pd 98059 has been researched along with Leukemia, Promyelocytic, Acute in 7 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Leukemia, Promyelocytic, Acute: An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The acute promyelocytic leukemia cell line NB4 was treated with bufalin, then the proliferation was evaluated by cell viability assay and apoptosis was detected by flow cytometry analysis." | 7.78 | Bufalin induces the apoptosis of acute promyelocytic leukemia cells via the downregulation of survivin expression. ( Gao, Y; Li, E; Liu, X; Liu, Y; Sun, H; Wang, Q; Wang, Y; Wang, Z; Zhu, Z, 2012) |
| " In this study, we report that acute promyelocytic leukemia (APL) cells exploit the Ras-MAPK activation pathway to phosphorylate at Ser112 and to inactivate the proapoptotic protein Bad, delaying arsenic trioxide (ATO)-induced apoptosis." | 7.73 | Arsenic trioxide (ATO) and MEK1 inhibition synergize to induce apoptosis in acute promyelocytic leukemia cells. ( Bonati, A; Lo-Coco, F; Lunghi, P; Pelicci, P; Pelicci, PG; Tabilio, A, 2005) |
| "The acute promyelocytic leukemia cell line NB4 was treated with bufalin, then the proliferation was evaluated by cell viability assay and apoptosis was detected by flow cytometry analysis." | 3.78 | Bufalin induces the apoptosis of acute promyelocytic leukemia cells via the downregulation of survivin expression. ( Gao, Y; Li, E; Liu, X; Liu, Y; Sun, H; Wang, Q; Wang, Y; Wang, Z; Zhu, Z, 2012) |
| " In this study, we report that acute promyelocytic leukemia (APL) cells exploit the Ras-MAPK activation pathway to phosphorylate at Ser112 and to inactivate the proapoptotic protein Bad, delaying arsenic trioxide (ATO)-induced apoptosis." | 3.73 | Arsenic trioxide (ATO) and MEK1 inhibition synergize to induce apoptosis in acute promyelocytic leukemia cells. ( Bonati, A; Lo-Coco, F; Lunghi, P; Pelicci, P; Pelicci, PG; Tabilio, A, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kikuchi, H | 1 |
| Yuan, B | 1 |
| Yuhara, E | 1 |
| Takagi, N | 1 |
| Toyoda, H | 1 |
| Tan, H | 1 |
| Ling, H | 1 |
| He, J | 1 |
| Yi, L | 1 |
| Zhou, J | 1 |
| Lin, M | 1 |
| Su, Q | 1 |
| Zhu, Z | 1 |
| Li, E | 1 |
| Liu, Y | 2 |
| Gao, Y | 1 |
| Sun, H | 1 |
| Wang, Y | 1 |
| Wang, Z | 1 |
| Liu, X | 2 |
| Wang, Q | 1 |
| López-Pedrera, C | 1 |
| Barbarroja, N | 1 |
| Buendía, P | 1 |
| Torres, A | 1 |
| Dorado, G | 1 |
| Velasco, F | 1 |
| Lunghi, P | 1 |
| Tabilio, A | 1 |
| Lo-Coco, F | 1 |
| Pelicci, PG | 1 |
| Pelicci, P | 1 |
| Bonati, A | 1 |
| Jin, JO | 1 |
| Park, HY | 1 |
| Kim, JW | 1 |
| Park, JI | 1 |
| Hong, YS | 1 |
| Min, do S | 1 |
| Kwak, JY | 1 |
| Song, X | 1 |
| Sheppard, HM | 1 |
| Norman, AW | 1 |
7 other studies available for pd 98059 and Leukemia, Promyelocytic, Acute
| Article | Year |
|---|---|
Involvement of histone H3 phosphorylation through p38 MAPK pathway activation in casticin-induced cytocidal effects against the human promyelocytic cell line HL-60.
Topics: Adenosine Triphosphate; Anthracenes; Antioxidants; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Cell | 2013 |
Inhibition of ERK and activation of p38 are involved in diallyl disulfide induced apoptosis of leukemia HL-60 cells.
Topics: Allyl Compounds; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Proliferation | 2008 |
Bufalin induces the apoptosis of acute promyelocytic leukemia cells via the downregulation of survivin expression.
Topics: Apoptosis; Bufanolides; Caspase 3; Cell Proliferation; Down-Regulation; Enzyme Activation; Flavonoid | 2012 |
Promyelocytic leukemia retinoid signaling targets regulate apoptosis,tissue factor and thrombomodulin expression.
Topics: Apoptosis; Benzoates; Cell Differentiation; Cell Line, Tumor; Flavonoids; Gene Expression; Humans; L | 2004 |
Arsenic trioxide (ATO) and MEK1 inhibition synergize to induce apoptosis in acute promyelocytic leukemia cells.
Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Drug Resistance, N | 2005 |
Phosphatidic acid induces the differentiation of human acute promyelocytic leukemic cells into dendritic cell-like.
Topics: Biomarkers; Cell Differentiation; Cytokines; Dendritic Cells; Extracellular Signal-Regulated MAP Kin | 2007 |
Mitogen-activated protein kinase is involved in the degradation of p53 protein in the bryostatin-1-induced differentiation of the acute promyelocytic leukemia NB4 cell line.
Topics: Bryostatins; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cysteine Endopeptid | 1999 |