pd 98059 has been researched along with Hypertrophy in 20 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Hypertrophy: General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our results show that leptin induced glomerular mesangial cell hypertrophy via PI 3-kinase and ERK1/2, and that hyperplasia and apoptosis were not altered by leptin." | 7.73 | Leptin induces rat glomerular mesangial cell hypertrophy, but does not regulate hyperplasia or apoptosis. ( Lee, MP; Orlov, D; Sweeney, G, 2005) |
| "The aim of this study was to evaluate in vivo the antiproliferative effect of an inhibitor of isoprenoids metabolism, lovastatin, in an experimental model of propylthiouracil-induced goiter." | 7.73 | HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway. ( Bifulco, M; Carella, C; Fiorentino, L; Gazzerro, P; Gerbasio, D; Laezza, C; Matarese, G; Mazziotti, G; Portella, G, 2006) |
| "Angiotensin II (Ang II), which is an important mediator of both vascular responsiveness and growth, has been shown to induce vascular smooth muscle cell (VSMC) hypertrophy via the activation of a complex series of intracellular signaling events." | 7.73 | Inhibitory effect of Hsp70 on angiotensin II-induced vascular smooth muscle cell hypertrophy. ( Im, CN; Seo, JS; Zheng, Y, 2006) |
| "Angiotensin II (AngII) induces G(1) phase arrest and hypertrophy of cultured renal proximal tubular cells." | 7.70 | Reactive oxygen species stimulate p44/42 mitogen-activated protein kinase and induce p27(Kip1): role in angiotensin II-mediated hypertrophy of proximal tubular cells. ( Hannken, T; Schroeder, R; Stahl, RAK; Wolf, G; Zahner, G, 2000) |
| "Taurine is a well documented antioxidant agent." | 5.35 | Effect of taurine on advanced glycation end products-induced hypertrophy in renal tubular epithelial cells. ( Chuang, LY; Guh, JY; Hsu, MS; Huang, JS; Yang, YL, 2008) |
| "Our results show that leptin induced glomerular mesangial cell hypertrophy via PI 3-kinase and ERK1/2, and that hyperplasia and apoptosis were not altered by leptin." | 3.73 | Leptin induces rat glomerular mesangial cell hypertrophy, but does not regulate hyperplasia or apoptosis. ( Lee, MP; Orlov, D; Sweeney, G, 2005) |
| "The aim of this study was to evaluate in vivo the antiproliferative effect of an inhibitor of isoprenoids metabolism, lovastatin, in an experimental model of propylthiouracil-induced goiter." | 3.73 | HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway. ( Bifulco, M; Carella, C; Fiorentino, L; Gazzerro, P; Gerbasio, D; Laezza, C; Matarese, G; Mazziotti, G; Portella, G, 2006) |
| "Angiotensin II (Ang II), which is an important mediator of both vascular responsiveness and growth, has been shown to induce vascular smooth muscle cell (VSMC) hypertrophy via the activation of a complex series of intracellular signaling events." | 3.73 | Inhibitory effect of Hsp70 on angiotensin II-induced vascular smooth muscle cell hypertrophy. ( Im, CN; Seo, JS; Zheng, Y, 2006) |
| " The interplay of MAPKs and STAT3 phosphorylation in regulating IL-1 beta-stimulated hypertrophy was investigated by evaluating the effect of MAPK inhibitors on atrial natriuretic factor (ANF) expression and myocyte morphology." | 3.71 | A role for the extracellular signal-regulated kinase and p38 mitogen-activated protein kinases in interleukin-1 beta-stimulated delayed signal tranducer and activator of transcription 3 activation, atrial natriuretic factor expression, and cardiac myocyte ( Bogoyevitch, MA; Long, CS; Ng, DC, 2001) |
| "Angiotensin II (AngII) induces G(1) phase arrest and hypertrophy of cultured renal proximal tubular cells." | 3.70 | Reactive oxygen species stimulate p44/42 mitogen-activated protein kinase and induce p27(Kip1): role in angiotensin II-mediated hypertrophy of proximal tubular cells. ( Hannken, T; Schroeder, R; Stahl, RAK; Wolf, G; Zahner, G, 2000) |
| "Taurine is a well documented antioxidant agent." | 1.35 | Effect of taurine on advanced glycation end products-induced hypertrophy in renal tubular epithelial cells. ( Chuang, LY; Guh, JY; Hsu, MS; Huang, JS; Yang, YL, 2008) |
| "Using a "two-hemorrhage" model of subarachnoid hemorrhage (SAH), this study investigated the function of ERK1/2 and vascular wall cell proliferation in pathological development of cerebral vasospasm." | 1.35 | Role of ERK1/2 and vascular cell proliferation in cerebral vasospasm after experimental subarachnoid hemorrhage. ( Chen, D; Chen, JJ; Guan, JH; Liu, YH; Yin, Q, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 15 (75.00) | 29.6817 |
| 2010's | 3 (15.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, JM | 1 |
| Kim, JD | 1 |
| Oh, EJ | 1 |
| Oh, SH | 1 |
| Lee, JH | 2 |
| Im, GI | 1 |
| Huang, JS | 1 |
| Chuang, LY | 1 |
| Guh, JY | 1 |
| Yang, YL | 1 |
| Hsu, MS | 1 |
| Chen, D | 1 |
| Chen, JJ | 1 |
| Yin, Q | 1 |
| Guan, JH | 1 |
| Liu, YH | 1 |
| Altamirano, F | 1 |
| Oyarce, C | 1 |
| Silva, P | 1 |
| Toyos, M | 1 |
| Wilson, C | 1 |
| Lavandero, S | 1 |
| Uhlén, P | 1 |
| Estrada, M | 1 |
| Prasadam, I | 1 |
| van Gennip, S | 1 |
| Friis, T | 1 |
| Shi, W | 1 |
| Crawford, R | 1 |
| Xiao, Y | 1 |
| Fahmi, A | 1 |
| Smart, N | 1 |
| Punn, A | 1 |
| Jabr, R | 1 |
| Marber, M | 1 |
| Heads, R | 1 |
| Haddad, F | 1 |
| Adams, GR | 1 |
| Bianchi, P | 1 |
| Pimentel, DR | 1 |
| Murphy, MP | 1 |
| Colucci, WS | 1 |
| Parini, A | 1 |
| Shin, HJ | 1 |
| Oh, J | 1 |
| Kang, SM | 1 |
| Shin, MJ | 1 |
| Hwang, KC | 1 |
| Jang, Y | 1 |
| Chung, JH | 1 |
| Lee, MP | 1 |
| Orlov, D | 1 |
| Sweeney, G | 1 |
| Laezza, C | 1 |
| Mazziotti, G | 1 |
| Fiorentino, L | 1 |
| Gazzerro, P | 1 |
| Portella, G | 1 |
| Gerbasio, D | 1 |
| Carella, C | 1 |
| Matarese, G | 1 |
| Bifulco, M | 1 |
| Zheng, Y | 1 |
| Im, CN | 1 |
| Seo, JS | 1 |
| Jacquemin, V | 1 |
| Butler-Browne, GS | 1 |
| Furling, D | 1 |
| Mouly, V | 1 |
| Adams, JW | 1 |
| Sah, VP | 1 |
| Henderson, SA | 1 |
| Brown, JH | 1 |
| Sekiguchi, K | 1 |
| Yokoyama, T | 1 |
| Kurabayashi, M | 1 |
| Okajima, F | 1 |
| Nagai, R | 1 |
| Muthalif, MM | 1 |
| Benter, IF | 1 |
| Khandekar, Z | 1 |
| Gaber, L | 1 |
| Estes, A | 1 |
| Malik, S | 1 |
| Parmentier, JH | 1 |
| Manne, V | 1 |
| Malik, KU | 1 |
| Hannken, T | 1 |
| Schroeder, R | 1 |
| Zahner, G | 1 |
| Stahl, RAK | 1 |
| Wolf, G | 1 |
| Zeidan, A | 1 |
| Nordström, I | 1 |
| Dreja, K | 1 |
| Malmqvist, U | 1 |
| Hellstrand, P | 1 |
| Ng, DC | 1 |
| Long, CS | 1 |
| Bogoyevitch, MA | 1 |
| Pham, FH | 1 |
| Cole, SM | 1 |
| Clerk, A | 1 |
20 other studies available for pd 98059 and Hypertrophy
| Article | Year |
|---|---|
PD98059-impregnated functional PLGA scaffold for direct tissue engineering promotes chondrogenesis and prevents hypertrophy from mesenchymal stem cells.
Topics: Adult; Animals; Chondrogenesis; Collagen; Disease Models, Animal; Flavonoids; Humans; Hypertrophy; I | 2014 |
Effect of taurine on advanced glycation end products-induced hypertrophy in renal tubular epithelial cells.
Topics: Animals; Antioxidants; Cell Cycle; Cell Proliferation; Collagen Type IV; Cyclin-Dependent Kinase Inh | 2008 |
Role of ERK1/2 and vascular cell proliferation in cerebral vasospasm after experimental subarachnoid hemorrhage.
Topics: Animals; Basilar Artery; Cell Proliferation; Disease Models, Animal; Enzyme Activation; Enzyme Inhib | 2009 |
Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway.
Topics: Androgens; Animals; Calcium; Calcium Signaling; Carrier Proteins; Cells, Cultured; Enzyme Activation | 2009 |
ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts.
Topics: Adult; Aged; Alkaline Phosphatase; Cartilage, Articular; Cell Communication; Cell Differentiation; C | 2010 |
p42/p44-MAPK and PI3K are sufficient for IL-6 family cytokines/gp130 to signal to hypertrophy and survival in cardiomyocytes in the absence of JAK/STAT activation.
Topics: Animals; Cell Survival; Cells, Cultured; Cytokine Receptor gp130; Flavonoids; Humans; Hypertrophy; I | 2013 |
Inhibition of MAP/ERK kinase prevents IGF-I-induced hypertrophy in rat muscles.
Topics: Adaptation, Physiological; Animals; Cell Division; Cyclin D1; Enzyme Inhibitors; Female; Flavonoids; | 2004 |
A new hypertrophic mechanism of serotonin in cardiac myocytes: receptor-independent ROS generation.
Topics: Adrenergic Uptake Inhibitors; Animals; Catalase; Cells, Cultured; Enzyme Activation; Flavonoids; Gen | 2005 |
Leptin induces hypertrophy via p38 mitogen-activated protein kinase in rat vascular smooth muscle cells.
Topics: Animals; Anthracenes; Aorta; Arteriosclerosis; Blotting, Western; Cells, Cultured; DNA; DNA-Binding | 2005 |
Leptin induces rat glomerular mesangial cell hypertrophy, but does not regulate hyperplasia or apoptosis.
Topics: Animals; Apoptosis; Cell Size; Cells, Cultured; Chromones; Extracellular Signal-Regulated MAP Kinase | 2005 |
HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway.
Topics: Animals; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Transf | 2006 |
Inhibitory effect of Hsp70 on angiotensin II-induced vascular smooth muscle cell hypertrophy.
Topics: Angiotensin II; Animals; Aorta; Cell Cycle Proteins; Cells, Cultured; Dual Specificity Phosphatase 1 | 2006 |
IL-13 mediates the recruitment of reserve cells for fusion during IGF-1-induced hypertrophy of human myotubes.
Topics: Cells, Cultured; Enzyme Inhibitors; Flavonoids; Humans; Hypertrophy; Imidazoles; Insulin-Like Growth | 2007 |
Tyrosine kinase and c-Jun NH2-terminal kinase mediate hypertrophic responses to prostaglandin F2alpha in cultured neonatal rat ventricular myocytes.
Topics: Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic AMP | 1998 |
Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.
Topics: Adrenergic beta-Agonists; Animals; Animals, Newborn; Cell Size; Endothelin-1; Enzyme Inhibitors; Fla | 1999 |
Contribution of Ras GTPase/MAP kinase and cytochrome P450 metabolites to deoxycorticosterone-salt-induced hypertension.
Topics: Alkyl and Aryl Transferases; Animals; Blood Pressure; Cytochrome P-450 Enzyme System; Desoxycorticos | 2000 |
Reactive oxygen species stimulate p44/42 mitogen-activated protein kinase and induce p27(Kip1): role in angiotensin II-mediated hypertrophy of proximal tubular cells.
Topics: Angiotensin II; Animals; Cell Cycle Proteins; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p27 | 2000 |
Stretch-dependent modulation of contractility and growth in smooth muscle of rat portal vein.
Topics: Animals; Benzoquinones; Cattle; Culture Media; Culture Media, Serum-Free; DNA Replication; Enzyme Ac | 2000 |
A role for the extracellular signal-regulated kinase and p38 mitogen-activated protein kinases in interleukin-1 beta-stimulated delayed signal tranducer and activator of transcription 3 activation, atrial natriuretic factor expression, and cardiac myocyte
Topics: Acute-Phase Proteins; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cell Nucleus; Cells, Cul | 2001 |
Regulation of cardiac myocyte protein synthesis through phosphatidylinositol 3' kinase and protein kinase B.
Topics: Animals; Animals, Newborn; Apoptosis; Blotting, Western; Carcinogens; Carrier Proteins; Chromones; E | 2001 |