pd 98059 has been researched along with Metabolic Acidosis in 3 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The alkalosis was completely blocked by the NHE inhibitor, cariporide, and by sodium-free bathing solutions, indicating it was mediated by NHE activation." | 3.77 | Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes. ( Ajiro, Y; Giles, WR; Saegusa, N; Spitzer, KW; Stafforini, DM, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ajiro, Y | 1 |
| Saegusa, N | 1 |
| Giles, WR | 1 |
| Stafforini, DM | 1 |
| Spitzer, KW | 1 |
| Haworth, RS | 1 |
| McCann, C | 1 |
| Snabaitis, AK | 1 |
| Roberts, NA | 1 |
| Avkiran, M | 1 |
| MartÃnez, D | 1 |
| Vermeulen, M | 1 |
| Trevani, A | 1 |
| Ceballos, A | 1 |
| Sabatté, J | 1 |
| Gamberale, R | 1 |
| Alvarez, ME | 1 |
| Salamone, G | 1 |
| Tanos, T | 1 |
| Coso, OA | 1 |
| Geffner, J | 1 |
3 other studies available for pd 98059 and Metabolic Acidosis
| Article | Year |
|---|---|
Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes.
Topics: Acidosis; Alkalosis; Animals; Azepines; Benzophenanthridines; Dose-Response Relationship, Drug; Flav | 2011 |
Stimulation of the plasma membrane Na+/H+ exchanger NHE1 by sustained intracellular acidosis. Evidence for a novel mechanism mediated by the ERK pathway.
Topics: Acidosis; Animals; Butadienes; Cell Membrane; Cells, Cultured; Chlorocebus aethiops; COS Cells; Enzy | 2003 |
Extracellular acidosis induces neutrophil activation by a mechanism dependent on activation of phosphatidylinositol 3-kinase/Akt and ERK pathways.
Topics: Acidosis; Androstadienes; Animals; Antigen Presentation; Calcium Signaling; Cell Shape; Endocytosis; | 2006 |