pd 98059 has been researched along with Granulocytic Leukemia, Chronic in 7 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The growth of maturing chronic myeloid leukemia cells is independent of BCR-ABL in the presence of growth factors." | 1.31 | The tyrosine kinase inhibitor CGP 57148 (ST1 571) induces apoptosis in BCR-ABL-positive cells by down-regulating BCL-X. ( Aulitzky, WE; Duyster, J; Götz, A; Hallek, M; Jonuleit, T; Michels, H; Oetzel, C; van der Kuip, H, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Borges, CS | 1 |
| Ferreira, AF | 1 |
| Almeida, VH | 1 |
| Gomes, FG | 1 |
| Berzoti-Coelho, MG | 1 |
| Cacemiro, MDC | 1 |
| Nunes, NS | 1 |
| Figueiredo-Pontes, LL | 1 |
| Simões, BP | 1 |
| Castro, FA | 1 |
| Monteiro, RQ | 1 |
| Pal, P | 1 |
| Kanaujiya, JK | 1 |
| Lochab, S | 1 |
| Tripathi, SB | 1 |
| Bhatt, ML | 1 |
| Singh, PK | 1 |
| Sanyal, S | 1 |
| Trivedi, AK | 1 |
| Huang, Q | 1 |
| Yang, Y | 1 |
| Li, X | 1 |
| Huang, S | 1 |
| Yang, KT | 1 |
| Wang, MC | 1 |
| Chen, JY | 1 |
| Hsu, MC | 1 |
| Hung, WC | 1 |
| Klejman, A | 1 |
| Rushen, L | 1 |
| Morrione, A | 1 |
| Slupianek, A | 1 |
| Skorski, T | 1 |
| Jin, L | 1 |
| Kato, A | 1 |
| Tabe, Y | 1 |
| Oetzel, C | 1 |
| Jonuleit, T | 1 |
| Götz, A | 1 |
| van der Kuip, H | 1 |
| Michels, H | 1 |
| Duyster, J | 1 |
| Hallek, M | 1 |
| Aulitzky, WE | 1 |
7 other studies available for pd 98059 and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
Crosstalk between BCR-ABL and protease-activated receptor 1 (PAR1) suggests a novel target in chronic myeloid leukemia.
Topics: Adult; Aged; Antineoplastic Agents; Apoptosis; Case-Control Studies; Cell Line, Tumor; Chromones; Di | 2018 |
2-D gel electrophoresis-based proteomic analysis reveals that ormeloxifen induces G0-G1 growth arrest and ERK-mediated apoptosis in chronic myeloid leukemia cells K562.
Topics: Apoptosis; Benzopyrans; Caspase 3; Cyclin-Dependent Kinase Inhibitor p21; DNA-Binding Proteins; Elec | 2011 |
Transcription suppression of SARI (suppressor of AP-1, regulated by IFN) by BCR-ABL in human leukemia cells.
Topics: Adolescent; Adult; Aged; Apoptosis; Basic-Leucine Zipper Transcription Factors; Benzamides; Blotting | 2011 |
Bcr-Abl oncogene stimulates Jab1 expression via cooperative interaction of β-catenin and STAT1 in chronic myeloid leukemia cells.
Topics: Antineoplastic Agents; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Benzamides; beta | 2011 |
Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571.
Topics: Androstadienes; Antineoplastic Agents; Benzamides; Caspase 3; Caspases; Chromones; Drug Synergism; E | 2002 |
[The anti-tumoral effect of PI3K inhibitor and MEK inhibitor combined with STI571 on chronic myeloid leukemia cells in a bone marrow stromal cell co-culture system].
Topics: Antineoplastic Agents; Apoptosis; Benzamides; Bone Marrow Cells; Cell Proliferation; Chromones; Cocu | 2006 |
The tyrosine kinase inhibitor CGP 57148 (ST1 571) induces apoptosis in BCR-ABL-positive cells by down-regulating BCL-X.
Topics: Animals; Apoptosis; bcl-X Protein; Benzamides; Caspase 3; Caspases; Cell Count; Cell Division; Chrom | 2000 |