pd 98059 has been researched along with Kahler Disease in 11 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The human multiple myeloma (MM) cell line 8226 encodes an activated K-ras allele and proliferates without requirement for the main MM growth and survival factor IL-6." | 1.31 | Proliferation of IL-6-independent multiple myeloma does not require the activity of extracellular signal-regulated kinases (ERK1/2). ( Fenton, RG; Zhang, B, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 9 (81.82) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, S | 1 |
| Ma, Z | 1 |
| Cai, H | 1 |
| Li, Q | 1 |
| Rong, W | 1 |
| Kawano, M | 1 |
| Zhang, B | 1 |
| Fenton, RG | 1 |
| Lentzsch, S | 2 |
| Gries, M | 1 |
| Janz, M | 1 |
| Bargou, R | 1 |
| Dörken, B | 1 |
| Mapara, MY | 1 |
| Hu, L | 2 |
| Shi, Y | 2 |
| Hsu, JH | 2 |
| Gera, J | 2 |
| Van Ness, B | 1 |
| Lichtenstein, A | 2 |
| Giuliani, N | 1 |
| Lunghi, P | 1 |
| Morandi, F | 1 |
| Colla, S | 1 |
| Bonomini, S | 1 |
| Hojden, M | 1 |
| Rizzoli, V | 1 |
| Bonati, A | 1 |
| Menu, E | 1 |
| Kooijman, R | 1 |
| Van Valckenborgh, E | 1 |
| Asosingh, K | 1 |
| Bakkus, M | 1 |
| Van Camp, B | 1 |
| Vanderkerken, K | 1 |
| Pei, XY | 1 |
| Li, W | 1 |
| Dai, Y | 1 |
| Dent, P | 1 |
| Grant, S | 1 |
| Arora, T | 1 |
| Floyd-Smith, G | 1 |
| Espy, MJ | 1 |
| Jelinek, DF | 1 |
| Podar, K | 1 |
| Tai, YT | 1 |
| Davies, FE | 1 |
| Sattler, M | 1 |
| Hideshima, T | 1 |
| Lin, BK | 1 |
| Gupta, D | 1 |
| Shima, Y | 1 |
| Chauhan, D | 1 |
| Mitsiades, C | 1 |
| Raje, N | 1 |
| Richardson, P | 1 |
| Anderson, KC | 1 |
| Thabard, W | 1 |
| Collette, M | 1 |
| Mellerin, MP | 1 |
| Puthier, D | 1 |
| Barillé, S | 1 |
| Bataille, R | 1 |
| Amiot, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 1 Study of the Effects of Huang-Lian-Jie-Du-Tang（HLJDT) on the Survival of Patients With Multiple Myeloma in Maintain Therapy[NCT02467647] | Phase 1 | 500 participants (Anticipated) | Interventional | 2015-01-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 other studies available for pd 98059 and Kahler Disease
| Article | Year |
|---|---|
Inhibitory effect of baicalein on IL-6-mediated signaling cascades in human myeloma cells.
Topics: Antineoplastic Agents, Hormonal; Antioxidants; bcl-X Protein; Cell Line, Tumor; Cell Proliferation; | 2010 |
Proliferation of IL-6-independent multiple myeloma does not require the activity of extracellular signal-regulated kinases (ERK1/2).
Topics: Antibiotics, Antineoplastic; Blotting, Western; Butadienes; Cell Cycle; Cell Division; Chromones; Do | 2002 |
Macrophage inflammatory protein 1-alpha (MIP-1 alpha ) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells.
Topics: Androstadienes; Cell Division; Cell Survival; Chemokine CCL3; Chemokine CCL4; Cytokines; Enzyme Acti | 2003 |
Downstream effectors of oncogenic ras in multiple myeloma cells.
Topics: Alkyl and Aryl Transferases; Cell Cycle; Chromones; DNA-Binding Proteins; Enzyme Inhibitors; Farnesy | 2003 |
Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis.
Topics: Cell Division; Down-Regulation; Flavonoids; Humans; Interleukin-6; MAP Kinase Kinase 1; Mitogen-Acti | 2004 |
Specific roles for the PI3K and the MEK-ERK pathway in IGF-1-stimulated chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: study in the 5T33MM model.
Topics: Animals; Cell Division; Cell Movement; Chemotaxis; Disease Models, Animal; Down-Regulation; Flavonoi | 2004 |
Dissecting the roles of checkpoint kinase 1/CDC2 and mitogen-activated protein kinase kinase 1/2/extracellular signal-regulated kinase 1/2 in relation to 7-hydroxystaurosporine-induced apoptosis in human multiple myeloma cells.
Topics: Apoptosis; CDC2 Protein Kinase; Cell Line, Tumor; Checkpoint Kinase 1; Enzyme Activation; Extracellu | 2006 |
Dissociation between IFN-alpha-induced anti-viral and growth signaling pathways.
Topics: 2',5'-Oligoadenylate Synthetase; Antiviral Agents; Calcium-Calmodulin-Dependent Protein Kinases; Cel | 1999 |
Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration.
Topics: Cell Division; Cell Movement; Endothelial Growth Factors; Extracellular Matrix Proteins; Flavonoids; | 2001 |
IL-6 upregulates its own receptor on some human myeloma cell lines.
Topics: Androstadienes; Antibodies, Monoclonal; Blotting, Northern; Enzyme Activation; Enzyme Inhibitors; Fl | 2001 |
Signal pathways involved in activation of p70S6K and phosphorylation of 4E-BP1 following exposure of multiple myeloma tumor cells to interleukin-6.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Carrier Proteins; Cell Cycle Proteins; Enzyme | 2002 |