pd 98059 has been researched along with Macular Degeneration in 3 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Macular Degeneration: Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kothary, PC | 2 |
| Badhwar, J | 1 |
| Weng, C | 1 |
| Del Monte, MA | 2 |
| Dridi, S | 1 |
| Hirano, Y | 1 |
| Tarallo, V | 1 |
| Kim, Y | 1 |
| Fowler, BJ | 1 |
| Ambati, BK | 1 |
| Bogdanovich, S | 1 |
| Chiodo, VA | 1 |
| Hauswirth, WW | 1 |
| Kugel, JF | 1 |
| Goodrich, JA | 1 |
| Ponicsan, SL | 1 |
| Hinton, DR | 1 |
| Kleinman, ME | 1 |
| Baffi, JZ | 1 |
| Gelfand, BD | 1 |
| Ambati, J | 1 |
3 other studies available for pd 98059 and Macular Degeneration
| Article | Year |
|---|---|
Impaired intracellular signaling may allow up-regulation of CTGF-synthesis and secondary peri-retinal fibrosis in human retinal pigment epithelial cells from patients with age-related macular degeneration.
Topics: Carbon Radioisotopes; Connective Tissue Growth Factor; Epithelial Cells; Fibrosis; Flavonoids; Gluco | 2010 |
ERK1/2 activation is a therapeutic target in age-related macular degeneration.
Topics: Animals; DEAD-box RNA Helicases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression R | 2012 |
A possible impaired signaling mechanism in human retinal pigment epithelial cells from patients with macular degeneration.
Topics: Case-Control Studies; Cell Count; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, D | 2008 |