiki, T; Fujimori, T; Furihata, T; Hori, H; Horiuchi, H; Kawamata, H; Kuroda, Y; Ohkura, Y; Omotehara, F; Shinagawa, Y; Tachibana, M; Yamazaki, T, 2004) |
| "[1986] Invasion Metastasis 6:302-12; Urtreger et al." | 1.31 | Heregulin inhibits proliferation via ERKs and phosphatidyl-inositol 3-kinase activation but regulates urokinase plasminogen activator independently of these pathways in metastatic mammary tumor cells. ( Aguirre Ghiso, J; Bal de Kier Joffé, E; Balañá, ME; Charreau, EH; Elizalde, PV; Labriola, L; Lupu, R; Pignataro, OP; Proietti, CJ; Proiettii, CJ; Puricelli, L; Salatino, M, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (8.00) | 18.2507 |
| 2000's | 12 (48.00) | 29.6817 |
| 2010's | 9 (36.00) | 24.3611 |
| 2020's | 2 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y | 1 |
| Liu, P | 1 |
| Shen, D | 2 |
| Liu, H | 2 |
| Xu, L | 2 |
| Wang, J | 3 |
| Sun, H | 1 |
| Wu, H | 1 |
| Ren, J | 2 |
| Wang, Y | 1 |
| Ware, T | 1 |
| Iaria, J | 1 |
| Ten Dijke, P | 1 |
| Zhu, HJ | 1 |
| Ishay-Ronen, D | 1 |
| Diepenbruck, M | 1 |
| Kalathur, RKR | 1 |
| Sugiyama, N | 1 |
| Tiede, S | 1 |
| Ivanek, R | 1 |
| Bantug, G | 1 |
| Morini, MF | 1 |
| Hess, C | 1 |
| Christofori, G | 1 |
| Dong, S | 1 |
| Kong, J | 2 |
| Kong, F | 1 |
| Gao, J | 2 |
| Ke, S | 1 |
| Wang, S | 1 |
| Ding, X | 1 |
| Sun, W | 1 |
| Zheng, L | 1 |
| Zhou, X | 1 |
| Qi, Y | 1 |
| Ko, SY | 1 |
| Ko, HA | 1 |
| Shieh, TM | 1 |
| Chang, WC | 1 |
| Chen, HI | 1 |
| Chang, SS | 1 |
| Lin, IH | 1 |
| Koh, SA | 1 |
| Lee, KH | 2 |
| Shen, XY | 1 |
| Wang, SH | 1 |
| Liang, ML | 1 |
| Wang, HB | 1 |
| Xiao, L | 1 |
| Wang, ZH | 1 |
| Leong, DT | 1 |
| Lim, J | 1 |
| Goh, X | 1 |
| Pratap, J | 1 |
| Pereira, BP | 1 |
| Kwok, HS | 1 |
| Nathan, SS | 1 |
| Dobson, JR | 1 |
| Lian, JB | 1 |
| Ito, Y | 1 |
| Voorhoeve, PM | 1 |
| Stein, GS | 1 |
| Salto-Tellez, M | 1 |
| Cool, SM | 1 |
| van Wijnen, AJ | 1 |
| Li, J | 2 |
| Jia, L | 1 |
| Zhao, P | 1 |
| Jiang, Y | 1 |
| Zhong, S | 1 |
| Chen, D | 1 |
| Pan, G | 1 |
| Zhang, X | 1 |
| Lu, J | 1 |
| Li, W | 1 |
| Fu, H | 1 |
| Zhang, S | 1 |
| Fan, B | 1 |
| Wang, G | 1 |
| Qi, F | 1 |
| Li, Z | 1 |
| Puricelli, L | 1 |
| Proietti, CJ | 1 |
| Proiettii, CJ | 1 |
| Labriola, L | 1 |
| Salatino, M | 1 |
| Balañá, ME | 1 |
| Aguirre Ghiso, J | 1 |
| Lupu, R | 1 |
| Pignataro, OP | 1 |
| Charreau, EH | 1 |
| Bal de Kier Joffé, E | 1 |
| Elizalde, PV | 1 |
| Mariano-Oliveira, A | 1 |
| Coelho, AL | 1 |
| Terruggi, CH | 1 |
| Selistre-de-Araújo, HS | 1 |
| Barja-Fidalgo, C | 1 |
| De Freitas, MS | 1 |
| Yoo, YG | 1 |
| Yeo, MG | 1 |
| Kim, DK | 1 |
| Park, H | 1 |
| Lee, MO | 1 |
| Deng, X | 1 |
| Horiuchi, H | 1 |
| Kawamata, H | 1 |
| Furihata, T | 1 |
| Omotehara, F | 1 |
| Hori, H | 1 |
| Shinagawa, Y | 1 |
| Ohkura, Y | 1 |
| Tachibana, M | 1 |
| Yamazaki, T | 1 |
| Ajiki, T | 1 |
| Kuroda, Y | 1 |
| Fujimori, T | 1 |
| Choi, EY | 1 |
| Kim, MK | 1 |
| Hyun, MS | 1 |
| Jang, BI | 1 |
| Kim, TN | 1 |
| Kim, SW | 1 |
| Song, SK | 1 |
| Kim, JH | 1 |
| Kim, JR | 1 |
| Honma, N | 1 |
| Genda, T | 1 |
| Matsuda, Y | 1 |
| Yamagiwa, S | 1 |
| Takamura, M | 1 |
| Ichida, T | 1 |
| Aoyagi, Y | 1 |
| Pan, Y | 1 |
| Zhao, L | 1 |
| Liang, J | 1 |
| Liu, J | 1 |
| Shi, Y | 1 |
| Liu, N | 1 |
| Zhang, G | 1 |
| Jin, H | 1 |
| Xie, H | 1 |
| Liu, Z | 1 |
| Fan, D | 1 |
| Jeney, A | 1 |
| Kenessey, I | 1 |
| Timár, F | 1 |
| Oláh, J | 1 |
| Pogány, G | 1 |
| Babó, I | 1 |
| Harisi, R | 1 |
| Saha, S | 1 |
| Chowdhury, P | 1 |
| Pal, A | 1 |
| Chakrabarti, MK | 1 |
| Zhou, JN | 2 |
| Ljungdahl, S | 1 |
| Shoshan, MC | 3 |
| Swedenborg, J | 1 |
| Linder, S | 3 |
| Seddighzadeh, M | 2 |
| Kronenwett, U | 1 |
| Auer, G | 2 |
| Sten-Linder, M | 1 |
| Wiman, B | 1 |
| Alaiya, AA | 1 |
1 review available for pd 98059 and Metastase
| Article | Year |
|---|---|
[Study of drugs against neoplastic metastasis].
Topics: Animals; Antineoplastic Agents; Cell Movement; Chromones; Deoxyuridine; Doxorubicin; Enzyme Inhibito | 2006 |
24 other studies available for pd 98059 and Metastase
| Article | Year |
|---|---|
FAM172A inhibits EMT in pancreatic cancer via ERK-MAPK signaling.
Topics: Adult; Aged; Cadherins; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Female; Flavonoids; Gen | 2020 |
Reactivation of BMP signaling by suboptimal concentrations of MEK inhibitor and FK506 reduces organ-specific breast cancer metastasis.
Topics: Animals; Bone Morphogenetic Proteins; Breast Neoplasms; Butadienes; Cell Line, Tumor; Cell Prolifera | 2020 |
Gain Fat-Lose Metastasis: Converting Invasive Breast Cancer Cells into Adipocytes Inhibits Cancer Metastasis.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; | 2019 |
Insufficient radiofrequency ablation promotes epithelial-mesenchymal transition of hepatocellular carcinoma cells through Akt and ERK signaling pathways.
Topics: Animals; Carcinoma, Hepatocellular; Catheter Ablation; Cell Line, Tumor; Chromones; Disease Progress | 2013 |
PLGF inhibition impairs metastasis of larynx carcinoma through MMP3 downregulation.
Topics: Blotting, Western; Cell Line, Tumor; Down-Regulation; Flavonoids; Gene Expression Regulation, Neopla | 2014 |
Cell migration is regulated by AGE-RAGE interaction in human oral cancer cells in vitro.
Topics: Adult; Cell Line, Tumor; Cell Movement; Cell Proliferation; Diabetes Complications; Diabetes Mellitu | 2014 |
HGF mediated upregulation of lipocalin 2 regulates MMP9 through nuclear factor-κB activation.
Topics: Acute-Phase Proteins; Cell Line; Cell Proliferation; Chromones; Flavonoids; Gene Expression Regulati | 2015 |
[The role and mechanism of CXCR4 and its ligand SDF-1 in the development of cervical cancer metastasis].
Topics: Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Chemokine CXCL12; Extracellula | 2008 |
Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility.
Topics: Adenocarcinoma; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Prolifera | 2010 |
Stable knockdown of clusterin by vectorbased RNA interference in a human breast cancer cell line inhibits tumour cell invasion and metastasis.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Clusterin; Extracell | 2012 |
Semaphorin 5A, an axon guidance molecule, enhances the invasion and metastasis of human gastric cancer through activation of MMP9.
Topics: Analysis of Variance; Cell Line, Tumor; Cell Movement; Flavonoids; Humans; Integrins; MAP Kinase Sig | 2013 |
[Molecular mechanism of FGF8b regulation of epithelial-mesenchymal transition in prostate cancer cells].
Topics: Epithelial-Mesenchymal Transition; Fibroblast Growth Factor 8; Flavonoids; Humans; Male; MAP Kinase | 2012 |
Heregulin inhibits proliferation via ERKs and phosphatidyl-inositol 3-kinase activation but regulates urokinase plasminogen activator independently of these pathways in metastatic mammary tumor cells.
Topics: Animals; Blotting, Western; Cell Division; Cell Movement; Dimerization; Dose-Response Relationship, | 2002 |
Alternagin-C, a nonRGD-disintegrin, induces neutrophil migration via integrin signaling.
Topics: Actins; Active Transport, Cell Nucleus; Amino Acid Motifs; Animals; Bothrops; Cell Movement; Cell Nu | 2003 |
Novel function of orphan nuclear receptor Nur77 in stabilizing hypoxia-inducible factor-1alpha.
Topics: Animals; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Nucleus; Disease Progression; DNA-Bind | 2004 |
Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion.
Topics: Blotting, Western; Calpain; Carcinogens; Cell Line, Tumor; Cell Movement; Disease Progression; Dose- | 2004 |
A MEK inhibitor (U0126) markedly inhibits direct liver invasion of orthotopically inoculated human gallbladder cancer cells in nude mice.
Topics: Animals; Butadienes; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Flavonoids; Gallbladder Neo | 2004 |
Regulation of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MEK/ERK activation in human stomach cancer cell lines.
Topics: Cell Line, Tumor; Cell Proliferation; Culture Media, Serum-Free; Dose-Response Relationship, Drug; E | 2006 |
MEK/ERK signaling is a critical mediator for integrin-induced cell scattering in highly metastatic hepatocellular carcinoma cells.
Topics: Actin Cytoskeleton; Cadherins; Carcinoma, Hepatocellular; Cell Adhesion; Cell Culture Techniques; Ce | 2006 |
Cellular prion protein promotes invasion and metastasis of gastric cancer.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; CD8-Positive T-Lymphocytes; Cell Adhesion; En | 2006 |
Downregulation of human colon carcinoma cell (COLO-205) proliferation through PKG-MAP kinase mediated signaling cascade by E. coli heat stable enterotoxin (STa), a potent anti-angiogenic and anti-metastatic molecule.
Topics: Aminoquinolines; Angiogenesis Inhibitors; Bacterial Toxins; Blotting, Western; Carbazoles; Cell Line | 2008 |
Activation of tissue-factor gene expression in breast carcinoma cells by stimulation of the RAF-ERK signaling pathway.
Topics: Base Sequence; Benzoquinones; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Dactin | 1998 |
ERK signalling in metastatic human MDA-MB-231 breast carcinoma cells is adapted to obtain high urokinase expression and rapid cell proliferation.
Topics: Breast Neoplasms; Cell Division; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme I | 1999 |
Inhibition of extracellular signal-regulated kinase 1/2 activity of the breast cancer cell line MDA-MB-231 leads to major alterations in the pattern of protein expression.
Topics: Breast Neoplasms; Cell Division; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensi | 2000 |