pd 98059 has been researched along with Invasiveness, Neoplasm in 72 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Curcumin is a potential anticancer agent for pancreatic cancer." | 5.51 | Curcumin attenuates hyperglycemia-driven EGF-induced invasive and migratory abilities of pancreatic cancer via suppression of the ERK and AKT pathways. ( Cao, L; Han, L; Li, W; Ma, Q; Wang, Z; Wu, Z; Xiao, X, 2019) |
| "Human pancreatic cancer Panc-1 cells were exposed to high glucose condition with or without resveratrol, N-acetylcysteine (NAC, a scavenger of free radicals), PD 98059 (an ERK inhibitor) or SB 203580 (a p38 MAPK inhibitor)." | 5.43 | Resveratrol inhibits hyperglycemia-driven ROS-induced invasion and migration of pancreatic cancer cells via suppression of the ERK and p38 MAPK signaling pathways. ( Cao, L; Chen, X; Li, W; Ma, Q; Xiao, X, 2016) |
| "Sulforaphane (SFN) was demonstrated to inhibit cell growth in a variety of tumors." | 5.40 | Sulforaphane inhibits invasion via activating ERK1/2 signaling in human glioblastoma U87MG and U373MG cells. ( Du, L; Li, C; Niu, J; Peng, X; Tian, H; Wu, W; Yang, G; Zhou, Y, 2014) |
| "Human breast cancer MCF-7 cells were exposed to resveratrol (2, 5 and 10 microM)." | 5.35 | Resveratrol inhibits heregulin-beta1-mediated matrix metalloproteinase-9 expression and cell invasion in human breast cancer cells. ( Chiang, EP; Sun, YC; Tang, FY, 2008) |
| "Curcumin is a potential anticancer agent for pancreatic cancer." | 1.51 | Curcumin attenuates hyperglycemia-driven EGF-induced invasive and migratory abilities of pancreatic cancer via suppression of the ERK and AKT pathways. ( Cao, L; Han, L; Li, W; Ma, Q; Wang, Z; Wu, Z; Xiao, X, 2019) |
| "Human pancreatic cancer Panc-1 cells were exposed to high glucose condition with or without resveratrol, N-acetylcysteine (NAC, a scavenger of free radicals), PD 98059 (an ERK inhibitor) or SB 203580 (a p38 MAPK inhibitor)." | 1.43 | Resveratrol inhibits hyperglycemia-driven ROS-induced invasion and migration of pancreatic cancer cells via suppression of the ERK and p38 MAPK signaling pathways. ( Cao, L; Chen, X; Li, W; Ma, Q; Xiao, X, 2016) |
| "After DEN-induced hepatocellular carcinoma (HCC) in rats showed increased phosphorylation of JNK1/2, p38, and ERK1/2, we next antagonized TGF-β1-induced phosphorylation of JNK1/2, p38, ERK1/2, Smad2/3 signaling in HepG2 cells using SP600125, SB203580, and PD98059, respectively." | 1.42 | MAPK inhibitors differently modulate TGF-β/Smad signaling in HepG2 cells. ( Boye, A; He, S; Jiang, Y; Kan, H; Wu, C; Yang, X; Yang, Y, 2015) |
| "Moreover, the motility of breast cancer cells was detected by wound-healing and transwell experiments." | 1.40 | CD44 targets Na(+)/H(+) exchanger 1 to mediate MDA-MB-231 cells' metastasis via the regulation of ERK1/2. ( Chang, G; Li, Q; Lin, Y; Ma, L; Pang, T; Wang, C; Wang, J; Xu, H; Zhang, H; Zhang, Y, 2014) |
| "Sulforaphane (SFN) was demonstrated to inhibit cell growth in a variety of tumors." | 1.40 | Sulforaphane inhibits invasion via activating ERK1/2 signaling in human glioblastoma U87MG and U373MG cells. ( Du, L; Li, C; Niu, J; Peng, X; Tian, H; Wu, W; Yang, G; Zhou, Y, 2014) |
| "Cadmium exposure has been linked to human cancers, including stomach cancer." | 1.40 | Cadmium induces urokinase-type plasminogen activator receptor expression and the cell invasiveness of human gastric cancer cells via the ERK-1/2, NF-κB, and AP-1 signaling pathways. ( Chay, KO; Joo, YE; Jung, YD; Khoi, PN; Kim, DH; Kim, HD; Kim, KK; Lian, S; Xia, Y, 2014) |
| "In high-grade ovarian cancer cultures, it has been shown that epidermal growth factor (EGF) induces cell invasion by activating an epithelial-mesenchymal transition (EMT)." | 1.38 | EGF-induced EMT and invasiveness in serous borderline ovarian tumor cells: a possible step in the transition to low-grade serous carcinoma cells? ( Auersperg, N; Cheng, JC; Leung, PC, 2012) |
| "EMT in prostate cancer induced by FGF8b can be mediated by ERK kinase pathway, in which mitogen-activated/extraceluer signal regulated kinase 1 (MEK1) may be a key factor." | 1.38 | [Molecular mechanism of FGF8b regulation of epithelial-mesenchymal transition in prostate cancer cells]. ( Fan, B; Li, Z; Liu, H; Qi, F; Wang, G, 2012) |
| "However, a direct role for leptin in endometrial cancer has not been demonstrated." | 1.37 | Leptin activates STAT3 and ERK1/2 pathways and induces endometrial cancer cell proliferation. ( Gong, C; Liu, Y; Lv, L; Sheng, H; Wang, D; Xiao, W; Yin, J, 2011) |
| "Human breast cancer MCF-7 cells were exposed to resveratrol (2, 5 and 10 microM)." | 1.35 | Resveratrol inhibits heregulin-beta1-mediated matrix metalloproteinase-9 expression and cell invasion in human breast cancer cells. ( Chiang, EP; Sun, YC; Tang, FY, 2008) |
| "The combined treatment of melanoma cells with sorafenib and rapamycin led to an approximately twofold increase of cell death compared with sorafenib monotreatment (P<0." | 1.35 | Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells. ( Flaherty, KT; Garbe, C; Kulms, D; Lasithiotakis, KG; Maczey, E; Meier, FE; Schittek, B; Sinnberg, TW, 2008) |
| "OVCAR3 ovarian cancer cells express three sphingosine 1-phosphate (S1P) receptors, S1P(1), S1P(2), and S1P(3), but not S1P(4)." | 1.34 | S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells. ( Bae, YS; Kim, JM; Kim, MK; Kim, SD; Lee, HY; Lee, SY; Park, KS; Ryu, SH, 2007) |
| "We previously reported that BC brain metastases, in a rat syngeneic model developed in our laboratory, have high expression and activity of MMP2." | 1.34 | MMP2 role in breast cancer brain metastasis development and its regulation by TIMP2 and ERK1/2. ( Kim, HT; Lungu, G; Mendes, O; Stoica, G, 2007) |
| "ATP stimulated prostate cancer cell invasion." | 1.33 | [ERK1/2 and p38 kinases are important regulators in P2Y receptor-mediated prostate cancer invasion]. ( Chen, L; Fang, WG; He, HY; Heng, WJ; Li, HM; Li, Y; You, JF, 2005) |
| " Treatment of cells with a second inhibitor of polyamine biosynthesis, the S-adenosylmethionine decarboxylase (SAMDC) inhibitor SAM486A, also resulted in a dosage dependent decrease in meprin alpha and MMP-7 mRNA." | 1.33 | Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells. ( Bond, JS; Manni, A; Matters, GL, 2005) |
| "Primary cancer of the gallbladder is not unusual." | 1.32 | A MEK inhibitor (U0126) markedly inhibits direct liver invasion of orthotopically inoculated human gallbladder cancer cells in nude mice. ( Ajiki, T; Fujimori, T; Furihata, T; Hori, H; Horiuchi, H; Kawamata, H; Kuroda, Y; Ohkura, Y; Omotehara, F; Shinagawa, Y; Tachibana, M; Yamazaki, T, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (5.56) | 18.2507 |
| 2000's | 37 (51.39) | 29.6817 |
| 2010's | 31 (43.06) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, YJ | 1 |
| Lin, WL | 1 |
| Chen, NF | 1 |
| Chuang, SK | 1 |
| Tseng, TH | 1 |
| Ghasemi, A | 1 |
| Hashemy, SI | 1 |
| Aghaei, M | 1 |
| Panjehpour, M | 1 |
| Na, HH | 1 |
| Kim, KC | 1 |
| Li, W | 3 |
| Wang, Z | 2 |
| Xiao, X | 2 |
| Han, L | 1 |
| Wu, Z | 1 |
| Ma, Q | 3 |
| Cao, L | 2 |
| Wang, H | 2 |
| Guan, Q | 1 |
| Nan, Y | 1 |
| Zhong, Y | 1 |
| Cao, W | 1 |
| Zhang, B | 1 |
| Ding, F | 1 |
| Zhang, W | 1 |
| Sun, B | 1 |
| Liu, Z | 2 |
| Lee, KH | 3 |
| Koh, SA | 2 |
| Kim, JR | 3 |
| Chang, G | 1 |
| Wang, J | 2 |
| Zhang, H | 2 |
| Zhang, Y | 5 |
| Wang, C | 2 |
| Xu, H | 1 |
| Lin, Y | 1 |
| Ma, L | 1 |
| Li, Q | 1 |
| Pang, T | 1 |
| Li, C | 1 |
| Zhou, Y | 2 |
| Peng, X | 1 |
| Du, L | 1 |
| Tian, H | 2 |
| Yang, G | 2 |
| Niu, J | 1 |
| Wu, W | 2 |
| Khoi, PN | 1 |
| Xia, Y | 1 |
| Lian, S | 1 |
| Kim, HD | 1 |
| Kim, DH | 1 |
| Joo, YE | 1 |
| Chay, KO | 1 |
| Kim, KK | 1 |
| Jung, YD | 1 |
| Wang, XG | 1 |
| Meng, Q | 1 |
| Qi, FM | 1 |
| Yang, QF | 1 |
| Boye, A | 1 |
| Kan, H | 1 |
| Wu, C | 1 |
| Jiang, Y | 2 |
| Yang, X | 2 |
| He, S | 1 |
| Yang, Y | 1 |
| Kim, HJ | 1 |
| Kang, GJ | 1 |
| Kim, EJ | 1 |
| Park, MK | 1 |
| Byun, HJ | 1 |
| Nam, S | 1 |
| Lee, H | 1 |
| Lee, CH | 1 |
| Chen, X | 2 |
| Geng, Y | 1 |
| Wu, S | 1 |
| Hu, Y | 1 |
| Lin, K | 1 |
| Yan, F | 1 |
| Liao, R | 1 |
| Farhan, M | 1 |
| Wang, T | 1 |
| Chen, J | 1 |
| Little, PJ | 1 |
| Zheng, W | 1 |
| Slipicevic, A | 1 |
| Jørgensen, K | 1 |
| Skrede, M | 1 |
| Rosnes, AK | 1 |
| Trøen, G | 1 |
| Davidson, B | 1 |
| Flørenes, VA | 1 |
| Kline, CL | 1 |
| Olson, TL | 1 |
| Irby, RB | 1 |
| Tencheva, TsS | 1 |
| Panov, IR | 1 |
| Hung, YH | 1 |
| Hung, WC | 1 |
| Habashy, HO | 1 |
| Powe, DG | 1 |
| Staka, CM | 1 |
| Rakha, EA | 1 |
| Ball, G | 1 |
| Green, AR | 1 |
| Aleskandarany, M | 1 |
| Paish, EC | 1 |
| Douglas Macmillan, R | 1 |
| Nicholson, RI | 1 |
| Ellis, IO | 1 |
| Gee, JM | 1 |
| Charni, F | 1 |
| Friand, V | 1 |
| Haddad, O | 1 |
| Hlawaty, H | 1 |
| Martin, L | 1 |
| Vassy, R | 1 |
| Oudar, O | 1 |
| Gattegno, L | 1 |
| Charnaux, N | 1 |
| Sutton, A | 1 |
| Han, F | 1 |
| Zhu, HG | 1 |
| Lu, Z | 1 |
| Ding, L | 1 |
| Hong, H | 1 |
| Hoggard, J | 1 |
| Lu, Q | 1 |
| Chen, YH | 1 |
| Liu, Y | 1 |
| Lv, L | 1 |
| Xiao, W | 1 |
| Gong, C | 1 |
| Yin, J | 1 |
| Wang, D | 1 |
| Sheng, H | 1 |
| Choi, EY | 1 |
| Kim, MK | 2 |
| Kim, KO | 1 |
| Lee, SH | 1 |
| Jang, BI | 1 |
| Kim, SW | 2 |
| Song, SK | 1 |
| Choi, JH | 1 |
| Swamydas, M | 1 |
| Nguyen, D | 2 |
| Allen, LD | 1 |
| Eddy, J | 1 |
| Dréau, D | 1 |
| Cheng, JC | 1 |
| Auersperg, N | 1 |
| Leung, PC | 1 |
| Lu, JT | 1 |
| Zhao, WD | 1 |
| He, W | 1 |
| Wei, W | 1 |
| Wang, Y | 1 |
| Li, L | 1 |
| Guo, X | 1 |
| Jin, X | 1 |
| Sun, W | 2 |
| Zhang, X | 2 |
| Xu, RC | 1 |
| Li, J | 2 |
| Jia, L | 1 |
| Zhao, P | 1 |
| Zhong, S | 1 |
| Chen, D | 1 |
| Zhou, L | 2 |
| Wang, DS | 1 |
| Li, QJ | 1 |
| Dou, KF | 1 |
| Pan, G | 1 |
| Ren, J | 1 |
| Lu, J | 1 |
| Fu, H | 1 |
| Zhang, S | 1 |
| Fan, B | 1 |
| Wang, G | 1 |
| Qi, F | 1 |
| Li, Z | 1 |
| Liu, H | 1 |
| Chen, HW | 1 |
| Chao, CY | 1 |
| Lin, LL | 1 |
| Lu, CY | 1 |
| Liu, KL | 1 |
| Lii, CK | 1 |
| Li, CC | 1 |
| Wu, R | 1 |
| Duan, L | 1 |
| Ye, L | 1 |
| Weng, Y | 1 |
| Luo, J | 1 |
| Tang, M | 1 |
| Shi, Q | 1 |
| He, T | 1 |
| Benbow, U | 1 |
| Tower, GB | 1 |
| Wyatt, CA | 1 |
| Buttice, G | 1 |
| Brinckerhoff, CE | 1 |
| Shin, EY | 1 |
| Ma, EK | 1 |
| Kim, CK | 1 |
| Kwak, SJ | 1 |
| Kim, EG | 1 |
| Katsanakis, KD | 1 |
| Gorgoulis, V | 1 |
| Papavassiliou, AG | 1 |
| Zoumpourlis, VK | 1 |
| Zhang, D | 1 |
| Brodt, P | 1 |
| Denkert, C | 2 |
| Koch, I | 1 |
| Berger, S | 1 |
| Köbel, M | 2 |
| Siegert, A | 2 |
| Hauptmann, S | 3 |
| Pola, S | 1 |
| Cattaneo, MG | 1 |
| Vicentini, LM | 1 |
| Santibáñez, JF | 1 |
| Olivares, D | 1 |
| Guerrero, J | 1 |
| Martínez, J | 1 |
| Rieger-Christ, KM | 1 |
| Lee, P | 1 |
| Zagha, R | 1 |
| Kosakowski, M | 1 |
| Moinzadeh, A | 1 |
| Stoffel, J | 1 |
| Ben-Ze'ev, A | 1 |
| Libertino, JA | 1 |
| Summerhayes, IC | 1 |
| Kobayashi, H | 1 |
| Suzuki, M | 1 |
| Kanayama, N | 1 |
| Terao, T | 1 |
| Xu, L | 1 |
| Deng, X | 1 |
| Manni, A | 2 |
| Washington, S | 1 |
| Mauger, D | 1 |
| Hackett, DA | 1 |
| Verderame, MF | 1 |
| Horiuchi, H | 1 |
| Kawamata, H | 1 |
| Furihata, T | 1 |
| Omotehara, F | 1 |
| Hori, H | 1 |
| Shinagawa, Y | 1 |
| Ohkura, Y | 1 |
| Tachibana, M | 1 |
| Yamazaki, T | 1 |
| Ajiki, T | 1 |
| Kuroda, Y | 1 |
| Fujimori, T | 1 |
| Chen, L | 1 |
| He, HY | 1 |
| Li, HM | 1 |
| You, JF | 1 |
| Heng, WJ | 1 |
| Li, Y | 1 |
| Fang, WG | 1 |
| Pohl, G | 1 |
| Schmitt, WD | 1 |
| Wang, TL | 1 |
| Shih, IeM | 1 |
| Matters, GL | 1 |
| Bond, JS | 1 |
| Kwak, HJ | 1 |
| Park, MJ | 1 |
| Cho, H | 1 |
| Park, CM | 1 |
| Moon, SI | 1 |
| Lee, HC | 1 |
| Park, IC | 1 |
| Kim, MS | 1 |
| Rhee, CH | 1 |
| Hong, SI | 1 |
| Suthiphongchai, T | 1 |
| Phimsen, S | 1 |
| Sakulkhu, U | 1 |
| Tohtong, R | 1 |
| Uemura, Y | 1 |
| Kobayashi, M | 1 |
| Nakata, H | 1 |
| Kubota, T | 1 |
| Bandobashi, K | 1 |
| Saito, T | 1 |
| Taguchi, H | 1 |
| Pan, Y | 1 |
| Zhao, L | 1 |
| Liang, J | 1 |
| Liu, J | 1 |
| Shi, Y | 1 |
| Liu, N | 1 |
| Zhang, G | 1 |
| Jin, H | 1 |
| Gao, J | 1 |
| Xie, H | 1 |
| Fan, D | 1 |
| Park, KS | 1 |
| Lee, HY | 1 |
| Kim, SD | 1 |
| Lee, SY | 1 |
| Kim, JM | 1 |
| Ryu, SH | 1 |
| Bae, YS | 1 |
| Hamilton, SR | 1 |
| Fard, SF | 1 |
| Paiwand, FF | 1 |
| Tolg, C | 1 |
| Veiseh, M | 1 |
| McCarthy, JB | 1 |
| Bissell, MJ | 1 |
| Koropatnick, J | 1 |
| Turley, EA | 1 |
| Mendes, O | 1 |
| Kim, HT | 1 |
| Lungu, G | 1 |
| Stoica, G | 1 |
| Tang, FY | 1 |
| Chiang, EP | 1 |
| Sun, YC | 1 |
| Lasithiotakis, KG | 1 |
| Sinnberg, TW | 1 |
| Schittek, B | 1 |
| Flaherty, KT | 1 |
| Kulms, D | 1 |
| Maczey, E | 1 |
| Garbe, C | 1 |
| Meier, FE | 1 |
| Simon, C | 3 |
| Juarez, J | 1 |
| Nicolson, GL | 1 |
| Boyd, D | 3 |
| Goepfert, H | 2 |
| Zhou, JN | 1 |
| Ljungdahl, S | 1 |
| Shoshan, MC | 1 |
| Swedenborg, J | 1 |
| Linder, S | 1 |
| Hicks, MJ | 1 |
| Nemechek, AJ | 1 |
| Mehta, R | 1 |
| O'Malley, BW | 1 |
| Flaitz, CM | 1 |
| Webb, DJ | 1 |
| Nguyen, DH | 1 |
| Gonias, SL | 1 |
| Vadlamudi, RK | 1 |
| Adam, L | 1 |
| Wang, RA | 1 |
| Mandal, M | 1 |
| Sahin, A | 1 |
| Chernoff, J | 1 |
| Hung, MC | 1 |
| Kumar, R | 1 |
| Thant, AA | 1 |
| Nawa, A | 1 |
| Kikkawa, F | 1 |
| Ichigotani, Y | 1 |
| Sein, TT | 1 |
| Amin, AR | 1 |
| Hamaguchi, M | 1 |
| Yao, J | 1 |
| Xiong, S | 1 |
| Klos, K | 1 |
| Nguyen, N | 1 |
| Grijalva, R | 1 |
| Li, P | 1 |
| Yu, D | 1 |
| Ge, X | 1 |
| Fu, YM | 1 |
| Meadows, GG | 1 |
| Leclere, A | 1 |
| Turzynski, A | 1 |
| Abiru, S | 1 |
| Nakao, K | 1 |
| Ichikawa, T | 1 |
| Migita, K | 1 |
| Shigeno, M | 1 |
| Sakamoto, M | 1 |
| Ishikawa, H | 1 |
| Hamasaki, K | 1 |
| Nakata, K | 1 |
| Eguchi, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Trial Aiming to Assess the Safety and Activity of the Combination of Cabozantinib Plus Lanreotide in Gastroenteropancreatic (GEP) and Thoracic Neuroendocrine Tumor (NET): The LOLA Trial[NCT04427787] | Phase 2 | 69 participants (Anticipated) | Interventional | 2020-06-20 | Recruiting | ||
| A Prospective Randomized Control Trial of the Effect of Sorafenib Combined With Aspirin in Preventing the Recurrence in High-risk Patients With Hepatocellular Carcinoma[NCT02748304] | 52 participants (Actual) | Interventional | 2016-04-30 | Terminated (stopped due to The enrollment of this study was slow. With the approval of lenvatinib in HCC,many patients choose the new drug, so subsequent enrollment may be more difficult.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
72 other studies available for pd 98059 and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Movement; Cell Proliferation; Coumarins; Dose | 2012 |
Leptin induces matrix metalloproteinase 7 expression to promote ovarian cancer cell invasion by activating ERK and JNK pathways.
Topics: Anthracenes; Cell Line, Tumor; Cell Movement; Female; Flavonoids; Gene Knockdown Techniques; Humans; | 2018 |
SETDB1-mediated FosB regulation via ERK2 is associated with an increase in cell invasiveness during anticancer drug treatment of A549 human lung cancer cells.
Topics: A549 Cells; Antineoplastic Agents; Cell Movement; Doxorubicin; Flavonoids; Gene Expression Regulatio | 2018 |
Curcumin attenuates hyperglycemia-driven EGF-induced invasive and migratory abilities of pancreatic cancer via suppression of the ERK and AKT pathways.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Curcumin; Epi | 2019 |
Overexpression of human MX2 gene suppresses cell proliferation, migration, and invasion via ERK/P38/NF-κB pathway in glioblastoma cells.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Fla | 2019 |
Expression of SLP-2 was associated with invasion of esophageal squamous cell carcinoma.
Topics: Blood Proteins; Blotting, Western; Butadienes; Carcinoma, Squamous Cell; Esophageal Neoplasms; Flavo | 2013 |
Hepatocyte growth factor-mediated gastrin-releasing peptide induces IL-8 expression through Ets-1 in gastric cancer cells.
Topics: Adenocarcinoma; Base Sequence; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Flavono | 2013 |
CD44 targets Na(+)/H(+) exchanger 1 to mediate MDA-MB-231 cells' metastasis via the regulation of ERK1/2.
Topics: Animals; Anti-Arrhythmia Agents; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cat | 2014 |
Sulforaphane inhibits invasion via activating ERK1/2 signaling in human glioblastoma U87MG and U373MG cells.
Topics: Anticarcinogenic Agents; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Survival; Dose-Res | 2014 |
Cadmium induces urokinase-type plasminogen activator receptor expression and the cell invasiveness of human gastric cancer cells via the ERK-1/2, NF-κB, and AP-1 signaling pathways.
Topics: Cadmium; Cell Line, Tumor; Cell Movement; Flavonoids; Gene Expression Regulation, Neoplastic; Humans | 2014 |
Blocking TGF-β inhibits breast cancer cell invasiveness via ERK/S100A4 signal.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Flavonoids; Humans; MAP Kinase Signaling | 2014 |
MAPK inhibitors differently modulate TGF-β/Smad signaling in HepG2 cells.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Flavonoi | 2015 |
Novel effects of sphingosylphosphorylcholine on invasion of breast cancer: Involvement of matrix metalloproteinase-3 secretion leading to WNT activation.
Topics: Breast Neoplasms; Caproates; Cell Line, Tumor; Female; Flavonoids; Gene Silencing; Humans; Matrix Me | 2016 |
Resveratrol inhibits hyperglycemia-driven ROS-induced invasion and migration of pancreatic cancer cells via suppression of the ERK and p38 MAPK signaling pathways.
Topics: Acetylcysteine; Cell Line, Tumor; Cell Movement; Diabetes Complications; Flavonoids; Free Radical Sc | 2016 |
Sulforaphane-cysteine suppresses invasion via downregulation of galectin-1 in human prostate cancer DU145 and PC3 cells.
Topics: Anticarcinogenic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cysteine; Down-Regulat | 2016 |
Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells.
Topics: Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Proliferation; Chromones; Flavonoids | 2016 |
The fatty acid binding protein 7 (FABP7) is involved in proliferation and invasion of melanoma cells.
Topics: Biomarkers, Tumor; Carcinogens; Carrier Proteins; Cell Nucleus; Cell Proliferation; Cytoplasm; Disea | 2008 |
Src activity alters alpha3 integrin expression in colon tumor cells.
Topics: Cell Adhesion; Cell Line, Tumor; Cell Movement; Chromones; Colonic Neoplasms; Down-Regulation; Extra | 2009 |
Intracerebral development of transplanted glioblastoma C6 cells in rats after preliminary exposure to neuropeptides and an MAPK inhibitor.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Brain Neoplasms; Cell Line, Tumor; Cell Prolife | 2008 |
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) enhances invasiveness of lung cancer cells by up-regulating contactin-1 via the alpha7 nicotinic acetylcholine receptor/ERK signaling pathway.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Bungarotoxins; Cell Adhesion Molecules, Neuronal; Contactin | 2009 |
Transferrin receptor (CD71) is a marker of poor prognosis in breast cancer and can predict response to tamoxifen.
Topics: Adult; Antigens, CD; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Carcinoma | 2010 |
Syndecan-1 and syndecan-4 are involved in RANTES/CCL5-induced migration and invasion of human hepatoma cells.
Topics: Anthracenes; Antibodies, Monoclonal; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; | 2009 |
Caveolin-1 regulating the invasion and expression of matrix metalloproteinase (MMPs) in pancreatic carcinoma cells.
Topics: Carcinoma; Caveolin 1; Cell Line, Tumor; Chromones; Epithelial Cells; Extracellular Signal-Regulated | 2010 |
Kiss-1 suppresses MMP-9 expression by activating p38 MAP kinase in human stomach cancer.
Topics: Cell Line, Tumor; Cell Proliferation; Down-Regulation; Enzyme Activation; Flavonoids; Gene Expressio | 2009 |
Claudin-7 inhibits human lung cancer cell migration and invasion through ERK/MAPK signaling pathway.
Topics: Cell Movement; Claudins; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Lung Neopla | 2011 |
Leptin activates STAT3 and ERK1/2 pathways and induces endometrial cancer cell proliferation.
Topics: Adenocarcinoma; Cell Line, Tumor; Cell Proliferation; Endometrial Neoplasms; Enzyme Inhibitors; Fema | 2011 |
Down-regulation of survivin suppresses uro-plasminogen activator through transcription factor JunB.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Flavonoids; Gene Expression Regulation, Neoplastic; | 2011 |
Progranulin stimulated by LPA promotes the migration of aggressive breast cancer cells.
Topics: Antibodies; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Flavonoids; Focal Adhesion Ki | 2011 |
EGF-induced EMT and invasiveness in serous borderline ovarian tumor cells: a possible step in the transition to low-grade serous carcinoma cells?
Topics: Cadherins; Cell Line, Tumor; Cell Movement; Chromones; Cystadenocarcinoma, Serous; Epidermal Growth | 2012 |
Hedgehog signaling pathway mediates invasion and metastasis of hepatocellular carcinoma via ERK pathway.
Topics: Adult; Aged; Blotting, Western; Butadienes; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Moveme | 2012 |
Interleukin-6 signaling regulates anchorage-independent growth, proliferation, adhesion and invasion in human ovarian cancer cells.
Topics: Androstadienes; Apoptosis; Cell Adhesion; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Tra | 2012 |
Stable knockdown of clusterin by vectorbased RNA interference in a human breast cancer cell line inhibits tumour cell invasion and metastasis.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Clusterin; Extracell | 2012 |
Downregulation of the Notch signaling pathway inhibits hepatocellular carcinoma cell invasion by inactivation of matrix metalloproteinase-2 and -9 and vascular endothelial growth factor.
Topics: Amyloid Precursor Protein Secretases; Antineoplastic Agents; Calcium-Calmodulin-Dependent Protein Ki | 2012 |
Semaphorin 5A, an axon guidance molecule, enhances the invasion and metastasis of human gastric cancer through activation of MMP9.
Topics: Analysis of Variance; Cell Line, Tumor; Cell Movement; Flavonoids; Humans; Integrins; MAP Kinase Sig | 2013 |
[Molecular mechanism of FGF8b regulation of epithelial-mesenchymal transition in prostate cancer cells].
Topics: Epithelial-Mesenchymal Transition; Fibroblast Growth Factor 8; Flavonoids; Humans; Male; MAP Kinase | 2012 |
Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells.
Topics: Adenocarcinoma; Androstadienes; Antineoplastic Agents; Breast Neoplasms; Carcinogens; Cell Movement; | 2013 |
S100A9 promotes the proliferation and invasion of HepG2 hepatocellular carcinoma cells via the activation of the MAPK signaling pathway.
Topics: Animals; Calgranulin B; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Transf | 2013 |
High levels of MMP-1 expression in the absence of the 2G single nucleotide polymorphism is mediated by p38 and ERK1/2 mitogen-activated protein kinases in VMM5 melanoma cells.
Topics: Collagen Type I; DNA; DNA-Binding Proteins; Flavonoids; Gene Expression Regulation, Enzymologic; Imi | 2002 |
Src/ERK but not phospholipase D is involved in keratinocyte growth factor-stimulated secretion of matrix metalloprotease-9 and urokinase-type plasminogen activator in SNU-16 human stomach cancer cell.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Collagen; Drug Combinations; Enzyme Inhibitors; Fibrob | 2002 |
The progression in the mouse skin carcinogenesis model correlates with ERK1/2 signaling.
Topics: Animals; Cell Transformation, Neoplastic; Disease Models, Animal; Flavonoids; Genes, ras; Immunohist | 2002 |
Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling.
Topics: Amino Acid Substitution; Androstadienes; Animals; Carcinoma, Lewis Lung; Chromones; Collagen; Drug C | 2003 |
Cytokine-suppressive anti-inflammatory drugs (CSAIDs) inhibit invasion and MMP-1 production of ovarian carcinoma cells.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Collagen; Cytokines; Drug Combinations; Enz | 2003 |
Anti-migratory and anti-invasive effect of somatostatin in human neuroblastoma cells: involvement of Rac and MAP kinase activity.
Topics: Androstadienes; Blotting, Western; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug | 2003 |
Cyclic AMP inhibits TGFbeta1-induced cell-scattering and invasiveness in murine-transformed keratinocytes.
Topics: Animals; Cell Line, Transformed; Cell Movement; Cell Transformation, Neoplastic; Colforsin; Cyclic A | 2003 |
Novel expression of N-cadherin elicits in vitro bladder cell invasion via the Akt signaling pathway.
Topics: Blotting, Western; Cadherins; Carcinoma; Cell Line, Tumor; Chromones; Clone Cells; Collagen; Drug Co | 2004 |
A soybean Kunitz trypsin inhibitor suppresses ovarian cancer cell invasion by blocking urokinase upregulation.
Topics: Binding, Competitive; Cell Line, Tumor; Cell Movement; Collagen; Depression, Chemical; Drug Combinat | 2004 |
Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion.
Topics: Blotting, Western; Calpain; Carcinogens; Cell Line, Tumor; Cell Movement; Disease Progression; Dose- | 2004 |
Cellular mechanisms mediating the anti-invasive properties of the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO) in human breast cancer cells.
Topics: Breast Neoplasms; Eflornithine; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; Mit | 2004 |
A MEK inhibitor (U0126) markedly inhibits direct liver invasion of orthotopically inoculated human gallbladder cancer cells in nude mice.
Topics: Animals; Butadienes; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Flavonoids; Gallbladder Neo | 2004 |
[ERK1/2 and p38 kinases are important regulators in P2Y receptor-mediated prostate cancer invasion].
Topics: Cell Line, Tumor; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Male; Mitogen-Activated Protein | 2005 |
Activation of mitogen-activated protein kinase is required for migration and invasion of placental site trophoblastic tumor.
Topics: Benzamides; Case-Control Studies; Cell Movement; Cells, Cultured; Enzyme Activation; Female; Flavono | 2005 |
Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells.
Topics: Amidines; Antineoplastic Agents; Breast Neoplasms; Down-Regulation; Eflornithine; Enzyme Inhibitors; | 2005 |
Transforming growth factor-beta1 induces tissue inhibitor of metalloproteinase-1 expression via activation of extracellular signal-regulated kinase and Sp1 in human fibrosarcoma cells.
Topics: Cell Movement; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fibrosarcoma; Flavonoi | 2006 |
PD98059-inhibited invasion of Dunning rat prostate cancer cells involves suppression of motility but not MMP-2 or uPA secretion.
Topics: Adenocarcinoma; Animals; Cell Adhesion; Cell Line, Tumor; Cell Movement; Extracellular Matrix; Extra | 2006 |
Effects of GM-CSF and M-CSF on tumor progression of lung cancer: roles of MEK1/ERK and AKT/PKB pathways.
Topics: Adenocarcinoma; Cell Death; Cell Line, Tumor; Chromones; Disease Progression; Enzyme Activation; Ext | 2006 |
Cellular prion protein promotes invasion and metastasis of gastric cancer.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; CD8-Positive T-Lymphocytes; Cell Adhesion; En | 2006 |
S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells.
Topics: Blotting, Western; Calcium; Cell Line, Tumor; Cell Movement; Chemotaxis; Chromones; Enzyme Inhibitor | 2007 |
The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells.
Topics: Antibodies, Monoclonal; Autocrine Communication; Breast Neoplasms; Cell Line, Tumor; Cell Movement; | 2007 |
MMP2 role in breast cancer brain metastasis development and its regulation by TIMP2 and ERK1/2.
Topics: Animals; Astrocytes; Brain Neoplasms; Culture Media, Conditioned; Disease Models, Animal; Female; Fl | 2007 |
Resveratrol inhibits heregulin-beta1-mediated matrix metalloproteinase-9 expression and cell invasion in human breast cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Enzyme Activation; Flavonoids | 2008 |
Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells.
Topics: Androstadienes; Apoptosis; Benzenesulfonates; Butadienes; Cell Line, Tumor; Cell Proliferation; Chro | 2008 |
Effect of PD 098059, a specific inhibitor of mitogen-activated protein kinase kinase, on urokinase expression and in vitro invasion.
Topics: Carcinoma, Squamous Cell; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulatio | 1996 |
Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamous Cell; Collagenases; Enzyme Activat | 1998 |
Activation of tissue-factor gene expression in breast carcinoma cells by stimulation of the RAF-ERK signaling pathway.
Topics: Base Sequence; Benzoquinones; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Dactin | 1998 |
PD 098059, an inhibitor of ERK1 activation, attenuates the in vivo invasiveness of head and neck squamous cell carcinoma.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme In | 1999 |
Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration and matrigel invasion.
Topics: Aprotinin; Autocrine Communication; Cell Movement; Collagen; Culture Media, Conditioned; Drug Combin | 2000 |
Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells.
Topics: Breast Neoplasms; Cell Adhesion; Cell Division; Cell Movement; Enzyme Activation; Epithelial Cells; | 2000 |
Fibronectin activates matrix metalloproteinase-9 secretion via the MEK1-MAPK and the PI3K-Akt pathways in ovarian cancer cells.
Topics: Androstadienes; Butadienes; Chromones; Enzyme Inhibitors; Female; Fibronectins; Flavonoids; Humans; | 2000 |
Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells.
Topics: Breast Neoplasms; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulati | 2001 |
U0126, a mitogen-activated protein kinase kinase inhibitor, inhibits the invasion of human A375 melanoma cells.
Topics: Butadienes; Enzyme Inhibitors; Flavonoids; Humans; Matrix Metalloproteinase 9; Melanoma; Mitogen-Act | 2002 |
An inhibitor of stress-activated MAP-kinases reduces invasion and MMP-2 expression of malignant melanoma cells.
Topics: Blotting, Northern; Cell Division; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gelatin; Gene Ex | 2002 |
Aspirin and NS-398 inhibit hepatocyte growth factor-induced invasiveness of human hepatoma cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carcinoma, Hepatocellular; Cyclooxygenase 2; Cyclo | 2002 |