pd 98059 has been researched along with Malignant Melanoma in 31 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study the molecular mechanism of epidermal growth factor receptor (EGFR) signaling pathway in mediating paclitaxel-resistance and improving paclitaxel sensitivity in human melanoma A375 cells." | 7.79 | [Molecular mechanism of chemosensitization to paclitaxel in human melanoma cells induced by targeting the EGFR signaling pathway]. ( Liu, YP; Luo, YH; Song, JG; Sun, P; Xu, HM; Zhang, L; Zhang, XJ, 2013) |
| "To study the molecular mechanism of epidermal growth factor receptor (EGFR) signaling pathway in mediating paclitaxel-resistance and improving paclitaxel sensitivity in human melanoma A375 cells." | 3.79 | [Molecular mechanism of chemosensitization to paclitaxel in human melanoma cells induced by targeting the EGFR signaling pathway]. ( Liu, YP; Luo, YH; Song, JG; Sun, P; Xu, HM; Zhang, L; Zhang, XJ, 2013) |
| "The present study was designed to assess the potential inhibitory activity of curcumin on the alpha-melanocyte stimulating hormone (alpha-MSH)-stimulated melanogenesis signal pathway in B16F10 melanoma cells." | 3.76 | Curcumin suppresses alpha-melanocyte stimulating hormone-stimulated melanogenesis in B16F10 cells. ( Choi, BT; Choi, YH; Jang, JY; Kim, BW; Lee, JH; Park, C, 2010) |
| "The combined treatment of melanoma cells with sorafenib and rapamycin led to an approximately twofold increase of cell death compared with sorafenib monotreatment (P<0." | 1.35 | Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells. ( Flaherty, KT; Garbe, C; Kulms, D; Lasithiotakis, KG; Maczey, E; Meier, FE; Schittek, B; Sinnberg, TW, 2008) |
| "Melanoma is a malignant skin cancer that displays a high rate of tumor cell migration and metastasis." | 1.34 | Enhancement of cell migration by corticotropin-releasing hormone through ERK1/2 pathway in murine melanoma cell line, B16F10. ( Bang, SI; Cho, D; Kim, TS; Park, H; Yang, Y, 2007) |
| "Importantly, in vivo treatment of human melanoma xenograft tumors in athymic nude mice with LeTx results in significant or complete tumor regression without apparent side effects, suggesting that inhibiting the MAPK signaling pathway may be a useful strategy for treating melanoma." | 1.31 | Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase. ( Duesbery, NS; Koo, HM; Leppla, SH; McWilliams, MJ; VanBrocklin, M; Vande Woude, GF, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 19 (61.29) | 29.6817 |
| 2010's | 10 (32.26) | 24.3611 |
| 2020's | 2 (6.45) | 2.80 |
| Authors | Studies |
|---|---|
| Chung, YC | 1 |
| Hyun, CG | 1 |
| Mekkawy, AI | 1 |
| Naguib, YW | 1 |
| Alhaj-Suliman, SO | 1 |
| Wafa, EI | 1 |
| Ebeid, K | 1 |
| Acri, T | 1 |
| Salem, AK | 1 |
| Zuo, Q | 1 |
| Liu, J | 1 |
| Huang, L | 1 |
| Qin, Y | 1 |
| Hawley, T | 1 |
| Seo, C | 1 |
| Merlino, G | 1 |
| Yu, Y | 1 |
| Kang, M | 1 |
| Park, SH | 1 |
| Park, SJ | 1 |
| Oh, SW | 1 |
| Yoo, JA | 1 |
| Kwon, K | 1 |
| Kim, J | 1 |
| Yu, E | 1 |
| Cho, JY | 1 |
| Lee, J | 1 |
| Zhang, XJ | 1 |
| Zhang, L | 1 |
| Liu, YP | 1 |
| Xu, HM | 1 |
| Sun, P | 1 |
| Song, JG | 1 |
| Luo, YH | 1 |
| Katona, É | 1 |
| Juhász, T | 1 |
| Somogyi, CS | 1 |
| Hajdú, T | 1 |
| Szász, C | 1 |
| Rácz, K | 1 |
| Kókai, E | 1 |
| Gergely, P | 1 |
| Zákány, R | 1 |
| Sato, K | 1 |
| Ando, R | 1 |
| Kobayashi, H | 1 |
| Nishio, T | 1 |
| Yan, F | 1 |
| Liao, R | 1 |
| Farhan, M | 1 |
| Wang, T | 1 |
| Chen, J | 1 |
| Wang, Z | 1 |
| Little, PJ | 1 |
| Zheng, W | 1 |
| Slipicevic, A | 2 |
| Jørgensen, K | 2 |
| Skrede, M | 2 |
| Rosnes, AK | 1 |
| Trøen, G | 1 |
| Davidson, B | 1 |
| Flørenes, VA | 2 |
| Li, J | 1 |
| Xu, M | 1 |
| Yang, Z | 1 |
| Li, A | 1 |
| Dong, J | 2 |
| Li, X | 1 |
| Guo, L | 1 |
| Sun, Y | 1 |
| Zhou, J | 1 |
| Gu, Y | 1 |
| Li, Y | 1 |
| Lee, JH | 1 |
| Jang, JY | 1 |
| Park, C | 1 |
| Kim, BW | 1 |
| Choi, YH | 1 |
| Choi, BT | 1 |
| Jalili, A | 1 |
| Moser, A | 1 |
| Pashenkov, M | 1 |
| Wagner, C | 1 |
| Pathria, G | 1 |
| Borgdorff, V | 1 |
| Gschaider, M | 1 |
| Stingl, G | 1 |
| Ramaswamy, S | 1 |
| Wagner, SN | 1 |
| Benbow, U | 2 |
| Tower, GB | 2 |
| Wyatt, CA | 1 |
| Buttice, G | 1 |
| Brinckerhoff, CE | 2 |
| Ishii, Y | 1 |
| Ogura, T | 1 |
| Tatemichi, M | 1 |
| Fujisawa, H | 1 |
| Otsuka, F | 1 |
| Esumi, H | 1 |
| Krasilnikov, M | 1 |
| Ivanov, VN | 1 |
| Ronai, Z | 1 |
| Chen, Y | 1 |
| Alm, K | 1 |
| Vujcic, S | 1 |
| Kramer, DL | 1 |
| Kee, K | 1 |
| Diegelman, P | 1 |
| Porter, CW | 1 |
| Siddiqui, FA | 1 |
| Siddiqui, TF | 1 |
| Francis, JL | 1 |
| Cruciani, V | 1 |
| Mikalsen, SO | 1 |
| Finn, GJ | 1 |
| Creaven, BS | 1 |
| Egan, DA | 1 |
| Wang, C | 1 |
| Wang, MW | 1 |
| Tashiro, S | 1 |
| Onodera, S | 1 |
| Ikejima, T | 1 |
| Yang, Y | 2 |
| Park, H | 1 |
| Kim, TS | 1 |
| Bang, SI | 1 |
| Cho, D | 1 |
| Arakawa, T | 1 |
| Yamamura, T | 1 |
| Hattori, T | 1 |
| Hayashi, H | 1 |
| Mori, A | 1 |
| Yoshida, A | 1 |
| Uchida, C | 1 |
| Kitagawa, M | 1 |
| Onozaki, K | 1 |
| Lasithiotakis, KG | 1 |
| Sinnberg, TW | 1 |
| Schittek, B | 1 |
| Flaherty, KT | 1 |
| Kulms, D | 1 |
| Maczey, E | 1 |
| Garbe, C | 1 |
| Meier, FE | 1 |
| Mandic, A | 1 |
| Viktorsson, K | 1 |
| Heiden, T | 1 |
| Hansson, J | 1 |
| Shoshan, MC | 1 |
| Kortylewski, M | 1 |
| Heinrich, PC | 1 |
| Kauffmann, ME | 1 |
| Böhm, M | 1 |
| MacKiewicz, A | 1 |
| Behrmann, I | 1 |
| Dhawan, P | 1 |
| Richmond, A | 1 |
| Koo, HM | 1 |
| VanBrocklin, M | 1 |
| McWilliams, MJ | 1 |
| Leppla, SH | 1 |
| Duesbery, NS | 1 |
| Vande Woude, GF | 1 |
| Ge, X | 1 |
| Fu, YM | 1 |
| Meadows, GG | 1 |
| Denkert, C | 1 |
| Siegert, A | 1 |
| Leclere, A | 1 |
| Turzynski, A | 1 |
| Hauptmann, S | 1 |
| Coon, CC | 1 |
| Vincenti, MP | 1 |
31 other studies available for pd 98059 and Malignant Melanoma
| Article | Year |
|---|---|
Inhibitory Effects of Pinostilbene Hydrate on Melanogenesis in B16F10 Melanoma Cells via ERK and p38 Signaling Pathways.
Topics: Animals; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; MAP Kinase Signal | 2020 |
Paclitaxel anticancer activity is enhanced by the MEK 1/2 inhibitor PD98059 in vitro and by PD98059-loaded nanoparticles in BRAF
Topics: Animals; Cell Line, Tumor; Flavonoids; Humans; Melanoma; Mice; Mitogen-Activated Protein Kinase Kina | 2021 |
AXL/AKT axis mediated-resistance to BRAF inhibitor depends on PTEN status in melanoma.
Topics: Animals; Antineoplastic Agents; Axl Receptor Tyrosine Kinase; Drug Resistance, Neoplasm; Flavonoids; | 2018 |
p44/42 MAPK signaling is a prime target activated by phenylethyl resorcinol in its anti-melanogenic action.
Topics: Animals; Benzhydryl Compounds; Cells, Cultured; Flavonoids; Gene Expression Regulation; Humans; Hype | 2019 |
[Molecular mechanism of chemosensitization to paclitaxel in human melanoma cells induced by targeting the EGFR signaling pathway].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chro | 2013 |
PP2B and ERK1/2 regulate hyaluronan synthesis of HT168 and WM35 human melanoma cell lines.
Topics: Calcineurin; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclosporine; Extracellular Signal | 2016 |
2-Ethoxybenzamide stimulates melanin synthesis in B16F1 melanoma cells via the CREB signaling pathway.
Topics: Animals; Cell Line, Tumor; CREB-Binding Protein; Flavonoids; MAP Kinase Signaling System; Melanins; | 2016 |
Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells.
Topics: Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Proliferation; Chromones; Flavonoids | 2016 |
The fatty acid binding protein 7 (FABP7) is involved in proliferation and invasion of melanoma cells.
Topics: Biomarkers, Tumor; Carcinogens; Carrier Proteins; Cell Nucleus; Cell Proliferation; Cytoplasm; Disea | 2008 |
Simultaneous inhibition of MEK and CDK4 leads to potent apoptosis in human melanoma cells.
Topics: Apoptosis; Cell Survival; Cyclin-Dependent Kinase 4; Extracellular Signal-Regulated MAP Kinases; Fla | 2010 |
Baicalein inhibits melanogenesis through activation of the ERK signaling pathway.
Topics: Animals; Cell Death; Cell Line, Tumor; Cell Survival; Down-Regulation; Enzyme Activation; Extracellu | 2010 |
Curcumin suppresses alpha-melanocyte stimulating hormone-stimulated melanogenesis in B16F10 cells.
Topics: alpha-MSH; Animals; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Survival; Chrom | 2010 |
Polo-like kinase 1 is a potential therapeutic target in human melanoma.
Topics: Apoptosis; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Flavonoids; G1 P | 2011 |
High levels of MMP-1 expression in the absence of the 2G single nucleotide polymorphism is mediated by p38 and ERK1/2 mitogen-activated protein kinases in VMM5 melanoma cells.
Topics: Collagen Type I; DNA; DNA-Binding Proteins; Flavonoids; Gene Expression Regulation, Enzymologic; Imi | 2002 |
Induction of matrix metalloproteinase gene transcription by nitric oxide and mechanisms of MMP-1 gene induction in human melanoma cell lines.
Topics: Blotting, Northern; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; DNA Primers; El | 2003 |
ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: implications towards sensitization to apoptosis.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Cell Nucleus; Chromones; DNA-Binding Pr | 2003 |
The role of mitogen-activated protein kinase activation in determining cellular outcomes in polyamine analogue-treated human melanoma cells.
Topics: Antineoplastic Agents; Apoptosis; Enzyme Activation; Flavonoids; Humans; Kinetics; Melanoma; Mitogen | 2003 |
Hemoglobin induces the production and release of matrix metalloproteinase-9 from human malignant cells.
Topics: Carcinoma; Cycloheximide; Enzyme Inhibitors; Flavonoids; Genistein; Hemoglobins; Humans; Leukemia, M | 2003 |
Phorbol ester phorbol-12-myristate-13-acetate promotes anchorage-independent growth and survival of melanomas through MEK-independent activation of ERK1/2.
Topics: Anoikis; Apoptosis; Butadienes; Carbazoles; Cell Adhesion; Cell Culture Techniques; Cell Cycle; Cell | 2005 |
Activation of mitogen activated protein kinase pathways and melanogenesis by novel nitro-derivatives of 7-hydroxycomarin in human malignant melanoma cells.
Topics: Antineoplastic Agents; Cell Differentiation; Cell Line, Tumor; Colforsin; Dose-Response Relationship | 2005 |
[Effect of protein kinase C on human melanoma A375-S2 cell death induced by evodiamine].
Topics: Apoptosis; Cell Line, Tumor; Evodia; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; | 2005 |
Enhancement of cell migration by corticotropin-releasing hormone through ERK1/2 pathway in murine melanoma cell line, B16F10.
Topics: Animals; Cell Line, Tumor; Cell Movement; Corticotropin-Releasing Hormone; Dose-Response Relationshi | 2007 |
Contribution of extracellular signal-regulated kinases to the IL-1-induced growth inhibition of human melanoma cells A375.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; Cell Proliferation; Flavonoids; Grow | 2008 |
Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells.
Topics: Androstadienes; Apoptosis; Benzenesulfonates; Butadienes; Cell Line, Tumor; Cell Proliferation; Chro | 2008 |
The MEK1 inhibitor PD98059 sensitizes C8161 melanoma cells to cisplatin-induced apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Cycle; Cell Survival; | 2001 |
Mitogen-activated protein kinases control p27/Kip1 expression and growth of human melanoma cells.
Topics: CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; | 2001 |
A novel NF-kappa B-inducing kinase-MAPK signaling pathway up-regulates NF-kappa B activity in melanoma cells.
Topics: Active Transport, Cell Nucleus; Cell Line; DNA; Dose-Response Relationship, Drug; Enzyme Activation; | 2002 |
Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase.
Topics: Adenylyl Cyclases; Animals; Antigens, Bacterial; Apoptosis; Bacillus anthracis; Bacterial Toxins; Ce | 2002 |
U0126, a mitogen-activated protein kinase kinase inhibitor, inhibits the invasion of human A375 melanoma cells.
Topics: Butadienes; Enzyme Inhibitors; Flavonoids; Humans; Matrix Metalloproteinase 9; Melanoma; Mitogen-Act | 2002 |
An inhibitor of stress-activated MAP-kinases reduces invasion and MMP-2 expression of malignant melanoma cells.
Topics: Blotting, Northern; Cell Division; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gelatin; Gene Ex | 2002 |
Erk 1/2 differentially regulates the expression from the 1G/2G single nucleotide polymorphism in the MMP-1 promoter in melanoma cells.
Topics: Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; I | 2002 |