pd 98059 has been researched along with Hormone-Dependent Neoplasms in 7 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tamoxifen (Tam) is widely used in chemotherapy of breast cancer." | 7.74 | Tamoxifen-induced rapid death of MCF-7 breast cancer cells is mediated via extracellularly signal-regulated kinase signaling and can be abrogated by estrogen. ( Härkönen, P; Kallio, A; Zheng, A, 2007) |
| "Tamoxifen (Tam) is widely used in chemotherapy of breast cancer." | 3.74 | Tamoxifen-induced rapid death of MCF-7 breast cancer cells is mediated via extracellularly signal-regulated kinase signaling and can be abrogated by estrogen. ( Härkönen, P; Kallio, A; Zheng, A, 2007) |
| "Treatment of androgen responsive prostate cancer cells with dihydrotestosterone leads to a rapid and reversible activation of mitogen-activated protein kinases MAPKs (also called extracellular signal-regulated kinases or Erks)." | 1.30 | Rapid signalling by androgen receptor in prostate cancer cells. ( Becker, M; Cato, AC; Klocker, H; Mink, S; Peterziel, H; Schonert, A, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van Duursen, MB | 1 |
| Nijmeijer, SM | 1 |
| Ruchirawat, S | 1 |
| van den Berg, M | 1 |
| Zelivianski, S | 1 |
| Spellman, M | 1 |
| Kellerman, M | 1 |
| Kakitelashvilli, V | 1 |
| Zhou, XW | 1 |
| Lugo, E | 1 |
| Lee, MS | 1 |
| Taylor, R | 1 |
| Davis, TL | 1 |
| Hauke, R | 1 |
| Lin, MF | 1 |
| Hu, X | 1 |
| Washington, S | 1 |
| Verderame, MF | 1 |
| Manni, A | 1 |
| Zheng, A | 1 |
| Kallio, A | 1 |
| Härkönen, P | 1 |
| Peterziel, H | 1 |
| Mink, S | 1 |
| Schonert, A | 1 |
| Becker, M | 1 |
| Klocker, H | 1 |
| Cato, AC | 1 |
| Lobenhofer, EK | 1 |
| Huper, G | 1 |
| Iglehart, JD | 1 |
| Marks, JR | 1 |
| Jeng, MH | 1 |
| Yue, W | 1 |
| Eischeid, A | 1 |
| Wang, JP | 1 |
| Santen, RJ | 1 |
7 other studies available for pd 98059 and Hormone-Dependent Neoplasms
| Article | Year |
|---|---|
Chemopreventive actions by enterolactone and 13 VIOXX-related lactone derivatives in H295R human adrenocortical carcinoma cells.
Topics: 4-Butyrolactone; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Cell Cycle; Cell Line, Tumor; E | 2010 |
ERK inhibitor PD98059 enhances docetaxel-induced apoptosis of androgen-independent human prostate cancer cells.
Topics: Apoptosis; bcl-X Protein; Butadienes; Docetaxel; Drug Synergism; Enzyme Inhibitors; Flavonoids; Huma | 2003 |
Interaction between Polyamines and the Mitogen-Activated Protein Kinase Pathway in the Regulation of Cell Cycle Variables in Breast Cancer Cells.
Topics: Breast Neoplasms; Butadienes; Calcium-Binding Proteins; Cell Cycle; Cell Growth Processes; Cell Line | 2005 |
Tamoxifen-induced rapid death of MCF-7 breast cancer cells is mediated via extracellularly signal-regulated kinase signaling and can be abrogated by estrogen.
Topics: Breast Neoplasms; Carcinoma; Cell Death; Cell Line, Tumor; Cell Nucleus; ErbB Receptors; Estrogens; | 2007 |
Rapid signalling by androgen receptor in prostate cancer cells.
Topics: Adenocarcinoma; Androgen Antagonists; Cell Nucleus; Cytoplasm; Dihydrotestosterone; DNA-Binding Prot | 1999 |
Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis.
Topics: Adenocarcinoma; Androstadienes; Breast Neoplasms; Butadienes; Chromones; Culture Media, Serum-Free; | 2000 |
Role of MAP kinase in the enhanced cell proliferation of long term estrogen deprived human breast cancer cells.
Topics: Breast Neoplasms; Cell Division; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Estradiol; | 2000 |