pd 98059 has been researched along with Hypertension in 24 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Angiotensin II (AngII) is the most important component of angiotensin, which has been regarded as a major contributor to the incidence of hypertension and vascular endothelial dysfunction." | 7.85 | Adipokine CTRP6 improves PPARγ activation to alleviate angiotensin II-induced hypertension and vascular endothelial dysfunction in spontaneously hypertensive rats. ( Bai, T; Chi, L; Guo, R; Hu, X; Tian, H; Zeng, H; Zhang, L; Zhang, W; Zhang, Y, 2017) |
| "We investigated if extracellular signal-regulated kinases (ERK) and oxidative stress are involved in the pathogenesis of arterial hypertension induced by chronic leptin administration in the rat." | 7.74 | Role of extracellular signal-regulated kinases (ERK) in leptin-induced hypertension. ( Bełtowski, J; Jamroz-Wiśniewska, A; Ksiazek, M; Widomska, S; Wójcicka, G, 2008) |
| "Angiotensin II (AngII) is the most important component of angiotensin, which has been regarded as a major contributor to the incidence of hypertension and vascular endothelial dysfunction." | 3.85 | Adipokine CTRP6 improves PPARγ activation to alleviate angiotensin II-induced hypertension and vascular endothelial dysfunction in spontaneously hypertensive rats. ( Bai, T; Chi, L; Guo, R; Hu, X; Tian, H; Zeng, H; Zhang, L; Zhang, W; Zhang, Y, 2017) |
| "We investigated if extracellular signal-regulated kinases (ERK) and oxidative stress are involved in the pathogenesis of arterial hypertension induced by chronic leptin administration in the rat." | 3.74 | Role of extracellular signal-regulated kinases (ERK) in leptin-induced hypertension. ( Bełtowski, J; Jamroz-Wiśniewska, A; Ksiazek, M; Widomska, S; Wójcicka, G, 2008) |
| "Hypertension was induced in Sprague-Dawley rats by infusing angiotensin II (200 ng/kg per min) through osmotic pumps for 12 days." | 3.72 | NAD(P)H oxidase activation by angiotensin II is dependent on p42/44 ERK-MAPK pathway activation in rat's vascular smooth muscle cells. ( de Champlain, J; El Midaoui, A; Laplante, MA; Wu, R, 2003) |
| "We investigated whether p42/p44 mitogen-activated protein kinase (MAPK) and/or p38 MAPK participates in the regulation of vascular smooth muscle contraction by endothelin-1 (ET-1) in Wistar-Kyoto rat (WKY) and spontaneously hypertensive rat (SHR)." | 3.72 | p38 Mitogen-activated protein kinase regulates vasoconstriction in spontaneously hypertensive rats. ( Ahn, HY; Fang, LH; Ha, TS; Kim, B; Kwon, S; Lee, SJ, 2004) |
| " PD 098,059 does not alter the responses evoked by microinjection of glutamate into the RVLM or brief apnea." | 3.71 | Differential role of kinases in brain stem of hypertensive and normotensive rats. ( Goodchild, AK; Pilowsky, PM; Seyedabadi, M, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 16 (66.67) | 29.6817 |
| 2010's | 6 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fu, C | 1 |
| Li, N | 1 |
| Yuan, Y | 1 |
| Wang, R | 1 |
| Chen, J | 1 |
| Yang, J | 1 |
| Guo, Z | 1 |
| Wang, S | 1 |
| Zhang, Y | 2 |
| Liu, Y | 2 |
| Dong, J | 1 |
| Tang, X | 1 |
| Xiao, Q | 1 |
| Yao, Q | 1 |
| Allen, M | 1 |
| Wang, Y | 1 |
| Gao, L | 1 |
| Qi, Y | 1 |
| Zhang, P | 1 |
| Chi, L | 1 |
| Hu, X | 1 |
| Zhang, W | 1 |
| Bai, T | 1 |
| Zhang, L | 1 |
| Zeng, H | 1 |
| Guo, R | 1 |
| Tian, H | 1 |
| Cheng, WH | 1 |
| Lu, PJ | 1 |
| Ho, WY | 1 |
| Tung, CS | 1 |
| Cheng, PW | 1 |
| Hsiao, M | 1 |
| Tseng, CJ | 1 |
| Ljuca, F | 1 |
| Drevenšek, G | 1 |
| Zerem, E | 1 |
| Jing, L | 1 |
| Zhang, J | 1 |
| Sun, J | 1 |
| Guo, F | 1 |
| An, X | 1 |
| Yang, K | 1 |
| Li, PA | 1 |
| Carter, RW | 1 |
| Kanagy, NL | 1 |
| Laplante, MA | 1 |
| Wu, R | 1 |
| El Midaoui, A | 1 |
| de Champlain, J | 1 |
| Kim, B | 4 |
| Kim, J | 4 |
| Bae, YM | 2 |
| Cho, SI | 1 |
| Kwon, SC | 1 |
| Jung, JY | 1 |
| Park, JC | 1 |
| Ahn, HY | 2 |
| Kwon, S | 1 |
| Fang, LH | 1 |
| Ha, TS | 1 |
| Lee, SJ | 1 |
| Lee, YR | 1 |
| Lee, CH | 1 |
| Choi, WH | 1 |
| Lee, CK | 2 |
| Cho, S | 1 |
| Lappas, G | 1 |
| Daou, GB | 1 |
| Anand-Srivastava, MB | 1 |
| Ryu, SK | 1 |
| Ahn, DS | 1 |
| Cho, YE | 1 |
| Choi, SK | 1 |
| Kim, YH | 1 |
| Morgan, KG | 1 |
| Lee, YH | 1 |
| Won, KJ | 1 |
| Lee, HM | 1 |
| Kim, HJ | 1 |
| Roh, HY | 1 |
| Park, HJ | 1 |
| Shin, HS | 1 |
| Park, TK | 1 |
| Lee, SM | 1 |
| Ding, L | 1 |
| Chapman, A | 1 |
| Boyd, R | 1 |
| Wang, HD | 1 |
| Wójcicka, G | 1 |
| Jamroz-Wiśniewska, A | 1 |
| Widomska, S | 1 |
| Ksiazek, M | 1 |
| Bełtowski, J | 1 |
| Touyz, RM | 3 |
| El Mabrouk, M | 2 |
| He, G | 3 |
| Wu, XH | 1 |
| Schiffrin, EL | 3 |
| Hamaguchi, A | 1 |
| Kim, S | 1 |
| Izumi, Y | 1 |
| Zhan, Y | 1 |
| Yamanaka, S | 1 |
| Iwao, H | 1 |
| Samain, E | 1 |
| Bouillier, H | 1 |
| Miserey, S | 1 |
| Perret, C | 1 |
| Renaud, JF | 1 |
| Safar, M | 1 |
| Dagher, G | 1 |
| Muthalif, MM | 2 |
| Benter, IF | 2 |
| Khandekar, Z | 2 |
| Gaber, L | 2 |
| Estes, A | 2 |
| Malik, S | 1 |
| Parmentier, JH | 2 |
| Manne, V | 1 |
| Malik, KU | 2 |
| Karzoun, NA | 1 |
| Saeed, AE | 1 |
| Diep, Q | 1 |
| Mardigyan, V | 1 |
| Seyedabadi, M | 1 |
| Goodchild, AK | 1 |
| Pilowsky, PM | 1 |
| Deschepper, C | 1 |
| Park, JB | 1 |
| Chen, X | 1 |
| Neves, MF | 1 |
| Virdis, A | 1 |
24 other studies available for pd 98059 and Hypertension
| Article | Year |
|---|---|
Chronic intermittent hypobaric hypoxia provides vascular protection in the aorta of the 2-kidney, 1-clip rat model of hypertension.
Topics: Acetylcholine; Animals; Anthracenes; Aorta; Basic Helix-Loop-Helix Transcription Factors; Blood Pres | 2018 |
Pathological cyclic strain promotes proliferation of vascular smooth muscle cells via the ACTH/ERK/STAT3 pathway.
Topics: Adrenocorticotropic Hormone; Animals; Biomechanical Phenomena; Cell Proliferation; Disease Models, A | 2018 |
Adipokine CTRP6 improves PPARγ activation to alleviate angiotensin II-induced hypertension and vascular endothelial dysfunction in spontaneously hypertensive rats.
Topics: Adipokines; Angiotensin II; Animals; Apoptosis; Blood Pressure; Brain; Cell Separation; Coronary Ves | 2017 |
Angiotensin II inhibits neuronal nitric oxide synthase activation through the ERK1/2-RSK signaling pathway to modulate central control of blood pressure.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Antioxida | 2010 |
Contribution of Ras farnesyl transferase, MAP kinase and cytochrome P-450 metabolites to endothelin-1 induced hypertension.
Topics: Alkyl and Aryl Transferases; Animals; Arachidonic Acid; Blood Pressure; Cytochrome P-450 Enzyme Syst | 2011 |
Inhibition of extracellular signal-regulated kinases ameliorates hypertension-induced renal vascular remodeling in rat models.
Topics: Animals; Endothelium, Vascular; Female; Flavonoids; Hypertension; Male; MAP Kinase Signaling System; | 2011 |
Tyrosine kinases regulate intracellular calcium during alpha(2)-adrenergic contraction in rat aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta; Brimonidine Tartrate; Calcium; Enzyme Inhibitors; Flavono | 2002 |
NAD(P)H oxidase activation by angiotensin II is dependent on p42/44 ERK-MAPK pathway activation in rat's vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Aorta; Blood Pressure; Disease Model | 2003 |
p38 mitogen-activated protein kinase contributes to the diminished aortic contraction by endothelin-1 in DOCA-salt hypertensive rats.
Topics: Animals; Aorta; Calmodulin-Binding Proteins; Desoxycorticosterone; Endothelin-1; Flavonoids; Hyperte | 2004 |
p38 Mitogen-activated protein kinase regulates vasoconstriction in spontaneously hypertensive rats.
Topics: Animals; Endothelin-1; Enzyme Inhibitors; Flavonoids; Hypertension; Imidazoles; Mitogen-Activated Pr | 2004 |
Mitogen-activated protein kinase contributes to elevated basal tone in aortic smooth muscle from hypertensive rats.
Topics: Amides; Animals; Aorta, Thoracic; Blood Pressure; Desoxycorticosterone; Dose-Response Relationship, | 2005 |
Oxidative stress contributes to the enhanced expression of Gialpha proteins and adenylyl cyclase signaling in vascular smooth muscle cells from spontaneously hypertensive rats.
Topics: Acetylcysteine; Adenylyl Cyclases; Animals; Antioxidants; Cells, Cultured; Colforsin; Flavonoids; GT | 2005 |
Augmented sphingosylphosphorylcholine-induced Ca2+-sensitization of mesenteric artery contraction in spontaneously hypertensive rat.
Topics: Amides; Animals; Calcium; Flavonoids; Hypertension; Mesenteric Arteries; Mitogen-Activated Protein K | 2006 |
Phorbol ester-induced contraction through p38 mitogen-activated protein kinase is diminished in aortas from DOCA-salt hypertensive rats.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Body Weight; Desoxycorticosterone; Enzyme Inhibitors; Flav | 2006 |
ERK activation contributes to regulation of spontaneous contractile tone via superoxide anion in isolated rat aorta of angiotensin II-induced hypertension.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Blood Pressure; Butadienes; Disease Models, Animal; Endoth | 2007 |
Role of extracellular signal-regulated kinases (ERK) in leptin-induced hypertension.
Topics: Animals; Aorta; Blood Pressure; Cyclic N-Oxides; Disease Models, Animal; Drug Administration Schedul | 2008 |
Mitogen-activated protein/extracellular signal-regulated kinase inhibition attenuates angiotensin II-mediated signaling and contraction in spontaneously hypertensive rat vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enz | 1999 |
Contribution of extracellular signal-regulated kinase to angiotensin II-induced transforming growth factor-beta1 expression in vascular smooth muscle cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Calcium-Calmodulin-Dependent Prote | 1999 |
Extracellular signal-regulated kinase pathway is involved in basic fibroblast growth factor effect on angiotensin II-induced Ca(2+) transient in vascular smooth muscle cell from Wistar-Kyoto and spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Calcium; Calcium Signaling; Cell Size; DNA; Enzyme Inhibitors; Fibroblast G | 2000 |
Contribution of Ras GTPase/MAP kinase and cytochrome P450 metabolites to deoxycorticosterone-salt-induced hypertension.
Topics: Alkyl and Aryl Transferases; Animals; Blood Pressure; Cytochrome P-450 Enzyme System; Desoxycorticos | 2000 |
Angiotensin II-induced hypertension: contribution of Ras GTPase/Mitogen-activated protein kinase and cytochrome P450 metabolites.
Topics: Alkyl and Aryl Transferases; Angiotensin II; Animals; Blood Pressure; Cytochrome P-450 CYP4A; Cytoch | 2000 |
Differential activation of extracellular signal-regulated protein kinase 1/2 and p38 mitogen activated-protein kinase by AT1 receptors in vascular smooth muscle cells from Wistar-Kyoto rats and spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Hypertension; Imidazoles; | 2001 |
Differential role of kinases in brain stem of hypertensive and normotensive rats.
Topics: Androstadienes; Angiotensin II; Animals; Apnea; Blood Pressure; Brain Stem; Enzyme Inhibitors; Flavo | 2001 |
Inhibition of mitogen-activated protein/extracellular signal-regulated kinase improves endothelial function and attenuates Ang II-induced contractility of mesenteric resistance arteries from spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Blood Pressure; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Hyper | 2002 |