pd 98059 has been researched along with Head and Neck Neoplasms in 6 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using UT-SCC5 and SAS head and neck cancer cells we established a differential phosphoproteomic approach for quantitative analysis of DNA repair proteins by stable isotope labeling with amino acids." | 1.42 | Quantitative proteomics unveiled: Regulation of DNA double strand break repair by EGFR involves PARP1. ( Dikomey, E; Gleißner, L; Hoffer, K; Kriegs, M; Kwiatkowski, M; Myllynen, L; Petersen, C; Riepen, B; Rothkamm, K; Schlüter, H; Wurlitzer, M, 2015) |
| "Stimulation of HNSCC cells with EGF caused a significant increase in migration (p < 0." | 1.37 | Inhibition of radiation induced migration of human head and neck squamous cell carcinoma cells by blocking of EGF receptor pathways. ( Arnold, W; Beck, C; Boulesteix, AL; Knopf, A; Margraf, J; Pickhard, AC; Pigorsch, S; Piontek, G; Reiter, R; Scherer, EQ; Schlegel, J; Stark, T, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Toulany, M | 1 |
| Minjgee, M | 1 |
| Saki, M | 1 |
| Holler, M | 1 |
| Meier, F | 1 |
| Eicheler, W | 1 |
| Rodemann, HP | 1 |
| Myllynen, L | 1 |
| Kwiatkowski, M | 1 |
| Gleißner, L | 1 |
| Riepen, B | 1 |
| Hoffer, K | 1 |
| Wurlitzer, M | 1 |
| Petersen, C | 1 |
| Dikomey, E | 1 |
| Rothkamm, K | 1 |
| Schlüter, H | 1 |
| Kriegs, M | 1 |
| Pickhard, AC | 1 |
| Margraf, J | 1 |
| Knopf, A | 1 |
| Stark, T | 1 |
| Piontek, G | 1 |
| Beck, C | 1 |
| Boulesteix, AL | 1 |
| Scherer, EQ | 1 |
| Pigorsch, S | 1 |
| Schlegel, J | 1 |
| Arnold, W | 1 |
| Reiter, R | 1 |
| Lamm, W | 1 |
| Vormittag, L | 1 |
| Turhani, D | 1 |
| Erovic, BM | 1 |
| Czembirek, C | 1 |
| Eder-Czembirek, C | 1 |
| Thurnher, D | 1 |
| Simon, C | 2 |
| Goepfert, H | 2 |
| Boyd, D | 2 |
| Hicks, MJ | 1 |
| Nemechek, AJ | 1 |
| Mehta, R | 1 |
| O'Malley, BW | 1 |
| Flaitz, CM | 1 |
6 other studies available for pd 98059 and Head and Neck Neoplasms
| Article | Year |
|---|---|
ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition.
Topics: Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell | 2014 |
Quantitative proteomics unveiled: Regulation of DNA double strand break repair by EGFR involves PARP1.
Topics: Carcinoma, Squamous Cell; DNA; DNA Breaks, Double-Stranded; DNA Repair; DNA-Binding Proteins; Enzyme | 2015 |
Inhibition of radiation induced migration of human head and neck squamous cell carcinoma cells by blocking of EGF receptor pathways.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Radiation; Ep | 2011 |
The effect of nimesulide, a selective cyclooxygenase-2 inhibitor, on Ets-1 and Ets-2 expression in head and neck cancer cell lines.
Topics: Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamous Cell; Cell Line | 2005 |
Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamous Cell; Collagenases; Enzyme Activat | 1998 |
PD 098059, an inhibitor of ERK1 activation, attenuates the in vivo invasiveness of head and neck squamous cell carcinoma.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme In | 1999 |