pd 98059 has been researched along with Hyperplasia in 10 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our results show that leptin induced glomerular mesangial cell hypertrophy via PI 3-kinase and ERK1/2, and that hyperplasia and apoptosis were not altered by leptin." | 7.73 | Leptin induces rat glomerular mesangial cell hypertrophy, but does not regulate hyperplasia or apoptosis. ( Lee, MP; Orlov, D; Sweeney, G, 2005) |
| "The aim of this study was to evaluate in vivo the antiproliferative effect of an inhibitor of isoprenoids metabolism, lovastatin, in an experimental model of propylthiouracil-induced goiter." | 7.73 | HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway. ( Bifulco, M; Carella, C; Fiorentino, L; Gazzerro, P; Gerbasio, D; Laezza, C; Matarese, G; Mazziotti, G; Portella, G, 2006) |
| "Our results show that leptin induced glomerular mesangial cell hypertrophy via PI 3-kinase and ERK1/2, and that hyperplasia and apoptosis were not altered by leptin." | 3.73 | Leptin induces rat glomerular mesangial cell hypertrophy, but does not regulate hyperplasia or apoptosis. ( Lee, MP; Orlov, D; Sweeney, G, 2005) |
| "The aim of this study was to evaluate in vivo the antiproliferative effect of an inhibitor of isoprenoids metabolism, lovastatin, in an experimental model of propylthiouracil-induced goiter." | 3.73 | HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway. ( Bifulco, M; Carella, C; Fiorentino, L; Gazzerro, P; Gerbasio, D; Laezza, C; Matarese, G; Mazziotti, G; Portella, G, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rho, O | 1 |
| Kiguchi, K | 1 |
| Jiang, G | 1 |
| DiGiovanni, J | 1 |
| Ni, J | 1 |
| Waldman, A | 1 |
| Khachigian, LM | 1 |
| Chandrakesan, P | 1 |
| Ahmed, I | 1 |
| Anwar, T | 1 |
| Wang, Y | 1 |
| Sarkar, S | 1 |
| Singh, P | 1 |
| Peleg, S | 1 |
| Umar, S | 1 |
| Tanabe, T | 1 |
| Kanoh, S | 1 |
| Tsushima, K | 1 |
| Yamazaki, Y | 1 |
| Kubo, K | 1 |
| Rubin, BK | 1 |
| Lee, MP | 1 |
| Orlov, D | 1 |
| Sweeney, G | 1 |
| Laezza, C | 1 |
| Mazziotti, G | 1 |
| Fiorentino, L | 1 |
| Gazzerro, P | 1 |
| Portella, G | 1 |
| Gerbasio, D | 1 |
| Carella, C | 1 |
| Matarese, G | 1 |
| Bifulco, M | 1 |
| Zou, Y | 1 |
| Qi, Y | 1 |
| Roztocil, E | 1 |
| Nicholl, SM | 1 |
| Davies, MG | 1 |
| Ruef, J | 1 |
| Meshel, AS | 1 |
| Hu, Z | 1 |
| Horaist, C | 1 |
| Ballinger, CA | 1 |
| Thompson, LJ | 1 |
| Subbarao, VD | 1 |
| Dumont, JA | 1 |
| Patterson, C | 1 |
| Kibbe, MR | 1 |
| Li, J | 1 |
| Nie, S | 1 |
| Watkins, SC | 1 |
| Lizonova, A | 1 |
| Kovesdi, I | 1 |
| Simmons, RL | 1 |
| Billiar, TR | 1 |
| Tzeng, E | 1 |
| Zeidan, A | 1 |
| Nordström, I | 1 |
| Dreja, K | 1 |
| Malmqvist, U | 1 |
| Hellstrand, P | 1 |
10 other studies available for pd 98059 and Hyperplasia
| Article | Year |
|---|---|
Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild-type and BK5.AktWT mice.
Topics: Animals; Antibiotics, Antineoplastic; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell | 2014 |
c-Jun regulates shear- and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins.
Topics: Adenoviridae; Animals; Blotting, Western; Carotid Arteries; Cell Line; Cells, Cultured; DNA, Catalyt | 2010 |
Novel changes in NF-{kappa}B activity during progression and regression phases of hyperplasia: role of MEK, ERK, and p38.
Topics: Animals; Chemokine CXCL1; Citrobacter rodentium; Colon; Colonic Diseases; Enterobacteriaceae Infecti | 2010 |
Clarithromycin inhibits interleukin-13-induced goblet cell hyperplasia in human airway cells.
Topics: Bronchi; Cell Differentiation; Clarithromycin; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Goblet | 2011 |
Leptin induces rat glomerular mesangial cell hypertrophy, but does not regulate hyperplasia or apoptosis.
Topics: Animals; Apoptosis; Cell Size; Cells, Cultured; Chromones; Extracellular Signal-Regulated MAP Kinase | 2005 |
HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway.
Topics: Animals; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Transf | 2006 |
Patterns of kinase activation induced by injury in the murine femoral artery.
Topics: Animals; Anthracenes; Calcium Signaling; Cell Division; Disease Models, Animal; Femoral Artery; Flav | 2007 |
Flavopiridol inhibits smooth muscle cell proliferation in vitro and neointimal formation In vivo after carotid injury in the rat.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carotid Arteries; Carotid Artery Injuries; Ca | 1999 |
Inducible nitric oxide synthase (iNOS) expression upregulates p21 and inhibits vascular smooth muscle cell proliferation through p42/44 mitogen-activated protein kinase activation and independent of p53 and cyclic guanosine monophosphate.
Topics: Animals; Carotid Arteries; Cell Division; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Flavonoi | 2000 |
Stretch-dependent modulation of contractility and growth in smooth muscle of rat portal vein.
Topics: Animals; Benzoquinones; Cattle; Culture Media; Culture Media, Serum-Free; DNA Replication; Enzyme Ac | 2000 |