pd 98059 has been researched along with Granulocytic Leukemia in 16 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cotylenin A has been isolated as a plant growth regulator." | 1.31 | Induction of the monocytic differentiation of myeloid leukaemia cells by cotylenin A, a plant growth regulator. ( Asahi, KI; Honma, Y; Ishii, Y; Tomoyasu, S; Yamada, K; Yamamoto-Yamaguchi, Y, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 13 (81.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hanson, DA | 1 |
| Ziegler, SF | 1 |
| Mora-Garcia, P | 1 |
| Pan, R | 1 |
| Sakamoto, KM | 1 |
| Senga, T | 1 |
| Iwamoto, T | 1 |
| Humphrey, SE | 1 |
| Yokota, T | 1 |
| Taparowsky, EJ | 1 |
| Hamaguchi, M | 1 |
| Siddiqui, FA | 1 |
| Siddiqui, TF | 1 |
| Francis, JL | 1 |
| Traore, K | 1 |
| Sharma, RB | 1 |
| Burek, CL | 1 |
| Trush, MA | 1 |
| Barge, RM | 1 |
| Dorrestijn, J | 1 |
| Falkenburg, JH | 1 |
| Willemze, R | 1 |
| Maassen, JA | 1 |
| Kang, CD | 1 |
| Do, IR | 1 |
| Kim, KW | 1 |
| Ahn, BK | 1 |
| Kim, SH | 1 |
| Chung, BS | 1 |
| Jhun, BH | 1 |
| Yoo, MA | 1 |
| Birkenkamp, KU | 1 |
| Esselink, MT | 1 |
| Kruijer, W | 1 |
| Vellenga, E | 1 |
| Ajenjo, N | 1 |
| Aaronson, DS | 1 |
| Ceballos, E | 1 |
| Richard, C | 1 |
| León, J | 1 |
| Crespo, P | 1 |
| Baines, P | 1 |
| Fisher, J | 1 |
| Truran, L | 1 |
| Davies, E | 1 |
| Hallett, M | 1 |
| Hoy, T | 1 |
| Burnett, AK | 1 |
| Quentmeier, H | 1 |
| Dirks, WG | 1 |
| Fleckenstein, D | 1 |
| Zaborski, M | 1 |
| Drexler, HG | 1 |
| Honma, Y | 2 |
| Ishii, Y | 2 |
| Kasukabe, T | 1 |
| Okabe-Kado, J | 1 |
| Yamamoto-Yamaguchi, Y | 2 |
| Kakegawa, T | 1 |
| Awaya, A | 1 |
| Stadheim, TA | 2 |
| Xiao, H | 1 |
| Eastman, A | 1 |
| Yamada, K | 1 |
| Asahi, KI | 1 |
| Tomoyasu, S | 1 |
| Koschmieder, S | 1 |
| Hofmann, WK | 1 |
| Kunert, J | 1 |
| Wagner, S | 1 |
| Ballas, K | 1 |
| Seipelt, G | 1 |
| Hoelzer, D | 1 |
| Ottmann, OG | 1 |
| Kalina, U | 1 |
| Kucera, GL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Protocol to Obtain Blood Samples for Leukemia Research[NCT00889031] | 187 participants (Actual) | Observational | 2009-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
16 other studies available for pd 98059 and Granulocytic Leukemia
| Article | Year |
|---|---|
Regulation of ionomycin-mediated granule release from rat basophil leukemia cells.
Topics: Animals; Basophils; Butadienes; Cell Degranulation; Drug Synergism; Enzyme Inhibitors; Flavonoids; I | 2002 |
G-CSF regulation of SRE-binding proteins in myeloid cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Granul | 2002 |
Stat3-dependent induction of BATF in M1 mouse myeloid leukemia cells.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Cell Division; DNA-Binding Proteins; Enzyme Inh | 2002 |
Hemoglobin induces the production and release of matrix metalloproteinase-9 from human malignant cells.
Topics: Carcinoma; Cycloheximide; Enzyme Inhibitors; Flavonoids; Genistein; Hemoglobins; Humans; Leukemia, M | 2003 |
Role of ROS and MAPK in TPA-induced ICAM-1 expression in the myeloid ML-1 cell line.
Topics: Blotting, Western; Butadienes; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Flavono | 2007 |
Unconventional rapid Erk1,2 activation is indispensable for proliferation of the growth factor-independent myeloid leukemic cell line KG1.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Calcium-Calmodulin-Depe | 1998 |
Role of Ras/ERK-dependent pathway in the erythroid differentiation of K562 cells.
Topics: Androstadienes; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; E | 1999 |
Differential effects of interleukin-3 and interleukin-1 on the proliferation and interleukin-6 protein secretion of acute myeloid leukemic cells; the involvement of ERK, p38 and STAT5.
Topics: Acute Disease; Cell Division; DNA; DNA-Binding Proteins; Flavonoids; Humans; I-kappa B Proteins; Imi | 1999 |
Myeloid leukemia cell growth and differentiation are independent of mitogen-activated protein kinase ERK1/2 activation.
Topics: Cell Differentiation; Cell Division; Enzyme Activation; Flavonoids; Humans; Leukemia, Myeloid; Lysop | 2000 |
The MEK inhibitor, PD98059, reduces survival but does not block acute myeloid leukemia blast maturation in vitro.
Topics: Acute Disease; Adult; Aged; bcl-2-Associated X Protein; Calcium-Calmodulin-Dependent Protein Kinases | 2000 |
Tumor necrosis factor-alpha-induced proliferation requires synthesis of granulocyte-macrophage colony-stimulating factor.
Topics: Apoptosis; Cell Division; Cytokines; Enzyme Inhibitors; Flavonoids; Granulocyte-Macrophage Colony-St | 2000 |
Induction of differentiation of human myeloid leukemia cells by novel synthetic neurotrophic pyrimidine derivatives.
Topics: Calcitriol; Cell Differentiation; Cell Division; Enzyme Activation; Enzyme Inhibitors; Flavonoids; G | 2001 |
Inhibition of extracellular signal-regulated kinase (ERK) mediates cell cycle phase independent apoptosis in vinblastine-treated ML-1 cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase Inhibitors; Cell Cycle; Drug Synergism; Enzyme | 2001 |
Induction of the monocytic differentiation of myeloid leukaemia cells by cotylenin A, a plant growth regulator.
Topics: Androstadienes; Antineoplastic Agents; Biomarkers; Cell Differentiation; Diterpenes; Enzyme Inhibito | 2001 |
TGF beta-induced SMAD2 phosphorylation predicts inhibition of thymidine incorporation in CD34+ cells from healthy donors, but not from patients with AML after MDS.
Topics: Acute Disease; Adult; Antigens, CD34; Cell Division; Disease Progression; DNA Replication; DNA-Bindi | 2001 |
c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for mitoxantrone- and anisomycin-induced apoptosis in HL-60 cells.
Topics: Anisomycin; Antineoplastic Agents; Apoptosis; Blotting, Western; DNA, Neoplasm; Flavonoids; HL-60 Ce | 2002 |