pd 98059 has been researched along with Innate Inflammatory Response in 58 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Inflammation activation and necroptosis involved in CA/CPR-induced CIRI were regulated by the ERK/calpain-2 signaling pathway." | 8.02 | Inhibition of extracellular signal-regulated kinase/calpain-2 pathway reduces neuroinflammation and necroptosis after cerebral ischemia-reperfusion injury in a rat model of cardiac arrest. ( Chen, MH; Li, N; Tian, XY; Wang, WY; Wu, ZJ; Xie, L; Yang, YG; Zhao, GY; Zou, XS, 2021) |
| "Inflammation activation and necroptosis involved in CA/CPR-induced CIRI were regulated by the ERK/calpain-2 signaling pathway." | 4.02 | Inhibition of extracellular signal-regulated kinase/calpain-2 pathway reduces neuroinflammation and necroptosis after cerebral ischemia-reperfusion injury in a rat model of cardiac arrest. ( Chen, MH; Li, N; Tian, XY; Wang, WY; Wu, ZJ; Xie, L; Yang, YG; Zhao, GY; Zou, XS, 2021) |
| "Although green tea polyphenol catechin is considered as a potential anti-inflammatory agent, its effect on bacterial component-induced inflammation has been poorly investigated." | 3.75 | The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits leukocyte activation by bacterial formylpeptide through the receptor FPR. ( Cui, Y; Hou, X; Le, Y; Ruan, L; Wang, JM; Wang, O; Zhu, J, 2009) |
| "Pulpitis was confirmed by hematoxylin-eosin staining." | 1.51 | Nav1.7 via Promotion of ERK in the Trigeminal Ganglion Plays an Important Role in the Induction of Pulpitis Inflammatory Pain. ( Jiang, W; Ni, L; Sun, J; Sun, S; Wang, W, 2019) |
| "Low-grade chronic inflammation is commonly found in patients with polycystic ovary syndrome (PCOS) who exhibit hyperandrogenism or hyperandrogenemia." | 1.42 | Testosterone enhances lipopolysaccharide-induced interleukin-6 and macrophage chemotactic protein-1 expression by activating the extracellular signal-regulated kinase 1/2/nuclear factor-κB signalling pathways in 3T3-L1 adipocytes. ( Chen, M; Huang, H; Lin, J; Su, C, 2015) |
| "Pretreatment with curcumin dose-dependently decreased DEHP-induced expression of ICAM-1 and IL-8 as well as phosphorylation of ERK1/2 and p38." | 1.38 | ICAM-1 and IL-8 are expressed by DEHP and suppressed by curcumin through ERK and p38 MAPK in human umbilical vein endothelial cells. ( Dong, S; Wang, J, 2012) |
| "Bradykinin (BK) is involved in bone resorption in chronic inflammatory diseases." | 1.38 | Chronic bradykinin treatment alters 1α,25-dihydroxyvitamin D3-induced calcium current modulation in pre-osteoblasts. ( Endoh, T; Sueishi, K; Tazaki, M; Uchida, Y, 2012) |
| "Cadmium is an environmentally widely dispersed and highly toxic heavy metal that has been classified as a human carcinogen." | 1.32 | Induction of orphan nuclear receptor Nur77 gene expression and its role in cadmium-induced apoptosis in lung. ( Chung, JH; Lee, BH; Lee, MO; Moon, CK; Oh, SH; Park, JD; Park, KK; Shin, HJ; Yeo, MG, 2004) |
| "In these studies, carrageenan-induced thermal hyperalgesia was evaluated in the mouse and the role of NGF and the MAPK pathway investigated." | 1.31 | Carrageenan-induced thermal hyperalgesia in the mouse: role of nerve growth factor and the mitogen-activated protein kinase pathway. ( Bingham, S; Davey, PT; Parsons, AA; Raval, P; Rogers, D; Sammons, MJ, 2000) |
| "Inflammation is initiated by activation of nuclear factor (NF)-kappaB, and paracellular permeability is enhanced via a Ca2+- and myosin light-chain kinase (MLCK)-dependent pathway." | 1.31 | EPEC-activated ERK1/2 participate in inflammatory response but not tight junction barrier disruption. ( Hecht, G; Koutsouris, A; Ramaswamy, A; Savkovic, SD, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 29 (50.00) | 29.6817 |
| 2010's | 25 (43.10) | 24.3611 |
| 2020's | 4 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, H | 1 |
| Yang, Y | 1 |
| Zhu, M | 1 |
| Shi, X | 1 |
| Ye, L | 1 |
| Zhang, S | 1 |
| Fang, H | 1 |
| Yu, W | 1 |
| Wang, WY | 1 |
| Xie, L | 1 |
| Zou, XS | 1 |
| Li, N | 1 |
| Yang, YG | 1 |
| Wu, ZJ | 1 |
| Tian, XY | 1 |
| Zhao, GY | 1 |
| Chen, MH | 1 |
| Li, J | 2 |
| Jia, Z | 1 |
| Zhang, Q | 1 |
| Dai, J | 1 |
| Kong, J | 1 |
| Fan, Z | 1 |
| Li, G | 1 |
| Liu, J | 2 |
| Li, YY | 1 |
| Andiappan, AK | 1 |
| Yan, Y | 1 |
| Tan, KS | 1 |
| Ong, HH | 1 |
| Thong, KT | 1 |
| Ong, YK | 1 |
| Yu, FG | 1 |
| Low, HB | 1 |
| Zhang, YL | 1 |
| Shi, L | 1 |
| Wang, DY | 1 |
| Sun, S | 1 |
| Sun, J | 1 |
| Jiang, W | 1 |
| Wang, W | 1 |
| Ni, L | 1 |
| Jiang, L | 2 |
| Qiao, Y | 1 |
| Wang, Z | 1 |
| Ma, X | 1 |
| Wang, H | 1 |
| Cha, JJ | 1 |
| Hyun, YY | 1 |
| Jee, YH | 1 |
| Lee, MJ | 2 |
| Han, KH | 1 |
| Kang, YS | 1 |
| Han, SY | 1 |
| Cha, DR | 1 |
| Takizawa, N | 1 |
| Sawada, S | 1 |
| Chosa, N | 1 |
| Ishisaki, A | 1 |
| Naruishi, K | 1 |
| Zhu, J | 2 |
| Liu, Y | 1 |
| Qian, W | 1 |
| Zhou, J | 1 |
| Gao, R | 1 |
| Xiao, H | 1 |
| Wang, J | 2 |
| Lisi, S | 1 |
| Sisto, M | 1 |
| D'Amore, M | 1 |
| Lofrumento, DD | 1 |
| Su, C | 1 |
| Chen, M | 1 |
| Huang, H | 1 |
| Lin, J | 1 |
| Kim, W | 1 |
| Kim, E | 1 |
| Yang, HJ | 1 |
| Kwon, T | 1 |
| Han, S | 1 |
| Lee, S | 1 |
| Youn, H | 1 |
| Jung, Y | 1 |
| Kang, C | 1 |
| Youn, B | 1 |
| Fernandes, CG | 1 |
| Rodrigues, MDN | 1 |
| Seminotti, B | 1 |
| Colín-González, AL | 1 |
| Santamaria, A | 1 |
| Quincozes-Santos, A | 1 |
| Wajner, M | 1 |
| Gonzalez, CD | 1 |
| Ledo, C | 1 |
| Giai, C | 1 |
| Garófalo, A | 1 |
| Gómez, MI | 1 |
| Jandhyala, DM | 1 |
| Ahluwalia, A | 1 |
| Schimmel, JJ | 1 |
| Rogers, AB | 1 |
| Leong, JM | 1 |
| Thorpe, CM | 1 |
| Xiong, C | 1 |
| Huang, Y | 1 |
| Kang, H | 1 |
| Zhang, T | 1 |
| Xu, F | 1 |
| Cai, X | 1 |
| Okazaki, M | 1 |
| Iwasaki, Y | 1 |
| Jing, H | 1 |
| Nishiyama, M | 1 |
| Taguchi, T | 1 |
| Tsugita, M | 1 |
| Taniguchi, Y | 1 |
| Kambayashi, M | 1 |
| Hashimoto, K | 1 |
| Hohensinner, PJ | 1 |
| Kaun, C | 1 |
| Rychli, K | 1 |
| Niessner, A | 1 |
| Pfaffenberger, S | 1 |
| Rega, G | 1 |
| Furnkranz, A | 1 |
| Uhrin, P | 1 |
| Zaujec, J | 1 |
| Afonyushkin, T | 1 |
| Bochkov, VN | 1 |
| Maurer, G | 1 |
| Huber, K | 1 |
| Wojta, J | 1 |
| Chen, HS | 1 |
| He, X | 1 |
| Qu, F | 1 |
| Kang, SM | 1 |
| Yu, Y | 1 |
| Liao, D | 1 |
| Lu, SJ | 1 |
| Wang, O | 1 |
| Ruan, L | 1 |
| Hou, X | 1 |
| Cui, Y | 1 |
| Wang, JM | 1 |
| Le, Y | 1 |
| Ohira, T | 1 |
| Arita, M | 1 |
| Omori, K | 1 |
| Recchiuti, A | 1 |
| Van Dyke, TE | 1 |
| Serhan, CN | 1 |
| Simões, RL | 1 |
| Niconi-de-Almeida, Y | 1 |
| da-Fé, AR | 1 |
| Barja-Fidalgo, C | 1 |
| Fierro, IM | 1 |
| Ara, T | 1 |
| Honjo, K | 1 |
| Fujinami, Y | 1 |
| Hattori, T | 1 |
| Imamura, Y | 1 |
| Wang, PL | 1 |
| Arce, F | 1 |
| Breckpot, K | 1 |
| Stephenson, H | 1 |
| Karwacz, K | 1 |
| Ehrenstein, MR | 1 |
| Collins, M | 1 |
| Escors, D | 1 |
| Healey, JH | 1 |
| Noh, K | 1 |
| Kim, KO | 1 |
| Patel, NR | 1 |
| Staples, JR | 1 |
| Minematsu, H | 1 |
| Nair, K | 1 |
| Lee, FY | 1 |
| Sugiura, S | 1 |
| Ishihara, Y | 1 |
| Komatsu, T | 1 |
| Hagiwara, M | 1 |
| Tanigawa, N | 1 |
| Kato, Y | 1 |
| Mizutani, H | 1 |
| Kawahara, K | 1 |
| Maruyama, I | 1 |
| Noguchi, T | 1 |
| Matsushita, K | 1 |
| Dong, S | 1 |
| Li, B | 1 |
| Lee, DS | 1 |
| Choi, HG | 1 |
| Kim, KS | 1 |
| Kang, DG | 1 |
| Lee, HS | 1 |
| Jeong, GS | 1 |
| Kim, YC | 1 |
| Uchida, Y | 1 |
| Endoh, T | 1 |
| Tazaki, M | 1 |
| Sueishi, K | 1 |
| Jang, M | 1 |
| Jung, HS | 1 |
| Kim, SH | 1 |
| Cho, IH | 1 |
| Bhatt, KH | 1 |
| Sodhi, A | 1 |
| Chakraborty, R | 1 |
| Chen, BR | 1 |
| Cheng, HH | 1 |
| Lin, WC | 1 |
| Wang, KH | 1 |
| Liou, JY | 1 |
| Chen, PF | 1 |
| Wu, KK | 1 |
| Jiang, JX | 1 |
| Zhang, Y | 1 |
| Ji, SH | 1 |
| Zhu, P | 1 |
| Wang, ZG | 1 |
| He, H | 1 |
| Farnell, MB | 1 |
| Kogut, MH | 1 |
| Denkert, C | 1 |
| Koch, I | 1 |
| Berger, S | 1 |
| Köbel, M | 1 |
| Siegert, A | 1 |
| Hauptmann, S | 1 |
| Kapoun, AM | 1 |
| Liang, F | 1 |
| O'Young, G | 1 |
| Damm, DL | 1 |
| Quon, D | 1 |
| White, RT | 1 |
| Munson, K | 1 |
| Lam, A | 1 |
| Schreiner, GF | 1 |
| Protter, AA | 1 |
| Shin, HJ | 1 |
| Lee, BH | 1 |
| Yeo, MG | 1 |
| Oh, SH | 1 |
| Park, JD | 1 |
| Park, KK | 1 |
| Chung, JH | 1 |
| Moon, CK | 1 |
| Lee, MO | 1 |
| Khreiss, T | 1 |
| József, L | 1 |
| Chan, JS | 1 |
| Filep, JG | 1 |
| Lin, SJ | 1 |
| Shyue, SK | 1 |
| Hung, YY | 1 |
| Chen, YH | 1 |
| Ku, HH | 1 |
| Chen, JW | 1 |
| Tam, KB | 1 |
| Chen, YL | 1 |
| Giltiay, NV | 1 |
| Karakashian, AA | 1 |
| Alimov, AP | 1 |
| Ligthle, S | 1 |
| Nikolova-Karakashian, MN | 1 |
| Wang, YY | 1 |
| Myhre, AE | 1 |
| Pettersen, SJ | 1 |
| Dahle, MK | 1 |
| Foster, SJ | 1 |
| Thiemermann, C | 1 |
| Bjørnland, K | 1 |
| Aasen, AO | 1 |
| Wang, JE | 1 |
| Kourylko, O | 1 |
| Fradette, C | 1 |
| Arcand, M | 1 |
| du Souich, P | 1 |
| Sawatzky, DA | 1 |
| Willoughby, DA | 1 |
| Colville-Nash, PR | 1 |
| Rossi, AG | 1 |
| Cho, SJ | 1 |
| Kang, MJ | 1 |
| Homer, RJ | 1 |
| Kang, HR | 1 |
| Zhang, X | 1 |
| Lee, PJ | 1 |
| Elias, JA | 1 |
| Lee, CG | 1 |
| Sell, H | 1 |
| Dietze-Schroeder, D | 1 |
| Kaiser, U | 1 |
| Eckel, J | 1 |
| Lewthwaite, JC | 1 |
| Clarkin, CE | 1 |
| Coates, AR | 1 |
| Poole, S | 1 |
| Lawrence, RA | 1 |
| Wheeler-Jones, CP | 1 |
| Pitsillides, AA | 1 |
| Singh, M | 1 |
| Henderson, B | 1 |
| Zhi, L | 1 |
| Ang, AD | 1 |
| Zhang, H | 1 |
| Moore, PK | 1 |
| Bhatia, M | 1 |
| Kimura, H | 1 |
| Li, X | 1 |
| Torii, K | 1 |
| Okada, T | 1 |
| Takahashi, N | 1 |
| Fujii, H | 1 |
| Ishihara, S | 1 |
| Yoshida, H | 1 |
| Hedges, JC | 1 |
| Singer, CA | 1 |
| Gerthoffer, WT | 1 |
| Sammons, MJ | 1 |
| Raval, P | 1 |
| Davey, PT | 1 |
| Rogers, D | 1 |
| Parsons, AA | 1 |
| Bingham, S | 1 |
| Lee, C | 1 |
| Miura, K | 1 |
| Liu, X | 1 |
| Zweier, JL | 1 |
| Lidington, EA | 1 |
| Haskard, DO | 1 |
| Mason, JC | 1 |
| Lee, J | 1 |
| Mira-Arbibe, L | 1 |
| Ulevitch, RJ | 1 |
| Suzuki, K | 1 |
| Hasegawa, T | 1 |
| Sakamoto, C | 1 |
| Zhou, YM | 1 |
| Hato, F | 1 |
| Hino, M | 1 |
| Tatsumi, N | 1 |
| Kitagawa, S | 1 |
| Ropert, C | 1 |
| Almeida, IC | 1 |
| Closel, M | 1 |
| Travassos, LR | 1 |
| Ferguson, MA | 1 |
| Cohen, P | 1 |
| Gazzinelli, RT | 1 |
| Savkovic, SD | 1 |
| Ramaswamy, A | 1 |
| Koutsouris, A | 1 |
| Hecht, G | 1 |
| McGilvray, ID | 1 |
| Tsai, V | 1 |
| Marshall, JC | 1 |
| Dackiw, AP | 1 |
| Rotstein, OD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Study Of The Usage Of Statins In A Community Heart Failure Population: The Impact of HMG Co-Enzyme A Reductase Inhibitors on Heart Structural Parameters, Brain Naturetic Peptide, Markers of Inflammation and Fibrosis[NCT00795912] | Phase 4 | 56 participants (Actual) | Interventional | 2003-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
58 other studies available for pd 98059 and Innate Inflammatory Response
| Article | Year |
|---|---|
Alteration in the expression of inflammatory cytokines in primary hippocampal astrocytes in response to MK-801 through ERK1/2 and PI3K signals.
Topics: Animals; Animals, Newborn; Apoptosis; Astrocytes; Cell Proliferation; Chromones; Cytokines; Dizocilp | 2021 |
Inhibition of extracellular signal-regulated kinase/calpain-2 pathway reduces neuroinflammation and necroptosis after cerebral ischemia-reperfusion injury in a rat model of cardiac arrest.
Topics: Animals; Brain Ischemia; Calpain; Dipeptides; Disease Models, Animal; Extracellular Signal-Regulated | 2021 |
Inhibition of ERK1/2 phosphorylation attenuates spinal cord injury induced astrocyte activation and inflammation through negatively regulating aquaporin-4 in rats.
Topics: Animals; Aquaporin 4; Astrocytes; Cell Proliferation; Disease Models, Animal; Female; Flavonoids; In | 2021 |
Role of IL-13Rα2 in modulating IL-13-induced MUC5AC and ciliary changes in healthy and CRSwNP mucosa.
Topics: Adolescent; Adult; Cells, Cultured; Dexamethasone; Female; Flavonoids; Glucocorticoids; Humans; Infl | 2018 |
Nav1.7 via Promotion of ERK in the Trigeminal Ganglion Plays an Important Role in the Induction of Pulpitis Inflammatory Pain.
Topics: Animals; Dental Pulp Cavity; Disease Models, Animal; Flavonoids; Gene Expression Regulation; Inflamm | 2019 |
Inhibition of microRNA-103 attenuates inflammation and endoplasmic reticulum stress in atherosclerosis through disrupting the PTEN-mediated MAPK signaling.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Cells, Cultured; Disease Models, Animal; Endoplasmic Re | 2020 |
Plasma concentration of soluble intercellular adhesion molecule-1 (sICAM-1) is elevated in type 2 diabetic patients, and sICAM-1 synthesis is associated with leptin-induced activation of the mitogen-activated protein kinase (MAPK) pathway.
Topics: Albuminuria; Blood Glucose; Body Mass Index; Cells, Cultured; Creatinine; Diabetes Mellitus, Type 2; | 2013 |
Secreted caveolin-1 enhances periodontal inflammation by targeting gingival fibroblasts.
Topics: Anthracenes; Blotting, Western; Caveolin 1; Cell Survival; Cells, Cultured; Extracellular Signal-Reg | 2013 |
MAPK and NF-κB pathways are involved in bisphenol A-induced TNF-α and IL-6 production in BV2 microglial cells.
Topics: Animals; Anthracenes; Anti-Inflammatory Agents; Benzhydryl Compounds; Cell Line; Endocrine Disruptor | 2015 |
Co-culture system of human salivary gland epithelial cells and immune cells from primary Sjögren's syndrome patients: an in vitro approach to study the effects of Rituximab on the activation of the Raf-1/ERK1/2 pathway.
Topics: B-Lymphocytes; Cells, Cultured; Coculture Techniques; Cytokines; Enzyme Activation; Epithelial Cells | 2015 |
Testosterone enhances lipopolysaccharide-induced interleukin-6 and macrophage chemotactic protein-1 expression by activating the extracellular signal-regulated kinase 1/2/nuclear factor-κB signalling pathways in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Chemokine CCL2; Female; Flavonoids; Gene Expression Regulation; I | 2015 |
Inhibition of hedgehog signalling attenuates UVB-induced skin photoageing.
Topics: Aging; Anilides; Animals; Cell Line; Cyclooxygenase 2; Cytokines; Drug Evaluation, Preclinical; Flav | 2015 |
Induction of a Proinflammatory Response in Cortical Astrocytes by the Major Metabolites Accumulating in HMG-CoA Lyase Deficiency: the Role of ERK Signaling Pathway in Cytokine Release.
Topics: Acetyl-CoA C-Acetyltransferase; Amino Acid Metabolism, Inborn Errors; Animals; Antioxidants; Astrocy | 2016 |
The Sbi Protein Contributes to Staphylococcus aureus Inflammatory Response during Systemic Infection.
Topics: Animals; Bacterial Proteins; Binding Sites, Antibody; Carrier Proteins; Chemokine CXCL1; ErbB Recept | 2015 |
Activation of the Classical Mitogen-Activated Protein Kinases Is Part of the Shiga Toxin-Induced Ribotoxic Stress Response and May Contribute to Shiga Toxin-Induced Inflammation.
Topics: Animals; Butadienes; Cell Line; Enterohemorrhagic Escherichia coli; Enzyme Activation; Epithelial Ce | 2016 |
Macrophage Inhibition Factor-Mediated CD74 Signal Modulate Inflammation and Matrix Metabolism in the Degenerated Cartilage Endplate Chondrocytes by Activating Extracellular Signal Regulated Kinase 1/2.
Topics: Adult; Antigens, Differentiation, B-Lymphocyte; Chondrocytes; Female; Flavonoids; Gene Expression; H | 2017 |
Insulin enhancement of cytokine-induced coagulation/inflammation-related gene transcription in hepatocytes.
Topics: Blood Coagulation; Cytokines; Drug Combinations; Flavonoids; Hepatocytes; Humans; Inflammation; Infl | 2008 |
The inflammatory mediator oncostatin M induces stromal derived factor-1 in human adult cardiac cells.
Topics: Adult; Animals; Cells, Cultured; Chemokine CCL1; Chemokine CCL5; Chemokine CXCL12; Fibroblasts; Flav | 2009 |
Differential roles of peripheral mitogen-activated protein kinase signal transduction pathways in bee venom-induced nociception and inflammation in conscious rats.
Topics: Animals; Bee Venoms; Behavior, Animal; Enzyme Inhibitors; Flavonoids; Hyperalgesia; Imidazoles; Infl | 2009 |
The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits leukocyte activation by bacterial formylpeptide through the receptor FPR.
Topics: Animals; Antioxidants; Calcium-Calmodulin-Dependent Protein Kinases; Camellia sinensis; Catechin; Ce | 2009 |
Resolvin E1 receptor activation signals phosphorylation and phagocytosis.
Topics: Animals; Cell Differentiation; CHO Cells; Cricetinae; Cricetulus; Eicosapentaenoic Acid; Flavonoids; | 2010 |
A synthetic analog of 15-epi-lipoxin A4 inhibits human monocyte apoptosis: involvement of ERK-2 and PI3-kinase.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Survival; Chrom | 2010 |
Preventive effects of a kampo medicine, orento on inflammatory responses in lipopolysaccharide treated human gingival fibroblasts.
Topics: Acetyltransferases; Anti-Inflammatory Agents; Cell Proliferation; Cell Survival; Dinoprostone; Dose- | 2010 |
Selective ERK activation differentiates mouse and human tolerogenic dendritic cells, expands antigen-specific regulatory T cells, and suppresses experimental inflammatory arthritis.
Topics: Analysis of Variance; Animals; Arthritis, Experimental; Butadienes; Cell Differentiation; Cell Line; | 2011 |
Commentary on an article by Kyucheol Noh, MD, et al.: "Targeting inflammatory kinase as an adjuvant treatment for osteosarcomas".
Topics: Animals; Apoptosis; Bone Neoplasms; Cell Death; Cell Survival; Doxorubicin; Flavonoids; Humans; Infl | 2011 |
Targeting inflammatory kinase as an adjuvant treatment for osteosarcomas.
Topics: Animals; Apoptosis; Bone Neoplasms; Cell Death; Cell Survival; Doxorubicin; Flavonoids; Flow Cytomet | 2011 |
Valproic acid increases susceptibility to endotoxin shock through enhanced release of high-mobility group box 1.
Topics: Animals; Blotting, Western; Cell Line; Cell Survival; Endotoxemia; Flavonoids; HMGB1 Protein; Inflam | 2011 |
ICAM-1 and IL-8 are expressed by DEHP and suppressed by curcumin through ERK and p38 MAPK in human umbilical vein endothelial cells.
Topics: Cell Line; Cell Survival; Curcumin; Diethylhexyl Phthalate; Endothelium, Vascular; Extracellular Sig | 2012 |
Sauchinone suppresses pro-inflammatory mediators by inducing heme oxygenase-1 in RAW264.7 macrophages.
Topics: Animals; Anti-Inflammatory Agents; Benzopyrans; Cell Line; Cyclooxygenase 2; Dioxoles; Drug Evaluati | 2011 |
Chronic bradykinin treatment alters 1α,25-dihydroxyvitamin D3-induced calcium current modulation in pre-osteoblasts.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Barium; Bone Resorption; Bradykinin; Calcit | 2012 |
Ethyl pyruvate attenuates formalin-induced inflammatory nociception by inhibiting neuronal ERK phosphorylation.
Topics: Animals; CD11 Antigens; Cell Shape; Edema; Extracellular Signal-Regulated MAP Kinases; Flavonoids; F | 2012 |
Peptidoglycan induced expression of peroxisome proliferator-activated receptor γ in mouse peritoneal macrophages: role of ERK and JNK MAP kinases.
Topics: Animals; Anthracenes; Cells, Cultured; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases | 2012 |
Quiescent fibroblasts are more active in mounting robust inflammatory responses than proliferative fibroblasts.
Topics: Acetophenones; Benzopyrans; Cell Movement; Cell Proliferation; Chromones; Cyclooxygenase 2; Enzyme I | 2012 |
Kinetics of mitogen-activated protein kinase family in lipopolysaccharide-stimulated mouse Kupffer cells and their role in cytokine production.
Topics: Animals; Cytokines; Female; Flavonoids; Imidazoles; Inflammation; Interleukin-10; Kinetics; Kupffer | 2002 |
Inflammatory agonist stimulation and signal pathway of oxidative burst in neonatal chicken heterophils.
Topics: Animals; Animals, Newborn; Chickens; Enzyme Inhibitors; Flavonoids; Fluoresceins; Imidazoles; Inflam | 2003 |
Cytokine-suppressive anti-inflammatory drugs (CSAIDs) inhibit invasion and MMP-1 production of ovarian carcinoma cells.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Collagen; Cytokines; Drug Combinations; Enz | 2003 |
B-type natriuretic peptide exerts broad functional opposition to transforming growth factor-beta in primary human cardiac fibroblasts: fibrosis, myofibroblast conversion, proliferation, and inflammation.
Topics: Adolescent; Blotting, Western; Butadienes; Cell Division; Cells, Cultured; Cyclic GMP; Enzyme Inhibi | 2004 |
Induction of orphan nuclear receptor Nur77 gene expression and its role in cadmium-induced apoptosis in lung.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cadmium; Cell Line, Tumor; Cell Survival; Cyclic AMP | 2004 |
Activation of extracellular signal-regulated kinase couples platelet-activating factor-induced adhesion and delayed apoptosis of human neutrophils.
Topics: Androstadienes; Apoptosis; bcl-Associated Death Protein; Carrier Proteins; Caspase 3; Caspases; CD11 | 2004 |
Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1 induced by tumor necrosis factor-alpha in human endothelial cells through the JNK/p38 pathways.
Topics: Anthracenes; Aorta; Arteriosclerosis; Cell Adhesion; Depression, Chemical; Endothelial Cells; Endoth | 2005 |
Ceramide- and ERK-dependent pathway for the activation of CCAAT/enhancer binding protein by interleukin-1beta in hepatocytes.
Topics: Active Transport, Cell Nucleus; Acute-Phase Proteins; Animals; Biological Transport; CCAAT-Enhancer- | 2005 |
Peptidoglycan of Staphylococcus aureus induces enhanced levels of matrix metalloproteinase-9 in human blood originating from neutrophils.
Topics: Chromones; Dose-Response Relationship, Drug; Endotoxemia; Enzyme Inhibitors; Enzyme-Linked Immunosor | 2005 |
Modulation of CYP1A2 and CYP3A6 catalytic activities by serum from rabbits with a turpentine-induced inflammatory reaction and interleukin 6.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Catalysis; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochr | 2006 |
The involvement of the apoptosis-modulating proteins ERK 1/2, Bcl-xL and Bax in the resolution of acute inflammation in vivo.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Blotting, Western; Carrageenan; Disea | 2006 |
Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling.
Topics: Animals; Bronchoalveolar Lavage; Caspases; Cell Death; Collagen; DNA; Early Growth Response Protein | 2006 |
Monocyte chemotactic protein-1 is a potential player in the negative cross-talk between adipose tissue and skeletal muscle.
Topics: Adipocytes; Adipose Tissue; Adult; Breast; Cells, Cultured; Chemokine CCL2; Chemokines; Cytokines; D | 2006 |
Highly homologous Mycobacterium tuberculosis chaperonin 60 proteins with differential CD14 dependencies stimulate cytokine production by human monocytes through cooperative activation of p38 and ERK1/2 mitogen-activated protein kinases.
Topics: Cells, Cultured; Chaperonin 60; Cytokines; Extracellular Signal-Regulated MAP Kinases; Flavonoids; H | 2007 |
Hydrogen sulfide induces the synthesis of proinflammatory cytokines in human monocyte cell line U937 via the ERK-NF-kappaB pathway.
Topics: CD11b Antigen; Cell Line; Cytokines; Dose-Response Relationship, Drug; Extracellular Signal-Regulate | 2007 |
A natural PPAR-gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, may act as an enhancer of PAI-1 in human proximal renal tubular cells under hypoxic and inflammatory conditions.
Topics: Cell Hypoxia; Cells, Cultured; Flavonoids; Genistein; Humans; Inflammation; Kidney Tubules, Proximal | 2008 |
Mitogen-activated protein kinases regulate cytokine gene expression in human airway myocytes.
Topics: Anti-Inflammatory Agents; Bronchi; Cell Line; Cytokines; Enzyme Activation; Enzyme Inhibitors; Flavo | 2000 |
Carrageenan-induced thermal hyperalgesia in the mouse: role of nerve growth factor and the mitogen-activated protein kinase pathway.
Topics: Analgesics, Opioid; Animals; Carrageenan; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Flavonoids; | 2000 |
Biphasic regulation of leukocyte superoxide generation by nitric oxide and peroxynitrite.
Topics: Blotting, Western; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electron Spin Resonance S | 2000 |
Induction of decay-accelerating factor by thrombin through a protease-activated receptor 1 and protein kinase C-dependent pathway protects vascular endothelial cells from complement-mediated injury.
Topics: CD55 Antigens; Cells, Cultured; Complement Activation; Complement System Proteins; Endothelial Growt | 2000 |
TAK1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide.
Topics: Androstadienes; Animals; Apoptosis; Cell Line; Chromones; Cysteine Proteinase Inhibitors; Enzyme Act | 2000 |
Cleavage of mitogen-activated protein kinases in human neutrophils undergoing apoptosis: role in decreased responsiveness to inflammatory cytokines.
Topics: Adult; Apoptosis; Caspases; Cell Adhesion; Cell Survival; Cells, Cultured; Cycloheximide; Cytokines; | 2001 |
Requirement of mitogen-activated protein kinases and I kappa B phosphorylation for induction of proinflammatory cytokines synthesis by macrophages indicates functional similarity of receptors triggered by glycosylphosphatidylinositol anchors from parasiti
Topics: Activating Transcription Factor 2; Animals; Cyclic AMP Response Element-Binding Protein; Cytokines; | 2001 |
EPEC-activated ERK1/2 participate in inflammatory response but not tight junction barrier disruption.
Topics: Calcium; Cells, Cultured; DNA-Binding Proteins; Electric Impedance; Enzyme Activation; Enzyme Inhibi | 2001 |
Monocyte adhesion and transmigration induce tissue factor expression: role of the mitogen-activated protein kinases.
Topics: Antibodies; CD18 Antigens; Cell Adhesion; Cell Movement; Cells, Cultured; Enzyme Activation; Enzyme | 2002 |