pd 98059 has been researched along with Glioma in 39 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, we investigated the anticancer potentials of Rhein, an anthraquinone derivative of most commonly used Chinese rhubarb on the rat F98 glioma cells." | 7.85 | Rhein induces apoptosis and autophagy in human and rat glioma cells and mediates cell differentiation by ERK inhibition. ( Chang, J; Cheng, HL; Lu, HC; Rao, J; Shi, JX; Tang, N; Zhuang, Z, 2017) |
| " We studied the involvement of mitogen-activated protein (MAP) kinase in hypoxia-induced apoptosis using cobalt chloride in C6 glioma cells." | 7.72 | Cobalt chloride-induced apoptosis and extracellular signal-regulated protein kinase 1/2 activation in rat C6 glioma cells. ( Kim, T; Kim, Y; Lee, H; Lee, I; Pyen, J; Yang, SJ, 2004) |
| "We have recently shown that endothelin-1 activates two types of Ca2+-permeable nonselective cation channels (NSCC-1 and NSCC-2) in C6 glioma cells." | 7.71 | Effects of extracellular Ca2+ influx on endothelin-1-induced intracellular mitogenic cascades in C6 glioma cells. ( Hashimoto, N; Kawanabe, Y; Masaki, T, 2002) |
| "Exposure of C6 glioma cells to endothelin-1 (ET-1) caused dose-dependent (10(-11) M to 10(-7) M) increments in intracellular calcium concentration ([Ca2+]i) and c-fos mRNA expression (4." | 7.70 | Endothelin-1 stimulates c-fos mRNA expression in C6 glioma cells via MAP kinase pathway. ( Leach, K; Mulholland, MW; Turner, D; Zhang, W, 1999) |
| " Here we show that the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells due to phospholipid hydrolysis by phospholipase D (PLD) is not inhibited by rapamycin or PD98059, specific inhibitors respectively of p70 S6 kinase and MAPKK (MEK) and thus of MAPKAP kinase-1beta but is still completely blocked by Ro31-8220." | 7.69 | Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD. ( Beale, G; Mallon, B; Morreale, A; Rumsby, M; Watson, J, 1997) |
| "Notably, co-treatment of C6 glioma cells with 400 µmol/l NaHS and AOAA (an inhibitor of CBS) largely suppressed the above NaHS-induced effects." | 5.42 | Exogenous hydrogen sulfide promotes C6 glioma cell growth through activation of the p38 MAPK/ERK1/2-COX-2 pathways. ( Chen, J; Feng, J; Guo, R; He, J; Liu, C; Lu, Y; Zhang, W; Zhang, Y; Zhen, Y, 2015) |
| "Glioma is the most common type of brain tumor, and has the worst prognosis in human malignancy." | 5.38 | L-Leucine induces growth arrest and persistent ERK activation in glioma cells. ( Matsuo, H; Nawashiro, H; Nomura, N; Osada, H; Otani, N; Shinomiya, N; Takeuchi, S; Toyooka, T; Wada, K, 2012) |
| "Baicalein is a flavonoid derived from the Scutellaria root." | 5.32 | Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells. ( Nakahata, N; Nakatani, K; Ohizumi, Y; Ohkubo, S; Tsuchiya, C, 2003) |
| "Substance P is a member of the tachykinin family of neuropeptides that plays an important role in pain transmission, neurogenic inflammatory diseases and the adaptive response to stress." | 5.31 | Substance P induced biosynthesis of the zinc finger transcription factor Egr-1 in human glioma cells requires activation of the epidermal growth factor receptor and of extracellular signal-regulated protein kinase. ( Al-Sarraj, A; Thiel, G, 2002) |
| "Lanthanum(III)chloride was also able to increase the net zinc uptake, but nevertheless apoptotic features and zinc toxicity were reduced." | 5.31 | Zinc induces apoptosis that can be suppressed by lanthanum in C6 rat glioma cells. ( Beyersmann, D; Haase, H; Wätjen, W, 2001) |
| "In this study, we investigated the anticancer potentials of Rhein, an anthraquinone derivative of most commonly used Chinese rhubarb on the rat F98 glioma cells." | 3.85 | Rhein induces apoptosis and autophagy in human and rat glioma cells and mediates cell differentiation by ERK inhibition. ( Chang, J; Cheng, HL; Lu, HC; Rao, J; Shi, JX; Tang, N; Zhuang, Z, 2017) |
| "Treatment of rat glioma C6 cells with the beta-receptor agonist isoproterenol induces a massive increase in cAMP." | 3.74 | Volatile anesthetics affect the morphology of rat glioma C6 cells via RhoA, ERK, and Akt activation. ( Gambaryan, S; Roewer, N; Tas, PW, 2007) |
| "The present study describes the ability of an anthraquinone derivative aloe emodin (AE) to reduce the cytotoxic activity of the platinum(II)-based anticancer agent cisplatin toward murine L929 fibrosarcoma and C6 glioma cell lines." | 3.73 | Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin. ( Kaludjerovic, GN; Maksimovic-Ivanic, D; Mijatovic, S; Miljkovic, D; Radovic, J; Sabo, TJ; Trajkovic, V, 2005) |
| " In this study, we investigated the effect of chemically unrelated NSAIDs in the proliferation of glioma cell lines and the possible mechanisms involved in indomethacin-mediated inhibition of proliferation in glioma cells lines." | 3.73 | Nonsteroidal anti-inflammatory drugs inhibit the growth of C6 and U138-MG glioma cell lines. ( Battastini, AM; Bernardi, A; Delgado-Cañedo, A; Jacques-Silva, MC; Lenz, G, 2006) |
| " We studied the involvement of mitogen-activated protein (MAP) kinase in hypoxia-induced apoptosis using cobalt chloride in C6 glioma cells." | 3.72 | Cobalt chloride-induced apoptosis and extracellular signal-regulated protein kinase 1/2 activation in rat C6 glioma cells. ( Kim, T; Kim, Y; Lee, H; Lee, I; Pyen, J; Yang, SJ, 2004) |
| " The dissociation of Hsp27 induced by exposure of U251 MG human glioma cells to metals (NaAsO2 and CdCl2), hypertonic stress (sorbitol and NaCI), or anisomycin, an activator of p38 mitogen-activated protein (MAP) kinase, was completely suppressed by the presence of SB 203580 or PD 169316, inhibitors of p38 MAP kinase, but not by PD 98059 and Uo 126, inhibitors of MAP kinase kinase (MEK), nor by staurosporine, Go 6983, and bisindolylmaleimide I, inhibitors of protein kinase C." | 3.71 | Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27. ( Inaguma, Y; Ito, H; Iwamoto, I; Kato, K; Lida, K, 2001) |
| "We have recently shown that endothelin-1 activates two types of Ca2+-permeable nonselective cation channels (NSCC-1 and NSCC-2) in C6 glioma cells." | 3.71 | Effects of extracellular Ca2+ influx on endothelin-1-induced intracellular mitogenic cascades in C6 glioma cells. ( Hashimoto, N; Kawanabe, Y; Masaki, T, 2002) |
| "Exposure of C6 glioma cells to endothelin-1 (ET-1) caused dose-dependent (10(-11) M to 10(-7) M) increments in intracellular calcium concentration ([Ca2+]i) and c-fos mRNA expression (4." | 3.70 | Endothelin-1 stimulates c-fos mRNA expression in C6 glioma cells via MAP kinase pathway. ( Leach, K; Mulholland, MW; Turner, D; Zhang, W, 1999) |
| "In rat type I astrocytes and C6 glioma cells, sphingosine 1-phosphate (S1P) clearly induced the expression of fibroblast growth factor-2 (FGF-2) mRNA to an extent comparable to that achieved by platelet-derived growth factor (PDGF) and endothelin." | 3.70 | Sphingosine 1-phosphate induces expression of early growth response-1 and fibroblast growth factor-2 through mechanism involving extracellular signal-regulated kinase in astroglial cells. ( Ishikawa, K; Okajima, F; Sato, K; Ui, M, 1999) |
| " Here we show that the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells due to phospholipid hydrolysis by phospholipase D (PLD) is not inhibited by rapamycin or PD98059, specific inhibitors respectively of p70 S6 kinase and MAPKK (MEK) and thus of MAPKAP kinase-1beta but is still completely blocked by Ro31-8220." | 3.69 | Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD. ( Beale, G; Mallon, B; Morreale, A; Rumsby, M; Watson, J, 1997) |
| "Notably, co-treatment of C6 glioma cells with 400 µmol/l NaHS and AOAA (an inhibitor of CBS) largely suppressed the above NaHS-induced effects." | 1.42 | Exogenous hydrogen sulfide promotes C6 glioma cell growth through activation of the p38 MAPK/ERK1/2-COX-2 pathways. ( Chen, J; Feng, J; Guo, R; He, J; Liu, C; Lu, Y; Zhang, W; Zhang, Y; Zhen, Y, 2015) |
| "Glioma is the most common type of brain tumor, and has the worst prognosis in human malignancy." | 1.38 | L-Leucine induces growth arrest and persistent ERK activation in glioma cells. ( Matsuo, H; Nawashiro, H; Nomura, N; Osada, H; Otani, N; Shinomiya, N; Takeuchi, S; Toyooka, T; Wada, K, 2012) |
| "Baicalein is a flavonoid derived from the Scutellaria root." | 1.32 | Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells. ( Nakahata, N; Nakatani, K; Ohizumi, Y; Ohkubo, S; Tsuchiya, C, 2003) |
| "Substance P is a member of the tachykinin family of neuropeptides that plays an important role in pain transmission, neurogenic inflammatory diseases and the adaptive response to stress." | 1.31 | Substance P induced biosynthesis of the zinc finger transcription factor Egr-1 in human glioma cells requires activation of the epidermal growth factor receptor and of extracellular signal-regulated protein kinase. ( Al-Sarraj, A; Thiel, G, 2002) |
| "Lanthanum(III)chloride was also able to increase the net zinc uptake, but nevertheless apoptotic features and zinc toxicity were reduced." | 1.31 | Zinc induces apoptosis that can be suppressed by lanthanum in C6 rat glioma cells. ( Beyersmann, D; Haase, H; Wätjen, W, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (20.51) | 18.2507 |
| 2000's | 23 (58.97) | 29.6817 |
| 2010's | 8 (20.51) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tang, N | 1 |
| Chang, J | 1 |
| Lu, HC | 1 |
| Zhuang, Z | 1 |
| Cheng, HL | 1 |
| Shi, JX | 1 |
| Rao, J | 1 |
| Sun, H | 1 |
| Yang, B | 1 |
| Zhang, H | 1 |
| Song, J | 1 |
| Zhang, Y | 3 |
| Xing, J | 1 |
| Yang, Z | 1 |
| Wei, C | 1 |
| Xu, T | 1 |
| Yu, Z | 1 |
| Xu, Z | 1 |
| Hou, M | 1 |
| Ji, M | 1 |
| Zhen, Y | 1 |
| Zhang, W | 2 |
| Liu, C | 1 |
| He, J | 1 |
| Lu, Y | 1 |
| Guo, R | 1 |
| Feng, J | 1 |
| Chen, J | 1 |
| Zheng, Y | 1 |
| Lin, L | 1 |
| Zheng, Z | 1 |
| Nabissi, M | 1 |
| Morelli, MB | 1 |
| Amantini, C | 1 |
| Farfariello, V | 1 |
| Ricci-Vitiani, L | 1 |
| Caprodossi, S | 1 |
| Arcella, A | 1 |
| Santoni, M | 1 |
| Giangaspero, F | 1 |
| De Maria, R | 1 |
| Santoni, G | 1 |
| Hueng, DY | 1 |
| Lin, GJ | 1 |
| Huang, SH | 1 |
| Liu, LW | 1 |
| Ju, DT | 1 |
| Chen, YW | 1 |
| Sytwu, HK | 1 |
| Chang, C | 1 |
| Huang, SM | 1 |
| Yeh, YS | 1 |
| Lee, HM | 1 |
| Ma, HI | 1 |
| Wu, J | 1 |
| Chien, CC | 1 |
| Yang, LY | 1 |
| Huang, GC | 1 |
| Cheng, MC | 1 |
| Lin, CT | 1 |
| Shen, SC | 1 |
| Chen, YC | 1 |
| Takeuchi, S | 1 |
| Nawashiro, H | 1 |
| Wada, K | 1 |
| Nomura, N | 1 |
| Toyooka, T | 1 |
| Otani, N | 1 |
| Osada, H | 1 |
| Matsuo, H | 1 |
| Shinomiya, N | 1 |
| Yang, XJ | 1 |
| Chen, GL | 1 |
| Yu, SC | 1 |
| Xu, C | 1 |
| Xin, YH | 1 |
| Li, TT | 1 |
| Shi, Y | 1 |
| Gu, A | 1 |
| Duan, JJ | 1 |
| Qian, C | 1 |
| Cui, YH | 1 |
| Zhang, X | 1 |
| Bian, XW | 1 |
| Al-Sarraj, A | 1 |
| Thiel, G | 1 |
| Nakahata, N | 2 |
| Tsuchiya, C | 1 |
| Nakatani, K | 1 |
| Ohizumi, Y | 2 |
| Ohkubo, S | 1 |
| Annabi, B | 1 |
| Thibeault, S | 1 |
| Moumdjian, R | 1 |
| Béliveau, R | 1 |
| Yang, SJ | 1 |
| Pyen, J | 1 |
| Lee, I | 1 |
| Lee, H | 1 |
| Kim, Y | 1 |
| Kim, T | 1 |
| Ma, G | 1 |
| Chen, S | 1 |
| Wang, X | 1 |
| Ba, M | 1 |
| Yang, H | 1 |
| Lu, G | 1 |
| Mijatovic, S | 1 |
| Maksimovic-Ivanic, D | 1 |
| Radovic, J | 1 |
| Miljkovic, D | 1 |
| Kaludjerovic, GN | 1 |
| Sabo, TJ | 1 |
| Trajkovic, V | 1 |
| Bernardi, A | 1 |
| Jacques-Silva, MC | 1 |
| Delgado-Cañedo, A | 1 |
| Lenz, G | 1 |
| Battastini, AM | 1 |
| Song, H | 1 |
| Moon, A | 1 |
| Tas, PW | 1 |
| Gambaryan, S | 1 |
| Roewer, N | 1 |
| Peng, CH | 1 |
| Huang, CN | 1 |
| Hsu, SP | 1 |
| Wang, CJ | 1 |
| Nishiya, T | 1 |
| Uehara, T | 1 |
| Edamatsu, H | 1 |
| Kaziro, Y | 1 |
| Itoh, H | 1 |
| Nomura, Y | 1 |
| Van Brocklyn, JR | 1 |
| Vandenheede, JR | 1 |
| Fertel, R | 1 |
| Yates, AJ | 1 |
| Rampersaud, AA | 1 |
| Morreale, A | 1 |
| Mallon, B | 1 |
| Beale, G | 1 |
| Watson, J | 1 |
| Rumsby, M | 1 |
| Adamczyk, M | 1 |
| Scherrer, E | 1 |
| Kupferberg, A | 1 |
| Malviya, AN | 1 |
| Mersel, M | 1 |
| Kutsuwa, M | 1 |
| Kyo, R | 1 |
| Kubo, M | 1 |
| Hayashi, K | 1 |
| Leach, K | 1 |
| Turner, D | 1 |
| Mulholland, MW | 1 |
| Imura, T | 1 |
| Shimohama, S | 1 |
| Kageyama, T | 1 |
| Kimura, J | 1 |
| Sato, K | 1 |
| Ishikawa, K | 1 |
| Ui, M | 1 |
| Okajima, F | 1 |
| Tu, MT | 1 |
| Luo, SF | 1 |
| Wang, CC | 1 |
| Chien, CS | 1 |
| Chiu, CT | 1 |
| Lin, CC | 1 |
| Yang, CM | 1 |
| Shinohara, H | 1 |
| Yagita, H | 1 |
| Ikawa, Y | 1 |
| Oyaizu, N | 1 |
| Leirdal, M | 1 |
| Sioud, M | 1 |
| Won, JS | 1 |
| Lee, JK | 1 |
| Suh, HW | 1 |
| Lakka, SS | 1 |
| Jasti, SL | 1 |
| Kyritsis, AP | 1 |
| Yung, WK | 1 |
| Ali-Osman, F | 1 |
| Nicolson, GL | 1 |
| Rao, JS | 1 |
| Roymans, D | 1 |
| Grobben, B | 1 |
| Claes, P | 1 |
| Slegers, H | 1 |
| Park, JS | 1 |
| Qiao, L | 1 |
| Su, ZZ | 1 |
| Hinman, D | 1 |
| Willoughby, K | 1 |
| McKinstry, R | 1 |
| Yacoub, A | 1 |
| Duigou, GJ | 1 |
| Young, CS | 1 |
| Grant, S | 1 |
| Hagan, MP | 1 |
| Ellis, E | 1 |
| Fisher, PB | 1 |
| Dent, P | 1 |
| Kato, K | 1 |
| Ito, H | 1 |
| Iwamoto, I | 1 |
| Lida, K | 1 |
| Inaguma, Y | 1 |
| Ramer, R | 1 |
| Brune, K | 1 |
| Pahl, A | 1 |
| Hinz, B | 1 |
| Haase, H | 1 |
| Wätjen, W | 1 |
| Beyersmann, D | 1 |
| Meyer, RG | 1 |
| Küpper, JH | 1 |
| Kandolf, R | 1 |
| Rodemann, HP | 1 |
| Kawanabe, Y | 1 |
| Hashimoto, N | 1 |
| Masaki, T | 1 |
39 other studies available for pd 98059 and Glioma
| Article | Year |
|---|---|
Rhein induces apoptosis and autophagy in human and rat glioma cells and mediates cell differentiation by ERK inhibition.
Topics: Animals; Anthraquinones; Apoptosis; Autophagy; Caspases; Cell Cycle; Cell Cycle Checkpoints; Cell Di | 2017 |
RRM2 is a potential prognostic biomarker with functional significance in glioma.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Flavonoids; Flow | 2019 |
Exogenous hydrogen sulfide promotes C6 glioma cell growth through activation of the p38 MAPK/ERK1/2-COX-2 pathways.
Topics: Animals; Brain Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclo | 2015 |
TGF-alpha induces upregulation and nuclear translocation of Hes1 in glioma cell.
Topics: Active Transport, Cell Nucleus; Amyloid Precursor Protein Secretases; Basic Helix-Loop-Helix Transcr | 2008 |
TRPV2 channel negatively controls glioma cell proliferation and resistance to Fas-induced apoptosis in ERK-dependent manner.
Topics: Apoptosis; bcl-X Protein; Cell Line, Tumor; Cell Proliferation; Extracellular Signal-Regulated MAP K | 2010 |
Inhibition of Nodal suppresses angiogenesis and growth of human gliomas.
Topics: Analysis of Variance; Animals; Benzamides; Brain Neoplasms; Cell Line, Transformed; Cell Proliferati | 2011 |
Vitamin K3-2,3-epoxide induction of apoptosis with activation of ROS-dependent ERK and JNK protein phosphorylation in human glioma cells.
Topics: Acetylcysteine; Anthracenes; Antineoplastic Agents; Apoptosis; Caspase 3; Caspase Inhibitors; Cell L | 2011 |
L-Leucine induces growth arrest and persistent ERK activation in glioma cells.
Topics: Amino Acids, Cyclic; Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, T | 2012 |
TGF-β1 enhances tumor-induced angiogenesis via JNK pathway and macrophage infiltration in an improved zebrafish embryo/xenograft glioma model.
Topics: Angiogenesis Inhibitors; Animals; Animals, Genetically Modified; Anthracenes; Cell Line, Tumor; Cell | 2013 |
Substance P induced biosynthesis of the zinc finger transcription factor Egr-1 in human glioma cells requires activation of the epidermal growth factor receptor and of extracellular signal-regulated protein kinase.
Topics: Culture Media, Serum-Free; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Inhibitors; | 2002 |
Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells.
Topics: Animals; Cell-Free System; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavan | 2003 |
Hyaluronan cell surface binding is induced by type I collagen and regulated by caveolae in glioma cells.
Topics: beta-Cyclodextrins; Caveolae; Cell Line, Tumor; Cell Membrane; Cholesterol; Collagen Type I; Colorin | 2004 |
Cobalt chloride-induced apoptosis and extracellular signal-regulated protein kinase 1/2 activation in rat C6 glioma cells.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Nucleus; Cell Size; Cobalt; DNA Fragmentation; DNA-Bindin | 2004 |
Short-term interleukin-1(beta) increases the release of secreted APP(alpha) via MEK1/2-dependent and JNK-dependent alpha-secretase cleavage in neuroglioma U251 cells.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Anthracenes; Aspartic Acid End | 2005 |
Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin.
Topics: Animals; Anthraquinones; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Cisplati | 2005 |
Nonsteroidal anti-inflammatory drugs inhibit the growth of C6 and U138-MG glioma cell lines.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Cell Proliferatio | 2006 |
Glial cell-derived neurotrophic factor (GDNF) promotes low-grade Hs683 glioma cell migration through JNK, ERK-1/2 and p38 MAPK signaling pathways.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Movement; Enzyme Activation; Enzyme Inhibitors; Flavonoids; | 2006 |
Volatile anesthetics affect the morphology of rat glioma C6 cells via RhoA, ERK, and Akt activation.
Topics: Adrenergic beta-Agonists; Amides; Anesthetics, Inhalation; Animals; Cell Line, Tumor; Cell Shape; Cu | 2007 |
Penta-acetyl geniposide-induced apoptosis involving transcription of NGF/p75 via MAPK-mediated AP-1 activation in C6 glioma cells.
Topics: Animals; Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Cell Line, T | 2007 |
Activation of Stat1 and subsequent transcription of inducible nitric oxide synthase gene in C6 glioma cells is independent of interferon-gamma-induced MAPK activation that is mediated by p21ras.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; DNA; DNA-Binding Proteins; Enzyme Activation; | 1997 |
Ganglioside GM1 activates the mitogen-activated protein kinase Erk2 and p70 S6 kinase in U-1242 MG human glioma cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Colforsin; Cyclic AMP; DNA; Enzyme Activation; Enzyme | 1997 |
Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD.
Topics: Androstadienes; Animals; Choline; Enzyme Inhibitors; Ethanolamine; Flavonoids; Glioma; Indoles; Phos | 1997 |
Inhibition of p42/p44 mitogen-activated protein kinase by oxysterols in rat astrocyte primary cultures and C6 glioma cell lines.
Topics: Animals; Astrocytes; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; | 1998 |
Analysis of inhibitory effects of scutellariae radix and baicalein on prostaglandin E2 production in rat C6 glioma cells.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Arachidonic Acid; Calcimycin; Calcium-Calmoduli | 1998 |
Endothelin-1 stimulates c-fos mRNA expression in C6 glioma cells via MAP kinase pathway.
Topics: Alkaloids; Benzophenanthridines; Calcium-Calmodulin-Dependent Protein Kinases; Endothelin-1; Enzyme | 1999 |
Selective induction of glial glutamate transporter GLT-1 by hypertonic stress in C6 glioma cells.
Topics: Alkaloids; Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Benzophenan | 1999 |
Sphingosine 1-phosphate induces expression of early growth response-1 and fibroblast growth factor-2 through mechanism involving extracellular signal-regulated kinase in astroglial cells.
Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; DNA-Binding Proteins; Early Growth Response | 1999 |
P2Y(2) receptor-mediated proliferation of C(6) glioma cells via activation of Ras/Raf/MEK/MAPK pathway.
Topics: Adenosine Triphosphate; Animals; Calcium; Cell Division; DNA; Enzyme Activation; Enzyme Inhibitors; | 2000 |
Fas drives cell cycle progression in glioma cells via extracellular signal-regulated kinase activation.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; Aspartic Acid; Caspase Inhibitors; Caspases; Cell Cycle; | 2000 |
Protein kinase Calpha isoform regulates the activation of the MAP kinase ERK1/2 in human glioma cells: involvement in cell survival and gene expression.
Topics: Blotting, Western; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Extracellular Matrix; Fibrob | 2000 |
Forskolin inhibits expression of inducible nitric oxide synthase mRNA via inhibiting the mitogen activated protein kinase in C6 cells.
Topics: Animals; Colforsin; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinase | 2001 |
Regulation of MMP-9 (type IV collagenase) production and invasiveness in gliomas by the extracellular signal-regulated kinase and jun amino-terminal kinase signaling cascades.
Topics: Brain Neoplasms; Enzyme Inhibitors; Flavonoids; Glioma; Humans; JNK Mitogen-Activated Protein Kinase | 2000 |
Protein tyrosine kinase-dependent regulation of adenylate cyclase and phosphatidylinositol 3-kinase activates the expression of glial fibrillary acidic protein upon induction of differentiation in rat c6 glioma.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Androstadienes; Animals; Anti-Bacterial Agents; Benzoqu | 2001 |
Ionizing radiation modulates vascular endothelial growth factor (VEGF) expression through multiple mitogen activated protein kinase dependent pathways.
Topics: Amino Acid Chloromethyl Ketones; Animals; Antigens, Differentiation; Apoptosis; Astrocytes; Cell Sur | 2001 |
Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27.
Topics: Anisomycin; Arsenites; Butadienes; Cadmium Chloride; Carcinogens; Dithiothreitol; Enzyme Inhibitors; | 2001 |
R(+)-methanandamide induces cyclooxygenase-2 expression in human neuroglioma cells via a non-cannabinoid receptor-mediated mechanism.
Topics: Analgesics, Non-Narcotic; Arachidonic Acids; Blotting, Western; Brain Neoplasms; Cannabinoid Recepto | 2001 |
Zinc induces apoptosis that can be suppressed by lanthanum in C6 rat glioma cells.
Topics: Aminoquinolines; Animals; Apoptosis; Central Nervous System Neoplasms; Cycloheximide; DNA Fragmentat | 2001 |
Early growth response-1 gene (Egr-1) promoter induction by ionizing radiation in U87 malignant glioma cells in vitro.
Topics: Androstadienes; Anisomycin; Blotting, Western; Colforsin; DNA-Binding Proteins; Early Growth Respons | 2002 |
Effects of extracellular Ca2+ influx on endothelin-1-induced intracellular mitogenic cascades in C6 glioma cells.
Topics: Acetamides; Animals; Brain Neoplasms; Calcium; Calcium Channel Blockers; Calcium Channels; DNA; Drug | 2002 |