pd 98059 has been researched along with Heart Disease, Ischemic in 14 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 11 (78.57) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, W | 1 |
| Liang, X | 1 |
| Fu, D | 1 |
| Tie, R | 1 |
| Xing, W | 1 |
| Ji, L | 1 |
| Liu, F | 1 |
| Zhang, H | 1 |
| Li, R | 1 |
| Clanachan, AS | 1 |
| Jaswal, JS | 1 |
| Gandhi, M | 1 |
| Bottorff, DA | 1 |
| Coughlin, J | 1 |
| Finegan, BA | 1 |
| Stone, JC | 1 |
| Hilfiker-Kleiner, D | 1 |
| Kaminski, K | 1 |
| Kaminska, A | 1 |
| Fuchs, M | 1 |
| Klein, G | 1 |
| Podewski, E | 1 |
| Grote, K | 1 |
| Kiian, I | 1 |
| Wollert, KC | 1 |
| Hilfiker, A | 1 |
| Drexler, H | 1 |
| Liu, HR | 1 |
| Gao, F | 1 |
| Tao, L | 1 |
| Yan, WL | 1 |
| Gao, E | 1 |
| Christopher, TA | 1 |
| Lopez, BL | 1 |
| Hu, A | 1 |
| Ma, XL | 2 |
| Mizukami, Y | 1 |
| Iwamatsu, A | 1 |
| Aki, T | 1 |
| Kimura, M | 1 |
| Nakamura, K | 1 |
| Nao, T | 1 |
| Okusa, T | 1 |
| Matsuzaki, M | 1 |
| Yoshida, K | 1 |
| Kobayashi, S | 1 |
| He, Z | 1 |
| Opland, DM | 1 |
| Way, KJ | 1 |
| Ueki, K | 1 |
| Bodyak, N | 1 |
| Kang, PM | 1 |
| Izumo, S | 1 |
| Kulkarni, RN | 1 |
| Wang, B | 1 |
| Liao, R | 1 |
| Kahn, CR | 1 |
| King, GL | 1 |
| Naitoh, K | 1 |
| Ichikawa, Y | 1 |
| Miura, T | 1 |
| Nakamura, Y | 1 |
| Miki, T | 1 |
| Ikeda, Y | 1 |
| Kobayashi, H | 1 |
| Nishihara, M | 1 |
| Ohori, K | 1 |
| Shimamoto, K | 1 |
| Pagel, PS | 1 |
| Krolikowski, JG | 1 |
| Shim, YH | 1 |
| Venkatapuram, S | 1 |
| Kersten, JR | 1 |
| Weihrauch, D | 1 |
| Warltier, DC | 1 |
| Pratt, PF | 1 |
| Nagarkatti, DS | 1 |
| Sha'afi, RI | 1 |
| Tauskela, JS | 1 |
| chakravarthy, BR | 1 |
| Murray, CL | 1 |
| Wang, Y | 1 |
| Comas, T | 1 |
| Hogan, M | 1 |
| Hakim, A | 1 |
| Morley, P | 1 |
| Brar, BK | 1 |
| Jonassen, AK | 1 |
| Stephanou, A | 1 |
| Santilli, G | 1 |
| Railson, J | 1 |
| Knight, RA | 1 |
| Yellon, DM | 1 |
| Latchman, DS | 1 |
| Yue, TL | 1 |
| Wang, C | 1 |
| Gu, JL | 1 |
| Kumar, S | 1 |
| Lee, JC | 1 |
| Feuerstein, GZ | 1 |
| Thomas, H | 1 |
| Maleeff, B | 1 |
| Ohlstein, EH | 1 |
| Moor, AN | 1 |
| Gan, XT | 1 |
| Karmazyn, M | 1 |
| Fliegel, L | 1 |
| Fryer, RM | 1 |
| Hsu, AK | 1 |
| Gross, GJ | 1 |
14 other studies available for pd 98059 and Heart Disease, Ischemic
| Article | Year |
|---|---|
Apocynum venetum leaf attenuates myocardial ischemia/reperfusion injury by inhibiting oxidative stress.
Topics: Androstadienes; Antioxidants; Apocynum; Apoptosis; Creatine Kinase; Drugs, Chinese Herbal; Flavonoid | 2015 |
Effects of inhibition of myocardial extracellular-responsive kinase and P38 mitogen-activated protein kinase on mechanical function of rat hearts after prolonged hypothermic ischemia.
Topics: Animals; Enzyme Activation; Flavonoids; Hypothermia, Induced; Imidazoles; Male; Mitogen-Activated Pr | 2003 |
Regulation of proangiogenic factor CCN1 in cardiac muscle: impact of ischemia, pressure overload, and neurohumoral activation.
Topics: Alkaloids; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoat | 2004 |
Antiapoptotic mechanisms of benidipine in the ischemic/reperfused heart.
Topics: Animals; Apoptosis; Calcium Channel Blockers; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Co | 2004 |
ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation.
Topics: Adenosine Triphosphate; Animals; Cell Death; Flavonoids; Hypoxia; MAP Kinase Kinase Kinases; Mitogen | 2004 |
Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia.
Topics: Androstadienes; Animals; Cells, Cultured; Coronary Vessels; Flavonoids; Humans; Insulin; Insulin Res | 2006 |
MitoKATP channel activation suppresses gap junction permeability in the ischemic myocardium by an ERK-dependent mechanism.
Topics: Adenosine Triphosphate; Animals; Cell Membrane Permeability; Connexin 43; Diazoxide; Enzyme Inhibito | 2006 |
Noble gases without anesthetic properties protect myocardium against infarction by activating prosurvival signaling kinases and inhibiting mitochondrial permeability transition in vivo.
Topics: Androstadienes; Animals; Argon; Atractyloside; Cardiotonic Agents; Disease Models, Animal; Enzyme Ac | 2007 |
Role of p38 MAP kinase in myocardial stress.
Topics: Adenosine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Cells, Cultured; En | 1998 |
Evidence from cultured rat cortical neurons of differences in the mechanism of ischemic preconditioning of brain and heart.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain Ischemia; Calcium; Calcium-Calmodulin-Dependent | 1999 |
Urocortin protects against ischemic and reperfusion injury via a MAPK-dependent pathway.
Topics: Animals; Cell Death; Cell Hypoxia; Cells, Cultured; Corticotropin-Releasing Hormone; Flavonoids; Hea | 2000 |
Inhibition of extracellular signal-regulated kinase enhances Ischemia/Reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart.
Topics: Animals; Animals, Newborn; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; | 2000 |
Activation of Na+/H+ exchanger-directed protein kinases in the ischemic and ischemic-reperfused rat myocardium.
Topics: Animals; Animals, Newborn; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Heart; Heart Ventricles; | 2001 |
ERK and p38 MAP kinase activation are components of opioid-induced delayed cardioprotection.
Topics: Analgesics; Animals; Blood Pressure; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Heart Rate; I | 2001 |