pd 98059 has been researched along with Idiopathic Parkinson Disease in 6 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Icariin pretreatment could ameliorate the decreased striatum DA content and the loss of TH-IR neurons in the SNpc induced by MPTP." | 1.46 | Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson's disease: Involvement of PI3K/Akt and MEK/ERK signaling pathways. ( Chen, L; Chen, WF; Chen, XH; Du, ZR; Teng, JJ; Wong, MS; Wu, L; Xu, AL, 2017) |
| "It is thought that Parkinson's disease involves apoptosis, and NGF prevents apoptosis in an in vivo model system." | 1.31 | Nerve growth factor prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells: relevance to therapeutical application for Parkinson's disease. ( Chiba, H; Shimoke, K, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, WF | 1 |
| Wu, L | 1 |
| Du, ZR | 1 |
| Chen, L | 1 |
| Xu, AL | 1 |
| Chen, XH | 1 |
| Teng, JJ | 1 |
| Wong, MS | 1 |
| Sun, X | 1 |
| Huang, L | 1 |
| Zhang, M | 1 |
| Sun, S | 1 |
| Wu, Y | 1 |
| Wang, G | 1 |
| Qi, C | 1 |
| Fan, GH | 1 |
| Zhou, HY | 1 |
| Chen, SD | 1 |
| Weng, Z | 1 |
| Signore, AP | 1 |
| Gao, Y | 1 |
| Wang, S | 1 |
| Zhang, F | 1 |
| Hastings, T | 1 |
| Yin, XM | 1 |
| Chen, J | 1 |
| Shimoke, K | 1 |
| Chiba, H | 1 |
| Kulich, SM | 1 |
| Chu, CT | 1 |
6 other studies available for pd 98059 and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson's disease: Involvement of PI3K/Akt and MEK/ERK signaling pathways.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Chromones; Corpus Striatum; Disease Models, A | 2017 |
Insulin like growth factor-1 prevents 1-mentyl-4-phenylphyridinium-induced apoptosis in PC12 cells through activation of glycogen synthase kinase-3beta.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis; Blotting, Western; Cell Survival; | 2010 |
PACAP protects neuronal differentiated PC12 cells against the neurotoxicity induced by a mitochondrial complex I inhibitor, rotenone.
Topics: Animals; Bucladesine; Caspase 3; Caspases; Cell Differentiation; Cell Survival; Colforsin; Dose-Resp | 2005 |
Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling.
Topics: Adipocytes; Animals; Apoptosis; Caspase 3; Caspase 9; Catecholamines; Cell Line; Cell Survival; CREB | 2007 |
Nerve growth factor prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells: relevance to therapeutical application for Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amino Acid Chloromethyl Ketones; Amino Acid Substituti | 2001 |
Sustained extracellular signal-regulated kinase activation by 6-hydroxydopamine: implications for Parkinson's disease.
Topics: Animals; Cell Line; Cell Survival; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Fla | 2001 |