pd 98059 has been researched along with Heart Failure in 5 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Angiotensin II (Ang II), acting via angiotensin type 1 receptors in the brain, activates the sympathetic nervous system in heart failure (HF)." | 7.74 | Angiotensin II-triggered p44/42 mitogen-activated protein kinase mediates sympathetic excitation in heart failure rats. ( Felder, RB; Wei, SG; Weiss, RM; Yu, Y; Zhang, ZH, 2008) |
| "Angiotensin II (Ang II), acting via angiotensin type 1 receptors in the brain, activates the sympathetic nervous system in heart failure (HF)." | 3.74 | Angiotensin II-triggered p44/42 mitogen-activated protein kinase mediates sympathetic excitation in heart failure rats. ( Felder, RB; Wei, SG; Weiss, RM; Yu, Y; Zhang, ZH, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, P | 1 |
| Sun, Y | 1 |
| Yang, J | 1 |
| Chen, S | 1 |
| Liu, AD | 1 |
| Holmberg, L | 1 |
| Huang, X | 1 |
| Tang, C | 1 |
| Du, J | 1 |
| Jin, H | 1 |
| Abdelhamid, G | 1 |
| El-Kadi, AO | 1 |
| Wei, SG | 1 |
| Yu, Y | 1 |
| Zhang, ZH | 1 |
| Weiss, RM | 1 |
| Felder, RB | 1 |
| Adams, V | 2 |
| Linke, A | 2 |
| Wisloff, U | 1 |
| Döring, C | 1 |
| Erbs, S | 1 |
| Kränkel, N | 1 |
| Witt, CC | 1 |
| Labeit, S | 1 |
| Müller-Werdan, U | 1 |
| Schuler, G | 2 |
| Hambrecht, R | 2 |
| Nehrhoff, B | 1 |
| Späte, U | 1 |
| Schulze, PC | 1 |
| Baur, A | 1 |
| Gielen, S | 1 |
5 other studies available for pd 98059 and Heart Failure
| Article | Year |
|---|---|
The ERK1/2 signaling pathway is involved in sulfur dioxide preconditioning-induced protection against cardiac dysfunction in isolated perfused rat heart subjected to myocardial ischemia/reperfusion.
Topics: Animals; Cardiotonic Agents; Flavonoids; Heart Failure; Humans; Ischemic Preconditioning; Male; MAP | 2013 |
Buthionine sulfoximine, an inhibitor of glutathione biosynthesis, induces expression of soluble epoxide hydrolase and markers of cellular hypertrophy in a rat cardiomyoblast cell line: roles of the NF-κB and MAPK signaling pathways.
Topics: Animals; Antioxidants; Atrial Natriuretic Factor; Butadienes; Buthionine Sulfoximine; Cardiomegaly; | 2015 |
Angiotensin II-triggered p44/42 mitogen-activated protein kinase mediates sympathetic excitation in heart failure rats.
Topics: Acute Disease; Analysis of Variance; Angiotensin II; Animals; Chronic Disease; Disease Models, Anima | 2008 |
Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility.
Topics: Animals; Animals, Newborn; Blotting, Western; Echocardiography; Flavonoids; Gene Expression; Heart F | 2007 |
Induction of iNOS expression in skeletal muscle by IL-1beta and NFkappaB activation: an in vitro and in vivo study.
Topics: Aged; Animals; Antioxidants; Blotting, Western; Case-Control Studies; Cytokines; Electrophoretic Mob | 2002 |