pd 98059 has been researched along with Hypoxia in 37 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The study investigated the functional consequences of chronic intermittent hypoxia (CIH) on aortic constriction induced by angiotensin II (Ang II) and the possible signaling involving ERK1/2 and contractile proteins such as myosin light chain kinase (MLCK), myosin phosphatase targeting subunit (MYPT1) and myosin light chain (MLC)." | 7.79 | ERK signaling mediates enhanced angiotensin II-induced rat aortic constriction following chronic intermittent hypoxia. ( Deng, Y; Guo, XL; Liu, HG; Liu, K; Shang, J; Xu, YJ, 2013) |
| " We studied the involvement of mitogen-activated protein (MAP) kinase in hypoxia-induced apoptosis using cobalt chloride in C6 glioma cells." | 7.72 | Cobalt chloride-induced apoptosis and extracellular signal-regulated protein kinase 1/2 activation in rat C6 glioma cells. ( Kim, T; Kim, Y; Lee, H; Lee, I; Pyen, J; Yang, SJ, 2004) |
| "Tissue hypoxemia is common in several pathological diseases, including vaso-occlusion in sickle cell disease and myocardial infarction." | 5.33 | A novel role of hypoxia-inducible factor in cobalt chloride- and hypoxia-mediated expression of IL-8 chemokine in human endothelial cells. ( Gonsalves, C; Johnson, C; Kalra, VK; Kim, KS; Rajagopal, V, 2006) |
| " The study investigated the functional consequences of chronic intermittent hypoxia (CIH) on aortic constriction induced by angiotensin II (Ang II) and the possible signaling involving ERK1/2 and contractile proteins such as myosin light chain kinase (MLCK), myosin phosphatase targeting subunit (MYPT1) and myosin light chain (MLC)." | 3.79 | ERK signaling mediates enhanced angiotensin II-induced rat aortic constriction following chronic intermittent hypoxia. ( Deng, Y; Guo, XL; Liu, HG; Liu, K; Shang, J; Xu, YJ, 2013) |
| " In vivo experiments in rats revealed that Egr-1 protein increases, whereas 11beta-HSD2 mRNA decreases, in kidney tissue after unilateral renal ischemia and in humans the renal activity of 11beta-HSD2 as assessed by the urinary ratio of (tetrahydrocortisol+5alpha-tetrahydrocortisol)/tetrahydrocortisone declined when volunteers were exposed to hypoxemia at high altitude up to 7000 m." | 3.72 | Hypoxia causes down-regulation of 11 beta-hydroxysteroid dehydrogenase type 2 by induction of Egr-1. ( Dick, B; Ferrari, P; Frey, BM; Frey, FJ; Heiniger, CD; Kostadinova, RM; Rochat, MK; Serra, A, 2003) |
| " We studied the involvement of mitogen-activated protein (MAP) kinase in hypoxia-induced apoptosis using cobalt chloride in C6 glioma cells." | 3.72 | Cobalt chloride-induced apoptosis and extracellular signal-regulated protein kinase 1/2 activation in rat C6 glioma cells. ( Kim, T; Kim, Y; Lee, H; Lee, I; Pyen, J; Yang, SJ, 2004) |
| "Tissue hypoxemia is common in several pathological diseases, including vaso-occlusion in sickle cell disease and myocardial infarction." | 1.33 | A novel role of hypoxia-inducible factor in cobalt chloride- and hypoxia-mediated expression of IL-8 chemokine in human endothelial cells. ( Gonsalves, C; Johnson, C; Kalra, VK; Kim, KS; Rajagopal, V, 2006) |
| "Addition of PGE(2) to PC-3ML human prostate cancer cells had no effect on HIF-1alpha mRNA levels." | 1.31 | Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line. ( Dosoretz, A; Holland, JF; Kirschenbaum, A; Levine, AC; Liu, XH; Lu, M; Yao, S, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (8.11) | 18.2507 |
| 2000's | 25 (67.57) | 29.6817 |
| 2010's | 9 (24.32) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fu, C | 1 |
| Li, N | 1 |
| Yuan, Y | 1 |
| Wang, R | 1 |
| Chen, J | 1 |
| Yang, J | 1 |
| Guo, Z | 1 |
| Wang, S | 1 |
| Zhang, Y | 1 |
| Liu, Y | 2 |
| Dong, J | 1 |
| Tan, Y | 1 |
| Nie, W | 1 |
| Chen, C | 2 |
| He, X | 1 |
| Xu, Y | 1 |
| Ma, X | 1 |
| Zhang, J | 1 |
| Tan, M | 1 |
| Rong, P | 1 |
| Wang, W | 1 |
| Zhang, QL | 1 |
| Cui, BR | 1 |
| Li, HY | 1 |
| Li, P | 1 |
| Hong, L | 1 |
| Liu, LP | 1 |
| Ding, DZ | 1 |
| Cui, X | 1 |
| Guo, XL | 1 |
| Deng, Y | 1 |
| Shang, J | 1 |
| Liu, K | 1 |
| Xu, YJ | 1 |
| Liu, HG | 1 |
| Cong, B | 1 |
| Wang, L | 1 |
| Zhu, X | 2 |
| Li, X | 1 |
| Liu, B | 1 |
| Ni, X | 1 |
| Dai, T | 1 |
| Zheng, H | 1 |
| Fu, GS | 1 |
| Chang, K | 1 |
| Xiao, D | 1 |
| Huang, X | 1 |
| Longo, LD | 1 |
| Zhang, L | 1 |
| Milano, G | 1 |
| von Segesser, LK | 1 |
| Morel, S | 1 |
| Joncic, A | 1 |
| Bianciardi, P | 1 |
| Vassalli, G | 1 |
| Samaja, M | 1 |
| Fu, H | 1 |
| Luo, F | 1 |
| Yang, L | 1 |
| Wu, W | 1 |
| Liu, X | 1 |
| Biswas, I | 1 |
| Garg, I | 1 |
| Singh, B | 1 |
| Khan, GA | 1 |
| Milner, PI | 1 |
| Smith, HC | 1 |
| Robinson, R | 1 |
| Wilkins, RJ | 1 |
| Gibson, JS | 1 |
| Liu, XH | 1 |
| Kirschenbaum, A | 1 |
| Lu, M | 1 |
| Yao, S | 1 |
| Dosoretz, A | 1 |
| Holland, JF | 1 |
| Levine, AC | 1 |
| Heiniger, CD | 1 |
| Kostadinova, RM | 1 |
| Rochat, MK | 1 |
| Serra, A | 1 |
| Ferrari, P | 1 |
| Dick, B | 1 |
| Frey, BM | 1 |
| Frey, FJ | 1 |
| Kietzmann, T | 1 |
| Jungermann, K | 1 |
| Görlach, A | 1 |
| Yoo, YG | 2 |
| Oh, SH | 1 |
| Park, ES | 1 |
| Cho, H | 1 |
| Lee, N | 1 |
| Park, H | 2 |
| Kim, DK | 2 |
| Yu, DY | 1 |
| Seong, JK | 1 |
| Lee, MO | 2 |
| Watanabe, D | 1 |
| Takagi, H | 1 |
| Suzuma, K | 1 |
| Suzuma, I | 1 |
| Oh, H | 1 |
| Ohashi, H | 1 |
| Kemmochi, S | 1 |
| Uemura, A | 1 |
| Ojima, T | 1 |
| Suganami, E | 1 |
| Miyamoto, N | 1 |
| Sato, Y | 1 |
| Honda, Y | 1 |
| Yeo, MG | 1 |
| Mizukami, Y | 1 |
| Iwamatsu, A | 1 |
| Aki, T | 1 |
| Kimura, M | 1 |
| Nakamura, K | 1 |
| Nao, T | 1 |
| Okusa, T | 1 |
| Matsuzaki, M | 1 |
| Yoshida, K | 1 |
| Kobayashi, S | 1 |
| Yang, SJ | 1 |
| Pyen, J | 1 |
| Lee, I | 1 |
| Lee, H | 1 |
| Kim, Y | 1 |
| Kim, T | 1 |
| Chao, W | 1 |
| Shen, Y | 2 |
| Zhao, H | 1 |
| Novikov, M | 1 |
| Schmidt, U | 1 |
| Rosenzweig, A | 1 |
| Liu, C | 1 |
| Shi, Y | 1 |
| Du, Y | 1 |
| Ning, X | 1 |
| Liu, N | 1 |
| Huang, D | 1 |
| Liang, J | 1 |
| Xue, Y | 1 |
| Fan, D | 1 |
| Kilic, E | 1 |
| Kilic, U | 1 |
| Soliz, J | 1 |
| Bassetti, CL | 1 |
| Gassmann, M | 1 |
| Hermann, DM | 1 |
| Lü, CL | 1 |
| Ye, H | 2 |
| Tang, XB | 1 |
| Zhu, DL | 1 |
| Woo, KJ | 1 |
| Lee, TJ | 1 |
| Park, JW | 1 |
| Kwon, TK | 1 |
| Frede, S | 1 |
| Stockmann, C | 1 |
| Freitag, P | 1 |
| Fandrey, J | 1 |
| Yu, L | 1 |
| Quinn, DA | 1 |
| Garg, HG | 1 |
| Hales, CA | 1 |
| Kim, KS | 1 |
| Rajagopal, V | 1 |
| Gonsalves, C | 1 |
| Johnson, C | 2 |
| Kalra, VK | 2 |
| Lu, C | 1 |
| Tang, X | 1 |
| Zhu, D | 1 |
| Ibe, BO | 1 |
| Abdallah, MF | 1 |
| Portugal, AM | 1 |
| Raj, JU | 1 |
| Sultana, C | 1 |
| Adayev, T | 1 |
| El-Sherif, Y | 1 |
| Barua, M | 1 |
| Penington, NJ | 1 |
| Banerjee, P | 1 |
| Richard, DE | 1 |
| Berra, E | 1 |
| Gothié, E | 1 |
| Roux, D | 1 |
| Pouysségur, J | 1 |
| Martín, ME | 1 |
| Muñoz, FM | 1 |
| Salinas, M | 1 |
| Fando, JL | 1 |
| Pore, N | 1 |
| Behrooz, A | 1 |
| Ismail-Beigi, F | 1 |
| Maity, A | 1 |
| Sun, HY | 1 |
| Zhao, RR | 1 |
| Zhi, JM | 1 |
| Seta, KA | 1 |
| Kim, R | 1 |
| Kim, HW | 1 |
| Millhorn, DE | 1 |
| Beitner-Johnson, D | 1 |
| Jin, K | 1 |
| Mao, XO | 1 |
| Zhu, Y | 1 |
| Greenberg, DA | 1 |
37 other studies available for pd 98059 and Hypoxia
| Article | Year |
|---|---|
Chronic intermittent hypobaric hypoxia provides vascular protection in the aorta of the 2-kidney, 1-clip rat model of hypertension.
Topics: Acetylcholine; Animals; Anthracenes; Aorta; Basic Helix-Loop-Helix Transcription Factors; Blood Pres | 2018 |
Mesenchymal stem cells alleviate hypoxia-induced oxidative stress and enhance the pro-survival pathways in porcine islets.
Topics: Animals; Apoptosis; Blotting, Western; Cell Death; Cell Survival; Flavonoids; Flow Cytometry; Humans | 2019 |
MAPK and PI3K pathways regulate hypoxia-induced atrial natriuretic peptide secretion by controlling HIF-1 alpha expression in beating rabbit atria.
Topics: Animals; Atrial Natriuretic Factor; Chromones; Female; Flavonoids; Heart Atria; Hypoxia; Hypoxia-Ind | 2013 |
ERK signaling mediates enhanced angiotensin II-induced rat aortic constriction following chronic intermittent hypoxia.
Topics: Angiotensin II; Animals; Aorta; Flavonoids; Hypoxia; Male; MAP Kinase Signaling System; Phosphorylat | 2013 |
SGK1 is involved in cardioprotection of urocortin-1 against hypoxia/reoxygenation in cardiomyocytes.
Topics: Animals; Animals, Newborn; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, C | 2014 |
Hypoxia confers protection against apoptosis via the PI3K/Akt pathway in endothelial progenitor cells.
Topics: Animals; Apoptosis; Cells, Cultured; Chromones; Endothelial Cells; Enzyme Activation; Enzyme Inhibit | 2008 |
Chronic hypoxia increases pressure-dependent myogenic tone of the uterine artery in pregnant sheep: role of ERK/PKC pathway.
Topics: Altitude; Animals; Arteries; Blood Pressure; Calcium; Carcinogens; Chronic Disease; Enzyme Inhibitor | 2009 |
Phosphorylation of phosphatidylinositol-3-kinase-protein kinase B and extracellular signal-regulated kinases 1/2 mediate reoxygenation-induced cardioprotection during hypoxia.
Topics: Animals; Chromones; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hypox | 2010 |
Hypoxia stimulates the expression of macrophage migration inhibitory factor in human vascular smooth muscle cells via HIF-1alpha dependent pathway.
Topics: Cell Movement; Cell Proliferation; Cells, Cultured; Endothelium, Vascular; Extracellular Signal-Regu | 2010 |
A key role of toll-like receptor 3 in tissue factor activation through extracellular signal regulated kinase 1/2 pathway in a murine hypoxia model.
Topics: Animals; Antibodies, Neutralizing; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinase | 2012 |
Growth factor regulation of intracellular pH homeostasis under hypoxic conditions in isolated equine articular chondrocytes.
Topics: Acid-Base Equilibrium; Androstadienes; Animals; Cartilage, Articular; Chondrocytes; Flavonoids; Home | 2013 |
Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line.
Topics: Active Transport, Cell Nucleus; Arachidonic Acid; Catalysis; Cell Nucleus; Culture Media, Serum-Free | 2002 |
Hypoxia causes down-regulation of 11 beta-hydroxysteroid dehydrogenase type 2 by induction of Egr-1.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Animals; Antimycin A; Cell Hypoxia; Cell Line; Cortison | 2003 |
Regulation of the hypoxia-dependent plasminogen activator inhibitor 1 expression by MAP kinases.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Line; Densitometry; Enzyme Inhibitors; Flavonoi | 2003 |
Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway.
Topics: Active Transport, Cell Nucleus; Androstadienes; Animals; Blotting, Western; Cell Line; Cell Nucleus; | 2003 |
Transcription factor Ets-1 mediates ischemia- and vascular endothelial growth factor-dependent retinal neovascularization.
Topics: Adenoviridae; Angiopoietin-2; Animals; Blotting, Northern; Blotting, Western; Butadienes; Carbazoles | 2004 |
Novel function of orphan nuclear receptor Nur77 in stabilizing hypoxia-inducible factor-1alpha.
Topics: Animals; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Nucleus; Disease Progression; DNA-Bind | 2004 |
ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation.
Topics: Adenosine Triphosphate; Animals; Cell Death; Flavonoids; Hypoxia; MAP Kinase Kinase Kinases; Mitogen | 2004 |
Cobalt chloride-induced apoptosis and extracellular signal-regulated protein kinase 1/2 activation in rat C6 glioma cells.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Nucleus; Cell Size; Cobalt; DNA Fragmentation; DNA-Bindin | 2004 |
Lipopolysaccharide improves cardiomyocyte survival and function after serum deprivation.
Topics: Adenoviridae; Androstadienes; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Calcium; Casp | 2005 |
Dual-specificity phosphatase DUSP1 protects overactivation of hypoxia-inducible factor 1 through inactivating ERK MAPK.
Topics: Cell Cycle Proteins; Cell Line, Tumor; Dual Specificity Phosphatase 1; Extracellular Signal-Regulate | 2005 |
Brain-derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and Akt pathways.
Topics: Androstadienes; Animals; bcl-X Protein; Brain; Brain Ischemia; Enzyme Activation; Enzyme Inhibitors; | 2005 |
ERK1/2 signaling pathway is involved in 15-hydroxyeicosatetraenoic acid-induced hypoxic pulmonary vasoconstriction.
Topics: Animals; Flavonoids; Hydroxyeicosatetraenoic Acids; Hypoxia; Male; MAP Kinase Signaling System; Musc | 2005 |
Desferrioxamine, an iron chelator, enhances HIF-1alpha accumulation via cyclooxygenase-2 signaling pathway.
Topics: Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Deferoxamine; Ferric Compounds; Fl | 2006 |
Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB.
Topics: Adrenomedullin; Cell Line; Electrophoretic Mobility Shift Assay; Flavonoids; Humans; Hypoxia; Hypoxi | 2006 |
Gene expression of cyclin-dependent kinase inhibitors and effect of heparin on their expression in mice with hypoxia-induced pulmonary hypertension.
Topics: Animals; Cell Cycle Proteins; Cells, Cultured; Cyclin D2; Cyclin-Dependent Kinase 2; Cyclin-Dependen | 2006 |
A novel role of hypoxia-inducible factor in cobalt chloride- and hypoxia-mediated expression of IL-8 chemokine in human endothelial cells.
Topics: Base Sequence; Cell Line, Transformed; Cells, Cultured; Chemokine CCL2; Chemotaxis, Leukocyte; Chrom | 2006 |
Role of 15-hydroxyeicosatetraenoic acid in phosphorylation of ERK1/2 and caldesmon in pulmonary arterial smooth muscle cells.
Topics: Animals; Blotting, Western; Calmodulin-Binding Proteins; Cell Nucleus; Cytosol; Enzyme Inhibitors; F | 2006 |
Platelet-activating factor stimulates ovine foetal pulmonary vascular smooth muscle cell proliferation: role of nuclear factor-kappa B and cyclin-dependent kinases.
Topics: Animals; Azepines; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinases; Dose-Response Rela | 2008 |
Cobalt chloride-induced signaling in endothelium leading to the augmented adherence of sickle red blood cells and transendothelial migration of monocyte-like HL-60 cells is blocked by PAF-receptor antagonist.
Topics: Adult; Anemia, Sickle Cell; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesi | 1999 |
Agonist stimulation of the serotonin1A receptor causes suppression of anoxia-induced apoptosis via mitogen-activated protein kinase in neuronal HN2-5 cells.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Androstadienes; Animals; Apoptosis; Calcium; Calcium-Calmodu | 1999 |
p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.
Topics: Animals; Cells, Cultured; DNA-Binding Proteins; Enzyme Inhibitors; Estradiol; Flavonoids; Gene Expre | 1999 |
Ischaemia induces changes in the association of the binding protein 4E-BP1 and eukaryotic initiation factor (eIF) 4G to eIF4E in differentiated PC12 cells.
Topics: Animals; Antibiotics, Antineoplastic; Carrier Proteins; Cell Survival; Enzyme Inhibitors; Eukaryotic | 2000 |
Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia.
Topics: Animals; Base Sequence; Cell Line, Transformed; Chromones; DNA; DNA-Binding Proteins; Down-Regulatio | 2001 |
Insulin-like growth factor I inhibits cardiomyocyte apoptosis and the underlying signal transduction pathways.
Topics: Androstadienes; Animals; Apoptosis; Cells, Cultured; DNA Fragmentation; Electrophoresis, Gel, Two-Di | 2000 |
Hypoxia-induced regulation of MAPK phosphatase-1 as identified by subtractive suppression hybridization and cDNA microarray analysis.
Topics: Animals; Blotting, Northern; Blotting, Western; Calcium; Cell Cycle Proteins; Cell Nucleus; Cobalt; | 2001 |
MEK and ERK protect hypoxic cortical neurons via phosphorylation of Bad.
Topics: Animals; bcl-Associated Death Protein; Brain Diseases; Carrier Proteins; Cell Survival; Cells, Cultu | 2002 |