pd 98059 and B-Cell Chronic Lymphocytic Leukemia studies

pd 98059 and B-Cell Chronic Lymphocytic Leukemia

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.

Research Excerpts

Excerpt	Relevance	Reference
"Four cell lines and all chronic lymphocytic leukemia cells were killed in 6 hours by vinblastine alone."	1.36	Vinblastine induces acute, cell cycle phase-independent apoptosis in some leukemias and lymphomas and can induce acute apoptosis in others when Mcl-1 is suppressed. ( Albershardt, TC; Bates, DJ; Eastman, A; Lowrey, CH; Salerni, BL, 2010)

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (33.33)	29.6817
2010's	2 (66.67)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

0 (0.00)

18.2507

2000's

1 (33.33)

29.6817

2010's

2 (66.67)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Salerni, BL	1
Bates, DJ	1
Albershardt, TC	1
Lowrey, CH	1
Eastman, A	1
Steele, AJ	1
Prentice, AG	1
Cwynarski, K	1
Hoffbrand, AV	1
Hart, SM	1
Lowdell, MW	1
Samuel, ER	1
Wickremasinghe, RG	1
Kawauchi, K	1
Ihjima, K	1
Yamada, O	1

Studies

Salerni, BL

Bates, DJ

Albershardt, TC

Lowrey, CH

Eastman, A

Steele, AJ

Prentice, AG

Cwynarski, K

Hoffbrand, AV

Hart, SM

Lowdell, MW

Samuel, ER

Wickremasinghe, RG

Kawauchi, K

Ihjima, K

Yamada, O

Trial	Phase	Enrollment	Study Type	Start Date	Status
Vinblastine Versus Oral Hydroxiurea in Newly Diagnosed AML With Hyperleukocytosis: a Phase 2 Clinical Study[NCT05062278]	Phase 2	46 participants (Anticipated)	Interventional	2021-07-26	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial

Phase

Enrollment

Study Type

Start Date

Status

Vinblastine Versus Oral Hydroxiurea in Newly Diagnosed AML With Hyperleukocytosis: a Phase 2 Clinical Study[NCT05062278]

Phase 2

46 participants (Anticipated)

Interventional

2021-07-26

Recruiting

[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Vinblastine induces acute, cell cycle phase-independent apoptosis in some leukemias and lymphomas and can induce acute apoptosis in others when Mcl-1 is suppressed. Molecular cancer therapeutics, 2010, Volume: 9, Issue:4 Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cycloheximide; Cytoprotection; Drug Screening Assays, Antit	2010
The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of cytoprotection by the microenvironment. Blood, 2010, Nov-25, Volume: 116, Issue:22 Topics: Apoptosis; bcl-X Protein; Bone Marrow Cells; Calcium-Calmodulin-Dependent Protein Kinases; Cytochrom	2010
IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3'-kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells. Journal of immunology (Baltimore, Md. : 1950), 2005, May-01, Volume: 174, Issue:9 Topics: Cell Line, Transformed; Chromones; DNA-Binding Proteins; Enzyme Inhibitors; Extracellular Signal-Reg	2005

Article

Year

Vinblastine induces acute, cell cycle phase-independent apoptosis in some leukemias and lymphomas and can induce acute apoptosis in others when Mcl-1 is suppressed.

Molecular cancer therapeutics, 2010, Volume: 9, Issue:4

Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cycloheximide; Cytoprotection; Drug Screening Assays, Antit

2010

The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of cytoprotection by the microenvironment.

Blood, 2010, Nov-25, Volume: 116, Issue:22

Topics: Apoptosis; bcl-X Protein; Bone Marrow Cells; Calcium-Calmodulin-Dependent Protein Kinases; Cytochrom

2010

IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3'-kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells.

Journal of immunology (Baltimore, Md. : 1950), 2005, May-01, Volume: 174, Issue:9

Topics: Cell Line, Transformed; Chromones; DNA-Binding Proteins; Enzyme Inhibitors; Extracellular Signal-Reg

2005

pd 98059 and B-Cell Chronic Lymphocytic Leukemia

Research Excerpts

Research

Studies (3)

Authors

Clinical Trials (1)

Trial Overview

Other Studies