Page last updated: 2024-11-02

pd 98059 and Hyperplasia

pd 98059 has been researched along with Hyperplasia in 10 studies

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.

Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.

Research Excerpts

ExcerptRelevanceReference
"Our results show that leptin induced glomerular mesangial cell hypertrophy via PI 3-kinase and ERK1/2, and that hyperplasia and apoptosis were not altered by leptin."7.73Leptin induces rat glomerular mesangial cell hypertrophy, but does not regulate hyperplasia or apoptosis. ( Lee, MP; Orlov, D; Sweeney, G, 2005)
"The aim of this study was to evaluate in vivo the antiproliferative effect of an inhibitor of isoprenoids metabolism, lovastatin, in an experimental model of propylthiouracil-induced goiter."7.73HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway. ( Bifulco, M; Carella, C; Fiorentino, L; Gazzerro, P; Gerbasio, D; Laezza, C; Matarese, G; Mazziotti, G; Portella, G, 2006)
"Our results show that leptin induced glomerular mesangial cell hypertrophy via PI 3-kinase and ERK1/2, and that hyperplasia and apoptosis were not altered by leptin."3.73Leptin induces rat glomerular mesangial cell hypertrophy, but does not regulate hyperplasia or apoptosis. ( Lee, MP; Orlov, D; Sweeney, G, 2005)
"The aim of this study was to evaluate in vivo the antiproliferative effect of an inhibitor of isoprenoids metabolism, lovastatin, in an experimental model of propylthiouracil-induced goiter."3.73HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway. ( Bifulco, M; Carella, C; Fiorentino, L; Gazzerro, P; Gerbasio, D; Laezza, C; Matarese, G; Mazziotti, G; Portella, G, 2006)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's5 (50.00)29.6817
2010's4 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rho, O1
Kiguchi, K1
Jiang, G1
DiGiovanni, J1
Ni, J1
Waldman, A1
Khachigian, LM1
Chandrakesan, P1
Ahmed, I1
Anwar, T1
Wang, Y1
Sarkar, S1
Singh, P1
Peleg, S1
Umar, S1
Tanabe, T1
Kanoh, S1
Tsushima, K1
Yamazaki, Y1
Kubo, K1
Rubin, BK1
Lee, MP1
Orlov, D1
Sweeney, G1
Laezza, C1
Mazziotti, G1
Fiorentino, L1
Gazzerro, P1
Portella, G1
Gerbasio, D1
Carella, C1
Matarese, G1
Bifulco, M1
Zou, Y1
Qi, Y1
Roztocil, E1
Nicholl, SM1
Davies, MG1
Ruef, J1
Meshel, AS1
Hu, Z1
Horaist, C1
Ballinger, CA1
Thompson, LJ1
Subbarao, VD1
Dumont, JA1
Patterson, C1
Kibbe, MR1
Li, J1
Nie, S1
Watkins, SC1
Lizonova, A1
Kovesdi, I1
Simmons, RL1
Billiar, TR1
Tzeng, E1
Zeidan, A1
Nordström, I1
Dreja, K1
Malmqvist, U1
Hellstrand, P1

Other Studies

10 other studies available for pd 98059 and Hyperplasia

ArticleYear
Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild-type and BK5.AktWT mice.
    Molecular carcinogenesis, 2014, Volume: 53, Issue:11

    Topics: Animals; Antibiotics, Antineoplastic; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell

2014
c-Jun regulates shear- and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins.
    The Journal of biological chemistry, 2010, Feb-05, Volume: 285, Issue:6

    Topics: Adenoviridae; Animals; Blotting, Western; Carotid Arteries; Cell Line; Cells, Cultured; DNA, Catalyt

2010
Novel changes in NF-{kappa}B activity during progression and regression phases of hyperplasia: role of MEK, ERK, and p38.
    The Journal of biological chemistry, 2010, Oct-22, Volume: 285, Issue:43

    Topics: Animals; Chemokine CXCL1; Citrobacter rodentium; Colon; Colonic Diseases; Enterobacteriaceae Infecti

2010
Clarithromycin inhibits interleukin-13-induced goblet cell hyperplasia in human airway cells.
    American journal of respiratory cell and molecular biology, 2011, Volume: 45, Issue:5

    Topics: Bronchi; Cell Differentiation; Clarithromycin; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Goblet

2011
Leptin induces rat glomerular mesangial cell hypertrophy, but does not regulate hyperplasia or apoptosis.
    International journal of obesity (2005), 2005, Volume: 29, Issue:12

    Topics: Animals; Apoptosis; Cell Size; Cells, Cultured; Chromones; Extracellular Signal-Regulated MAP Kinase

2005
HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway.
    Journal of molecular medicine (Berlin, Germany), 2006, Volume: 84, Issue:11

    Topics: Animals; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Transf

2006
Patterns of kinase activation induced by injury in the murine femoral artery.
    The Journal of surgical research, 2007, Volume: 142, Issue:2

    Topics: Animals; Anthracenes; Calcium Signaling; Cell Division; Disease Models, Animal; Femoral Artery; Flav

2007
Flavopiridol inhibits smooth muscle cell proliferation in vitro and neointimal formation In vivo after carotid injury in the rat.
    Circulation, 1999, Aug-10, Volume: 100, Issue:6

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carotid Arteries; Carotid Artery Injuries; Ca

1999
Inducible nitric oxide synthase (iNOS) expression upregulates p21 and inhibits vascular smooth muscle cell proliferation through p42/44 mitogen-activated protein kinase activation and independent of p53 and cyclic guanosine monophosphate.
    Journal of vascular surgery, 2000, Volume: 31, Issue:6

    Topics: Animals; Carotid Arteries; Cell Division; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Flavonoi

2000
Stretch-dependent modulation of contractility and growth in smooth muscle of rat portal vein.
    Circulation research, 2000, Aug-04, Volume: 87, Issue:3

    Topics: Animals; Benzoquinones; Cattle; Culture Media; Culture Media, Serum-Free; DNA Replication; Enzyme Ac

2000